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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for en1b_en2a+en2b_gbx1_emx1

Z-value: 0.99

Motif logo

Transcription factors associated with en1b_en2a+en2b_gbx1_emx1

Gene Symbol Gene ID Gene Info
ENSDARG00000098730 engrailed homeobox 1b
ENSDARG00000026599 engrailed homeobox 2a
ENSDARG00000038868 engrailed homeobox 2b
ENSDARG00000115233 engrailed homeobox 2a
ENSDARG00000071418 gastrulation brain homeobox 1
ENSDARG00000039569 empty spiracles homeobox 1

Activity-expression correlation:

Activity profile of en1b_en2a+en2b_gbx1_emx1 motif

Sorted Z-values of en1b_en2a+en2b_gbx1_emx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_64732036 20.43 ENSDART00000073950
olfactomedin 1a
chr5_+_64732270 17.24 ENSDART00000134241
olfactomedin 1a
chr7_+_30787903 16.99 ENSDART00000174000
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr23_+_44741500 15.99 ENSDART00000166421
ATPase Na+/K+ transporting subunit beta 2a
chr22_+_17828267 15.47 ENSDART00000136016
hyaluronan and proteoglycan link protein 4
chr23_+_40460333 15.21 ENSDART00000184658
SOGA family member 3b
chr1_-_50859053 14.30 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr24_-_41320037 13.31 ENSDART00000129058
Ras homolog, mTORC1 binding
chr19_-_5805923 13.27 ENSDART00000134340
si:ch211-264f5.8
chr16_+_5774977 12.38 ENSDART00000134202
cholecystokinin a
chr2_+_50608099 12.16 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr22_+_17205608 11.57 ENSDART00000181267
RAB3B, member RAS oncogene family
chr25_+_21324588 11.31 ENSDART00000151842
leucine rich repeat neuronal 3a
chr21_+_28958471 10.78 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr7_+_32722227 10.15 ENSDART00000126565
si:ch211-150g13.3
chr7_+_13418812 10.09 ENSDART00000191905
ENSDART00000091567
diacylglycerol lipase, alpha
chr16_+_47207691 10.07 ENSDART00000062507
islet cell autoantigen 1
chr12_+_24342303 9.75 ENSDART00000111239
neurexin 1a
chr15_-_9272328 9.68 ENSDART00000172114
calmodulin 2a (phosphorylase kinase, delta)
chr18_+_11506561 9.68 ENSDART00000121647
protein arginine methyltransferase 8
chr8_-_50888806 9.37 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr4_+_11384891 9.33 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
piccolo presynaptic cytomatrix protein a
chr6_-_6487876 9.27 ENSDART00000137642
centrosomal protein 170Ab
chr9_+_38372216 9.26 ENSDART00000141895
phospholipase C, delta 4b
chr21_-_39177564 9.23 ENSDART00000065143
unc-119 homolog b (C. elegans)
chr1_+_16397063 9.16 ENSDART00000159794
mitochondrial calcium uptake family, member 3a
chr18_+_9615147 9.02 ENSDART00000160284
piccolo presynaptic cytomatrix protein b
chr6_+_39232245 8.89 ENSDART00000187351
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr19_+_14921000 8.76 ENSDART00000144052
opioid receptor, delta 1a
chr24_+_16547035 8.63 ENSDART00000164319
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr22_+_4488454 8.58 ENSDART00000170620
cortexin 1
chr23_+_26946744 8.37 ENSDART00000115141
calcium channel, voltage-dependent, beta 3b
chr7_-_72261721 8.20 ENSDART00000172229
RAS guanyl releasing protein 2
chr7_+_23515966 8.03 ENSDART00000186893
ENSDART00000186189
zgc:109889
chr25_-_32869794 7.95 ENSDART00000162784
transmembrane protein 266
chr2_-_31936966 7.93 ENSDART00000169484
ENSDART00000192492
ENSDART00000027689
amphiphysin
chr21_+_26390549 7.91 ENSDART00000185643
thymosin, beta
chr1_-_10647484 7.43 ENSDART00000164541
ENSDART00000188958
ENSDART00000190904
si:dkey-31e10.1
chr1_+_34696503 7.40 ENSDART00000186106

chr10_+_15255198 7.26 ENSDART00000139047
ENSDART00000172107
ENSDART00000183413
ENSDART00000185314
very low density lipoprotein receptor
chr5_-_23280098 7.18 ENSDART00000126540
ENSDART00000051533
proteolipid protein 1b
chr20_-_9462433 7.07 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr2_-_14390627 7.07 ENSDART00000172367
SH3-domain GRB2-like (endophilin) interacting protein 1b
chr25_+_3326885 7.07 ENSDART00000104866
lactate dehydrogenase Bb
chr7_-_25895189 7.06 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
CD99 molecule-like 2
chr11_-_42554290 7.04 ENSDART00000130573
ATPase H+ transporting accessory protein 1 like a
chr23_+_28582865 7.01 ENSDART00000020296
L1 cell adhesion molecule, paralog a
chr6_+_21001264 6.91 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr2_-_11512819 6.84 ENSDART00000142013
proenkephalin a
chr10_+_15777064 6.49 ENSDART00000114483
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr7_+_15872357 6.43 ENSDART00000165757
paired box 6b
chr4_+_21129752 6.24 ENSDART00000169764
synaptotagmin Ia
chr19_-_5103141 6.23 ENSDART00000150952
triosephosphate isomerase 1a
chr3_+_13637383 6.10 ENSDART00000166000
si:ch211-194b1.1
chr16_-_29437373 6.10 ENSDART00000148405
si:ch211-113g11.6
chr2_-_32558795 6.09 ENSDART00000140026
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr16_+_46111849 5.96 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr7_-_24699985 5.95 ENSDART00000052802
calbindin 2b
chr1_+_49266886 5.87 ENSDART00000137179
calcyon neuron-specific vesicular protein
chr19_+_5543072 5.87 ENSDART00000082080
junction plakoglobin b
chr20_-_9436521 5.86 ENSDART00000133000
zgc:101840
chr17_+_24722646 5.79 ENSDART00000138356
mitochondrial fission regulator 1-like
chr1_-_10647307 5.76 ENSDART00000103548
si:dkey-31e10.1
chr21_+_6751760 5.75 ENSDART00000135914
olfactomedin 1b
chr23_-_333457 5.72 ENSDART00000114486
UHRF1 binding protein 1
chr19_-_20113696 5.70 ENSDART00000188813
neuropeptide Y
chr17_+_31185276 5.62 ENSDART00000062887
dispatched homolog 2 (Drosophila)
chr11_+_25129013 5.58 ENSDART00000132879
ndrg family member 3a
chr20_-_46362606 5.56 ENSDART00000153087
BCL2 modifying factor 2
chr9_+_17983463 5.53 ENSDART00000182150
A kinase (PRKA) anchor protein 11
chr19_-_30524952 5.43 ENSDART00000103506
hippocalcin like 4
chr17_-_12336987 5.34 ENSDART00000172001
synaptosomal-associated protein, 25b
chr22_+_5176255 5.33 ENSDART00000092647
ceramide synthase 1
chr11_+_30057762 5.33 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr3_+_34919810 5.29 ENSDART00000055264
carbonic anhydrase Xb
chr20_+_27020201 5.25 ENSDART00000126919
ENSDART00000016014
chromogranin A
chr21_+_6751405 5.19 ENSDART00000037265
ENSDART00000146371
olfactomedin 1b
chr16_+_20161805 5.08 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr18_-_1185772 5.06 ENSDART00000143245
neuroplastin b
chr9_-_20372977 5.02 ENSDART00000113418
immunoglobulin superfamily, member 3
chr1_+_33668236 4.99 ENSDART00000122316
ENSDART00000102184
ADP-ribosylation factor-like 13b
chr11_-_44801968 4.98 ENSDART00000161846
microtubule-associated protein 1 light chain 3 gamma
chr11_-_30158191 4.91 ENSDART00000155278
ENSDART00000156121
Scm polycomb group protein like 2
chr5_+_30624183 4.91 ENSDART00000141444
ATP-binding cassette, sub-family G (WHITE), member 4a
chr14_+_8940326 4.85 ENSDART00000159920
ribosomal protein S6 kinase a, like
chr15_+_44366556 4.82 ENSDART00000133449
guanylate cyclase 1 soluble subunit alpha 2
chr3_+_33341640 4.79 ENSDART00000186352
peptide YYa
chr24_-_31843173 4.69 ENSDART00000185782
STEAP family member 2, metalloreductase
chr11_+_38280454 4.67 ENSDART00000171496
si:dkey-166c18.1
chr20_-_31808779 4.64 ENSDART00000133788
syntaxin binding protein 5a (tomosyn)
chr13_-_29420885 4.61 ENSDART00000024225
choline O-acetyltransferase a
chr15_-_11683529 4.59 ENSDART00000161445
fukutin related protein
chr20_+_34933183 4.55 ENSDART00000062738
synaptosomal-associated protein, 25a
chr18_+_28106139 4.49 ENSDART00000089615
KIAA1549-like b
chr2_+_20332044 4.48 ENSDART00000112131
phospholipid phosphatase related 4a
chr1_-_38756870 4.45 ENSDART00000130324
ENSDART00000148404
glycoprotein M6Ab
chr15_-_33925851 4.44 ENSDART00000187807
ENSDART00000187780
myelin associated glycoprotein
chr21_+_34088110 4.44 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr1_-_47071979 4.43 ENSDART00000160817
intersectin 1 (SH3 domain protein)
chr7_+_71547747 4.42 ENSDART00000180869
adenylate cyclase activating polypeptide 1a
chr11_+_28476298 4.42 ENSDART00000122319
leucine rich repeat containing 38b
chr19_-_31402429 4.39 ENSDART00000137292
transmembrane protein 106Bb
chr5_-_12219572 4.39 ENSDART00000167834
nitric oxide synthase 1 (neuronal)
chr15_+_5277761 4.37 ENSDART00000153954
si:ch1073-166e24.4
chr16_-_29458806 4.30 ENSDART00000047931
leucine rich repeat and Ig domain containing 4b
chr25_+_7784582 4.25 ENSDART00000155016
diacylglycerol kinase, zeta b
chr1_-_46981134 4.23 ENSDART00000130607
pbx/knotted 1 homeobox 1.2
chr12_-_18393408 4.21 ENSDART00000159674
target of myb1 like 2 membrane trafficking protein
chr18_-_8857137 4.20 ENSDART00000126331
proline-rich transmembrane protein 4
chr12_+_2446837 4.19 ENSDART00000112032
si:dkey-191m6.4
chr8_+_49778486 4.12 ENSDART00000131732
neurotrophic tyrosine kinase, receptor, type 2a
chr13_+_38430466 4.12 ENSDART00000132691
adhesion G protein-coupled receptor B3
chr9_+_52492639 4.12 ENSDART00000078939
membrane-associated ring finger (C3HC4) 4
chr20_+_19238382 4.10 ENSDART00000136757
fibronectin type III domain containing 4a
chr10_+_15255012 4.07 ENSDART00000023766
very low density lipoprotein receptor
chr18_-_40708537 4.06 ENSDART00000077577
si:ch211-132b12.8
chr15_+_23799461 4.05 ENSDART00000154885
si:ch211-167j9.4
chr21_-_42100471 4.03 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_4849789 4.03 ENSDART00000130818
ENSDART00000127751
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr15_-_22074315 3.95 ENSDART00000149830
dopamine receptor D2a
chr8_+_22930627 3.93 ENSDART00000187860
synaptophysin a
chr17_+_23298928 3.91 ENSDART00000153652
zgc:165461
chr20_+_35382482 3.89 ENSDART00000135284
visinin-like 1a
chr3_+_1637358 3.85 ENSDART00000180266

chr3_-_60827402 3.84 ENSDART00000053494
ankyrin repeat and sterile alpha motif domain containing 4B
chr17_-_28198099 3.84 ENSDART00000156143
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr4_+_9400012 3.80 ENSDART00000191960
transmembrane and tetratricopeptide repeat containing 1
chr23_+_4646194 3.79 ENSDART00000092344

chr10_+_42690374 3.79 ENSDART00000123496
Rho-related BTB domain containing 2b
chr17_-_200316 3.77 ENSDART00000190561

chr12_+_31744217 3.71 ENSDART00000190361
si:dkey-49c17.3
chr19_-_5865766 3.69 ENSDART00000191007

chr23_-_14990865 3.68 ENSDART00000147799
ndrg family member 3b
chr13_+_15838151 3.65 ENSDART00000008987
kinesin light chain 1a
chr9_-_32753535 3.64 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr5_-_21970881 3.63 ENSDART00000182907
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr14_-_32016615 3.63 ENSDART00000105761
zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
chr2_-_11258547 3.62 ENSDART00000165803
ENSDART00000193817
solute carrier family 44, member 5a
chr14_-_34044369 3.60 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cytoplasmic FMR1 interacting protein 2
chr18_+_24921587 3.60 ENSDART00000191345
repulsive guidance molecule family member a
chr6_-_2133737 3.60 ENSDART00000158535
V-set and transmembrane domain containing 2 like
chr6_+_27667359 3.57 ENSDART00000159624
ENSDART00000049177
RAB6B, member RAS oncogene family a
chr18_+_10884996 3.57 ENSDART00000147613
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr22_+_5176693 3.56 ENSDART00000160927
ceramide synthase 1
chr10_+_8680730 3.52 ENSDART00000011987
islet1, like
chr9_-_44295071 3.51 ENSDART00000011837
neuronal differentiation 1
chr15_+_15856178 3.49 ENSDART00000080338
dual specificity phosphatase 14
chr8_-_49908978 3.49 ENSDART00000172642
ATP/GTP binding protein 1
chr20_+_26349002 3.46 ENSDART00000152842
spectrin repeat containing, nuclear envelope 1a
chr2_-_31302615 3.43 ENSDART00000034784
ENSDART00000060812
adenylate cyclase activating polypeptide 1b
chr24_-_5786759 3.41 ENSDART00000152069
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2b
chr5_-_50992690 3.38 ENSDART00000149553
ENSDART00000097460
ENSDART00000192021
3-hydroxy-3-methylglutaryl-CoA reductase a
chr20_-_35040041 3.38 ENSDART00000131919
kinesin family member 26Bb
chr20_-_29864390 3.35 ENSDART00000161834
ENSDART00000132278
ring finger protein 144ab
chr6_-_12275836 3.35 ENSDART00000189980
plakophilin 4
chr20_+_27087539 3.34 ENSDART00000062094
transmembrane protein 251
chr25_+_3327071 3.34 ENSDART00000136131
ENSDART00000133243
lactate dehydrogenase Bb
chr9_-_31278048 3.32 ENSDART00000022204
zic family member 5 (odd-paired homolog, Drosophila)
chr9_-_38156894 3.31 ENSDART00000134759
si:dkey-219c10.4
chr7_+_34487833 3.30 ENSDART00000173854
CLN6, transmembrane ER protein a
chr3_+_22035863 3.29 ENSDART00000177169
cell division cycle 27
chr18_-_2433011 3.28 ENSDART00000181922
ENSDART00000193276

chr8_+_7756893 3.27 ENSDART00000191894
FYVE, RhoGEF and PH domain containing 1
chr3_-_61099004 3.24 ENSDART00000112043
calcium channel, voltage-dependent, gamma subunit 4b
chr6_-_36198052 3.24 ENSDART00000086627
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2
chr17_-_12389259 3.22 ENSDART00000185724
synaptosomal-associated protein, 25b
chr2_-_21082695 3.21 ENSDART00000032502
nebulette
chr10_+_7709724 3.19 ENSDART00000097670
gamma-glutamyl carboxylase
chr2_+_6253246 3.18 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr8_+_18624658 3.16 ENSDART00000089141
fibronectin type III and SPRY domain containing 1
chr25_-_19224298 3.15 ENSDART00000149917
aggrecan b
chr3_-_15210491 3.15 ENSDART00000037906
HIRA interacting protein 3
chr12_+_21298317 3.14 ENSDART00000178562
carbonic anhydrase Xa
chr11_-_472547 3.13 ENSDART00000005923
zgc:77375
chr15_-_590787 3.11 ENSDART00000189367
si:ch73-144d13.5
chr20_-_28404362 3.11 ENSDART00000055932
ENSDART00000188161
phosphatidylinositol glycan anchor biosynthesis, class H
chr1_+_7517454 3.10 ENSDART00000016139
LanC antibiotic synthetase component C-like 1 (bacterial)
chr22_+_27090136 3.09 ENSDART00000136770
si:dkey-246e1.3
chr2_+_26237322 3.08 ENSDART00000030520
paralemmin 1b
chr18_+_1154189 3.08 ENSDART00000135090
si:ch1073-75f15.2
chr25_-_13363286 3.05 ENSDART00000163735
ENSDART00000169119
NDRG family member 4
chr19_-_30510259 3.04 ENSDART00000135128
ENSDART00000186169
ENSDART00000182974
ENSDART00000187797
BCL2 associated athanogene 6, like
chr21_+_42226113 3.03 ENSDART00000170362
gamma-aminobutyric acid type A receptor beta2 subunit
chr24_-_11057305 3.03 ENSDART00000186494
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr1_-_18811517 3.03 ENSDART00000142026
si:dkey-167i21.2
chr2_-_56385373 3.02 ENSDART00000169101
ceramide synthase 4b
chr1_+_18811679 2.98 ENSDART00000078610
solute carrier family 25, member 51a
chr15_+_33865312 2.98 ENSDART00000166141
tektin 1
chr6_-_48473694 2.96 ENSDART00000154237
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr6_-_40352215 2.92 ENSDART00000103992
tubulin tyrosine ligase-like family, member 3
chr5_+_37903790 2.92 ENSDART00000162470
transmembrane protease, serine 4b
chr3_+_13842554 2.92 ENSDART00000162317
ENSDART00000158068
interleukin enhancer binding factor 3b
chr3_+_32443395 2.91 ENSDART00000188447
proline rich 12b
chr24_-_27400017 2.90 ENSDART00000145829
chemokine (C-C motif) ligand 34b, duplicate 1
chr16_-_27628994 2.88 ENSDART00000157407
NAC alpha domain containing
chr14_-_30474346 2.88 ENSDART00000173051
ENSDART00000173124
mitochondrial calcium uptake family, member 3b
chr13_-_36911118 2.87 ENSDART00000048739
tripartite motif containing 9
chr4_-_15420452 2.86 ENSDART00000016230
plexin A4
chr24_+_10310577 2.86 ENSDART00000141718
OTU deubiquitinase with linear linkage specificity a
chr10_-_5581487 2.85 ENSDART00000141943
spleen tyrosine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of en1b_en2a+en2b_gbx1_emx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 37.7 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
2.5 10.1 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
2.2 8.8 GO:0038003 opioid receptor signaling pathway(GO:0038003)
2.1 6.2 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
2.0 7.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.8 18.4 GO:1904071 presynaptic active zone assembly(GO:1904071)
1.8 5.3 GO:0002792 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
1.7 5.0 GO:1903441 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
1.6 6.2 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.5 4.6 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
1.5 6.0 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
1.5 4.4 GO:0098917 retrograde trans-synaptic signaling(GO:0098917) retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
1.4 5.7 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
1.3 5.3 GO:0060074 synapse maturation(GO:0060074)
1.3 6.3 GO:0016322 neuron remodeling(GO:0016322)
1.2 5.9 GO:0002159 desmosome assembly(GO:0002159)
1.2 4.7 GO:0015677 copper ion import(GO:0015677)
1.2 9.2 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
1.1 3.3 GO:0046069 cGMP catabolic process(GO:0046069)
1.0 4.9 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
1.0 2.9 GO:0007414 axonal defasciculation(GO:0007414)
1.0 2.9 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.9 6.4 GO:0090104 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.9 4.6 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.9 3.6 GO:0021742 abducens nucleus development(GO:0021742)
0.9 3.6 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.9 3.5 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.8 16.0 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.8 2.4 GO:0009750 response to fructose(GO:0009750)
0.8 11.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.8 4.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.7 2.2 GO:0006089 lactate metabolic process(GO:0006089)
0.7 3.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.7 10.8 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.7 2.1 GO:1904869 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.7 9.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.7 10.2 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.7 6.1 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.7 2.0 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.7 2.0 GO:0097376 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.6 1.9 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.6 3.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.6 10.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.6 11.8 GO:0050796 regulation of insulin secretion(GO:0050796)
0.6 1.7 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.6 2.8 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.5 3.2 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.5 4.8 GO:0007631 feeding behavior(GO:0007631)
0.5 2.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.5 2.5 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.5 2.9 GO:1990108 protein linear deubiquitination(GO:1990108)
0.5 3.3 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.5 1.9 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.4 4.9 GO:0033344 cholesterol efflux(GO:0033344)
0.4 0.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.4 3.4 GO:0043090 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
0.4 12.6 GO:0007340 acrosome reaction(GO:0007340)
0.4 1.2 GO:2000434 regulation of protein neddylation(GO:2000434)
0.4 7.6 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.4 12.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 5.4 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.4 9.7 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.4 2.3 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 9.6 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.4 1.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.4 7.2 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.3 4.4 GO:0030073 insulin secretion(GO:0030073)
0.3 1.0 GO:0045887 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.3 6.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 1.0 GO:0021527 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519) spinal cord association neuron differentiation(GO:0021527)
0.3 3.3 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.3 3.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.3 4.3 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.3 1.6 GO:0071422 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.3 1.5 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.3 3.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.3 0.9 GO:0051958 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.3 12.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.3 3.8 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.3 4.4 GO:0032418 lysosome localization(GO:0032418)
0.3 5.0 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.3 5.2 GO:0000266 mitochondrial fission(GO:0000266)
0.3 1.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.3 2.2 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.3 1.4 GO:0052651 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.3 2.5 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.3 3.3 GO:0045842 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.3 7.9 GO:0070593 dendrite self-avoidance(GO:0070593)
0.3 1.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.3 0.8 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.3 2.9 GO:0001964 startle response(GO:0001964)
0.3 1.6 GO:0098900 regulation of action potential(GO:0098900)
0.3 19.6 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.3 1.0 GO:1901825 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.3 4.6 GO:0050708 regulation of protein secretion(GO:0050708)
0.3 2.0 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.3 4.6 GO:0016082 synaptic vesicle priming(GO:0016082)
0.2 1.0 GO:0048739 response to muscle stretch(GO:0035994) cardiac muscle fiber development(GO:0048739)
0.2 1.5 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.2 1.2 GO:0000012 single strand break repair(GO:0000012)
0.2 12.4 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.2 4.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 3.7 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.2 1.4 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.2 0.9 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.2 5.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 3.3 GO:0046847 filopodium assembly(GO:0046847)
0.2 0.9 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 1.9 GO:0006465 signal peptide processing(GO:0006465)
0.2 8.5 GO:0036269 swimming behavior(GO:0036269)
0.2 3.8 GO:0050795 regulation of behavior(GO:0050795)
0.2 1.0 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 3.7 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.2 0.6 GO:0045830 regulation of isotype switching(GO:0045191) positive regulation of isotype switching(GO:0045830)
0.2 0.7 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.2 3.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.2 2.6 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.2 7.9 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.2 0.9 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.2 18.8 GO:0010506 regulation of autophagy(GO:0010506)
0.2 0.3 GO:0030858 positive regulation of epithelial cell differentiation(GO:0030858)
0.2 0.5 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.2 1.5 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.2 1.3 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.2 1.5 GO:0060114 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.2 1.1 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.2 0.8 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 1.1 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.2 0.6 GO:0018343 protein farnesylation(GO:0018343)
0.2 0.5 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.2 0.8 GO:0061072 iris morphogenesis(GO:0061072)
0.2 0.9 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.2 1.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 6.2 GO:0007586 digestion(GO:0007586)
0.1 1.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.9 GO:0021767 mammillary body development(GO:0021767)
0.1 0.6 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.1 0.4 GO:0032263 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
0.1 1.4 GO:1903828 negative regulation of cellular protein localization(GO:1903828)
0.1 0.7 GO:0007172 signal complex assembly(GO:0007172)
0.1 11.0 GO:0008203 cholesterol metabolic process(GO:0008203)
0.1 9.9 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 0.3 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.1 8.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 2.1 GO:0045471 response to ethanol(GO:0045471)
0.1 1.4 GO:0042044 fluid transport(GO:0042044)
0.1 1.3 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.1 1.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 1.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 1.2 GO:0061074 regulation of neural retina development(GO:0061074)
0.1 0.9 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.6 GO:1901906 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 9.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.8 GO:0071467 cellular response to pH(GO:0071467)
0.1 0.7 GO:0035627 ceramide transport(GO:0035627)
0.1 0.2 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 3.3 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 4.0 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.4 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.1 1.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 4.9 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.1 0.7 GO:0036372 opsin transport(GO:0036372)
0.1 1.4 GO:0007020 microtubule nucleation(GO:0007020)
0.1 0.9 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.9 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 3.1 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 0.9 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 0.8 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 2.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 0.5 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1 35.5 GO:0099537 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) trans-synaptic signaling(GO:0099537)
0.1 0.7 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 2.3 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.1 0.5 GO:0097032 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.1 1.9 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 3.8 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 13.9 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 3.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 4.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.8 GO:0008089 anterograde axonal transport(GO:0008089)
0.1 0.3 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.1 3.8 GO:0035195 gene silencing by miRNA(GO:0035195)
0.1 3.9 GO:0032880 regulation of protein localization(GO:0032880)
0.1 0.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 2.6 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.1 3.1 GO:0006612 protein targeting to membrane(GO:0006612)
0.1 0.6 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 1.3 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.1 0.6 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 1.6 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.1 0.4 GO:0014721 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721) slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.2 GO:0051039 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.1 3.8 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.1 1.5 GO:0035308 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.1 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.4 GO:0021576 hindbrain formation(GO:0021576)
0.1 0.3 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 2.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.1 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.6 GO:0007032 endosome organization(GO:0007032)
0.1 0.3 GO:0051645 Golgi localization(GO:0051645)
0.1 4.2 GO:0030517 negative regulation of axon extension(GO:0030517) negative regulation of axonogenesis(GO:0050771)
0.1 2.9 GO:0034341 monocyte chemotaxis(GO:0002548) response to interferon-gamma(GO:0034341) cellular response to interferon-gamma(GO:0071346)
0.1 0.3 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 3.2 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 0.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.2 GO:0032637 interleukin-8 production(GO:0032637) regulation of interleukin-8 production(GO:0032677) positive regulation of interleukin-8 production(GO:0032757)
0.1 0.5 GO:0050885 neuromuscular process controlling balance(GO:0050885) equilibrioception(GO:0050957)
0.1 0.4 GO:0010165 response to X-ray(GO:0010165)
0.1 0.2 GO:0010595 positive regulation of endothelial cell migration(GO:0010595)
0.1 2.7 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 0.2 GO:0046104 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 0.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 0.7 GO:0030301 cholesterol transport(GO:0030301)
0.1 1.0 GO:0042073 intraciliary transport(GO:0042073)
0.1 4.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.6 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.0 2.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0048211 Golgi vesicle docking(GO:0048211)
0.0 0.7 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 10.7 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.0 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 0.8 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 2.6 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.0 1.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.7 GO:0001935 endothelial cell proliferation(GO:0001935)
0.0 0.3 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 1.8 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 1.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.9 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 2.9 GO:0003341 cilium movement(GO:0003341)
0.0 2.2 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 0.6 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 0.3 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.0 1.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.8 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 4.5 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.9 GO:0035329 hippo signaling(GO:0035329)
0.0 0.7 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 3.5 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 1.0 GO:0039020 pronephric nephron tubule development(GO:0039020)
0.0 0.2 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 0.2 GO:2000243 positive regulation of oocyte development(GO:0060282) positive regulation of reproductive process(GO:2000243)
0.0 0.2 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 1.1 GO:0009648 photoperiodism(GO:0009648)
0.0 0.8 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 2.1 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 0.5 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.2 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.4 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.6 GO:0040001 establishment of mitotic spindle localization(GO:0040001)
0.0 0.5 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.0 0.1 GO:0036268 swimming(GO:0036268)
0.0 0.8 GO:0006497 protein lipidation(GO:0006497) lipoprotein biosynthetic process(GO:0042158)
0.0 1.2 GO:1990542 mitochondrial transmembrane transport(GO:1990542)
0.0 1.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.9 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.5 GO:0033619 membrane protein proteolysis(GO:0033619)
0.0 1.5 GO:0007030 Golgi organization(GO:0007030)
0.0 0.4 GO:0035459 cargo loading into vesicle(GO:0035459)
0.0 0.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.6 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 1.2 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.2 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.1 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.0 0.1 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0 1.0 GO:0048675 axon extension(GO:0048675)
0.0 0.8 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 2.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.5 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.7 GO:0050769 positive regulation of neurogenesis(GO:0050769)
0.0 0.2 GO:0032324 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:0060021 palate development(GO:0060021)
0.0 0.9 GO:0031101 fin regeneration(GO:0031101)
0.0 0.2 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 1.2 GO:0097190 apoptotic signaling pathway(GO:0097190)
0.0 0.1 GO:0060088 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.7 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 4.8 GO:0045892 negative regulation of transcription, DNA-templated(GO:0045892)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.8 18.4 GO:0098982 GABA-ergic synapse(GO:0098982)
1.8 10.8 GO:0005955 calcineurin complex(GO:0005955)
1.6 16.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
1.2 6.2 GO:0042584 chromaffin granule membrane(GO:0042584)
1.2 7.0 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
1.1 5.3 GO:0042583 chromaffin granule(GO:0042583)
1.1 6.3 GO:0043083 synaptic cleft(GO:0043083)
1.0 11.5 GO:0044295 axonal growth cone(GO:0044295)
0.9 9.2 GO:0045171 intercellular bridge(GO:0045171)
0.8 13.5 GO:0031209 SCAR complex(GO:0031209)
0.8 11.3 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.8 10.5 GO:1990246 uniplex complex(GO:1990246)
0.6 3.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.6 10.1 GO:0030667 secretory granule membrane(GO:0030667)
0.6 2.2 GO:0035060 brahma complex(GO:0035060)
0.5 1.9 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.5 2.9 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.5 3.3 GO:0071818 BAT3 complex(GO:0071818)
0.4 2.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.4 2.9 GO:0016586 RSC complex(GO:0016586)
0.3 12.8 GO:0043679 axon terminus(GO:0043679)
0.3 12.1 GO:0000421 autophagosome membrane(GO:0000421)
0.3 1.3 GO:1990498 mitotic spindle microtubule(GO:1990498)
0.3 1.6 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.3 2.9 GO:0071797 LUBAC complex(GO:0071797)
0.3 4.7 GO:0071564 npBAF complex(GO:0071564)
0.3 32.0 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.3 5.0 GO:0043209 myelin sheath(GO:0043209)
0.3 3.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 5.9 GO:0043204 perikaryon(GO:0043204)
0.3 7.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.2 GO:0032021 NELF complex(GO:0032021)
0.2 4.0 GO:0005682 U5 snRNP(GO:0005682)
0.2 13.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 5.7 GO:0035371 microtubule plus-end(GO:0035371)
0.2 1.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 3.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 4.6 GO:0043025 neuronal cell body(GO:0043025)
0.2 13.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 31.8 GO:0008021 synaptic vesicle(GO:0008021)
0.2 4.7 GO:0060170 ciliary membrane(GO:0060170)
0.2 3.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 4.6 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.2 32.1 GO:0030424 axon(GO:0030424)
0.2 85.6 GO:0045202 synapse(GO:0045202)
0.2 0.6 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.2 0.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.7 GO:0070724 BMP receptor complex(GO:0070724)
0.1 1.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.7 GO:0005879 axonemal microtubule(GO:0005879)
0.1 2.5 GO:0000813 ESCRT I complex(GO:0000813)
0.1 6.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 5.3 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 0.7 GO:0000798 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.1 3.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.9 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.5 GO:0034657 GID complex(GO:0034657)
0.1 0.7 GO:0035517 PR-DUB complex(GO:0035517)
0.1 1.7 GO:0030426 growth cone(GO:0030426)
0.1 3.7 GO:0031201 SNARE complex(GO:0031201)
0.1 5.0 GO:0031902 late endosome membrane(GO:0031902)
0.1 0.8 GO:0000243 commitment complex(GO:0000243)
0.1 1.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.5 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.3 GO:0070743 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.1 17.7 GO:0043005 neuron projection(GO:0043005)
0.1 5.3 GO:0005871 kinesin complex(GO:0005871)
0.1 2.0 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.4 GO:0000801 central element(GO:0000801)
0.1 4.3 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 1.5 GO:0034703 cation channel complex(GO:0034703)
0.1 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 6.2 GO:0016459 myosin complex(GO:0016459)
0.1 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.8 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 19.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 2.4 GO:0031514 motile cilium(GO:0031514)
0.0 1.9 GO:0016605 PML body(GO:0016605)
0.0 0.9 GO:0030057 desmosome(GO:0030057)
0.0 3.0 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 2.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 3.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.0 3.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.0 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.2 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 2.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 1.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0072379 ER membrane insertion complex(GO:0072379)
0.0 23.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 8.3 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.1 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 1.5 GO:0005925 focal adhesion(GO:0005925)
0.0 0.8 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 GO:0038046 enkephalin receptor activity(GO:0038046)
2.8 11.3 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
2.1 10.5 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
2.1 6.2 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
2.0 7.9 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
1.8 10.8 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
1.6 6.2 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
1.4 7.0 GO:0008046 axon guidance receptor activity(GO:0008046)
1.4 9.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
1.2 3.7 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
1.2 4.7 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
1.2 1.2 GO:0004457 lactate dehydrogenase activity(GO:0004457)
1.1 10.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.0 18.4 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
1.0 23.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.9 3.6 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.9 9.7 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.8 9.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.8 3.2 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.8 11.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.8 15.0 GO:0001671 ATPase activator activity(GO:0001671)
0.7 3.6 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.7 2.0 GO:0031716 calcitonin receptor binding(GO:0031716)
0.7 5.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.7 2.0 GO:0031834 neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
0.6 2.6 GO:0015369 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.6 4.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.6 1.8 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.6 22.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 3.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.5 6.7 GO:0031628 opioid receptor binding(GO:0031628)
0.5 16.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.5 2.4 GO:0043295 glutathione binding(GO:0043295)
0.5 7.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.5 4.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.5 16.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 3.7 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.4 4.9 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.4 5.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.4 7.9 GO:0003785 actin monomer binding(GO:0003785)
0.4 5.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.4 5.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.4 2.6 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.4 2.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.4 13.5 GO:0019003 GDP binding(GO:0019003)
0.4 1.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.4 2.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.3 1.4 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.3 2.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 4.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 1.6 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.3 11.2 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.3 8.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 0.9 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.3 0.9 GO:0019777 Atg12 transferase activity(GO:0019777)
0.3 1.2 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.3 3.2 GO:0035804 structural constituent of egg coat(GO:0035804)
0.3 4.6 GO:0045159 myosin II binding(GO:0045159)
0.3 7.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 1.0 GO:0052885 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.3 0.8 GO:0004061 arylformamidase activity(GO:0004061)
0.2 3.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 4.4 GO:0033691 sialic acid binding(GO:0033691)
0.2 1.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2 7.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 1.2 GO:1902388 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.2 1.6 GO:0070888 E-box binding(GO:0070888)
0.2 1.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 3.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 0.9 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.2 2.0 GO:0004359 glutaminase activity(GO:0004359)
0.2 7.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 3.0 GO:0070628 proteasome binding(GO:0070628)
0.2 6.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 5.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 2.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 8.9 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.2 1.0 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.2 1.2 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.2 4.9 GO:0051018 protein kinase A binding(GO:0051018)
0.2 3.6 GO:0015026 coreceptor activity(GO:0015026)
0.2 0.9 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 3.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 14.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 4.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 2.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 8.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 3.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.2 4.5 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 0.5 GO:0070336 flap-structured DNA binding(GO:0070336)
0.2 8.8 GO:0044325 ion channel binding(GO:0044325)
0.2 1.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 1.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 0.8 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.2 1.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.6 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.2 1.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 3.2 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.2 2.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.6 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 1.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.4 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.1 0.4 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 2.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 5.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 3.1 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 2.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.2 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.0 GO:0016530 metallochaperone activity(GO:0016530)
0.1 1.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.6 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 7.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 0.9 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.8 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.1 1.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.9 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.1 2.0 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 4.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.4 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.1 3.4 GO:0050661 NADP binding(GO:0050661)
0.1 0.4 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.1 2.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.5 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.0 GO:0045503 dynein light chain binding(GO:0045503)
0.1 0.9 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 2.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 4.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 4.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.1 0.3 GO:0035671 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 9.7 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.4 GO:0044389 ubiquitin-like protein ligase binding(GO:0044389)
0.1 1.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.7 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 1.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.5 GO:0031267 small GTPase binding(GO:0031267)
0.1 0.5 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.1 0.2 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
0.1 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 1.8 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 2.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.4 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.8 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.2 GO:0043531 ADP binding(GO:0043531)
0.0 0.6 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 2.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 2.4 GO:0030276 clathrin binding(GO:0030276)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.1 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 2.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 4.2 GO:0060090 binding, bridging(GO:0060090)
0.0 1.1 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 4.9 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.3 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 13.9 GO:0003924 GTPase activity(GO:0003924)
0.0 1.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 11.8 GO:0015631 tubulin binding(GO:0015631)
0.0 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.5 GO:0008200 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.0 0.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 3.6 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 4.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.4 GO:0004970 ionotropic glutamate receptor activity(GO:0004970) NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.1 GO:0016917 GABA receptor activity(GO:0016917)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.6 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.6 GO:0046332 SMAD binding(GO:0046332)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.7 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.5 11.3 PID REELIN PATHWAY Reelin signaling pathway
0.3 8.2 PID RAS PATHWAY Regulation of Ras family activation
0.3 11.6 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.3 9.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 3.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.2 12.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 5.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 1.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 4.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 2.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 0.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 3.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 3.6 PID BMP PATHWAY BMP receptor signaling
0.1 0.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.4 PID ARF 3PATHWAY Arf1 pathway
0.1 4.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 1.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 0.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.3 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 1.6 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 0.7 PID RHOA PATHWAY RhoA signaling pathway
0.1 1.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 0.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.8 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID INSULIN PATHWAY Insulin Pathway
0.0 0.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.9 8.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.6 3.8 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.6 10.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.4 8.9 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.4 11.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.4 7.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.4 2.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.4 3.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.3 4.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 2.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 2.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 3.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 2.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 7.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 1.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 3.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 3.0 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 1.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 3.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 1.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 0.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.0 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.4 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 0.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.8 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 3.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 0.6 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 5.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 3.7 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.7 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.4 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME MEIOSIS Genes involved in Meiosis