Project
PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
Navigation
Downloads
Results for esr1+esr2a+esr2b
Z-value: 1.08
Motif logo
Transcription factors associated with esr1+esr2a+esr2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| esr2b | dr11_v1_chr13_+_37022601_37022632 | -0.41 | 4.7e-05 | Click! |
| esr2a | dr11_v1_chr20_+_21595244_21595244 | -0.25 | 1.7e-02 | Click! |
| esr1 | dr11_v1_chr20_-_26382284_26382284 | -0.15 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_55032439 Show fit | 8.16 |
ENSDART00000164232
ENSDART00000158845 ENSDART00000157584 ENSDART00000026359 ENSDART00000122794 ENSDART00000183742 |
myosin binding protein Hb |
|
| chr5_-_71722257 Show fit | 7.71 |
ENSDART00000013404
|
adenylate kinase 1 |
|
| chr20_+_54738210 Show fit | 7.50 |
ENSDART00000151399
|
p21 protein (Cdc42/Rac)-activated kinase 7 |
|
| chr1_-_59176949 Show fit | 6.67 |
ENSDART00000128742
|
|
|
| chr25_-_19374710 Show fit | 6.08 |
ENSDART00000184483
ENSDART00000188706 |
microtubule-associated protein 1Ab |
|
| chr9_+_54644626 Show fit | 5.80 |
ENSDART00000190609
|
EGF-like-domain, multiple 6 |
|
| chr6_-_40722200 Show fit | 5.71 |
ENSDART00000035101
|
kelch repeat and BTB (POZ) domain containing 12 |
|
| chr5_-_55395964 Show fit | 5.57 |
ENSDART00000145791
|
prune homolog 2 (Drosophila) |
|
| chr12_-_4683325 Show fit | 5.23 |
ENSDART00000152771
|
si:ch211-255p10.3 |
|
| chr20_+_5564042 Show fit | 5.05 |
ENSDART00000090934
ENSDART00000127050 |
neurexin 3b |
Network of associatons between targets according to the STRING database.
First level regulatory network of esr1+esr2a+esr2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.7 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 10.9 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 0.1 | 9.8 | GO:0001756 | somitogenesis(GO:0001756) |
| 0.4 | 9.4 | GO:0031114 | regulation of microtubule depolymerization(GO:0031114) |
| 0.1 | 9.0 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.4 | 8.7 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.1 | 7.7 | GO:0009180 | ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) |
| 1.8 | 7.0 | GO:0015820 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.6 | 7.0 | GO:0006797 | polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798) |
| 0.1 | 7.0 | GO:0042391 | regulation of membrane potential(GO:0042391) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 36.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 21.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 11.8 | GO:0044297 | cell body(GO:0044297) |
| 0.1 | 11.5 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.2 | 11.2 | GO:0005865 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.2 | 11.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.3 | 10.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 10.6 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 9.3 | GO:0030054 | cell junction(GO:0030054) |
| 0.4 | 9.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 44.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.2 | 12.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 10.4 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.2 | 9.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 9.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 8.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 8.3 | GO:0051393 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.0 | 8.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.6 | 7.7 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.9 | 7.5 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 3.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 3.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.1 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 2.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 2.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 8.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 8.2 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.5 | 7.9 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.3 | 7.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 5.6 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.3 | 5.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 4.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 4.6 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.4 | 3.7 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |