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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for foxa3

Z-value: 1.36

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Transcription factors associated with foxa3

Gene Symbol Gene ID Gene Info
foxa3
ENSDARG00000012788 forkhead box A3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxa3dr11_v1_chr18_-_46354269_463542690.622.9e-11Click!

Activity profile of foxa3 motif

Sorted Z-values of foxa3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_23978978 33.83 ENSDART00000058964
ENSDART00000135084
apoa2
apolipoprotein A-II
chr2_+_10134345 23.15 ENSDART00000100725
ahsg2
alpha-2-HS-glycoprotein 2
chr5_+_32345187 20.76 ENSDART00000147132
c9
complement component 9
chr5_-_16351306 20.35 ENSDART00000168643
CABZ01088700.1

chr5_+_28830643 19.55 ENSDART00000051448
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_+_28830388 18.81 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr20_+_6142433 18.45 ENSDART00000054084
ENSDART00000136986
ttr
transthyretin (prealbumin, amyloidosis type I)
chr5_+_28857969 17.02 ENSDART00000149850
si:ch211-186e20.2
si:ch211-186e20.2
chr11_+_13223625 17.02 ENSDART00000161275
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr21_-_1625976 16.39 ENSDART00000066621
vmo1b
vitelline membrane outer layer 1 homolog b
chr5_+_28848870 16.34 ENSDART00000149563
zgc:174259
zgc:174259
chr2_-_38035235 16.31 ENSDART00000075904
cbln5
cerebellin 5
chr5_+_28849155 16.28 ENSDART00000079090
zgc:174259
zgc:174259
chr22_-_36856405 16.24 ENSDART00000029588
kng1
kininogen 1
chr16_+_23913943 14.24 ENSDART00000175404
ENSDART00000129525
apoa4b.1
apolipoprotein A-IV b, tandem duplicate 1
chr15_-_26552393 14.02 ENSDART00000150152
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr16_-_54455573 13.74 ENSDART00000075275
pklr
pyruvate kinase L/R
chr15_+_14856307 13.17 ENSDART00000167213
diabloa
diablo, IAP-binding mitochondrial protein a
chr9_-_23253870 13.14 ENSDART00000143657
ENSDART00000169911
acmsd
aminocarboxymuconate semialdehyde decarboxylase
chr5_+_28858345 12.45 ENSDART00000111180
si:ch211-186e20.2
si:ch211-186e20.2
chr15_-_26552652 12.22 ENSDART00000152336
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr4_-_6373735 12.05 ENSDART00000140100
MDFIC
si:ch73-156e19.1
chr14_-_36799280 11.92 ENSDART00000168615
rnf130
ring finger protein 130
chr2_+_20539402 11.67 ENSDART00000129585
si:ch73-14h1.2
si:ch73-14h1.2
chr18_+_35842933 11.41 ENSDART00000151587
ENSDART00000131121
ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
chr11_-_7380674 11.24 ENSDART00000014979
ENSDART00000103418
vtg3
vitellogenin 3, phosvitinless
chr6_-_13206255 11.04 ENSDART00000065373
eef1b2
eukaryotic translation elongation factor 1 beta 2
chr25_-_13188678 10.85 ENSDART00000125754
si:ch211-147m6.1
si:ch211-147m6.1
chr17_-_23709347 10.69 ENSDART00000124661
papss2a
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr5_+_28797771 10.60 ENSDART00000188845
ENSDART00000149066
si:ch211-186e20.7
si:ch211-186e20.7
chr18_-_16795262 10.29 ENSDART00000048722
ampd3b
adenosine monophosphate deaminase 3b
chr2_+_37875789 9.81 ENSDART00000036318
ENSDART00000127679
cbln13
cerebellin 13
chr20_+_15015557 9.66 ENSDART00000039345
myoc
myocilin
chr23_+_26026383 9.65 ENSDART00000141553
pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr12_-_26064480 9.44 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
ldb3b
LIM domain binding 3b
chr3_-_50865079 9.43 ENSDART00000164295
pmp22a
peripheral myelin protein 22a
chr13_+_22480857 8.82 ENSDART00000078721
ENSDART00000044719
ENSDART00000130957
ENSDART00000078757
ENSDART00000130424
ENSDART00000078747
ldb3a
LIM domain binding 3a
chr22_-_10110959 8.81 ENSDART00000031005
ENSDART00000147580
gls2b
glutaminase 2b (liver, mitochondrial)
chr8_+_49570884 8.75 ENSDART00000182117
ENSDART00000108613
rasef
RAS and EF-hand domain containing
chr14_+_32918484 8.74 ENSDART00000105721
lnx2b
ligand of numb-protein X 2b
chr16_-_17713859 8.32 ENSDART00000149275
zgc:174935
zgc:174935
chr21_-_39081107 8.30 ENSDART00000075935
vtnb
vitronectin b
chr2_-_5475910 7.97 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
proca
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr16_-_21785261 7.86 ENSDART00000078858
si:ch73-86n18.1
si:ch73-86n18.1
chr21_-_25295087 7.82 ENSDART00000087910
ENSDART00000147860
st14b
suppression of tumorigenicity 14 (colon carcinoma) b
chr14_+_20893065 7.76 ENSDART00000079452
lygl1
lysozyme g-like 1
chr6_+_52918537 7.59 ENSDART00000174229
or137-1
odorant receptor, family H, subfamily 137, member 1
chr7_+_34305903 7.42 ENSDART00000173575
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr17_+_24036791 7.37 ENSDART00000140767
b3gnt2b
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2b
chr21_-_20840714 7.35 ENSDART00000144861
ENSDART00000139430
c6
complement component 6
chr4_-_12795436 7.35 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr21_+_17768174 7.27 ENSDART00000141380
rxraa
retinoid X receptor, alpha a
chr23_+_27703749 7.08 ENSDART00000027224
lmbr1l
limb development membrane protein 1-like
chr1_+_36651059 6.95 ENSDART00000187475
ednraa
endothelin receptor type Aa
chr23_-_21515182 6.94 ENSDART00000142000
rnf207b
ring finger protein 207b
chr24_-_26369185 6.94 ENSDART00000080039
lrrc31
leucine rich repeat containing 31
chr11_-_11336986 6.82 ENSDART00000016677
zgc:77929
zgc:77929
chr18_+_17611627 6.73 ENSDART00000046891
cetp
cholesteryl ester transfer protein, plasma
chr8_+_39795918 6.54 ENSDART00000143413
si:ch211-170d8.2
si:ch211-170d8.2
chr19_+_7636941 6.41 ENSDART00000081611
ENSDART00000163805
ENSDART00000112404
cgnb
cingulin b
chr25_-_30344117 6.40 ENSDART00000167077
pdia3
protein disulfide isomerase family A, member 3
chr21_-_35419486 6.40 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr3_+_12744083 6.29 ENSDART00000158554
ENSDART00000169545
cyp2k21
cytochrome P450, family 2, subfamily k, polypeptide 21
chr17_+_30843881 6.07 ENSDART00000149600
ENSDART00000148547
tpp1
tripeptidyl peptidase I
chr14_-_4120636 6.06 ENSDART00000059230
irf2
interferon regulatory factor 2
chr4_-_12795030 6.06 ENSDART00000150427
b2m
beta-2-microglobulin
chr25_-_13188214 6.03 ENSDART00000187298
si:ch211-147m6.1
si:ch211-147m6.1
chr18_+_20566817 5.96 ENSDART00000100716
bida
BH3 interacting domain death agonist
chr5_-_66160415 5.94 ENSDART00000073895
mboat4
membrane bound O-acyltransferase domain containing 4
chr7_+_13995792 5.81 ENSDART00000091470
furina
furin (paired basic amino acid cleaving enzyme) a
chr24_-_31306724 5.78 ENSDART00000165399
acp5b
acid phosphatase 5b, tartrate resistant
chr6_-_8736766 5.77 ENSDART00000143956
cavin2b
caveolae associated protein 2b
chr3_+_12484008 5.74 ENSDART00000182229
vasnb
vasorin b
chr15_-_25365319 5.67 ENSDART00000152651
cluha
clustered mitochondria (cluA/CLU1) homolog a
chr6_-_38930726 5.65 ENSDART00000154151
hdac7b
histone deacetylase 7b
chr20_+_52546186 5.61 ENSDART00000110777
ENSDART00000153377
ENSDART00000153013
ENSDART00000042704
eef1db
eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
chr3_+_23743139 5.56 ENSDART00000187409
hoxb3a
homeobox B3a
chr24_+_19542323 5.55 ENSDART00000140379
ENSDART00000142830
sulf1
sulfatase 1
chr5_+_42092227 5.52 ENSDART00000097583
ENSDART00000171678
ubb
ubiquitin B
chr21_-_22951604 5.42 ENSDART00000083449
ENSDART00000180129
dub
duboraya
chr4_+_12358822 5.35 ENSDART00000172557
ENSDART00000150627
pimr168
Pim proto-oncogene, serine/threonine kinase, related 168
chr2_-_32262287 5.24 ENSDART00000056621
ENSDART00000039717
fam49ba
family with sequence similarity 49, member Ba
chr25_+_14087045 5.14 ENSDART00000155770
actc1c
actin, alpha, cardiac muscle 1c
chr13_-_40726865 5.13 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr8_+_24747865 5.04 ENSDART00000078656
slc16a4
solute carrier family 16, member 4
chr24_+_25258904 5.01 ENSDART00000155714
gabrr3b
gamma-aminobutyric acid (GABA) A receptor, rho 3b
chr6_-_53048291 4.99 ENSDART00000103267
fam212ab
family with sequence similarity 212, member Ab
chr10_-_15128771 4.86 ENSDART00000101261
spp1
secreted phosphoprotein 1
chr19_-_46091497 4.83 ENSDART00000178772
ENSDART00000167255
ptdss1b
si:dkey-108k24.2
phosphatidylserine synthase 1b
si:dkey-108k24.2
chr2_+_25839940 4.81 ENSDART00000139927
eif5a2
eukaryotic translation initiation factor 5A2
chr7_-_5029478 4.78 ENSDART00000193819
ltb4r
leukotriene B4 receptor
chr2_+_25840463 4.72 ENSDART00000125178
eif5a2
eukaryotic translation initiation factor 5A2
chr4_-_1914228 4.69 ENSDART00000087835
ano6
anoctamin 6
chr1_-_44940830 4.64 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
tmem176
transmembrane protein 176
chr3_+_29941777 4.61 ENSDART00000113889
ifi35
interferon-induced protein 35
chr20_-_9980318 4.60 ENSDART00000080664
ACTC1
zgc:86709
chr2_+_23731194 4.57 ENSDART00000155747
slc22a13a
solute carrier family 22 member 13a
chr3_-_41292569 4.53 ENSDART00000111856
sdk1a
sidekick cell adhesion molecule 1a
chr16_+_11724230 4.49 ENSDART00000060266
ceacam1
carcinoembryonic antigen-related cell adhesion molecule 1
chr9_-_29497916 4.47 ENSDART00000060246
dnajc3a
DnaJ (Hsp40) homolog, subfamily C, member 3a
chr17_+_8799661 4.42 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr6_-_25384526 4.38 ENSDART00000160544
PKN2 (1 of many)
zgc:153916
chr3_-_6719232 4.25 ENSDART00000154294
atg4db
autophagy related 4D, cysteine peptidase b
chr20_+_51104367 4.23 ENSDART00000073981
eif2s1b
eukaryotic translation initiation factor 2, subunit 1 alpha b
chr22_+_7497319 4.15 ENSDART00000034564
CELA1 (1 of many)
zgc:92511
chr4_+_14981854 4.15 ENSDART00000067046
cax1
cation/H+ exchanger protein 1
chr18_-_44847855 4.11 ENSDART00000086823
srpr
signal recognition particle receptor (docking protein)
chr3_+_32571929 4.09 ENSDART00000151025
si:ch73-248e21.1
si:ch73-248e21.1
chr24_-_26485098 4.06 ENSDART00000135496
ENSDART00000009609
ENSDART00000133782
ENSDART00000141029
ENSDART00000113739
eif5a
eukaryotic translation initiation factor 5A
chr16_+_36748538 3.93 ENSDART00000139069
decr1
2,4-dienoyl CoA reductase 1, mitochondrial
chr23_+_42813415 3.89 ENSDART00000055577
myl9a
myosin, light chain 9a, regulatory
chr1_+_36612660 3.87 ENSDART00000190784
ednraa
endothelin receptor type Aa
chr23_-_44848961 3.86 ENSDART00000136839
wu:fb72h05
wu:fb72h05
chr14_-_6931889 3.86 ENSDART00000166439
si:ch211-266k2.1
si:ch211-266k2.1
chr17_-_42988356 3.85 ENSDART00000024558
zgc:92137
zgc:92137
chr8_-_43923788 3.75 ENSDART00000146152
adgrd1
adhesion G protein-coupled receptor D1
chr21_+_37436907 3.75 ENSDART00000182611
ENSDART00000076328
pgrmc1
progesterone receptor membrane component 1
chr7_+_58730201 3.72 ENSDART00000073640
plag1
pleiomorphic adenoma gene 1
chr2_+_38161318 3.70 ENSDART00000044264
mmp14b
matrix metallopeptidase 14b (membrane-inserted)
chr5_-_54712159 3.68 ENSDART00000149207
ccnb1
cyclin B1
chr7_+_4682659 3.65 ENSDART00000112697
si:ch211-225k7.2
si:ch211-225k7.2
chr7_+_20512419 3.60 ENSDART00000173907
si:dkey-19b23.14
si:dkey-19b23.14
chr10_+_23553533 3.57 ENSDART00000159654
CR847844.2

chr15_-_44052927 3.53 ENSDART00000166209
wu:fb44b02
wu:fb44b02
chr4_+_17310143 3.53 ENSDART00000004717
igf1
insulin-like growth factor 1
chr1_+_9153141 3.50 ENSDART00000081343
plk1
polo-like kinase 1 (Drosophila)
chr11_-_30634286 3.48 ENSDART00000191019
zgc:153665
zgc:153665
chr9_-_34396264 3.47 ENSDART00000045754
grtp1b
growth hormone regulated TBC protein 1b
chr10_-_11385155 3.46 ENSDART00000064214
plac8.1
placenta-specific 8, tandem duplicate 1
chr10_+_15603082 3.42 ENSDART00000024450
zfand5b
zinc finger, AN1-type domain 5b
chr7_+_13830052 3.39 ENSDART00000191360
abhd2a
abhydrolase domain containing 2a
chr3_+_15828999 3.39 ENSDART00000104397
tmem11
transmembrane protein 11
chr15_+_15390882 3.39 ENSDART00000062024
ca4b
carbonic anhydrase IV b
chr15_-_25571865 3.37 ENSDART00000077836
mmp20b
matrix metallopeptidase 20b (enamelysin)
chr21_+_30549512 3.36 ENSDART00000132831
rab38c
RAB38c, member of RAS oncogene family
chr7_-_51300277 3.34 ENSDART00000174174
gc2
guanylyl cyclase 2
chr11_+_21137948 3.33 ENSDART00000110673
il10
interleukin 10
chr13_+_46803979 3.32 ENSDART00000159260
CU695232.1

chr5_-_32292965 3.31 ENSDART00000183522
ENSDART00000131983
myhz1.2
myosin, heavy polypeptide 1.2, skeletal muscle
chr1_+_1805294 3.28 ENSDART00000103850
atp1a1a.3
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr3_+_2719243 3.27 ENSDART00000189256
CR388047.3

chr7_+_48705227 3.23 ENSDART00000174034
AL929208.1

chr24_-_32025637 3.19 ENSDART00000180448
ENSDART00000159034
rsu1
Ras suppressor protein 1
chr21_-_17296789 3.18 ENSDART00000192180
gfi1b
growth factor independent 1B transcription repressor
chr11_+_2391469 3.13 ENSDART00000182121
igfbp6a
insulin-like growth factor binding protein 6a
chr3_-_43770876 3.13 ENSDART00000160162
zgc:92162
zgc:92162
chr5_-_20194876 3.11 ENSDART00000122587
dao.1
D-amino-acid oxidase, tandem duplicate 1
chr12_-_2993095 3.10 ENSDART00000152316
si:dkey-202c14.3
si:dkey-202c14.3
chr3_+_32129632 3.07 ENSDART00000174522
zgc:109934
zgc:109934
chr15_-_37719679 3.07 ENSDART00000184025
si:dkey-117a8.1
si:dkey-117a8.1
chr12_-_29301022 3.04 ENSDART00000187826
sh2d4bb
SH2 domain containing 4Bb
chr13_-_47403154 3.04 ENSDART00000114318
bcl2l11
BCL2 like 11
chr7_-_32020100 3.03 ENSDART00000185433
kif18a
kinesin family member 18A
chr22_-_14128716 3.02 ENSDART00000140323
si:ch211-246m6.4
si:ch211-246m6.4
chr11_-_183328 3.02 ENSDART00000168562
avil
advillin
chr8_-_3312384 3.02 ENSDART00000035965
fut9b
fucosyltransferase 9b
chr8_+_30456161 3.01 ENSDART00000085894
pgm5
phosphoglucomutase 5
chr16_-_35952789 3.00 ENSDART00000180118
eva1ba
eva-1 homolog Ba (C. elegans)
chr4_-_30055196 2.99 ENSDART00000139539
si:rp71-7l19.2
si:rp71-7l19.2
chr7_-_17570923 2.99 ENSDART00000188476
ENSDART00000080624
nitr5
novel immune-type receptor 5
chr5_-_34875858 2.99 ENSDART00000085086
arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr15_+_36187434 2.97 ENSDART00000181536
ENSDART00000099501
ENSDART00000154432
masp1
mannan-binding lectin serine peptidase 1
chr15_-_8191841 2.94 ENSDART00000156663
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr17_-_53439866 2.94 ENSDART00000154826
mycbp
c-myc binding protein
chr16_-_25233515 2.93 ENSDART00000058943
zgc:110182
zgc:110182
chr3_-_55525627 2.91 ENSDART00000189234
tex2
testis expressed 2
chr19_-_19720744 2.90 ENSDART00000170636
evx1
even-skipped homeobox 1
chr7_-_13906409 2.87 ENSDART00000062257
slc39a1
solute carrier family 39 (zinc transporter), member 1
chr3_+_13559199 2.85 ENSDART00000166547
si:ch73-106n3.1
si:ch73-106n3.1
chr17_+_4400738 2.84 ENSDART00000170204
si:zfos-364h11.1
si:zfos-364h11.1
chr23_-_21215311 2.83 ENSDART00000112424
megf6a
multiple EGF-like-domains 6a
chr2_-_27330181 2.81 ENSDART00000137053
tmx3a
thioredoxin related transmembrane protein 3a
chr16_-_13992646 2.81 ENSDART00000139623
si:dkey-85k15.6
si:dkey-85k15.6
chr11_+_2391649 2.80 ENSDART00000104571
igfbp6a
insulin-like growth factor binding protein 6a
chr17_+_33418475 2.78 ENSDART00000169145
snap23.1
synaptosomal-associated protein 23.1
chr15_-_669476 2.77 ENSDART00000153687
ENSDART00000030603
si:ch211-210b2.2
si:ch211-210b2.2
chr11_-_25539323 2.77 ENSDART00000155785
si:dkey-245f22.3
si:dkey-245f22.3
chr8_-_25690966 2.74 ENSDART00000033701
sema3ga
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga
chr22_+_24673168 2.73 ENSDART00000135257
si:rp71-23d18.8
si:rp71-23d18.8
chr8_-_31701157 2.72 ENSDART00000141799
fbxo4
F-box protein 4
chr3_-_41292275 2.70 ENSDART00000144088
sdk1a
sidekick cell adhesion molecule 1a
chr3_-_56871330 2.68 ENSDART00000014103
zgc:112148
zgc:112148
chr19_+_30867845 2.67 ENSDART00000047461
mfsd2ab
major facilitator superfamily domain containing 2ab
chr15_+_24644016 2.66 ENSDART00000043292
smtnl
smoothelin, like
chr3_+_32492467 2.66 ENSDART00000151329
trpm4a
transient receptor potential cation channel, subfamily M, member 4a
chr16_-_38001040 2.63 ENSDART00000133861
ENSDART00000138711
ENSDART00000143846
ENSDART00000146564
si:ch211-198c19.3
si:ch211-198c19.3
chr8_+_30780985 2.62 ENSDART00000193971
ENSDART00000111533
tas2r200.2
taste receptor, type 2, member 200, tandem duplicate 2
chr5_+_29726428 2.60 ENSDART00000143183
ddx31
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr11_+_1584747 2.57 ENSDART00000154583
si:dkey-40c23.2
si:dkey-40c23.2
chr7_-_58729894 2.55 ENSDART00000149347
chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr1_+_49668423 2.54 ENSDART00000150880
tsga10
testis specific, 10
chr25_+_7982979 2.53 ENSDART00000171904
ucmab
upper zone of growth plate and cartilage matrix associated b
chr23_-_29357764 2.53 ENSDART00000156512
si:ch211-129o18.4
si:ch211-129o18.4
chr13_+_40692804 2.51 ENSDART00000109822
hps1
Hermansky-Pudlak syndrome 1
chr3_+_5575313 2.50 ENSDART00000134693
ENSDART00000101807
si:ch211-106h11.3
si:ch211-106h11.3
chr8_-_20245892 2.50 ENSDART00000136911
acer1
alkaline ceramidase 1
chr5_-_14509137 2.48 ENSDART00000180742
si:ch211-244o22.2
si:ch211-244o22.2
chr8_-_19313510 2.45 ENSDART00000164780
ENSDART00000137133
rgl1
ral guanine nucleotide dissociation stimulator-like 1
chr8_-_27858458 2.43 ENSDART00000132632
ENSDART00000136562
cttnbp2nlb
CTTNBP2 N-terminal like b
chr6_+_13206516 2.41 ENSDART00000036927
ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
4.3 17.0 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
3.6 10.7 GO:0050427 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
2.6 13.2 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
2.6 7.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
2.3 16.2 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
2.3 6.9 GO:1903779 regulation of cardiac conduction(GO:1903779)
2.2 6.7 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
2.2 13.1 GO:0019805 quinolinate biosynthetic process(GO:0019805) quinolinate metabolic process(GO:0046874)
1.9 13.6 GO:0045901 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
1.9 157.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
1.8 5.4 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
1.8 10.8 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
1.7 16.7 GO:0072337 modified amino acid transport(GO:0072337)
1.6 4.7 GO:0002407 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
1.5 6.0 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
1.2 3.7 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
1.2 13.4 GO:0045824 negative regulation of innate immune response(GO:0045824)
1.1 8.8 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
1.1 7.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.9 2.8 GO:0010359 regulation of anion channel activity(GO:0010359)
0.9 2.7 GO:0002369 T cell cytokine production(GO:0002369)
0.9 3.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.8 3.1 GO:0009080 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.7 2.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.7 4.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.7 10.3 GO:0032264 IMP salvage(GO:0032264)
0.7 2.2 GO:0045141 telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.7 2.2 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.7 2.8 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.7 5.5 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.7 3.4 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.7 3.4 GO:0097186 amelogenesis(GO:0097186)
0.6 1.9 GO:0045601 negative regulation of epithelial cell differentiation(GO:0030857) regulation of endothelial cell differentiation(GO:0045601)
0.6 2.5 GO:1903232 melanosome assembly(GO:1903232)
0.6 1.8 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.6 7.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.6 9.7 GO:0001952 regulation of cell-matrix adhesion(GO:0001952)
0.5 2.2 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.5 5.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.5 2.7 GO:0045056 transcytosis(GO:0045056)
0.5 7.4 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.5 5.8 GO:0045453 bone resorption(GO:0045453)
0.5 7.1 GO:0032094 response to food(GO:0032094)
0.5 1.5 GO:1900364 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)
0.5 2.0 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.5 2.0 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.5 1.9 GO:2000392 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.5 4.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.4 35.8 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.4 6.9 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.4 5.8 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.4 3.7 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.4 3.7 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.4 1.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.4 3.1 GO:0050482 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.4 1.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4 1.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.3 2.0 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 8.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.3 11.2 GO:0032355 response to estradiol(GO:0032355)
0.3 2.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) embryonic skeletal joint development(GO:0072498)
0.3 16.6 GO:0006414 translational elongation(GO:0006414)
0.3 1.1 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.3 7.3 GO:0019835 cytolysis(GO:0019835)
0.3 1.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.3 1.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 2.0 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 2.6 GO:0050909 sensory perception of taste(GO:0050909)
0.2 2.5 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.2 0.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 2.9 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.2 5.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.2 1.5 GO:0070207 protein homotrimerization(GO:0070207)
0.2 13.7 GO:0006096 glycolytic process(GO:0006096)
0.2 5.6 GO:1903039 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.2 4.4 GO:0031297 replication fork processing(GO:0031297)
0.2 0.6 GO:0019323 pentose catabolic process(GO:0019323)
0.2 2.5 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.2 1.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.2 3.4 GO:0032438 melanosome organization(GO:0032438)
0.2 0.9 GO:0050996 positive regulation of lipid catabolic process(GO:0050996)
0.2 5.4 GO:0032526 response to retinoic acid(GO:0032526)
0.2 3.3 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.2 2.5 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.2 1.8 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.2 1.3 GO:0030320 cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 1.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.2 4.3 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.2 3.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 2.9 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 1.5 GO:0051601 exocyst localization(GO:0051601)
0.1 0.6 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 3.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.9 GO:0009217 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.1 2.1 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 0.4 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 1.5 GO:0048938 myelination of lateral line nerve axons(GO:0048897) posterior lateral line nerve glial cell differentiation(GO:0048931) myelination of posterior lateral line nerve axons(GO:0048932) lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048938) posterior lateral line nerve glial cell development(GO:0048941) posterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048942)
0.1 1.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 8.0 GO:0007596 blood coagulation(GO:0007596)
0.1 7.2 GO:0010842 retina layer formation(GO:0010842)
0.1 1.6 GO:0035108 limb morphogenesis(GO:0035108)
0.1 1.2 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 2.8 GO:0051014 actin filament severing(GO:0051014)
0.1 9.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.9 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 2.0 GO:0097178 ruffle assembly(GO:0097178)
0.1 7.1 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 0.5 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 13.8 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.1 0.4 GO:0090342 regulation of cell aging(GO:0090342)
0.1 7.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 1.6 GO:0031167 rRNA methylation(GO:0031167)
0.1 5.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 2.7 GO:2001236 regulation of extrinsic apoptotic signaling pathway(GO:2001236)
0.1 0.9 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.1 0.6 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 2.3 GO:0060037 pharyngeal system development(GO:0060037)
0.1 3.3 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.1 2.4 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.8 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1 4.9 GO:0060348 bone development(GO:0060348)
0.1 0.6 GO:0006857 oligopeptide transport(GO:0006857)
0.1 9.2 GO:0001756 somitogenesis(GO:0001756)
0.1 3.5 GO:0032465 regulation of cytokinesis(GO:0032465)
0.1 1.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 0.7 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 3.2 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 2.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 3.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.5 GO:0046958 learning(GO:0007612) nonassociative learning(GO:0046958) habituation(GO:0046959)
0.1 3.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 7.1 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.1 2.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 9.9 GO:0014032 neural crest cell development(GO:0014032)
0.0 1.7 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 3.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 3.0 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 8.1 GO:0045597 positive regulation of cell differentiation(GO:0045597)
0.0 2.2 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0006574 valine catabolic process(GO:0006574)
0.0 1.2 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 2.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 7.0 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.7 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 3.0 GO:0009617 response to bacterium(GO:0009617)
0.0 1.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 3.5 GO:0009953 dorsal/ventral pattern formation(GO:0009953)
0.0 0.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 1.6 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 7.2 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.6 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 2.5 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.9 GO:0030901 midbrain development(GO:0030901)
0.0 7.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.0 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.3 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.7 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.7 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 8.7 GO:0006955 immune response(GO:0006955)
0.0 7.2 GO:0019941 modification-dependent protein catabolic process(GO:0019941)
0.0 0.9 GO:0016573 histone acetylation(GO:0016573)
0.0 2.6 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.8 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
2.4 9.6 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
2.4 16.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
2.2 13.4 GO:0042612 MHC class I protein complex(GO:0042612)
1.4 4.2 GO:0043614 multi-eIF complex(GO:0043614)
1.2 3.7 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.8 3.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.8 3.0 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.6 4.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.6 2.5 GO:0031085 BLOC-3 complex(GO:0031085)
0.6 8.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.6 1.7 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.5 2.0 GO:0035339 SPOTS complex(GO:0035339)
0.5 7.3 GO:0005579 membrane attack complex(GO:0005579)
0.4 1.2 GO:0043202 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.4 18.4 GO:0031941 filamentous actin(GO:0031941)
0.4 1.9 GO:0032433 filopodium tip(GO:0032433)
0.3 1.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 9.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 7.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 11.0 GO:0005643 nuclear pore(GO:0005643)
0.2 1.9 GO:0034451 centriolar satellite(GO:0034451)
0.2 11.6 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.2 203.6 GO:0005615 extracellular space(GO:0005615)
0.2 0.9 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 4.2 GO:0031672 A band(GO:0031672)
0.1 5.8 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 5.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 6.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 12.9 GO:0016459 myosin complex(GO:0016459)
0.1 2.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 3.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 4.3 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 1.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 10.8 GO:0031012 extracellular matrix(GO:0031012)
0.1 1.0 GO:0005682 U5 snRNP(GO:0005682)
0.1 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 6.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.5 GO:0000145 exocyst(GO:0000145)
0.0 1.5 GO:0042641 actomyosin(GO:0042641)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 20.6 GO:0005576 extracellular region(GO:0005576)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.7 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 7.1 GO:0005764 lysosome(GO:0005764)
0.0 2.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.6 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.7 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.7 GO:0030496 midbody(GO:0030496)
0.0 4.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.2 GO:0005930 axoneme(GO:0005930)
0.0 8.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 4.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 20.2 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.1 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 10.7 GO:0005739 mitochondrion(GO:0005739)
0.0 1.1 GO:0043025 neuronal cell body(GO:0043025)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 18.5 GO:0070324 thyroid hormone binding(GO:0070324)
4.3 17.0 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
3.6 10.7 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
2.5 7.4 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
2.3 13.7 GO:0004743 pyruvate kinase activity(GO:0004743)
1.9 7.8 GO:0003796 lysozyme activity(GO:0003796)
1.7 5.1 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
1.6 11.2 GO:0045735 nutrient reservoir activity(GO:0045735)
1.5 10.8 GO:0004962 endothelin receptor activity(GO:0004962)
1.2 137.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.0 4.2 GO:0051139 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
1.0 39.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
1.0 8.8 GO:0004359 glutaminase activity(GO:0004359)
1.0 5.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.9 10.3 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.9 18.4 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.8 3.1 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.7 5.8 GO:0003993 acid phosphatase activity(GO:0003993)
0.7 2.2 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.7 2.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.7 4.8 GO:0004974 leukotriene receptor activity(GO:0004974)
0.7 30.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.7 5.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.6 5.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.6 1.7 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.6 3.4 GO:0008126 acetylesterase activity(GO:0008126)
0.6 2.8 GO:0016972 thiol oxidase activity(GO:0016972)
0.5 5.9 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.5 7.4 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.5 6.4 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.5 6.9 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.5 6.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.4 2.5 GO:0017040 ceramidase activity(GO:0017040)
0.4 2.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.4 1.2 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.3 5.5 GO:0031386 protein tag(GO:0031386)
0.3 3.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3 5.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 2.2 GO:0070888 E-box binding(GO:0070888)
0.3 5.8 GO:0005080 protein kinase C binding(GO:0005080)
0.3 0.9 GO:0070186 growth hormone receptor binding(GO:0005131) growth hormone activity(GO:0070186)
0.3 1.6 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.3 8.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 13.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 3.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 2.0 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.3 6.7 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.3 1.3 GO:0016531 copper chaperone activity(GO:0016531)
0.3 3.0 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.2 7.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 1.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 2.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 1.2 GO:0004630 phospholipase D activity(GO:0004630)
0.2 1.7 GO:0050700 CARD domain binding(GO:0050700)
0.2 1.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 0.5 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.1 0.9 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 3.1 GO:0004875 complement receptor activity(GO:0004875)
0.1 0.6 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 4.5 GO:0051087 chaperone binding(GO:0051087)
0.1 28.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 3.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 4.2 GO:0043022 ribosome binding(GO:0043022)
0.1 2.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.7 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 2.0 GO:0070411 I-SMAD binding(GO:0070411)
0.1 6.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 3.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 5.9 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 4.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.9 GO:0048256 flap endonuclease activity(GO:0048256)
0.1 2.0 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 3.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 4.7 GO:0005254 chloride channel activity(GO:0005254)
0.1 1.5 GO:0008143 poly(A) binding(GO:0008143)
0.1 2.7 GO:0099604 ligand-gated calcium channel activity(GO:0099604)
0.1 2.9 GO:0005109 frizzled binding(GO:0005109)
0.1 2.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 2.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.2 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.1 3.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 3.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 2.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.1 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.6 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 1.4 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 22.7 GO:0008289 lipid binding(GO:0008289)
0.0 1.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 2.6 GO:0003724 RNA helicase activity(GO:0003724)
0.0 5.4 GO:0005125 cytokine activity(GO:0005125)
0.0 0.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 18.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 5.2 GO:0042393 histone binding(GO:0042393)
0.0 1.8 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 16.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.7 32.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 13.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.4 3.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4 4.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 37.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 7.2 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 1.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.2 3.5 PID IGF1 PATHWAY IGF1 pathway
0.2 1.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 2.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 12.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.4 ST GA13 PATHWAY G alpha 13 Pathway
0.1 6.4 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.4 PID ARF6 PATHWAY Arf6 signaling events
0.1 3.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 2.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.8 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 1.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.9 PID NOTCH PATHWAY Notch signaling pathway
0.1 1.8 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 2.4 PID TNF PATHWAY TNF receptor signaling pathway
0.1 1.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.3 PID FGF PATHWAY FGF signaling pathway
0.0 2.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID AURORA B PATHWAY Aurora B signaling
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 34.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
2.7 13.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.2 31.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
1.1 23.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.1 16.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
1.0 13.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.9 18.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.7 6.7 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.6 6.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5 13.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.5 4.8 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.4 7.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 6.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.4 10.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.4 2.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 4.9 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.3 3.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 3.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 10.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 3.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 1.3 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.2 2.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 2.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.3 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.1 1.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 2.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.0 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 11.0 REACTOME TRANSLATION Genes involved in Translation
0.1 2.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 1.8 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 2.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.1 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 2.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters