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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for e2f4

Z-value: 0.58

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Transcription factors associated with e2f4

Gene Symbol Gene ID Gene Info
e2f4
ENSDARG00000101578 E2F transcription factor 4
e2f4
ENSDARG00000109320 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f4dr11_v1_chr25_+_17405458_17405458-0.643.9e-12Click!

Activity profile of e2f4 motif

Sorted Z-values of e2f4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_24814866 7.14 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr19_-_48391415 7.07 ENSDART00000170726
ENSDART00000169577
si:ch73-359m17.2
si:ch73-359m17.2
chr10_+_6884123 4.56 ENSDART00000149095
ENSDART00000148772
ENSDART00000149334
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr25_+_192116 3.62 ENSDART00000153983
zgc:114188
zgc:114188
chr4_-_75175407 3.36 ENSDART00000180125
CABZ01043953.1

chr14_+_94603 3.18 ENSDART00000162480
mcm7
minichromosome maintenance complex component 7
chr22_+_3153876 3.05 ENSDART00000163327
rpl36
ribosomal protein L36
chr20_+_35445462 2.98 ENSDART00000124497
tdrd6
tudor domain containing 6
chr4_-_17725008 2.91 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr7_-_6429031 2.81 ENSDART00000173413
zgc:112234
zgc:112234
chr7_+_24881680 2.80 ENSDART00000058843
krcp
kelch repeat-containing protein
chr24_+_21621654 2.71 ENSDART00000002595
rpl21
ribosomal protein L21
chr16_+_54780544 2.58 ENSDART00000126646
si:zfos-1192g2.3
si:zfos-1192g2.3
chr25_-_35124576 2.56 ENSDART00000128017
zgc:171759
zgc:171759
chr23_-_45568816 2.34 ENSDART00000076086
cyp17a2
cytochrome P450, family 17, subfamily A, polypeptide 2
chr11_-_45152702 2.32 ENSDART00000168066
afmid
arylformamidase
chr7_-_6415991 2.20 ENSDART00000173349
CU457819.3
Histone H3.2
chr17_-_15189397 2.13 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr25_-_774350 2.08 ENSDART00000166321
ENSDART00000160386
IRAK4
interleukin 1 receptor associated kinase 4
chr3_+_58119571 2.02 ENSDART00000108979
si:ch211-256e16.4
si:ch211-256e16.4
chr7_-_6459481 2.02 ENSDART00000173158
zgc:112234
zgc:112234
chr7_-_6345507 2.01 ENSDART00000173032
CU457819.4
Histone H3.2
chr11_+_31680513 2.01 ENSDART00000139900
ENSDART00000040305
diaph3
diaphanous-related formin 3
chr25_+_35067318 1.98 ENSDART00000186828
CU302436.1

chr3_-_61592417 1.93 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr25_-_36370292 1.92 ENSDART00000152766
CR354435.1
Histone H2B 1/2
chr25_-_35109536 1.86 ENSDART00000185229
CU302436.5

chr10_+_6010570 1.76 ENSDART00000190025
ENSDART00000163680
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr7_+_5960491 1.66 ENSDART00000145370
zgc:112234
zgc:112234
chr25_+_35155676 1.63 ENSDART00000114598
zgc:112234
zgc:112234
chr7_-_73854476 1.57 ENSDART00000186481
zgc:173552
zgc:173552
chr14_+_94946 1.57 ENSDART00000165766
ENSDART00000163778
mcm7
minichromosome maintenance complex component 7
chr10_+_406146 1.55 ENSDART00000145124
dact3a
dishevelled-binding antagonist of beta-catenin 3a
chr25_+_35058088 1.53 ENSDART00000156838
zgc:112234
zgc:112234
chr20_-_33462961 1.53 ENSDART00000135927
si:dkey-65b13.1
si:dkey-65b13.1
chr6_+_58725653 1.49 ENSDART00000190584
igsf8
immunoglobulin superfamily, member 8
chr25_+_35062353 1.48 ENSDART00000089844
zgc:113983
zgc:113983
chr10_-_37487612 1.38 ENSDART00000167964
ENSDART00000171326
si:dkey-65j4.2
si:dkey-65j4.2
chr17_+_43889371 1.35 ENSDART00000156871
ENSDART00000154702
msh4
mutS homolog 4
chr24_+_7153628 1.25 ENSDART00000147715
si:dkeyp-101e12.1
si:dkeyp-101e12.1
chr3_-_7897563 1.25 ENSDART00000185232
ubn2b
ubinuclein 2b
chr19_-_47570672 1.25 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr17_-_50020672 1.22 ENSDART00000188942
filip1a
filamin A interacting protein 1a
chr20_-_29498178 1.08 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr14_-_6402769 1.07 ENSDART00000121552
slc44a1b
solute carrier family 44 (choline transporter), member 1b
chr7_+_34453185 1.01 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr13_-_45942000 0.99 ENSDART00000158534
ENSDART00000171822
ENSDART00000166442
si:ch211-62a1.4
si:ch211-62a1.4
chr6_+_50381347 0.93 ENSDART00000055504
cyc1
cytochrome c-1
chr2_-_57378748 0.91 ENSDART00000149235
tcf3a
transcription factor 3a
chr3_+_29641181 0.90 ENSDART00000151517
eif3d
eukaryotic translation initiation factor 3, subunit D
chr24_+_41690545 0.85 ENSDART00000160069
lama1
laminin, alpha 1
chr13_+_48359573 0.85 ENSDART00000161959
ENSDART00000165311
msh6
mutS homolog 6 (E. coli)
chr6_-_57722816 0.77 ENSDART00000186163
cbfa2t2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr18_+_17020967 0.75 ENSDART00000189168
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr13_+_15933168 0.63 ENSDART00000131390
fignl1
fidgetin-like 1
chr4_+_72742212 0.62 ENSDART00000171021
rab3ip
RAB3A interacting protein (rabin3)
chr14_-_52521460 0.60 ENSDART00000172110
GPR151
G protein-coupled receptor 151
chr3_-_7897305 0.56 ENSDART00000169757
ubn2b
ubinuclein 2b
chr16_+_35595312 0.49 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr7_+_20393386 0.46 ENSDART00000173471
si:dkey-33c9.6
si:dkey-33c9.6
chr3_-_16227683 0.39 ENSDART00000111707
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr6_-_425378 0.37 ENSDART00000192190
fam83fb
family with sequence similarity 83, member Fb
chr17_-_11368662 0.32 ENSDART00000159061
ENSDART00000188694
ENSDART00000190932
si:ch211-185a18.2
si:ch211-185a18.2
chr8_+_8947623 0.13 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.6 1.8 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.4 4.7 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 2.3 GO:0008207 C21-steroid hormone metabolic process(GO:0008207)
0.3 0.9 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.3 2.3 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.3 0.9 GO:0006290 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3 3.0 GO:0030719 P granule organization(GO:0030719)
0.2 4.6 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.2 2.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 1.4 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.9 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 8.1 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 3.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.5 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.9 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0 2.9 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 2.1 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.6 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 1.0 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.6 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 4.7 GO:0006412 translation(GO:0006412)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0033391 chromatoid body(GO:0033391)
0.3 0.9 GO:0032301 MutSalpha complex(GO:0032301)
0.3 4.7 GO:0042555 MCM complex(GO:0042555)
0.2 0.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 0.6 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.2 4.6 GO:0043186 P granule(GO:0043186)
0.1 0.9 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 5.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.1 GO:0043596 nuclear replication fork(GO:0043596)
0.1 5.6 GO:0000786 nucleosome(GO:0000786)
0.1 1.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.9 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 3.6 GO:0005840 ribosome(GO:0005840)
0.0 7.1 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.7 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.8 2.3 GO:0004061 arylformamidase activity(GO:0004061)
0.6 1.8 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.6 2.9 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.4 2.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 2.3 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 0.9 GO:0098808 mRNA cap binding(GO:0098808)
0.3 0.9 GO:0032404 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.3 7.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 2.0 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 2.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 1.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 4.6 GO:0003724 RNA helicase activity(GO:0003724)
0.0 9.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 5.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.9 GO:0009055 electron carrier activity(GO:0009055)
0.0 7.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.5 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.7 PID ATR PATHWAY ATR signaling pathway
0.1 0.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.3 PID E2F PATHWAY E2F transcription factor network
0.0 2.0 PID CDC42 PATHWAY CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 2.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 2.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 2.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 2.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 6.7 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 1.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions