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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for en1a
Z-value: 1.29
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Transcription factors associated with en1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| en1a | dr11_v1_chr9_-_785444_785444 | -0.63 | 6.5e-12 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_-_26018424 Show fit | 19.78 |
ENSDART00000089332
|
acyl-CoA synthetase bubblegum family member 1 |
|
| chr2_-_51794472 Show fit | 17.87 |
ENSDART00000186652
|
|
|
| chr16_+_23924040 Show fit | 17.71 |
ENSDART00000161124
|
si:dkey-7f3.14 |
|
| chr24_-_24983047 Show fit | 16.49 |
ENSDART00000066631
|
solute carrier family 51, alpha subunit |
|
| chr10_+_28428222 Show fit | 16.40 |
ENSDART00000135003
|
si:ch211-222e20.4 |
|
| chr25_-_26018240 Show fit | 16.16 |
ENSDART00000150800
|
acyl-CoA synthetase bubblegum family member 1 |
|
| chr8_-_50147948 Show fit | 15.87 |
ENSDART00000149010
|
haptoglobin |
|
| chr20_-_25518488 Show fit | 14.40 |
ENSDART00000186993
|
cytochrome P450, family 2, subfamily N, polypeptide 13 |
|
| chr13_-_34858500 Show fit | 12.98 |
ENSDART00000184843
|
serine palmitoyltransferase, long chain base subunit 3 |
|
| chr14_-_21123551 Show fit | 12.48 |
ENSDART00000171679
ENSDART00000165882 |
si:dkey-74k8.4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of en1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 35.9 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.0 | 31.6 | GO:0006508 | proteolysis(GO:0006508) |
| 0.6 | 29.2 | GO:0042737 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 1.2 | 16.8 | GO:0070328 | acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328) |
| 1.2 | 16.5 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 1.3 | 13.0 | GO:0046512 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) |
| 0.4 | 12.6 | GO:0019835 | cytolysis(GO:0019835) |
| 0.9 | 12.1 | GO:0006603 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
| 0.8 | 12.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 2.3 | 11.3 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 44.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 14.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.3 | 13.0 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.1 | 12.7 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.7 | 11.6 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 7.3 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 5.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 5.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 5.0 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.6 | 4.8 | GO:0032783 | ELL-EAF complex(GO:0032783) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 47.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.8 | 35.9 | GO:0016405 | CoA-ligase activity(GO:0016405) |
| 0.4 | 29.2 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.1 | 22.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.4 | 16.8 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 1.9 | 13.0 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.9 | 12.1 | GO:0004111 | creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
| 0.2 | 11.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.6 | 10.1 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) |
| 0.0 | 9.9 | GO:0005525 | GTP binding(GO:0005525) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 16.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 15.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 8.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 5.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 4.0 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 3.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 3.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.4 | 3.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 2.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 13.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.1 | 12.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.7 | 11.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.5 | 9.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 9.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.3 | 5.9 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.3 | 5.1 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 4.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.5 | 4.8 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |