ISMARA results: figla

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for figla

Z-value: 1.42

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Transcription factors associated with figla

Gene Symbol	Gene ID	Gene Info
figla NCBI UniProt	ENSDARG00000087166	folliculogenesis specific bHLH transcription factor
figla NCBI UniProt	ENSDARG00000115572	folliculogenesis specific bHLH transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
figla	dr11_v1_chr5_-_13848296_13848296	0.28	5.7e-03	Click!

Activity profile of figla motif

Sorted Z-values of figla motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_30404096 Show fit	25.45	ENSDART00000103475	agr2 NCBI UniProt Show fit	anterior gradient 2
chr5_-_29531948 Show fit	16.01	ENSDART00000098360	arrdc1a NCBI UniProt Show fit	arrestin domain containing 1a
chr20_-_21672970 Show fit	15.82	ENSDART00000133286	si:ch211-207i1.2 NCBI UniProt Show fit	si:ch211-207i1.2
chr14_+_34514336 Show fit	15.32	ENSDART00000024440	foxi3b NCBI UniProt Show fit	forkhead box I3b
chr3_+_36424055 Show fit	14.97	ENSDART00000170318	si:ch1073-443f11.2 NCBI UniProt Show fit	si:ch1073-443f11.2
chr5_-_23696926 Show fit	13.47	ENSDART00000021462	rnf128a NCBI UniProt Show fit	ring finger protein 128a
chr13_+_33606739 Show fit	12.91	ENSDART00000026464	cfl1l NCBI UniProt Show fit	cofilin 1 (non-muscle), like
chr9_+_17309195 Show fit	12.69	ENSDART00000048548	scel NCBI UniProt Show fit	sciellin
chr22_-_17677947 Show fit	12.50	ENSDART00000139911	tjp3 NCBI UniProt Show fit	tight junction protein 3
chr19_-_30403922 Show fit	11.89	ENSDART00000181841	agr2 NCBI UniProt Show fit	anterior gradient 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of figla

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	37.3	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
6.6	26.3	GO:0009957	epidermal cell fate specification(GO:0009957)
0.1	19.2	GO:0030198	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.4	17.4	GO:0043297	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1	16.7	GO:0042127	regulation of cell proliferation(GO:0042127)
0.4	16.3	GO:0030199	collagen fibril organization(GO:0030199)
0.3	14.3	GO:0042737	drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.7	14.0	GO:0048251	elastic fiber assembly(GO:0048251)
4.3	12.9	GO:0030043	actin filament fragmentation(GO:0030043)
2.6	12.8	GO:0003210	cardiac atrium formation(GO:0003210)

Showing 1 to 10 of 194 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	61.7	GO:0005576	extracellular region(GO:0005576)
0.4	46.9	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1	28.3	GO:0031012	extracellular matrix(GO:0031012)
0.3	23.0	GO:0005581	collagen trimer(GO:0005581)
1.0	19.7	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	16.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.7	14.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.1	12.7	GO:0030141	secretory granule(GO:0030141)
0.1	11.6	GO:0016324	apical plasma membrane(GO:0016324)
0.1	11.6	GO:0005882	intermediate filament(GO:0005882)

Showing 1 to 10 of 80 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	40.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3	36.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.3	35.4	GO:0042803	protein homodimerization activity(GO:0042803)
0.2	27.3	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2	23.9	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	23.0	GO:0005198	structural molecule activity(GO:0005198)
0.3	17.9	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1	16.2	GO:0003774	motor activity(GO:0003774)
3.2	16.0	GO:1990756	protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.0	13.3	GO:0003779	actin binding(GO:0003779)

Showing 1 to 10 of 134 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	26.7	PID CMYB PATHWAY	C-MYB transcription factor network
0.5	22.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	16.6	NABA COLLAGENS	Genes encoding collagen proteins
0.3	8.1	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.2	7.8	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	7.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	6.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	6.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.2	5.9	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.2	5.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	16.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	12.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.8	11.5	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.1	8.9	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.9	8.5	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	8.5	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	7.8	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
1.2	7.0	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.3	6.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates

Showing 1 to 10 of 48 entries

Results for figla

Z-value: 1.42

Motif logo

Transcription factors associated with figla

Activity-expression correlation:

Activity profile of figla motif

Sorted Z-values of figla motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of figla

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: