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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for fosb+fosl2+si:ch211-153j24.3

Z-value: 1.16

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Transcription factors associated with fosb+fosl2+si:ch211-153j24.3

Gene Symbol Gene ID Gene Info
fosl2
ENSDARG00000040623 fos-like antigen 2
fosb
ENSDARG00000055751 FBJ murine osteosarcoma viral oncogene homolog B
si_ch211-153j24.3
ENSDARG00000068428 si_ch211-153j24.3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-153j24.3dr11_v1_chr20_+_46560258_46560258-0.525.6e-08Click!
fosl2dr11_v1_chr17_+_41302660_413026600.132.0e-01Click!
fosbdr11_v1_chr18_+_36770166_367701660.084.5e-01Click!

Activity profile of fosb+fosl2+si:ch211-153j24.3 motif

Sorted Z-values of fosb+fosl2+si:ch211-153j24.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_5595546 13.91 ENSDART00000191825
cyp1a
cytochrome P450, family 1, subfamily A
chr25_-_22187397 13.22 ENSDART00000123211
ENSDART00000139110
pkp3a
plakophilin 3a
chr25_+_13191391 12.46 ENSDART00000109937
si:ch211-147m6.2
si:ch211-147m6.2
chr21_-_2415808 11.70 ENSDART00000171179
si:ch211-241b2.5
si:ch211-241b2.5
chr16_+_23403602 10.99 ENSDART00000159848
s100w
S100 calcium binding protein W
chr14_-_11456724 10.27 ENSDART00000110424
si:ch211-153b23.4
si:ch211-153b23.4
chr1_+_14253118 10.17 ENSDART00000161996
cxcl8a
chemokine (C-X-C motif) ligand 8a
chr16_-_22930925 9.56 ENSDART00000133819
si:dkey-246i14.3
si:dkey-246i14.3
chr7_+_25033924 9.47 ENSDART00000170873
sb:cb1058
sb:cb1058
chr11_-_24681292 9.35 ENSDART00000089601
olfml3b
olfactomedin-like 3b
chr19_+_7567763 8.74 ENSDART00000140411
s100a11
S100 calcium binding protein A11
chr17_-_53359028 8.18 ENSDART00000185218
CABZ01068208.1

chr20_+_26880668 8.07 ENSDART00000077769
serpinb1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr2_+_30379650 7.93 ENSDART00000129542
crispld1b
cysteine-rich secretory protein LCCL domain containing 1b
chr21_+_5636008 7.86 ENSDART00000158385
shroom3
shroom family member 3
chr11_-_18253111 7.77 ENSDART00000125984
mustn1b
musculoskeletal, embryonic nuclear protein 1b
chr25_+_13191615 7.67 ENSDART00000168849
si:ch211-147m6.2
si:ch211-147m6.2
chr12_-_15205087 7.55 ENSDART00000010068
sult1st6
sulfotransferase family 1, cytosolic sulfotransferase 6
chr12_+_25945560 7.22 ENSDART00000109799
mmrn2b
multimerin 2b
chr14_-_1538600 7.18 ENSDART00000180925
CABZ01109480.1

chr3_-_48259289 7.18 ENSDART00000160717
znf750
zinc finger protein 750
chr8_+_6576940 6.86 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr9_+_426392 6.77 ENSDART00000172515
bzw1b
basic leucine zipper and W2 domains 1b
chr5_-_29531948 6.71 ENSDART00000098360
arrdc1a
arrestin domain containing 1a
chr23_+_4324625 6.60 ENSDART00000146302
ENSDART00000136792
ENSDART00000135027
ENSDART00000179819
sgk2a
serum/glucocorticoid regulated kinase 2a
chr12_-_212843 6.34 ENSDART00000083574
CABZ01102039.1

chr6_-_35439406 6.12 ENSDART00000073784
rgs5a
regulator of G protein signaling 5a
chr16_-_21785261 5.97 ENSDART00000078858
si:ch73-86n18.1
si:ch73-86n18.1
chr4_+_16715267 5.95 ENSDART00000143849
pkp2
plakophilin 2
chr1_+_59073436 5.92 ENSDART00000161642
MFAP4 (1 of many)
si:zfos-2330d3.3
chr16_+_23960744 5.89 ENSDART00000058965
apoeb
apolipoprotein Eb
chr5_-_25582721 5.88 ENSDART00000123986
anxa1a
annexin A1a
chr2_+_31671545 5.86 ENSDART00000145446
ackr4a
atypical chemokine receptor 4a
chr10_+_4987766 5.82 ENSDART00000121959
si:ch73-234b20.5
si:ch73-234b20.5
chr3_+_32118670 5.77 ENSDART00000055287
ENSDART00000111688
zgc:109934
zgc:109934
chr22_-_15593824 5.68 ENSDART00000123125
tpm4a
tropomyosin 4a
chr17_+_21452258 5.65 ENSDART00000157098
pla2g4f.1
phospholipase A2, group IVF, tandem duplicate 1
chr6_+_7507390 5.65 ENSDART00000149285
erbb3a
erb-b2 receptor tyrosine kinase 3a
chr7_+_33172066 5.64 ENSDART00000174013
si:ch211-194p6.12
si:ch211-194p6.12
chr3_-_32859335 5.56 ENSDART00000158916
si:dkey-16l2.20
si:dkey-16l2.20
chr19_+_4061699 5.55 ENSDART00000158309
ENSDART00000166512
btr25
btr26
bloodthirsty-related gene family, member 25
bloodthirsty-related gene family, member 26
chr10_+_187760 5.49 ENSDART00000161007
ENSDART00000160651
ets2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
chr3_+_1179601 5.36 ENSDART00000173378
triobpb
TRIO and F-actin binding protein b
chr25_-_22191733 5.35 ENSDART00000067478
pkp3a
plakophilin 3a
chr2_-_985417 5.33 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr24_+_264839 5.28 ENSDART00000066872
ccr12b.2
chemokine (C-C motif) receptor 12b, tandem duplicate 2
chr15_+_963292 5.28 ENSDART00000156586
alox5b.2
arachidonate 5-lipoxygenase b, tandem duplicate 2
chr9_-_9992697 5.16 ENSDART00000123415
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr19_+_348729 5.12 ENSDART00000114284
mcl1a
MCL1, BCL2 family apoptosis regulator a
chr13_-_37122217 5.08 ENSDART00000133242
syne2b
spectrin repeat containing, nuclear envelope 2b
chr19_+_2670130 4.96 ENSDART00000152152
si:ch73-24k9.2
si:ch73-24k9.2
chr9_-_21838045 4.88 ENSDART00000147471
acod1
aconitate decarboxylase 1
chr23_+_1730663 4.77 ENSDART00000149545
tgm1
transglutaminase 1, K polypeptide
chr4_+_25181572 4.77 ENSDART00000078529
ENSDART00000136643
kin
Kin17 DNA and RNA binding protein
chr4_-_77216726 4.75 ENSDART00000099943
psmb10
proteasome subunit beta 10
chr7_-_32981559 4.67 ENSDART00000175614
pkp3b
plakophilin 3b
chr16_+_49005321 4.66 ENSDART00000160919
CABZ01068499.1

chr6_-_442163 4.63 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
grap2b
GRB2-related adaptor protein 2b
chr1_+_41588170 4.62 ENSDART00000139175
si:dkey-56e3.2
si:dkey-56e3.2
chr22_+_16497670 4.60 ENSDART00000014330
ier5
immediate early response 5
chr7_+_17443567 4.55 ENSDART00000060383
nitr2b
novel immune-type receptor 2b
chr6_+_39108858 4.53 ENSDART00000154232
ENSDART00000192092
prss60.3
protease, serine, 60.3
chr14_-_34605607 4.52 ENSDART00000191608
afap1l1a
actin filament associated protein 1-like 1a
chr6_-_41091151 4.51 ENSDART00000154963
ENSDART00000153818
srsf3a
serine/arginine-rich splicing factor 3a
chr20_+_7084154 4.51 ENSDART00000136448
ftr85
finTRIM family, member 85
chr23_+_19213472 4.47 ENSDART00000185985
apobec2b
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2b
chr15_-_4568154 4.34 ENSDART00000155254
rffl
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr14_+_33882973 4.33 ENSDART00000019396
clic2
chloride intracellular channel 2
chr5_+_35398745 4.32 ENSDART00000098010
ptger4b
prostaglandin E receptor 4 (subtype EP4) b
chr7_+_15736230 4.27 ENSDART00000109942
mctp2b
multiple C2 domains, transmembrane 2b
chr19_-_7420867 4.21 ENSDART00000081741
rab25a
RAB25, member RAS oncogene family a
chr5_+_38200807 4.20 ENSDART00000100769
hsd20b2
hydroxysteroid (20-beta) dehydrogenase 2
chr22_-_22337382 4.18 ENSDART00000144684
si:ch211-129c21.1
si:ch211-129c21.1
chr8_+_44358443 4.11 ENSDART00000189130
ENSDART00000189212
CU914776.2

chr8_-_20291922 4.11 ENSDART00000148304
myo1f
myosin IF
chr7_-_20611039 4.10 ENSDART00000170422
si:dkey-19b23.8
si:dkey-19b23.8
chr17_+_32623931 4.10 ENSDART00000144217
ctsba
cathepsin Ba
chr11_+_37638873 4.07 ENSDART00000186384
ENSDART00000184291
ENSDART00000131782
ENSDART00000140502
sh2d5
SH2 domain containing 5
chr2_-_41861040 4.03 ENSDART00000045763
keap1a
kelch-like ECH-associated protein 1a
chr1_-_47122058 4.00 ENSDART00000159925
ENSDART00000101143
ENSDART00000176803
mhc1zea
major histocompatibility complex class I ZEA
chr13_-_15982707 3.95 ENSDART00000186911
ENSDART00000181072
ikzf1
IKAROS family zinc finger 1 (Ikaros)
chr5_+_24089334 3.85 ENSDART00000183748
tp53
tumor protein p53
chr19_+_37118547 3.81 ENSDART00000103163
cx30.9
connexin 30.9
chr8_-_18010735 3.79 ENSDART00000125014
acot11b
acyl-CoA thioesterase 11b
chr2_+_15100742 3.73 ENSDART00000027171
f3b
coagulation factor IIIb
chr18_-_45617146 3.73 ENSDART00000146543
wt1b
wilms tumor 1b
chr7_-_25697285 3.72 ENSDART00000082620
dysf
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
chr4_+_77933084 3.66 ENSDART00000148728
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr25_+_4954220 3.63 ENSDART00000156034
si:ch73-265h17.2
si:ch73-265h17.2
chr21_+_11778823 3.60 ENSDART00000031786
glrx
glutaredoxin (thioltransferase)
chr22_+_19247255 3.60 ENSDART00000144053
si:dkey-21e2.10
si:dkey-21e2.10
chr23_-_42752387 3.51 ENSDART00000149781
si:ch73-217n20.1
si:ch73-217n20.1
chr4_-_13518381 3.49 ENSDART00000067153
ifng1-1
interferon, gamma 1-1
chr17_-_26868169 3.48 ENSDART00000157204
si:dkey-221l4.10
si:dkey-221l4.10
chr23_+_5524247 3.46 ENSDART00000189679
ENSDART00000083622
tead3a
TEA domain family member 3 a
chr24_-_33366188 3.44 ENSDART00000074161
slc4a2b
solute carrier family 4 (anion exchanger), member 2b
chr4_-_41582875 3.41 ENSDART00000182308
ENSDART00000172173
ENSDART00000163135
si:dkeyp-44d3.5
si:dkeyp-44d3.5
chr5_-_1047504 3.40 ENSDART00000159346
mbd2
methyl-CpG binding domain protein 2
chr25_+_32474031 3.39 ENSDART00000152124
sqor
sulfide quinone oxidoreductase
chr8_-_7603516 3.33 ENSDART00000179826
ENSDART00000190153
irak1
interleukin-1 receptor-associated kinase 1
chr3_-_8765165 3.31 ENSDART00000191131
CABZ01058333.1

chr9_+_20483846 3.26 ENSDART00000192067
ENSDART00000145111
parp4
poly (ADP-ribose) polymerase family, member 4
chr8_+_28695914 3.25 ENSDART00000033386
ocstamp
osteoclast stimulatory transmembrane protein
chr23_-_30045661 3.22 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr5_-_67762434 3.18 ENSDART00000167301
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr10_+_28428222 3.17 ENSDART00000135003
si:ch211-222e20.4
si:ch211-222e20.4
chr5_+_54400971 3.14 ENSDART00000169695
bspry
B-box and SPRY domain containing
chr5_+_42064144 3.14 ENSDART00000035235
si:ch211-202a12.4
si:ch211-202a12.4
chr1_-_59139599 3.13 ENSDART00000152233
si:ch1073-110a20.3
si:ch1073-110a20.3
chr15_-_37733238 3.12 ENSDART00000115178
si:dkey-42l23.7
si:dkey-42l23.7
chr6_+_56147812 3.09 ENSDART00000150219
tfap2c
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr16_-_24832038 3.08 ENSDART00000153731
si:dkey-79d12.5
si:dkey-79d12.5
chr25_-_173165 3.06 ENSDART00000193594
CABZ01114053.1

chr25_+_29474583 3.06 ENSDART00000191189
il17rel
interleukin 17 receptor E-like
chr23_-_39636195 3.05 ENSDART00000144439
vwa1
von Willebrand factor A domain containing 1
chr18_+_50526290 3.04 ENSDART00000175194
ubl7b
ubiquitin-like 7b (bone marrow stromal cell-derived)
chr14_-_34605804 3.00 ENSDART00000144547
afap1l1a
actin filament associated protein 1-like 1a
chr13_+_18533005 2.96 ENSDART00000136024
ftr14l
finTRIM family, member 14-like
chr12_-_22355430 2.90 ENSDART00000153296
ENSDART00000056919
ENSDART00000159036
nsfb
N-ethylmaleimide-sensitive factor b
chr2_-_3437862 2.87 ENSDART00000053012
cyp8b1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr13_-_51846224 2.87 ENSDART00000184663
LT631684.2

chr24_+_260902 2.86 ENSDART00000151992
ccr12b.1
chemokine (C-C motif) receptor 12b, tandem duplicate 1
chr11_-_27821 2.84 ENSDART00000158769
ENSDART00000172970
ENSDART00000173118
ENSDART00000168674
ENSDART00000163545
ENSDART00000173411
ENSDART00000172132
sp1
sp1 transcription factor
chr23_-_1017605 2.84 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr16_-_28878080 2.81 ENSDART00000149501
si:dkey-239n17.4
si:dkey-239n17.4
chr15_-_38129845 2.81 ENSDART00000057095
si:dkey-24p1.1
si:dkey-24p1.1
chr3_+_29476085 2.77 ENSDART00000184495
ENSDART00000181058
fam83fa
family with sequence similarity 83, member Fa
chr8_-_7603700 2.76 ENSDART00000137975
irak1
interleukin-1 receptor-associated kinase 1
chr5_+_1933131 2.75 ENSDART00000061693
si:ch73-55i23.1
si:ch73-55i23.1
chr22_+_19218733 2.75 ENSDART00000183212
ENSDART00000133595
si:dkey-21e2.7
si:dkey-21e2.7
chr24_-_6078222 2.74 ENSDART00000146830
apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr19_+_24374196 2.72 ENSDART00000140732
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr7_+_14005111 2.61 ENSDART00000187365
furina
furin (paired basic amino acid cleaving enzyme) a
chr5_-_43959972 2.60 ENSDART00000180517
si:ch211-204c21.1
si:ch211-204c21.1
chr5_-_9760173 2.60 ENSDART00000172523
ddr2l
discoidin domain receptor family, member 2, like
chr16_-_33816082 2.58 ENSDART00000181769
rspo1
R-spondin 1
chr4_+_77971104 2.58 ENSDART00000188609
zgc:113921
zgc:113921
chr21_-_28640316 2.54 ENSDART00000128237
nrg2a
neuregulin 2a
chr25_+_23336310 2.53 ENSDART00000156457
ptprjb.2
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 2
chr24_-_23998897 2.52 ENSDART00000130053
zmp:0000000991
zmp:0000000991
chr6_-_37744430 2.52 ENSDART00000150177
ENSDART00000149722
nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr22_-_10110959 2.51 ENSDART00000031005
ENSDART00000147580
gls2b
glutaminase 2b (liver, mitochondrial)
chr23_-_1017428 2.51 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr4_-_19742300 2.50 ENSDART00000066964
ENSDART00000100952
hgfa
hepatocyte growth factor a
chr25_+_13205878 2.49 ENSDART00000162319
ENSDART00000162283
si:ch211-147m6.2
si:ch211-147m6.2
chr11_+_13630107 2.46 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr13_+_23988442 2.45 ENSDART00000010918
agt
angiotensinogen
chr3_-_21094437 2.37 ENSDART00000153739
ENSDART00000109790
nlk1
nemo-like kinase, type 1
chr8_-_22288258 2.34 ENSDART00000140978
ENSDART00000100046
si:ch211-147a11.3
si:ch211-147a11.3
chr12_+_48784731 2.34 ENSDART00000158348
zmiz1b
zinc finger, MIZ-type containing 1b
chr5_+_4564233 2.32 ENSDART00000193435
CABZ01058647.1

chr17_+_6667441 2.32 ENSDART00000123503
ENSDART00000180381
ENSDART00000156140
smc6
structural maintenance of chromosomes 6
chr25_+_8955530 2.32 ENSDART00000156444
si:ch211-256a21.4
si:ch211-256a21.4
chr4_-_75505048 2.29 ENSDART00000163665
si:dkey-71l4.5
si:dkey-71l4.5
chr11_+_10975012 2.29 ENSDART00000192872
itgb6
integrin, beta 6
chr25_+_13498188 2.28 ENSDART00000015710
snrkb
SNF related kinase b
chr8_+_8671229 2.27 ENSDART00000131963
usp11
ubiquitin specific peptidase 11
chr7_+_56453646 2.25 ENSDART00000112483
slc22a31
solute carrier family 22, member 31
chr16_-_51288178 2.23 ENSDART00000079864
zgc:173729
zgc:173729
chr6_+_51713076 2.22 ENSDART00000146281
ripor3
RIPOR family member 3
chr12_-_19250854 2.21 ENSDART00000152844
cdc42ep1a
CDC42 effector protein (Rho GTPase binding) 1a
chr3_+_17616201 2.21 ENSDART00000156775
rab5c
RAB5C, member RAS oncogene family
chr15_-_41382344 2.20 ENSDART00000190445
ENSDART00000189776
si:dkey-121n8.7
si:dkey-121n8.7
chr11_+_21050326 2.19 ENSDART00000065984
zgc:113307
zgc:113307
chr8_-_38105053 2.18 ENSDART00000131546
adgra2
adhesion G protein-coupled receptor A2
chr19_-_33212023 2.17 ENSDART00000189209
trib1
tribbles pseudokinase 1
chr21_+_45316330 2.17 ENSDART00000056474
ENSDART00000149314
ENSDART00000149272
ENSDART00000149156
ENSDART00000099497
tcf7
transcription factor 7
chr4_+_70191443 2.17 ENSDART00000164404
si:dkey-3h2.4
si:dkey-3h2.4
chr13_-_50567658 2.15 ENSDART00000132281
blnk
B cell linker
chr15_+_42559910 2.14 ENSDART00000075785
cldn17
claudin 17
chr20_-_49889111 2.13 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr4_+_68939074 2.11 ENSDART00000180232
si:dkey-264f17.2
si:dkey-264f17.2
chr23_-_6865946 2.10 ENSDART00000056426
ftr58
finTRIM family, member 58
chr22_+_39084829 2.08 ENSDART00000002826
gmppb
GDP-mannose pyrophosphorylase B
chr16_-_16481046 2.08 ENSDART00000158704
nbeal2
neurobeachin-like 2
chr15_-_31177324 2.06 ENSDART00000008854
wsb1
WD repeat and SOCS box containing 1
chr16_+_25245857 2.06 ENSDART00000155220
klhl38b
kelch-like family member 38b
chr4_+_77735212 2.05 ENSDART00000160716
si:dkey-238k10.1
si:dkey-238k10.1
chr3_-_34069637 2.04 ENSDART00000151588
ighv9-1
immunoglobulin heavy variable 9-1
chr4_+_77948970 2.02 ENSDART00000149636
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr11_+_13629528 2.02 ENSDART00000186509
si:ch211-1a19.3
si:ch211-1a19.3
chr7_-_5125799 2.02 ENSDART00000173390
ltb4r2a
leukotriene B4 receptor 2a
chr1_-_33380340 2.01 ENSDART00000181515
cd99
CD99 molecule
chr3_-_584950 2.00 ENSDART00000164752
dicp1.1
diverse immunoglobulin domain-containing protein 1.1
chr4_-_32456788 1.99 ENSDART00000151862
si:dkey-16p6.1
si:dkey-16p6.1
chr14_-_16807206 1.97 ENSDART00000157957
tcirg1b
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr24_+_42074143 1.96 ENSDART00000170514
top1mt
DNA topoisomerase I mitochondrial
chr19_+_42847306 1.95 ENSDART00000135164
pdcd6ip
programmed cell death 6 interacting protein
chr4_-_75899294 1.95 ENSDART00000157887
si:dkey-261j11.3
si:dkey-261j11.3
chr1_-_59411901 1.93 ENSDART00000167015
si:ch211-188p14.4
si:ch211-188p14.4
chr11_-_23501467 1.92 ENSDART00000169066
plekha6
pleckstrin homology domain containing, family A member 6
chr4_-_70131926 1.91 ENSDART00000108511
si:ch211-208f21.3
si:ch211-208f21.3
chr2_-_6519017 1.91 ENSDART00000181716
rgs1
regulator of G protein signaling 1
chr14_+_21699414 1.88 ENSDART00000169942
stx3a
syntaxin 3A
chr17_-_15600455 1.85 ENSDART00000110272
ENSDART00000156911
si:ch211-266g18.9
si:ch211-266g18.9
chr21_-_21020708 1.80 ENSDART00000064032
eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr4_+_5317483 1.79 ENSDART00000150366
si:ch211-214j24.10
si:ch211-214j24.10
chr1_+_55452892 1.78 ENSDART00000122508
CR788255.1

chr19_+_15441022 1.77 ENSDART00000098970
ENSDART00000140276
lin28a
lin-28 homolog A (C. elegans)
chr7_+_20298333 1.77 ENSDART00000023089
ENSDART00000131019
acadvl
acyl-CoA dehydrogenase very long chain

Network of associatons between targets according to the STRING database.

First level regulatory network of fosb+fosl2+si:ch211-153j24.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.2 GO:0002676 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
2.0 5.9 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
1.6 7.8 GO:0035988 chondrocyte proliferation(GO:0035988)
1.5 4.5 GO:0043388 positive regulation of DNA binding(GO:0043388)
1.3 3.9 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
1.1 3.4 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
1.1 11.7 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
1.0 10.3 GO:0006450 regulation of translational fidelity(GO:0006450)
1.0 5.9 GO:0033031 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.0 5.8 GO:0070254 mucus secretion(GO:0070254)
0.9 3.7 GO:0042117 plasma membrane repair(GO:0001778) monocyte activation(GO:0042117)
0.9 4.3 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.9 6.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.8 4.2 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.8 4.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.7 2.2 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.7 2.9 GO:0048211 Golgi vesicle docking(GO:0048211)
0.7 4.9 GO:1903426 regulation of reactive oxygen species biosynthetic process(GO:1903426)
0.7 6.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.7 5.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.6 9.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.6 5.7 GO:0044857 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.5 1.6 GO:0097095 frontonasal suture morphogenesis(GO:0097095)
0.5 2.2 GO:0033153 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.5 2.1 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.5 1.4 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.4 5.3 GO:0019372 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.4 1.7 GO:0003241 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.4 1.9 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.4 4.1 GO:0021683 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 2.5 GO:0060343 trabecula formation(GO:0060343) heart trabecula formation(GO:0060347) skin epidermis development(GO:0098773)
0.4 8.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.3 2.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.3 2.5 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.3 7.9 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.3 7.6 GO:0051923 sulfation(GO:0051923)
0.2 1.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 1.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 3.1 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.2 3.5 GO:0031641 regulation of myelination(GO:0031641)
0.2 0.9 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 2.3 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.2 1.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.2 2.2 GO:0031268 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.2 3.9 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.2 0.7 GO:0009750 response to fructose(GO:0009750)
0.2 2.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 4.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 5.4 GO:0031100 organ regeneration(GO:0031100)
0.2 5.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.2 3.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 2.6 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.2 1.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 4.2 GO:0033555 multicellular organismal response to stress(GO:0033555)
0.2 1.8 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 2.6 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 1.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 2.9 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.2 1.1 GO:1902292 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.2 1.7 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.2 15.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 2.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.2 1.2 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.2 2.0 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 3.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.9 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 18.5 GO:0007043 cell-cell junction assembly(GO:0007043)
0.1 13.9 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 4.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 2.5 GO:0015693 magnesium ion transport(GO:0015693)
0.1 2.4 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.1 2.0 GO:0006265 DNA topological change(GO:0006265)
0.1 0.6 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 1.1 GO:0034205 beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.1 1.8 GO:0043248 proteasome assembly(GO:0043248)
0.1 3.5 GO:0035329 hippo signaling(GO:0035329)
0.1 0.4 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 2.0 GO:0035723 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.1 0.6 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 4.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 2.5 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.1 3.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 4.1 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 4.3 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 0.9 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 2.6 GO:0006826 iron ion transport(GO:0006826)
0.1 1.5 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 3.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 2.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 1.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 5.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 1.7 GO:0021986 habenula development(GO:0021986)
0.1 0.9 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.1 2.6 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.1 2.7 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.4 GO:0008210 estrogen biosynthetic process(GO:0006703) estrogen metabolic process(GO:0008210)
0.0 3.6 GO:0007596 blood coagulation(GO:0007596)
0.0 1.8 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 1.4 GO:0072348 sulfur compound transport(GO:0072348)
0.0 1.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.9 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 2.9 GO:0008203 cholesterol metabolic process(GO:0008203) secondary alcohol metabolic process(GO:1902652)
0.0 3.1 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 3.8 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 2.2 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.2 GO:0070935 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967) 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.4 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 5.1 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 2.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.5 GO:0034620 cellular response to unfolded protein(GO:0034620)
0.0 5.2 GO:0009617 response to bacterium(GO:0009617)
0.0 3.8 GO:0006821 chloride transport(GO:0006821)
0.0 0.2 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 2.7 GO:0031101 fin regeneration(GO:0031101)
0.0 3.3 GO:0008544 epidermis development(GO:0008544)
0.0 1.6 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.8 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.2 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.4 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.9 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.2 GO:0061055 myotome development(GO:0061055)
0.0 1.2 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0072672 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.0 1.9 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 2.3 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 4.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.5 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 4.7 GO:0006887 exocytosis(GO:0006887)
0.0 0.3 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.0 2.2 GO:0006260 DNA replication(GO:0006260)
0.0 4.2 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.0 1.1 GO:0010970 establishment of localization by movement along microtubule(GO:0010970)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.9 GO:0006400 tRNA modification(GO:0006400)
0.0 0.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 1.0 GO:0048545 response to steroid hormone(GO:0048545)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.9 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
1.2 23.2 GO:0030057 desmosome(GO:0030057)
1.2 3.5 GO:0043220 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.8 2.3 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.6 4.0 GO:0016234 inclusion body(GO:0016234)
0.5 2.2 GO:1990909 Wnt signalosome(GO:1990909)
0.5 6.0 GO:0014704 intercalated disc(GO:0014704)
0.5 7.5 GO:0002102 podosome(GO:0002102)
0.4 5.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.4 7.3 GO:0009925 basal plasma membrane(GO:0009925)
0.3 2.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 3.7 GO:0030315 T-tubule(GO:0030315)
0.2 1.1 GO:0000811 GINS complex(GO:0000811)
0.2 3.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 2.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 1.8 GO:0042788 polysomal ribosome(GO:0042788)
0.2 7.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 0.9 GO:0005899 insulin receptor complex(GO:0005899)
0.2 4.7 GO:0005839 proteasome core complex(GO:0005839)
0.2 6.9 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.2 2.0 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.2 0.5 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.2 1.7 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.8 GO:0016589 NURF complex(GO:0016589)
0.1 35.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 5.3 GO:0016342 catenin complex(GO:0016342)
0.1 2.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 18.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 1.5 GO:0005869 dynactin complex(GO:0005869)
0.1 7.7 GO:0031201 SNARE complex(GO:0031201)
0.1 1.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.6 GO:0005921 gap junction(GO:0005921)
0.1 5.4 GO:0055037 recycling endosome(GO:0055037)
0.1 4.3 GO:0034707 chloride channel complex(GO:0034707)
0.1 7.0 GO:0016607 nuclear speck(GO:0016607)
0.1 5.3 GO:0005604 basement membrane(GO:0005604)
0.1 6.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 0.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 6.3 GO:0005769 early endosome(GO:0005769)
0.0 5.0 GO:0005884 actin filament(GO:0005884)
0.0 5.7 GO:0016459 myosin complex(GO:0016459)
0.0 3.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.0 GO:0005795 Golgi stack(GO:0005795)
0.0 3.8 GO:0098791 trans-Golgi network(GO:0005802) Golgi subcompartment(GO:0098791)
0.0 1.5 GO:0030018 Z disc(GO:0030018)
0.0 0.6 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 2.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 6.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 2.1 GO:0005871 kinesin complex(GO:0005871)
0.0 26.7 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 4.0 GO:0000785 chromatin(GO:0000785)
0.0 0.1 GO:0032300 mismatch repair complex(GO:0032300)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.2 GO:0005153 interleukin-8 receptor binding(GO:0005153)
2.3 13.9 GO:0070330 aromatase activity(GO:0070330)
2.0 5.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
1.3 6.7 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
1.1 5.6 GO:0038132 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
1.1 3.4 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
1.0 6.0 GO:0019215 intermediate filament binding(GO:0019215)
1.0 5.9 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
1.0 2.9 GO:0008397 sterol 12-alpha-hydroxylase activity(GO:0008397)
0.8 7.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.8 8.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.8 5.3 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.7 2.2 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.7 19.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 4.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.6 1.8 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.5 3.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.5 2.1 GO:0008905 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.5 2.0 GO:0033149 FFAT motif binding(GO:0033149)
0.5 11.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 4.3 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.4 1.7 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.4 1.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.4 2.6 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.4 14.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 1.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.3 1.7 GO:0017040 ceramidase activity(GO:0017040)
0.3 2.6 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.3 2.0 GO:0004974 leukotriene receptor activity(GO:0004974)
0.3 1.4 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.3 2.5 GO:0004359 glutaminase activity(GO:0004359)
0.3 1.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.3 3.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 24.6 GO:0045296 cadherin binding(GO:0045296)
0.2 4.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 5.6 GO:0070492 oligosaccharide binding(GO:0070492)
0.2 3.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 3.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 10.3 GO:0000049 tRNA binding(GO:0000049)
0.2 4.6 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.2 4.1 GO:0004875 complement receptor activity(GO:0004875)
0.2 3.1 GO:0031386 protein tag(GO:0031386)
0.2 1.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.2 0.7 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.2 2.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.2 1.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 0.9 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.2 3.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 1.7 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.1 2.0 GO:0051117 ATPase binding(GO:0051117)
0.1 2.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 7.5 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 3.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 8.0 GO:0003823 antigen binding(GO:0003823)
0.1 6.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 7.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 5.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.5 GO:0030544 Hsp70 protein binding(GO:0030544) Hsp90 protein binding(GO:0051879)
0.1 2.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 3.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 5.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 4.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.1 GO:0045503 dynein light chain binding(GO:0045503)
0.1 18.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 2.5 GO:0004707 MAP kinase activity(GO:0004707)
0.1 3.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.8 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 0.7 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 6.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 2.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 14.7 GO:0051015 actin filament binding(GO:0051015)
0.0 5.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 1.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.4 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 1.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 4.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.8 GO:0005254 chloride channel activity(GO:0005254)
0.0 6.6 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 1.5 GO:0008201 heparin binding(GO:0008201)
0.0 1.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.5 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 9.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.3 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.8 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.1 GO:1900750 oligopeptide binding(GO:1900750)
0.0 2.0 GO:0008134 transcription factor binding(GO:0008134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 3.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 2.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 5.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 4.8 PID TNF PATHWAY TNF receptor signaling pathway
0.1 3.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.6 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.4 PID AP1 PATHWAY AP-1 transcription factor network
0.1 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 3.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 7.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 4.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.4 2.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.4 3.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 3.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 2.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 1.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 2.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 3.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 5.3 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.8 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.8 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 2.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 1.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 3.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 2.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 2.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 3.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.7 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules