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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for etv7

Z-value: 0.89

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Transcription factors associated with etv7

Gene Symbol Gene ID Gene Info
etv7
ENSDARG00000089434 ETS variant transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
etv7dr11_v1_chr23_-_5101847_51018470.623.2e-11Click!

Activity profile of etv7 motif

Sorted Z-values of etv7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_45001842 7.06 ENSDART00000037797
sult2st3
sulfotransferase family 2, cytosolic sulfotransferase 3
chr11_-_18254 6.98 ENSDART00000167814
prr13
proline rich 13
chr11_-_18449 6.66 ENSDART00000172050
prr13
proline rich 13
chr6_+_52212927 6.12 ENSDART00000143458
ywhaba
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a
chr6_+_52212574 5.15 ENSDART00000025940
ywhaba
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a
chr22_-_24297510 4.12 ENSDART00000163297
si:ch211-117l17.6
si:ch211-117l17.6
chr6_+_112579 4.08 ENSDART00000034505
ap1m2
adaptor-related protein complex 1, mu 2 subunit
chr18_-_50799510 4.07 ENSDART00000174373
taldo1
transaldolase 1
chr5_-_38777852 3.97 ENSDART00000131603
si:dkey-58f10.4
si:dkey-58f10.4
chr8_-_45430817 3.89 ENSDART00000150067
ENSDART00000112394
ywhabb
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b
chr6_-_57426097 3.46 ENSDART00000171531
znfx1
zinc finger, NFX1-type containing 1
chr7_-_26049282 3.33 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr7_+_26545911 3.15 ENSDART00000135313
tnk1
tyrosine kinase, non-receptor, 1
chr22_-_6194517 3.02 ENSDART00000134757
ENSDART00000181598
ENSDART00000129829
si:rp71-36a1.5
si:rp71-36a1.5
chr3_-_16055432 2.89 ENSDART00000123621
ENSDART00000023859
atp6v0ca
ATPase H+ transporting V0 subunit ca
chr9_+_44304980 2.89 ENSDART00000147990
ssfa2
sperm specific antigen 2
chr16_+_21789703 2.75 ENSDART00000153617
trim108
tripartite motif containing 108
chr22_-_347424 2.74 ENSDART00000067633
necap2
NECAP endocytosis associated 2
chr23_+_20644511 2.67 ENSDART00000133131
uba1
ubiquitin-like modifier activating enzyme 1
chr1_-_354115 2.61 ENSDART00000141590
ENSDART00000098627
pros1
protein S
chr21_-_36453594 2.59 ENSDART00000193176
cnot8
CCR4-NOT transcription complex, subunit 8
chr9_-_33136990 2.51 ENSDART00000131742
slc5a3b
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3b
chr19_+_348729 2.51 ENSDART00000114284
mcl1a
MCL1, BCL2 family apoptosis regulator a
chr19_+_47290287 2.42 ENSDART00000078382
tpmt.1
thiopurine S-methyltransferase, tandem duplicate 1
chr20_-_1439256 2.42 ENSDART00000002928
themis
thymocyte selection associated
chr10_-_1697037 2.37 ENSDART00000125188
ENSDART00000002985
srsf9
serine/arginine-rich splicing factor 9
chr3_-_25492361 2.35 ENSDART00000147322
ENSDART00000055473
grb2b
growth factor receptor-bound protein 2b
chr20_+_51199666 2.32 ENSDART00000169321
hsp90ab1
heat shock protein 90, alpha (cytosolic), class B member 1
chr1_+_12049229 2.28 ENSDART00000103403
ENSDART00000137697
saraf
store-operated calcium entry-associated regulatory factor
chr25_-_37338048 2.28 ENSDART00000073439
trim44
tripartite motif containing 44
chr7_-_33351485 2.28 ENSDART00000146420
anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr1_+_54889733 2.19 ENSDART00000140375
zfyve27
zinc finger, FYVE domain containing 27
chr4_+_77957611 2.18 ENSDART00000156692
arfgap3
ADP-ribosylation factor GTPase activating protein 3
chr17_+_34244345 2.17 ENSDART00000006058
eif2s1a
eukaryotic translation initiation factor 2, subunit 1 alpha a
chr7_+_26545502 2.16 ENSDART00000140528
tnk1
tyrosine kinase, non-receptor, 1
chr1_+_54766943 2.15 ENSDART00000144759
nlrc6
NLR family CARD domain containing 6
chr21_+_19858627 2.14 ENSDART00000147010
fybb
FYN binding protein b
chr18_+_50707179 2.12 ENSDART00000160206
rap2b
RAP2B, member of RAS oncogene family
chr21_+_27513859 2.11 ENSDART00000065420
pacs1a
phosphofurin acidic cluster sorting protein 1a
chr22_+_9862243 2.10 ENSDART00000105942
si:dkey-253d23.3
si:dkey-253d23.3
chr16_+_13860299 2.09 ENSDART00000121998
grwd1
glutamate-rich WD repeat containing 1
chr12_-_46315898 2.08 ENSDART00000153138
si:ch211-226h7.3
si:ch211-226h7.3
chr5_-_4297459 2.07 ENSDART00000018895
srrt
serrate RNA effector molecule homolog (Arabidopsis)
chr6_-_30859656 2.07 ENSDART00000156235
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr11_+_3959495 2.02 ENSDART00000122953
gnl3
guanine nucleotide binding protein-like 3 (nucleolar)
chr2_-_24317240 1.98 ENSDART00000078975
trnau1apb
tRNA selenocysteine 1 associated protein 1b
chr9_+_42269059 1.95 ENSDART00000113435
si:dkey-10c21.1
si:dkey-10c21.1
chr2_-_37134169 1.94 ENSDART00000146123
ENSDART00000146533
ENSDART00000040427
elavl1a
ELAV like RNA binding protein 1a
chr1_-_46505310 1.93 ENSDART00000178072
si:busm1-105l16.2
si:busm1-105l16.2
chr8_-_31053872 1.93 ENSDART00000109885
snrnp200
small nuclear ribonucleoprotein 200 (U5)
chr17_-_43863700 1.90 ENSDART00000157530
ahsa1b
AHA1, activator of heat shock protein ATPase homolog 1b
chr1_+_51407520 1.88 ENSDART00000074294
actr2a
ARP2 actin related protein 2a homolog
chr20_-_4793450 1.83 ENSDART00000053870
galca
galactosylceramidase a
chr8_+_52530889 1.83 ENSDART00000127729
ENSDART00000170360
ENSDART00000162687
stambpb
STAM binding protein b
chr6_-_19381993 1.79 ENSDART00000164114
grb2a
growth factor receptor-bound protein 2a
chr13_-_28263856 1.76 ENSDART00000041036
ENSDART00000079806
smap1
small ArfGAP 1
chr22_+_16535575 1.75 ENSDART00000083063
tal1
T-cell acute lymphocytic leukemia 1
chr7_+_29177191 1.74 ENSDART00000008096
aph1b
APH1B gamma secretase subunit
chr7_+_29962559 1.69 ENSDART00000075538
fbxo22
F-box protein 22
chr1_+_59314675 1.67 ENSDART00000161872
ENSDART00000160658
ENSDART00000169792
ENSDART00000160735
parn
poly(A)-specific ribonuclease (deadenylation nuclease)
chr16_+_54829574 1.66 ENSDART00000148392
pabpc1a
poly(A) binding protein, cytoplasmic 1a
chr8_+_4803906 1.66 ENSDART00000045533
tmem127
transmembrane protein 127
chr21_+_21621042 1.65 ENSDART00000134907
tgfb1b
transforming growth factor, beta 1b
chr5_+_872299 1.65 ENSDART00000130042
fubp3
far upstream element (FUSE) binding protein 3
chr10_-_105100 1.62 ENSDART00000145716
ttc3
tetratricopeptide repeat domain 3
chr8_-_17184482 1.62 ENSDART00000025803
pola2
polymerase (DNA directed), alpha 2
chr15_-_1941042 1.58 ENSDART00000112946
ENSDART00000155504
dock10
dedicator of cytokinesis 10
chr21_-_18932761 1.57 ENSDART00000140129
med15
mediator complex subunit 15
chr15_+_37545855 1.54 ENSDART00000099456
psenen
presenilin enhancer gamma secretase subunit
chr13_-_4979029 1.52 ENSDART00000132931
nolc1
nucleolar and coiled-body phosphoprotein 1
chr20_-_37820939 1.49 ENSDART00000032978
nsl1
NSL1, MIS12 kinetochore complex component
chr14_+_12178915 1.49 ENSDART00000054626
hdac3
histone deacetylase 3
chr14_+_23668730 1.49 ENSDART00000157741
med12
mediator complex subunit 12
chr16_+_38338721 1.45 ENSDART00000076528
ENSDART00000142885
gabpb2b
GA binding protein transcription factor, beta subunit 2b
chr22_-_22242884 1.44 ENSDART00000020937
hdgfl2
HDGF like 2
chr7_-_50272912 1.40 ENSDART00000098842
hsd17b12b
hydroxysteroid (17-beta) dehydrogenase 12b
chr19_-_37508571 1.38 ENSDART00000018255
ilf2
interleukin enhancer binding factor 2
chr2_-_58142854 1.36 ENSDART00000169909
CABZ01110881.1

chr15_-_34567370 1.35 ENSDART00000099793
sostdc1a
sclerostin domain containing 1a
chr4_+_9612574 1.34 ENSDART00000150336
ENSDART00000041289
ENSDART00000150828
tmem243b
transmembrane protein 243, mitochondrial b
chr13_+_5978809 1.34 ENSDART00000102563
ENSDART00000121598
phf10
PHD finger protein 10
chr21_-_36453417 1.33 ENSDART00000018350
cnot8
CCR4-NOT transcription complex, subunit 8
chr13_+_39532050 1.31 ENSDART00000019379
marveld1
MARVEL domain containing 1
chr15_-_26931541 1.31 ENSDART00000027563
ccdc9
coiled-coil domain containing 9
chr16_-_9453591 1.29 ENSDART00000126154
prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr23_+_39611688 1.28 ENSDART00000034690
otud3
OTU deubiquitinase 3
chr15_+_37546391 1.28 ENSDART00000186625
psenen
presenilin enhancer gamma secretase subunit
chr16_+_53489676 1.27 ENSDART00000074653
grinab
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding)
chr25_-_3230187 1.27 ENSDART00000160545
cib1
calcium and integrin binding 1 (calmyrin)
chr22_+_16320076 1.23 ENSDART00000164161
osbpl1a
oxysterol binding protein-like 1A
chr6_-_31364475 1.21 ENSDART00000145715
ENSDART00000134370
ak4
adenylate kinase 4
chr16_+_54829293 1.19 ENSDART00000024729
pabpc1a
poly(A) binding protein, cytoplasmic 1a
chr6_+_49723289 1.12 ENSDART00000190452
stx16
syntaxin 16
chr25_+_245438 1.10 ENSDART00000004689
zgc:92481
zgc:92481
chr13_-_44819254 1.10 ENSDART00000131673
si:dkeyp-2e4.8
si:dkeyp-2e4.8
chr2_+_35854242 1.09 ENSDART00000134918
dhx9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr13_+_6188759 1.09 ENSDART00000161062
ppm1g
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr13_+_6189203 1.08 ENSDART00000109665
ppm1g
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr21_-_44556148 1.07 ENSDART00000163955
brcc3
BRCA1/BRCA2-containing complex, subunit 3
chr13_-_3324764 1.06 ENSDART00000102748
ENSDART00000114040
ubr2
ubiquitin protein ligase E3 component n-recognin 2
chr6_+_18367388 1.05 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr16_+_33931032 1.05 ENSDART00000167240
snip1
Smad nuclear interacting protein
chr24_+_33462800 1.03 ENSDART00000166666
ENSDART00000050826
rmc1
regulator of MON1-CCZ1
chr20_+_37820992 0.99 ENSDART00000064692
tatdn3
TatD DNase domain containing 3
chr2_+_58008980 0.98 ENSDART00000171264
si:ch211-155e24.3
si:ch211-155e24.3
chr22_+_9523479 0.98 ENSDART00000189473
ENSDART00000143953
strip1
striatin interacting protein 1
chr16_+_12730311 0.97 ENSDART00000162030
ENSDART00000124544
epn1
epsin 1
chr16_+_33930864 0.97 ENSDART00000125945
snip1
Smad nuclear interacting protein
chr1_+_11107688 0.97 ENSDART00000109858
knstrn
kinetochore-localized astrin/SPAG5 binding protein
chr3_-_15444396 0.96 ENSDART00000104361
si:dkey-56d12.4
si:dkey-56d12.4
chr3_-_35554809 0.93 ENSDART00000010944
dctn5
dynactin 5
chr22_+_9862466 0.89 ENSDART00000146864
si:dkey-253d23.3
si:dkey-253d23.3
chr20_+_39344889 0.87 ENSDART00000009164
esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr8_+_7854130 0.85 ENSDART00000165575
cxxc1a
CXXC finger protein 1a
chr8_+_387622 0.84 ENSDART00000167361
pym1
PYM homolog 1, exon junction complex associated factor
chr25_+_469855 0.84 ENSDART00000104717
rsl24d1
ribosomal L24 domain containing 1
chr5_-_50084310 0.83 ENSDART00000074599
ENSDART00000189970
fam172a
family with sequence similarity 172, member A
chr19_+_42660158 0.83 ENSDART00000018328
fbxl2
F-box and leucine-rich repeat protein 2
chr14_+_49220026 0.81 ENSDART00000063643
ENSDART00000128744
rmnd5b
required for meiotic nuclear division 5 homolog B
chr5_+_4366431 0.81 ENSDART00000168560
ENSDART00000149185
sat1a.2
spermidine/spermine N1-acetyltransferase 1a, duplicate 2
chr21_+_33454147 0.80 ENSDART00000053208
rps14
ribosomal protein S14
chr25_-_13659249 0.78 ENSDART00000045488
csnk2a2b
casein kinase 2, alpha prime polypeptide b
chr2_+_26479676 0.77 ENSDART00000056795
ENSDART00000144837
hectd3
HECT domain containing 3
chr17_+_43863708 0.77 ENSDART00000133874
ENSDART00000140316
ENSDART00000142929
ENSDART00000148090
zgc:66313
zgc:66313
chr4_-_2637689 0.76 ENSDART00000192550
ENSDART00000021953
ENSDART00000150344
cog5
component of oligomeric golgi complex 5
chr5_-_68495967 0.75 ENSDART00000188107
ephb4a
eph receptor B4a
chr6_-_55958705 0.75 ENSDART00000155963
eya2
EYA transcriptional coactivator and phosphatase 2
chr1_-_56213723 0.71 ENSDART00000142505
ENSDART00000137237
si:dkey-76b14.2
si:dkey-76b14.2
chr13_+_49727333 0.70 ENSDART00000168799
ENSDART00000037559
ggps1
geranylgeranyl diphosphate synthase 1
chr2_+_2772447 0.70 ENSDART00000124882
thoc1
THO complex 1
chr11_+_5681762 0.70 ENSDART00000179139
arid3a
AT rich interactive domain 3A (BRIGHT-like)
chr3_+_301479 0.69 ENSDART00000165169
CABZ01075611.1

chr17_-_51121525 0.69 ENSDART00000130412
ENSDART00000013418
aqr
aquarius intron-binding spliceosomal factor
chr13_-_330004 0.68 ENSDART00000093149
ddx21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
chr16_-_51889734 0.67 ENSDART00000012055
rpl28
ribosomal protein L28
chr12_+_10115964 0.67 ENSDART00000152369
si:dkeyp-118b1.2
si:dkeyp-118b1.2
chr5_+_483965 0.67 ENSDART00000150007
tek
TEK tyrosine kinase, endothelial
chr21_-_33126697 0.65 ENSDART00000189293
ENSDART00000084559
CU019662.1

chr18_+_15778110 0.63 ENSDART00000014188
ube2na
ubiquitin-conjugating enzyme E2Na
chr10_+_36439293 0.63 ENSDART00000043802
uspl1
ubiquitin specific peptidase like 1
chr20_+_27093042 0.63 ENSDART00000024595
ubr7
ubiquitin protein ligase E3 component n-recognin 7
chr5_+_3927989 0.62 ENSDART00000030125
znhit3
zinc finger, HIT-type containing 3
chr12_-_4408828 0.61 ENSDART00000152447
si:ch211-173d10.1
si:ch211-173d10.1
chr18_-_40884087 0.60 ENSDART00000059194
snrpd2
small nuclear ribonucleoprotein D2 polypeptide
chr20_+_4793516 0.59 ENSDART00000053875
lgals8a
galectin 8a
chr11_+_2699951 0.59 ENSDART00000082512
tmem167b
transmembrane protein 167B
chr20_-_37831849 0.58 ENSDART00000188483
ENSDART00000153005
ENSDART00000142364
si:ch211-147d7.5
si:ch211-147d7.5
chr3_-_23474416 0.56 ENSDART00000161672
si:dkey-225f5.5
si:dkey-225f5.5
chr6_+_60125033 0.55 ENSDART00000148557
ENSDART00000008224
aurka
aurora kinase A
chr5_-_24124118 0.55 ENSDART00000051550
capga
capping protein (actin filament), gelsolin-like a
chr3_+_28831450 0.55 ENSDART00000055422
flr
fleer
chr19_+_9050852 0.54 ENSDART00000151031
ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr13_-_5978433 0.52 ENSDART00000102555
actr2b
ARP2 actin related protein 2b homolog
chr14_+_52408619 0.44 ENSDART00000163856
noa1
nitric oxide associated 1
chr5_+_32490238 0.38 ENSDART00000191839
ndor1
NADPH dependent diflavin oxidoreductase 1
chr21_-_44556411 0.37 ENSDART00000163983
brcc3
BRCA1/BRCA2-containing complex, subunit 3
chr25_-_3627130 0.35 ENSDART00000171863
si:ch211-272n13.3
si:ch211-272n13.3
chr6_+_49722970 0.35 ENSDART00000155934
ENSDART00000154738
stx16
syntaxin 16
chr17_-_681142 0.35 ENSDART00000165583
soul3
heme-binding protein soul3
chr22_-_506522 0.35 ENSDART00000106645
ENSDART00000067637
dstyk
dual serine/threonine and tyrosine protein kinase
chr7_+_26762958 0.33 ENSDART00000167956
ENSDART00000134717
tspan18a
tetraspanin 18a
chr11_-_16975190 0.31 ENSDART00000122222
suclg2
succinate-CoA ligase, GDP-forming, beta subunit
chr22_+_22260210 0.31 ENSDART00000017755
ubxn6
UBX domain protein 6
chr10_+_17747880 0.31 ENSDART00000135044
pigo
phosphatidylinositol glycan anchor biosynthesis, class O
chr7_-_52334840 0.25 ENSDART00000174173
CR938716.1

chr21_-_45073764 0.24 ENSDART00000181390
ENSDART00000063714
rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
chr23_+_45229198 0.22 ENSDART00000172445
ttc39b
tetratricopeptide repeat domain 39B
chr8_-_6918721 0.21 ENSDART00000014915
asb6
ankyrin repeat and SOCS box containing 6
chr16_-_34477805 0.20 ENSDART00000136546
serinc2l
serine incorporator 2, like
chr7_+_44608224 0.19 ENSDART00000005033
cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr15_+_32249062 0.18 ENSDART00000133867
ENSDART00000152545
ENSDART00000082315
ENSDART00000152513
ENSDART00000152139
arfip2a
ADP-ribosylation factor interacting protein 2a
chr13_-_35760969 0.18 ENSDART00000127476
erlec1
endoplasmic reticulum lectin 1
chr16_+_38337783 0.17 ENSDART00000135008
gabpb2b
GA binding protein transcription factor, beta subunit 2b
chr9_-_37637179 0.14 ENSDART00000188143
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr13_-_35761266 0.12 ENSDART00000190217
erlec1
endoplasmic reticulum lectin 1
chr4_+_29773917 0.11 ENSDART00000170798
BX530097.1

chr3_+_62140077 0.11 ENSDART00000108945
GID4
GID complex subunit 4 homolog
chr1_+_6225493 0.11 ENSDART00000145378
fastkd2
FAST kinase domains 2
chr9_-_7287375 0.10 ENSDART00000128352
mitd1
MIT, microtubule interacting and transport, domain containing 1
chr24_+_4373355 0.06 ENSDART00000179062
ENSDART00000093256
ENSDART00000138943
ccny
cyclin Y
chr19_+_27479838 0.05 ENSDART00000103922
atat1
alpha tubulin acetyltransferase 1
chr9_-_29003245 0.01 ENSDART00000183391
ENSDART00000188836
ptpn4a
protein tyrosine phosphatase, non-receptor type 4a

Network of associatons between targets according to the STRING database.

First level regulatory network of etv7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0042730 fibrinolysis(GO:0042730)
0.8 4.1 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.8 2.4 GO:0043383 negative T cell selection(GO:0043383)
0.8 2.3 GO:0036363 transforming growth factor beta activation(GO:0036363) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
0.7 2.2 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.6 4.3 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.6 1.7 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.5 4.6 GO:0007220 Notch receptor processing(GO:0007220)
0.5 1.4 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.4 2.1 GO:0031053 primary miRNA processing(GO:0031053)
0.4 2.0 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.4 1.5 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.4 2.2 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.4 3.2 GO:0060036 notochord cell vacuolation(GO:0060036)
0.4 3.9 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.3 2.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.3 7.4 GO:1901654 response to ketone(GO:1901654)
0.3 1.9 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.3 1.3 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.3 2.4 GO:1905168 positive regulation of double-strand break repair via homologous recombination(GO:1905168) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.3 0.9 GO:0034421 post-translational protein acetylation(GO:0034421)
0.3 0.8 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.2 2.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.2 1.8 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.2 1.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 0.8 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.2 1.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 2.5 GO:0006020 inositol metabolic process(GO:0006020)
0.2 1.7 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.2 1.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.2 0.6 GO:0000212 meiotic spindle organization(GO:0000212)
0.2 1.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 1.2 GO:0009180 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.2 2.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 2.0 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.1 1.5 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.1 0.6 GO:0030575 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576) protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
0.1 1.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 11.3 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 0.8 GO:0035475 angioblast cell migration involved in selective angioblast sprouting(GO:0035475)
0.1 0.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 1.8 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 2.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.6 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.8 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 1.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 0.5 GO:0036372 opsin transport(GO:0036372)
0.1 3.8 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.1 2.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 2.1 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.7 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 1.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 3.3 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.7 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.3 GO:1901215 negative regulation of neuron death(GO:1901215)
0.0 2.2 GO:0006413 translational initiation(GO:0006413)
0.0 0.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.4 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 3.0 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.0 2.8 GO:0006417 regulation of translation(GO:0006417)
0.0 1.1 GO:0009615 response to virus(GO:0009615)
0.0 5.3 GO:0045087 innate immune response(GO:0045087)
0.0 0.5 GO:0051014 actin filament severing(GO:0051014)
0.0 1.1 GO:1990266 neutrophil migration(GO:1990266)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.3 GO:0008366 ensheathment of neurons(GO:0007272) axon ensheathment(GO:0008366) myelination(GO:0042552)
0.0 0.1 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.5 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.0 0.1 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 1.9 GO:0030218 erythrocyte differentiation(GO:0030218)
0.0 0.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 2.7 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.0 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0043614 multi-eIF complex(GO:0043614)
0.6 4.6 GO:0070765 gamma-secretase complex(GO:0070765)
0.5 2.2 GO:0032584 growth cone membrane(GO:0032584)
0.3 1.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 3.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 1.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 2.9 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 1.4 GO:0070552 BRISC complex(GO:0070552)
0.2 2.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 0.8 GO:0034657 GID complex(GO:0034657)
0.1 4.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.5 GO:0005879 axonemal microtubule(GO:0005879)
0.1 0.3 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.1 0.7 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.0 GO:0034451 centriolar satellite(GO:0034451)
0.1 2.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.1 2.4 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.9 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 0.8 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 2.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.8 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)
0.0 1.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.5 GO:0030880 RNA polymerase complex(GO:0030880)
0.0 4.4 GO:0016604 nuclear body(GO:0016604)
0.0 0.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 4.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 7.1 GO:0005730 nucleolus(GO:0005730)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.5 GO:0031201 SNARE complex(GO:0031201)
0.0 1.5 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.3 GO:0030125 clathrin vesicle coat(GO:0030125)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0008119 thiopurine S-methyltransferase activity(GO:0008119)
0.7 2.2 GO:0043621 protein self-association(GO:0043621)
0.7 4.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.4 2.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.4 2.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.4 5.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 1.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 3.9 GO:0070122 isopeptidase activity(GO:0070122)
0.2 2.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 0.5 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.2 4.1 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 1.4 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 1.4 GO:0036122 BMP binding(GO:0036122)
0.2 0.8 GO:0035197 siRNA binding(GO:0035197)
0.1 2.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.8 GO:0019809 spermidine binding(GO:0019809)
0.1 0.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.3 GO:0004776 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.1 2.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.4 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.1 1.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 2.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.6 GO:0035173 histone kinase activity(GO:0035173)
0.1 0.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 5.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 3.0 GO:0043022 ribosome binding(GO:0043022)
0.1 2.1 GO:0019003 GDP binding(GO:0019003)
0.1 4.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 3.3 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 3.7 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.2 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 2.1 GO:0044325 ion channel binding(GO:0044325)
0.0 1.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 4.1 GO:0004386 helicase activity(GO:0004386)
0.0 0.8 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.7 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 1.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 2.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 3.5 GO:0042393 histone binding(GO:0042393)
0.0 6.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 4.5 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 1.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.3 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 3.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 3.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 3.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.5 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.5 2.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.5 4.6 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.4 4.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 5.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.6 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 1.6 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 1.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 2.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 4.1 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 2.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 2.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 4.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)