ISMARA results: ets2

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for ets2

Z-value: 0.98

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Transcription factors associated with ets2

Gene Symbol	Gene ID	Gene Info
ets2 NCBI UniProt	ENSDARG00000103980	v-ets avian erythroblastosis virus E26 oncogene homolog 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ets2	dr11_v1_chr10_+_187760_187764	0.37	2.4e-04	Click!

Activity profile of ets2 motif

Sorted Z-values of ets2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_+_25765734 Show fit	10.83	ENSDART00000021664	cldnb NCBI UniProt Show fit	claudin b
chr15_-_29598679 Show fit	10.53	ENSDART00000155153	si:ch211-207n23.2 NCBI UniProt Show fit	si:ch211-207n23.2
chr1_-_37383539 Show fit	9.76	ENSDART00000127579	scpp1 NCBI UniProt Show fit	secretory calcium-binding phosphoprotein 1
chr8_+_3379815 Show fit	9.74	ENSDART00000155995	FUT9 (1 of many) NCBI UniProt Show fit	zgc:136963
chr15_-_2652640 Show fit	7.12	ENSDART00000146094	cldnf NCBI UniProt Show fit	claudin f
chr16_+_38201840 Show fit	6.97	ENSDART00000044971	myo1eb NCBI UniProt Show fit	myosin IE, b
chr11_+_25278772 Show fit	6.46	ENSDART00000188630	cyldb NCBI UniProt Show fit	cylindromatosis (turban tumor syndrome), b
chr1_-_37383741 Show fit	6.37	ENSDART00000193155 ENSDART00000191887 ENSDART00000189077	scpp1 NCBI UniProt Show fit	secretory calcium-binding phosphoprotein 1
chr5_-_55981288 Show fit	6.24	ENSDART00000146616	si:dkey-189h5.6 NCBI UniProt Show fit	si:dkey-189h5.6
chr15_-_29598444 Show fit	6.13	ENSDART00000154847	si:ch211-207n23.2 NCBI UniProt Show fit	si:ch211-207n23.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ets2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	17.9	GO:0043297	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.3	10.6	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.4	8.6	GO:0045841	mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) negative regulation of mitotic metaphase/anaphase transition(GO:0045841) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.1	7.9	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.1	7.3	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.2	7.0	GO:0003094	glomerular filtration(GO:0003094)
0.0	6.9	GO:0006412	translation(GO:0006412)
0.6	6.5	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.2	6.3	GO:0051014	actin filament severing(GO:0051014)
0.1	6.1	GO:0006892	post-Golgi vesicle-mediated transport(GO:0006892)

Showing 1 to 10 of 205 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	30.0	GO:0005576	extracellular region(GO:0005576)
0.1	16.8	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1	16.0	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1	12.6	GO:0000776	kinetochore(GO:0000776)
0.0	11.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	10.2	GO:0005925	focal adhesion(GO:0005925)
0.2	9.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.2	9.1	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.3	7.7	GO:0030131	clathrin adaptor complex(GO:0030131)
0.1	7.3	GO:0005764	lysosome(GO:0005764)

Showing 1 to 10 of 121 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	16.7	GO:0051015	actin filament binding(GO:0051015)
0.0	9.4	GO:0005198	structural molecule activity(GO:0005198)
0.1	9.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	8.9	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	8.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	8.0	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.5	7.6	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.3	6.9	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1	6.7	GO:0030898	actin-dependent ATPase activity(GO:0030898)

Showing 1 to 10 of 145 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.4	PID P73PATHWAY	p73 transcription factor network
0.2	4.9	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	4.9	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	4.1	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	3.8	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	3.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	3.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	3.4	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.2	2.7	PID ALK2 PATHWAY	ALK2 signaling events
0.1	2.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.5	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.1	9.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	9.4	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3	7.6	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.5	6.0	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3	4.5	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.3	4.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	4.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	4.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.3	3.8	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins

Showing 1 to 10 of 64 entries

Results for ets2

Z-value: 0.98

Motif logo

Transcription factors associated with ets2

Activity-expression correlation:

Activity profile of ets2 motif

Sorted Z-values of ets2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ets2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: