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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for egr4

Z-value: 0.34

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Transcription factors associated with egr4

Gene Symbol Gene ID Gene Info
egr4
ENSDARG00000077799 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr4dr11_v1_chr23_+_45579497_455794970.405.8e-05Click!

Activity profile of egr4 motif

Sorted Z-values of egr4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_48753873 4.81 ENSDART00000189556
CABZ01044731.1

chr10_+_19554604 2.83 ENSDART00000063806
atp6v1b2
ATPase H+ transporting V1 subunit B2
chr24_-_24146875 2.71 ENSDART00000173052
map7d2b
MAP7 domain containing 2b
chr12_+_35650321 2.49 ENSDART00000190446
BX255898.1

chr2_-_31301929 2.39 ENSDART00000191992
ENSDART00000190723
adcyap1b
adenylate cyclase activating polypeptide 1b
chr7_-_44963154 2.37 ENSDART00000073735
rrad
Ras-related associated with diabetes
chr5_+_64739762 2.14 ENSDART00000161112
ENSDART00000135610
ENSDART00000002908
olfm1a
olfactomedin 1a
chr8_+_23165749 2.01 ENSDART00000063057
dnajc5aa
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr2_+_38924975 1.96 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr23_+_41799748 1.61 ENSDART00000144257
pdyn
prodynorphin
chr19_+_342094 1.47 ENSDART00000151013
ENSDART00000187622
ensaa
endosulfine alpha a
chr3_+_31897029 1.37 ENSDART00000146275
strada
ste20-related kinase adaptor alpha
chr14_+_36220479 1.31 ENSDART00000148319
pitx2
paired-like homeodomain 2
chr14_-_35400671 1.28 ENSDART00000129676
lsm11
LSM11, U7 small nuclear RNA associated
chr11_+_12719944 1.25 ENSDART00000054837
ENSDART00000144954
ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr17_-_15657029 1.21 ENSDART00000153925
fut9a
fucosyltransferase 9a
chr23_+_41800052 1.20 ENSDART00000141484
pdyn
prodynorphin
chr3_+_24537023 1.16 ENSDART00000077702
sp100.1
SP110 nuclear body protein, tandem duplicate 1
chr6_+_40661703 1.13 ENSDART00000142492
eno1b
enolase 1b, (alpha)
chr18_+_3169579 1.12 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr11_+_12720171 1.09 ENSDART00000135761
ENSDART00000122812
ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr25_-_207214 1.06 ENSDART00000193448
FP236318.3

chr5_-_14390445 1.03 ENSDART00000026120
ap3m2
adaptor-related protein complex 3, mu 2 subunit
chr23_+_40460333 1.00 ENSDART00000184658
soga3b
SOGA family member 3b
chr13_+_35925490 0.98 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr6_+_42819337 0.95 ENSDART00000046498
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr16_+_27614989 0.88 ENSDART00000005625
glipr2l
GLI pathogenesis-related 2, like
chr5_-_2689753 0.88 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr17_+_15297398 0.87 ENSDART00000156574
si:ch211-270g19.5
si:ch211-270g19.5
chr10_-_15919839 0.84 ENSDART00000065032
pip5k1ba
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr14_-_21218891 0.83 ENSDART00000158294
ppp2r2cb
protein phosphatase 2, regulatory subunit B, gamma b
chr25_+_13406069 0.83 ENSDART00000010495
znrf1
zinc and ring finger 1
chr2_+_16710889 0.80 ENSDART00000017852
ubxn7
UBX domain protein 7
chr12_-_7639120 0.78 ENSDART00000126712
ENSDART00000126219
ccdc6b
coiled-coil domain containing 6b
chr1_-_7917062 0.73 ENSDART00000177068
mmd2b
monocyte to macrophage differentiation-associated 2b
chr6_-_23117348 0.71 ENSDART00000154941
ENSDART00000154252
ten1
TEN1 CST complex subunit
chr3_-_32180796 0.71 ENSDART00000133191
ENSDART00000055308
pih1d1
PIH1 domain containing 1
chr1_-_10473630 0.68 ENSDART00000040116
tnrc5
trinucleotide repeat containing 5
chr20_-_10065130 0.65 ENSDART00000134439
znf770
zinc finger protein 770
chr6_+_2271559 0.65 ENSDART00000165223
pbx1b
pre-B-cell leukemia homeobox 1b
chr24_+_24831727 0.64 ENSDART00000080969
trim55b
tripartite motif containing 55b
chr22_+_1806235 0.62 ENSDART00000158966
znf1168
zinc finger protein 1168
chr20_+_28803642 0.60 ENSDART00000188526
fntb
farnesyltransferase, CAAX box, beta
chr16_-_40508624 0.58 ENSDART00000075718
ndufaf6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr21_-_43398457 0.55 ENSDART00000166530
ccni2
cyclin I family, member 2
chr12_-_23129453 0.53 ENSDART00000077453
armc4
armadillo repeat containing 4
chr5_+_51443009 0.52 ENSDART00000083350
rasgrf2b
Ras protein-specific guanine nucleotide-releasing factor 2b
chr20_+_9211237 0.52 ENSDART00000139527
si:ch211-59d15.4
si:ch211-59d15.4
chr21_-_43398122 0.44 ENSDART00000050533
ccni2
cyclin I family, member 2
chr6_+_42818963 0.44 ENSDART00000184833
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr18_+_20481982 0.43 ENSDART00000128139
kbtbd4
kelch repeat and BTB (POZ) domain containing 4
chr23_+_9067131 0.43 ENSDART00000144533
ccm2l
cerebral cavernous malformation 2-like
chr22_+_10713713 0.43 ENSDART00000122349
hiat1b
hippocampus abundant transcript 1b
chr3_-_1520657 0.41 ENSDART00000053201
polr2f
polymerase (RNA) II (DNA directed) polypeptide F
chr5_+_61941610 0.40 ENSDART00000168808
si:dkeyp-117b8.4
si:dkeyp-117b8.4
chr9_-_30363770 0.39 ENSDART00000147030
sytl5
synaptotagmin-like 5
chr13_-_44834895 0.39 ENSDART00000135573
si:dkeyp-2e4.5
si:dkeyp-2e4.5
chr13_-_49666615 0.38 ENSDART00000148083
tomm20a
translocase of outer mitochondrial membrane 20
chr3_+_22984098 0.37 ENSDART00000043190
lsm12a
LSM12 homolog a
chr24_-_39354829 0.37 ENSDART00000169108
kcnj12a
potassium inwardly-rectifying channel, subfamily J, member 12a
chr16_+_53519048 0.36 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr22_-_20720427 0.33 ENSDART00000105532
oaz1a
ornithine decarboxylase antizyme 1a
chr22_-_9839003 0.28 ENSDART00000193573
si:dkey-253d23.2
si:dkey-253d23.2
chr11_+_14049131 0.28 ENSDART00000172471
grin3bb
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb
chr3_-_7106678 0.27 ENSDART00000175293
ENSDART00000187732
ENSDART00000158652
zgc:113102
BX005085.2
zgc:113102

chr23_-_524780 0.27 ENSDART00000055139
col9a3
collagen, type IX, alpha 3
chr5_-_21030934 0.27 ENSDART00000133461
ENSDART00000098667
camk2b1
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr21_-_31238244 0.25 ENSDART00000159678
tpst1l
tyrosylprotein sulfotransferase 1, like
chr8_+_45294767 0.24 ENSDART00000191527
ubap2b
ubiquitin associated protein 2b
chr4_-_9579299 0.16 ENSDART00000183079
ENSDART00000192968
ENSDART00000091809
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr22_-_34872533 0.16 ENSDART00000167176
slit1b
slit homolog 1b (Drosophila)
chr3_+_16722014 0.15 ENSDART00000008711
gys1
glycogen synthase 1 (muscle)
chr12_+_499881 0.15 ENSDART00000167527
mprip
myosin phosphatase Rho interacting protein
chr11_+_3308656 0.15 ENSDART00000082458
sarnp
SAP domain containing ribonucleoprotein
chr21_+_33172526 0.14 ENSDART00000183532
arl3l1
ADP-ribosylation factor-like 3, like 1
chr2_+_51194657 0.14 ENSDART00000161381
lrrc24
leucine rich repeat containing 24
chr1_-_47431453 0.13 ENSDART00000101104
gja5b
gap junction protein, alpha 5b
chr4_+_70556298 0.09 ENSDART00000170985
si:dkey-11d20.1
si:dkey-11d20.1
chr18_+_8901846 0.08 ENSDART00000132109
ENSDART00000144247
si:dkey-5i3.5
si:dkey-5i3.5
chr7_+_41340520 0.06 ENSDART00000005127
garem
GRB2 associated, regulator of MAPK1
chr8_-_52859301 0.04 ENSDART00000162004
nr5a1a
nuclear receptor subfamily 5, group A, member 1a
chr16_-_54405976 0.03 ENSDART00000055395
osr2
odd-skipped related transciption factor 2
chr3_+_16662209 0.03 ENSDART00000190556
zgc:55558
zgc:55558
chr23_+_804119 0.02 ENSDART00000148163
frmd4bb
FERM domain containing 4Bb
chr19_+_5480327 0.01 ENSDART00000148794
jupb
junction plakoglobin b
chr18_+_20482369 0.00 ENSDART00000100668
kbtbd4
kelch repeat and BTB (POZ) domain containing 4
chr13_-_36418921 0.00 ENSDART00000135804
dcaf5
ddb1 and cul4 associated factor 5

Network of associatons between targets according to the STRING database.

First level regulatory network of egr4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.3 1.3 GO:0061072 iris morphogenesis(GO:0061072)
0.2 1.0 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 2.1 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.2 1.1 GO:0003232 bulbus arteriosus development(GO:0003232)
0.2 1.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 0.7 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.2 0.6 GO:0018343 protein farnesylation(GO:0018343)
0.1 1.1 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 2.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 1.2 GO:0036065 fucosylation(GO:0036065)
0.1 0.9 GO:0043462 regulation of ATPase activity(GO:0043462)
0.0 4.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 2.8 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.3 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.7 GO:0019835 cytolysis(GO:0019835)
0.0 0.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.2 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.3 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 1.0 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.0 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0030534 adult behavior(GO:0030534)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1990879 CST complex(GO:1990879)
0.2 0.7 GO:0097255 R2TP complex(GO:0097255)
0.2 2.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 0.6 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 1.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 2.8 GO:0043679 axon terminus(GO:0043679)
0.1 2.4 GO:0043204 perikaryon(GO:0043204)
0.1 0.9 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 2.3 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.3 GO:0030532 small nuclear ribonucleoprotein complex(GO:0030532)
0.0 0.1 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.2 2.8 GO:0031628 opioid receptor binding(GO:0031628)
0.2 0.7 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 0.9 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 4.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.2 0.6 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 1.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 1.5 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 1.4 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.3 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.0 1.3 GO:0017069 snRNA binding(GO:0017069)
0.0 0.3 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.8 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160) ionotropic glutamate receptor binding(GO:0035255)
0.0 1.0 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 1.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.1 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 2.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.4 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.2 2.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 1.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.2 3.7 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 1.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis