ISMARA results: fli1b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for fli1b

Z-value: 2.11

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Transcription factors associated with fli1b

Gene Symbol	Gene ID	Gene Info
fli1b NCBI UniProt	ENSDARG00000040080	Fli-1 proto-oncogene, ETS transcription factor b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
fli1b	dr11_v1_chr16_+_42018041_42018042	0.77	1.3e-19	Click!

Activity profile of fli1b motif

Sorted Z-values of fli1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_38285671 Show fit	30.03	ENSDART00000061432	ccl38a.4 NCBI UniProt Show fit	chemokine (C-C motif) ligand 38, duplicate 4
chr21_+_25765734 Show fit	21.17	ENSDART00000021664	cldnb NCBI UniProt Show fit	claudin b
chr14_-_40797117 Show fit	20.52	ENSDART00000122369	elf1 NCBI UniProt Show fit	E74-like ETS transcription factor 1
chr18_-_48517040 Show fit	20.43	ENSDART00000143645	kcnj1a.3 NCBI UniProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3
chr1_-_37383539 Show fit	20.31	ENSDART00000127579	scpp1 NCBI UniProt Show fit	secretory calcium-binding phosphoprotein 1
chr8_+_3379815 Show fit	20.02	ENSDART00000155995	FUT9 (1 of many) NCBI UniProt Show fit	zgc:136963
chr18_-_48500545 Show fit	18.74	ENSDART00000058989 ENSDART00000098450	kcnj1a.6 NCBI UniProt Show fit kcnj1a.5 NCBI UniProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6 potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 5
chr13_+_30696286 Show fit	17.69	ENSDART00000192411	cxcl18a.1 NCBI UniProt Show fit	chemokine (C-X-C motif) ligand 18a, duplicate 1
chr23_-_10175898 Show fit	16.71	ENSDART00000146185	krt5 NCBI UniProt Show fit	keratin 5
chr17_-_37395460 Show fit	15.91	ENSDART00000148160 ENSDART00000075975	crip1 NCBI UniProt Show fit	cysteine-rich protein 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of fli1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	53.6	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
1.0	40.6	GO:0002548	monocyte chemotaxis(GO:0002548)
0.1	37.4	GO:0043087	regulation of GTPase activity(GO:0043087)
0.7	35.8	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.4	33.2	GO:0007179	transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.4	32.3	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.7	30.2	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.6	28.3	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.3	25.0	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.3	24.7	GO:0030048	actin filament-based movement(GO:0030048)

Showing 1 to 10 of 248 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	96.5	GO:0005615	extracellular space(GO:0005615)
0.4	56.1	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.2	53.9	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	44.4	GO:0005884	actin filament(GO:0005884)
3.1	33.8	GO:0045095	keratin filament(GO:0045095)
0.3	29.6	GO:0005604	basement membrane(GO:0005604)
0.2	22.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	22.3	GO:0072686	mitotic spindle(GO:0072686)
0.4	19.6	GO:0030496	midbody(GO:0030496)
0.2	17.7	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)

Showing 1 to 10 of 110 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	70.1	GO:0005198	structural molecule activity(GO:0005198)
0.2	60.3	GO:0051015	actin filament binding(GO:0051015)
0.9	58.3	GO:0008009	chemokine activity(GO:0008009)
0.5	53.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
3.6	50.7	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1	37.2	GO:0005096	GTPase activator activity(GO:0005096)
0.5	36.6	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3	33.0	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.2	28.4	GO:0000149	SNARE binding(GO:0000149)
0.1	28.1	GO:0019901	protein kinase binding(GO:0019901)

Showing 1 to 10 of 190 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	33.2	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.5	24.5	PID RAC1 PATHWAY	RAC1 signaling pathway
0.5	24.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.6	21.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.3	16.8	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	12.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	11.2	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.5	10.9	PID IL4 2PATHWAY	IL4-mediated signaling events
0.8	10.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.7	10.4	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	31.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	20.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	17.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.8	13.5	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.9	11.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	9.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.0	8.9	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.4	8.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.2	7.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.2	7.4	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions

Showing 1 to 10 of 76 entries

Results for fli1b

Z-value: 2.11

Motif logo

Transcription factors associated with fli1b

Activity-expression correlation:

Activity profile of fli1b motif

Sorted Z-values of fli1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of fli1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: