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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for fosaa+fosab+fosl1a
Z-value: 2.10
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Transcription factors associated with fosaa+fosab+fosl1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fosaa | dr11_v1_chr17_-_50234004_50234004 | -0.15 | 1.5e-01 | Click! |
| fosl1a | dr11_v1_chr14_-_30747686_30747686 | 0.12 | 2.6e-01 | Click! |
| fosab | dr11_v1_chr20_-_46554440_46554440 | 0.00 | 9.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_44883805 Show fit | 62.95 |
ENSDART00000182805
|
si:ch73-361h17.1 |
|
| chr17_-_6514962 Show fit | 17.41 |
ENSDART00000163514
|
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma b |
|
| chr13_+_2394534 Show fit | 14.83 |
ENSDART00000172535
ENSDART00000006990 |
ELOVL fatty acid elongase 5 |
|
| chr1_-_56080112 Show fit | 14.57 |
ENSDART00000075469
ENSDART00000161473 |
complement component c3a, duplicate 6 |
|
| chr1_-_20928772 Show fit | 14.09 |
ENSDART00000078277
|
methylsterol monooxygenase 1 |
|
| chr19_+_14109348 Show fit | 13.62 |
ENSDART00000159015
|
zgc:175136 |
|
| chr7_+_34794829 Show fit | 13.20 |
ENSDART00000009698
ENSDART00000075089 ENSDART00000173456 |
epithelial splicing regulatory protein 2 |
|
| chr22_+_38173960 Show fit | 12.93 |
ENSDART00000010537
|
ceruloplasmin |
|
| chr11_+_29537756 Show fit | 12.89 |
ENSDART00000103388
|
wu:fi42e03 |
|
| chr24_+_17334682 Show fit | 12.24 |
ENSDART00000018868
|
protein disulfide isomerase family A, member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of fosaa+fosab+fosl1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 46.8 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.9 | 38.0 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 1.6 | 33.9 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.3 | 24.8 | GO:0071466 | cellular response to xenobiotic stimulus(GO:0071466) |
| 0.2 | 22.3 | GO:0006956 | complement activation(GO:0006956) |
| 0.2 | 20.1 | GO:0034976 | response to endoplasmic reticulum stress(GO:0034976) |
| 0.1 | 19.1 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 1.4 | 18.5 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.9 | 16.7 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.5 | 13.8 | GO:0031100 | organ regeneration(GO:0031100) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 100.9 | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175) |
| 0.5 | 68.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.9 | 40.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 26.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 25.1 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 24.1 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 22.7 | GO:0005829 | cytosol(GO:0005829) |
| 6.3 | 18.9 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.3 | 18.0 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 16.4 | GO:0005819 | spindle(GO:0005819) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 33.9 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 29.4 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.4 | 25.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.9 | 24.4 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.1 | 23.5 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 2.9 | 17.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.2 | 17.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 1.2 | 15.1 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 2.0 | 14.1 | GO:0000254 | C-4 methylsterol oxidase activity(GO:0000254) |
| 0.5 | 13.2 | GO:0050661 | NADP binding(GO:0050661) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 61.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.7 | 23.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 22.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 22.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 13.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 11.4 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.2 | 10.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.6 | 9.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.3 | 9.6 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.3 | 8.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 80.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 3.3 | 32.7 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 1.4 | 26.7 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |
| 2.1 | 25.5 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 1.1 | 23.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.4 | 20.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 19.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.1 | 18.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.8 | 18.3 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.4 | 17.2 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |