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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for ebf3a-2+ebf3b

Z-value: 0.92

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Transcription factors associated with ebf3a-2+ebf3b

Gene Symbol Gene ID Gene Info
ebf3b
ENSDARG00000091287 EBF transcription factor 3b
ebf3a-2
ENSDARG00000100244 EBF transcription factor 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ebf3adr11_v1_chr12_+_42436328_424363280.571.7e-09Click!
ebf3bdr11_v1_chr17_-_20229812_202298120.295.1e-03Click!

Activity profile of ebf3a-2+ebf3b motif

Sorted Z-values of ebf3a-2+ebf3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_37559570 9.96 ENSDART00000085522
hspb6
heat shock protein, alpha-crystallin-related, b6
chr20_+_34933183 8.42 ENSDART00000062738
snap25a
synaptosomal-associated protein, 25a
chr8_+_31821396 7.92 ENSDART00000077053
plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr21_+_5129513 7.18 ENSDART00000102572
thbs4b
thrombospondin 4b
chr15_-_24869826 6.36 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr1_-_21409877 5.54 ENSDART00000102782
gria2a
glutamate receptor, ionotropic, AMPA 2a
chr23_-_21471022 5.45 ENSDART00000104206
her4.2
hairy-related 4, tandem duplicate 2
chr2_+_5371492 5.43 ENSDART00000139762
si:ch1073-184j22.1
si:ch1073-184j22.1
chr23_-_5683147 5.39 ENSDART00000102766
ENSDART00000067351
tnnt2a
troponin T type 2a (cardiac)
chr12_+_6195191 5.38 ENSDART00000043236
ENSDART00000186420
prkg1b
protein kinase, cGMP-dependent, type Ib
chr8_-_1051438 5.32 ENSDART00000067093
ENSDART00000170737
smyd1b
SET and MYND domain containing 1b
chr25_+_21324588 5.10 ENSDART00000151842
lrrn3a
leucine rich repeat neuronal 3a
chr13_-_31452516 5.06 ENSDART00000193268
rtn1a
reticulon 1a
chr9_-_7673856 5.06 ENSDART00000102715
tuba8l3
tubulin, alpha 8 like 3
chr23_+_21455152 5.02 ENSDART00000158511
ENSDART00000161321
ENSDART00000160731
ENSDART00000137573
her4.2
hairy-related 4, tandem duplicate 2
chr10_-_25769334 4.97 ENSDART00000134176
postna
periostin, osteoblast specific factor a
chr22_+_11756040 4.38 ENSDART00000105808
krt97
keratin 97
chr7_+_38811800 4.35 ENSDART00000052322
zgc:110699
zgc:110699
chr15_+_1372343 4.24 ENSDART00000152285
schip1
schwannomin interacting protein 1
chr9_-_31278048 4.15 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr6_-_40697585 3.93 ENSDART00000113196
si:ch211-157b11.14
si:ch211-157b11.14
chr17_+_17955063 3.89 ENSDART00000104999
ccdc85ca
coiled-coil domain containing 85C, a
chr17_+_45454943 3.82 ENSDART00000074838
kcnk3b
potassium channel, subfamily K, member 3b
chr6_+_45932276 3.78 ENSDART00000103491
rbp7b
retinol binding protein 7b, cellular
chr24_+_3972260 3.72 ENSDART00000131753
pfkpa
phosphofructokinase, platelet a
chr3_+_13559199 3.42 ENSDART00000166547
si:ch73-106n3.1
si:ch73-106n3.1
chr17_-_15611744 3.39 ENSDART00000010496
fhl5
four and a half LIM domains 5
chr15_+_16521785 3.31 ENSDART00000062191
galnt17
polypeptide N-acetylgalactosaminyltransferase 17
chr9_-_98982 3.27 ENSDART00000147882
lims2
LIM and senescent cell antigen-like domains 2
chr19_-_8880688 3.22 ENSDART00000039629
celf3a
cugbp, Elav-like family member 3a
chr16_-_32013913 3.07 ENSDART00000030282
ENSDART00000138701
gstk1
glutathione S-transferase kappa 1
chr3_-_28665291 2.99 ENSDART00000151670
fbxl16
F-box and leucine-rich repeat protein 16
chr3_+_50310684 2.98 ENSDART00000112152
gas7a
growth arrest-specific 7a
chr17_+_45602640 2.96 ENSDART00000153822
si:ch211-202f3.4
si:ch211-202f3.4
chr7_+_66822229 2.95 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr9_-_36924388 2.92 ENSDART00000059756
ralba
v-ral simian leukemia viral oncogene homolog Ba (ras related)
chr3_+_16722014 2.74 ENSDART00000008711
gys1
glycogen synthase 1 (muscle)
chr25_-_24074500 2.73 ENSDART00000040410
th
tyrosine hydroxylase
chr15_-_1941042 2.69 ENSDART00000112946
ENSDART00000155504
dock10
dedicator of cytokinesis 10
chr25_-_20523927 2.67 ENSDART00000114448
si:ch211-269c21.2
si:ch211-269c21.2
chr25_+_35706493 2.66 ENSDART00000176741
kif21a
kinesin family member 21A
chr16_-_9869056 2.62 ENSDART00000149312
ncalda
neurocalcin delta a
chr2_-_30987538 2.61 ENSDART00000148157
emilin2a
elastin microfibril interfacer 2a
chr20_-_53321499 2.58 ENSDART00000179894
ENSDART00000127427
ENSDART00000084952
wasf1
WAS protein family, member 1
chr17_+_38566717 2.46 ENSDART00000145147
sptb
spectrin, beta, erythrocytic
chr13_-_13751017 2.46 ENSDART00000180182
ky
kyphoscoliosis peptidase
chr5_-_25174420 2.44 ENSDART00000141554
abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr4_-_9008846 2.43 ENSDART00000164632
ENSDART00000091876
scube1
signal peptide, CUB domain, EGF-like 1
chr21_-_24632778 2.40 ENSDART00000132533
ENSDART00000058370
arhgap32b
Rho GTPase activating protein 32b
chr2_-_39675829 2.31 ENSDART00000147821
spsb4a
splA/ryanodine receptor domain and SOCS box containing 4a
chr5_-_19052184 2.29 ENSDART00000133330
fam214b
family with sequence similarity 214, member B
chr2_-_37465517 2.28 ENSDART00000139983
si:dkey-57k2.6
si:dkey-57k2.6
chr22_+_11775269 2.21 ENSDART00000140272
krt96
keratin 96
chr7_-_52558495 2.21 ENSDART00000138263
ENSDART00000009938
ENSDART00000174292
ENSDART00000174218
ENSDART00000174335
tcf12
transcription factor 12
chr6_+_55277419 2.17 ENSDART00000083670
CABZ01041604.1

chr24_+_4977862 2.12 ENSDART00000114537
zic4
zic family member 4
chr2_-_32551178 2.08 ENSDART00000145603
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr13_+_17702853 2.04 ENSDART00000145438
si:dkey-27m7.4
si:dkey-27m7.4
chr17_+_53425730 2.04 ENSDART00000127617
fabp10b
fatty acid binding protein 10b, liver basic
chr23_-_5032587 2.03 ENSDART00000163903
kcna2b
potassium voltage-gated channel, shaker-related subfamily, member 2b
chr2_+_38608290 1.97 ENSDART00000159066
cdh24b
cadherin 24, type 2b
chr6_+_2951645 1.95 ENSDART00000183181
ENSDART00000181271
ptprfa
protein tyrosine phosphatase, receptor type, f, a
chr7_-_18554603 1.94 ENSDART00000108938
msantd1
Myb/SANT-like DNA-binding domain containing 1
chr16_-_47483142 1.91 ENSDART00000147072
cthrc1b
collagen triple helix repeat containing 1b
chr20_-_25669813 1.87 ENSDART00000153118
si:dkeyp-117h8.2
si:dkeyp-117h8.2
chr6_-_49673476 1.83 ENSDART00000112226
apcdd1l
adenomatosis polyposis coli down-regulated 1-like
chr11_-_27501027 1.83 ENSDART00000065889
wnt7aa
wingless-type MMTV integration site family, member 7Aa
chr1_+_40562540 1.80 ENSDART00000122059
scoca
short coiled-coil protein a
chr12_-_28548789 1.76 ENSDART00000153062
si:ch73-180n10.1
si:ch73-180n10.1
chr10_-_42237304 1.75 ENSDART00000140341
tcf7l1a
transcription factor 7 like 1a
chr6_+_7250824 1.73 ENSDART00000177226
dzip1
DAZ interacting zinc finger protein 1
chr24_-_10828560 1.71 ENSDART00000132282
fam49bb
family with sequence similarity 49, member Bb
chr13_-_31622195 1.70 ENSDART00000057432
six1a
SIX homeobox 1a
chr17_+_24222190 1.67 ENSDART00000181698
ENSDART00000189411
ehbp1
EH domain binding protein 1
chr8_+_30671060 1.66 ENSDART00000193749
adora2aa
adenosine A2a receptor a
chr16_-_36093776 1.65 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr1_+_49878000 1.61 ENSDART00000047876
lef1
lymphoid enhancer-binding factor 1
chr25_+_34915576 1.60 ENSDART00000073441
sntb2
syntrophin, beta 2
chr8_+_29856013 1.60 ENSDART00000061981
ENSDART00000149610
hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
chr11_-_31039533 1.58 ENSDART00000127355
ier2b
immediate early response 2b
chr17_+_25955003 1.58 ENSDART00000156029
grid1a
glutamate receptor, ionotropic, delta 1a
chr16_+_20198064 1.57 ENSDART00000006037
colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr9_-_33081781 1.55 ENSDART00000165748
zgc:172053
zgc:172053
chr16_-_35952789 1.53 ENSDART00000180118
eva1ba
eva-1 homolog Ba (C. elegans)
chr4_+_37992753 1.51 ENSDART00000193890
CR759843.2

chr18_-_47103131 1.51 ENSDART00000188553
CABZ01039304.1

chr24_+_4978055 1.47 ENSDART00000045813
zic4
zic family member 4
chr11_+_13071645 1.47 ENSDART00000162259
zfyve9b
zinc finger, FYVE domain containing 9b
chr21_-_38853737 1.47 ENSDART00000184100
tlr22
toll-like receptor 22
chr6_+_45692026 1.44 ENSDART00000164759
cntn4
contactin 4
chr23_-_16692312 1.43 ENSDART00000046784
fkbp1ab
FK506 binding protein 1Ab
chr23_-_36003282 1.42 ENSDART00000103150
calcoco1a
calcium binding and coiled-coil domain 1a
chr2_-_55317035 1.39 ENSDART00000169382
ENSDART00000097874
tpm4b
tropomyosin 4b
chr17_+_28533102 1.36 ENSDART00000156218
mdga2a
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr16_-_34212912 1.36 ENSDART00000145017
phactr4b
phosphatase and actin regulator 4b
chr11_-_25324534 1.34 ENSDART00000158598
si:ch211-232b12.5
si:ch211-232b12.5
chr21_+_21374277 1.30 ENSDART00000079431
rtn2b
reticulon 2b
chr13_+_17702522 1.27 ENSDART00000057913
si:dkey-27m7.4
si:dkey-27m7.4
chr2_-_56649883 1.26 ENSDART00000191786
gpx4b
glutathione peroxidase 4b
chr4_+_5193198 1.22 ENSDART00000067388
fgf23
fibroblast growth factor 23
chr11_+_7580079 1.21 ENSDART00000091550
ENSDART00000193223
ENSDART00000193386
adgrl2a
adhesion G protein-coupled receptor L2a
chr19_+_9459050 1.19 ENSDART00000186419
si:ch211-288g17.3
si:ch211-288g17.3
chr4_-_28958601 1.19 ENSDART00000111294
zgc:174315
zgc:174315
chr17_-_45247151 1.18 ENSDART00000186230
ttbk2a
tau tubulin kinase 2a
chr10_-_5022176 1.17 ENSDART00000148277
hnrnpdl
heterogeneous nuclear ribonucleoprotein D-like
chr25_-_21716326 1.16 ENSDART00000152011
DOCK4 (1 of many)
si:dkey-81e3.1
chr24_-_13364311 1.15 ENSDART00000183808
KCNB2
si:dkey-192j17.1
chr20_+_18209895 1.13 ENSDART00000111063
kctd1
potassium channel tetramerization domain containing 1
chr24_+_32472155 1.13 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr14_-_2196267 1.12 ENSDART00000161674
ENSDART00000125674
pcdh2ab8
pcdh2ab9
protocadherin 2 alpha b 8
protocadherin 2 alpha b 9
chr7_-_33949246 1.11 ENSDART00000173513
pias1a
protein inhibitor of activated STAT, 1a
chr7_+_39410180 1.06 ENSDART00000168641
CT030188.1

chr7_-_52334840 1.06 ENSDART00000174173
CR938716.1

chr5_+_57726425 1.03 ENSDART00000134684
fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr10_-_5016997 1.02 ENSDART00000101414
hnrnpd
heterogeneous nuclear ribonucleoprotein D
chr5_+_27267186 1.01 ENSDART00000182238
ENSDART00000087857
unc5db
unc-5 netrin receptor Db
chr4_-_30712588 1.00 ENSDART00000142393
si:dkey-16p19.5
si:dkey-16p19.5
chr21_-_37194365 0.98 ENSDART00000100286
fgfr4
fibroblast growth factor receptor 4
chr16_-_47245563 0.97 ENSDART00000190225
LO017877.2

chr17_-_21441464 0.95 ENSDART00000031490
vax1
ventral anterior homeobox 1
chr5_+_32141790 0.93 ENSDART00000041504
tescb
tescalcin b
chr7_-_40630698 0.91 ENSDART00000134547
ube3c
ubiquitin protein ligase E3C
chr22_-_10470663 0.91 ENSDART00000143352
omd
osteomodulin
chr9_+_23714406 0.89 ENSDART00000189445
gypc
glycophorin C (Gerbich blood group)
chr3_-_55649319 0.87 ENSDART00000176127
axin2
axin 2 (conductin, axil)
chr2_-_10943093 0.87 ENSDART00000148999
ssbp3a
single stranded DNA binding protein 3a
chr24_+_1294176 0.87 ENSDART00000106637
si:ch73-134f24.1
si:ch73-134f24.1
chr6_-_42036685 0.87 ENSDART00000155174
GPR62 (1 of many)
si:dkeyp-111e5.4
chr22_-_23253252 0.87 ENSDART00000175556
lhx9
LIM homeobox 9
chr1_+_16548733 0.85 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr2_-_32457919 0.78 ENSDART00000132792
ENSDART00000041319
slc4a2a
solute carrier family 4 (anion exchanger), member 2a
chr23_+_21459263 0.78 ENSDART00000104209
her4.3
hairy-related 4, tandem duplicate 3
chr18_+_9382847 0.78 ENSDART00000061886
sema3ab
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr7_+_39410393 0.77 ENSDART00000158561
ENSDART00000185173
CT030188.1

chr17_+_13763425 0.75 ENSDART00000105175
lrfn5a
leucine rich repeat and fibronectin type III domain containing 5a
chr12_-_46176115 0.75 ENSDART00000152848
si:ch211-226h7.8
si:ch211-226h7.8
chr8_-_25422186 0.74 ENSDART00000113492
ENSDART00000131736
kcnq2a
potassium voltage-gated channel, KQT-like subfamily, member 2a
chr19_-_336777 0.68 ENSDART00000138837
golph3l
golgi phosphoprotein 3-like
chr23_+_20931030 0.67 ENSDART00000167014
pax7b
paired box 7b
chr9_-_37637179 0.67 ENSDART00000188143
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr6_+_102506 0.67 ENSDART00000172678
ldlrb
low density lipoprotein receptor b
chr22_+_2844865 0.66 ENSDART00000139123
si:dkey-20i20.4
si:dkey-20i20.4
chr6_+_58406014 0.64 ENSDART00000044241
kcnq2b
potassium voltage-gated channel, KQT-like subfamily, member 2b
chr25_+_34915762 0.61 ENSDART00000191776
sntb2
syntrophin, beta 2
chr6_+_51779863 0.60 ENSDART00000108534
tmem74b
transmembrane protein 74B
chr10_+_10972795 0.60 ENSDART00000127331
cdc37l1
cell division cycle 37-like 1
chr11_-_33857911 0.56 ENSDART00000165370
nxph2b
neurexophilin 2b
chr4_-_760560 0.53 ENSDART00000103601
agbl5
ATP/GTP binding protein-like 5
chr10_+_11286741 0.52 ENSDART00000187822
si:ch211-126i22.5
si:ch211-126i22.5
chr19_+_1370504 0.50 ENSDART00000158946
dgat1a
diacylglycerol O-acyltransferase 1a
chr3_-_25813426 0.50 ENSDART00000039482
ntn1b
netrin 1b
chr4_-_9579299 0.47 ENSDART00000183079
ENSDART00000192968
ENSDART00000091809
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr14_+_22129096 0.46 ENSDART00000132514
ccng1
cyclin G1
chr24_-_27400017 0.45 ENSDART00000145829
ccl34b.1
chemokine (C-C motif) ligand 34b, duplicate 1
chr5_+_23634665 0.44 ENSDART00000125161
cx39.9
connexin 39.9
chr25_-_13549577 0.40 ENSDART00000166772
ano10b
anoctamin 10b
chr9_-_33063083 0.40 ENSDART00000048550
si:ch211-125e6.5
si:ch211-125e6.5
chr3_+_23247325 0.39 ENSDART00000114190
ppp1r9ba
protein phosphatase 1, regulatory subunit 9Ba
chr12_+_18906407 0.39 ENSDART00000105854
josd1
Josephin domain containing 1
chr19_-_10043142 0.38 ENSDART00000193016
grin2da
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a
chr2_-_144393 0.37 ENSDART00000156008
adcy1b
adenylate cyclase 1b
chr11_+_6159595 0.37 ENSDART00000178367
slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr21_-_37194669 0.34 ENSDART00000192748
fgfr4
fibroblast growth factor receptor 4
chr4_-_4756349 0.33 ENSDART00000057507
ssbp1
single-stranded DNA binding protein 1
chr13_+_1928361 0.31 ENSDART00000164764
hmgcll1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chr18_-_210478 0.29 ENSDART00000136693
tm2d3
TM2 domain containing 3
chr23_+_16948049 0.26 ENSDART00000139449
si:dkey-147f3.4
si:dkey-147f3.4
chr1_-_8963484 0.26 ENSDART00000188035
socs1b
suppressor of cytokine signaling 1b
chr8_-_21988833 0.26 ENSDART00000167708
nphp4
nephronophthisis 4
chr10_+_11286925 0.25 ENSDART00000143615
si:ch211-126i22.5
si:ch211-126i22.5
chr13_-_25408387 0.25 ENSDART00000002741
itprip
inositol 1,4,5-trisphosphate receptor interacting protein
chr4_+_8638622 0.22 ENSDART00000186829
wnt5b
wingless-type MMTV integration site family, member 5b
chr23_+_35672542 0.22 ENSDART00000046268
pmelb
premelanosome protein b
chr5_+_38900249 0.21 ENSDART00000097856
fras1
Fraser extracellular matrix complex subunit 1
chr24_+_25794318 0.21 ENSDART00000143395
sh3kbp1
SH3-domain kinase binding protein 1
chr18_-_26781616 0.20 ENSDART00000136776
ENSDART00000076484
kti12
KTI12 chromatin associated homolog
chr20_+_2039518 0.20 ENSDART00000043157
CABZ01088134.1

chr8_-_15182232 0.18 ENSDART00000138855
bcar3
BCAR3, NSP family adaptor protein
chr21_-_14775724 0.14 ENSDART00000043239
glulc
glutamate-ammonia ligase (glutamine synthase) c
chr10_-_27199135 0.12 ENSDART00000189511
ENSDART00000180314
auts2a
autism susceptibility candidate 2a
chr18_+_30441740 0.11 ENSDART00000189074
gse1
Gse1 coiled-coil protein
chr3_-_43646733 0.10 ENSDART00000180959
axin1
axin 1
chr1_-_191971 0.10 ENSDART00000164091
ENSDART00000159237
grtp1a
growth hormone regulated TBC protein 1a
chr13_+_3954715 0.09 ENSDART00000182477
ENSDART00000192142
ENSDART00000190962
lrrc73
leucine rich repeat containing 73
chr4_-_69127091 0.07 ENSDART00000136092
si:ch211-209j12.3
si:ch211-209j12.3
chr23_+_19814371 0.06 ENSDART00000182897
emd
emerin (Emery-Dreifuss muscular dystrophy)
chr13_-_17723417 0.04 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr19_+_19756425 0.03 ENSDART00000167606
hoxa3a
homeobox A3a
chr15_+_35718354 0.03 ENSDART00000110003
nyap2a
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2a
chr17_-_22324727 0.03 ENSDART00000160341
CU104709.1

chr20_-_33966148 0.02 ENSDART00000148111
selp
selectin P
chr8_+_21297217 0.01 ENSDART00000142836
itpr3
inositol 1,4,5-trisphosphate receptor, type 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ebf3a-2+ebf3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.4 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
1.2 7.2 GO:0035989 tendon development(GO:0035989)
0.9 2.7 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.7 4.2 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.7 3.3 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.6 3.6 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.6 4.1 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.5 12.1 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.5 5.3 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.5 1.4 GO:0021611 facial nerve formation(GO:0021611)
0.4 1.8 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.4 1.7 GO:0014857 skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.4 3.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 5.5 GO:0048899 anterior lateral line development(GO:0048899)
0.3 3.7 GO:0061621 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 0.9 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.3 0.6 GO:0097377 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.3 8.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.3 1.8 GO:0061635 regulation of protein complex stability(GO:0061635)
0.2 2.1 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 2.0 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.2 3.9 GO:0014823 response to activity(GO:0014823)
0.2 1.4 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 3.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 2.6 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 0.5 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.2 3.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 1.2 GO:0030320 cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.7 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.1 0.8 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.1 1.0 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259)
0.1 0.7 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.3 GO:0051095 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.1 1.0 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.5 GO:0035608 protein deglutamylation(GO:0035608)
0.1 1.0 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.3 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.1 3.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.7 GO:0050975 sensory perception of touch(GO:0050975)
0.1 0.5 GO:0098815 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 1.6 GO:0042446 hormone biosynthetic process(GO:0042446)
0.1 0.7 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 2.7 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 2.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.7 GO:1903039 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.1 0.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 3.2 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 4.6 GO:0042552 myelination(GO:0042552)
0.0 1.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 3.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 2.7 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.0 4.9 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 1.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.8 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.6 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.4 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.9 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.4 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 3.1 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 1.5 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 6.7 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.6 GO:0050821 protein stabilization(GO:0050821)
0.0 0.2 GO:0072554 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.0 0.5 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 3.4 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 3.0 GO:0030041 actin filament polymerization(GO:0030041)
0.0 7.1 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.2 GO:0032438 melanosome organization(GO:0032438)
0.0 1.2 GO:1990266 neutrophil migration(GO:1990266)
0.0 3.3 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.5 2.5 GO:0008091 spectrin(GO:0008091)
0.3 2.4 GO:0001650 fibrillar center(GO:0001650)
0.3 3.7 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.3 5.3 GO:0031430 M band(GO:0031430)
0.2 1.4 GO:0043194 axon initial segment(GO:0043194)
0.2 2.6 GO:0031209 SCAR complex(GO:0031209)
0.2 3.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 2.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 7.2 GO:0016529 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.1 2.1 GO:0071564 npBAF complex(GO:0071564)
0.1 5.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 5.4 GO:0005861 troponin complex(GO:0005861)
0.1 2.2 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 9.9 GO:0005882 intermediate filament(GO:0005882)
0.1 2.7 GO:0043204 perikaryon(GO:0043204)
0.1 5.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 6.0 GO:0005884 actin filament(GO:0005884)
0.0 3.4 GO:0030018 Z disc(GO:0030018)
0.0 0.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.4 GO:0035869 ciliary transition zone(GO:0035869)
0.0 2.0 GO:0016342 catenin complex(GO:0016342)
0.0 3.5 GO:0005925 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.0 2.7 GO:0005871 kinesin complex(GO:0005871)
0.0 3.8 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 3.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.7 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 2.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.4 GO:0030027 lamellipodium(GO:0030027)
0.0 5.1 GO:0005874 microtubule(GO:0005874)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.0 GO:0016604 nuclear body(GO:0016604)
0.0 6.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.9 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.5 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0005252 open rectifier potassium channel activity(GO:0005252)
0.9 5.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.7 2.7 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.5 5.4 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.4 5.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 1.0 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.3 3.7 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.3 2.7 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.3 2.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.3 1.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.2 1.2 GO:0034046 poly(G) binding(GO:0034046)
0.2 5.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.2 8.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 3.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 1.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 7.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.6 GO:0008301 DNA binding, bending(GO:0008301)
0.1 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.9 GO:0019003 GDP binding(GO:0019003)
0.1 0.3 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.1 0.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 3.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.6 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1 0.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.4 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 0.5 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 0.7 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 1.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 5.4 GO:0005179 hormone activity(GO:0005179)
0.0 2.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 3.8 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 2.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 14.4 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.1 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 2.4 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.6 GO:0051087 chaperone binding(GO:0051087)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 2.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 2.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 4.4 GO:0051015 actin filament binding(GO:0051015)
0.0 2.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 6.1 GO:0046983 protein dimerization activity(GO:0046983)
0.0 1.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.6 GO:0008083 growth factor activity(GO:0008083)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 3.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 2.1 PID FGF PATHWAY FGF signaling pathway
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 2.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 2.1 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 1.6 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 2.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 2.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.7 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo