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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for e2f2_e2f5
Z-value: 1.55
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Transcription factors associated with e2f2_e2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e2f5 | dr11_v1_chr2_-_31686353_31686403 | 0.55 | 6.9e-09 | Click! |
| E2F2 | dr11_v1_chr17_-_27266053_27266053 | 0.43 | 1.7e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_2892250 Show fit | 19.74 |
ENSDART00000140695
|
cell division cycle associated 7a |
|
| chr3_-_54607166 Show fit | 17.93 |
ENSDART00000021977
|
DNA (cytosine-5-)-methyltransferase 1 |
|
| chr13_+_8255106 Show fit | 14.28 |
ENSDART00000080465
|
helicase, lymphoid specific |
|
| chr11_-_11792766 Show fit | 13.90 |
ENSDART00000011657
|
cell division cycle 6 homolog (S. cerevisiae) |
|
| chr20_+_39344889 Show fit | 13.89 |
ENSDART00000009164
|
establishment of sister chromatid cohesion N-acetyltransferase 2 |
|
| chr3_+_25999477 Show fit | 10.94 |
ENSDART00000024316
|
minichromosome maintenance complex component 5 |
|
| chr19_-_47571797 Show fit | 10.22 |
ENSDART00000166180
ENSDART00000168134 |
ribonucleotide reductase M2 polypeptide |
|
| chr24_-_35561672 Show fit | 9.86 |
ENSDART00000058564
|
minichromosome maintenance complex component 4 |
|
| chr13_-_13030851 Show fit | 8.83 |
ENSDART00000009499
|
nuclear receptor binding SET domain protein 2 |
|
| chr1_+_19538299 Show fit | 8.43 |
ENSDART00000109416
|
structural maintenance of chromosomes 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of e2f2_e2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 37.6 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 3.0 | 32.7 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.8 | 29.7 | GO:0048538 | thymus development(GO:0048538) |
| 2.3 | 29.3 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 1.8 | 24.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 2.9 | 20.5 | GO:1902292 | cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975) |
| 2.4 | 19.4 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 2.4 | 17.0 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 4.6 | 13.9 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 2.9 | 8.8 | GO:0097676 | histone H3-K36 dimethylation(GO:0097676) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 112.1 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 43.5 | GO:0005829 | cytosol(GO:0005829) |
| 1.8 | 33.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 26.1 | GO:0005730 | nucleolus(GO:0005730) |
| 2.1 | 23.0 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 17.7 | GO:0000785 | chromatin(GO:0000785) |
| 2.4 | 16.9 | GO:0031261 | DNA replication preinitiation complex(GO:0031261) |
| 0.0 | 9.7 | GO:0042175 | endoplasmic reticulum membrane(GO:0005789) nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175) |
| 0.2 | 7.1 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 1.3 | 6.6 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 64.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 3.9 | 27.3 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.4 | 20.9 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 1.4 | 18.6 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 2.0 | 14.0 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.1 | 13.7 | GO:0016407 | acetyltransferase activity(GO:0016407) |
| 0.1 | 10.3 | GO:0042393 | histone binding(GO:0042393) |
| 0.6 | 9.6 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.0 | 9.3 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 1.8 | 7.2 | GO:0070182 | DNA polymerase binding(GO:0070182) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 77.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 14.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 13.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 1.1 | 12.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.4 | 12.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 6.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 5.7 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.2 | 4.7 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 3.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 44.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 3.1 | 42.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 2.8 | 42.4 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 1.9 | 17.0 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.6 | 8.7 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.8 | 8.6 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 4.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 3.7 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.4 | 3.3 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 3.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |