ISMARA results: foxa3

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for foxa3

Z-value: 1.36

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Transcription factors associated with foxa3

Gene Symbol	Gene ID	Gene Info
foxa3 NCBI UniProt	ENSDARG00000012788	forkhead box A3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
foxa3	dr11_v1_chr18_-_46354269_46354269	0.62	2.9e-11	Click!

Activity profile of foxa3 motif

Sorted Z-values of foxa3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_23978978 Show fit	33.83	ENSDART00000058964 ENSDART00000135084	apoa2 NCBI UniProt Show fit	apolipoprotein A-II
chr2_+_10134345 Show fit	23.15	ENSDART00000100725	ahsg2 NCBI UniProt Show fit	alpha-2-HS-glycoprotein 2
chr5_+_32345187 Show fit	20.76	ENSDART00000147132	c9 NCBI UniProt Show fit	complement component 9
chr5_-_16351306 Show fit	20.35	ENSDART00000168643	CABZ01088700.1 NCBI UniProt Show fit
chr5_+_28830643 Show fit	19.55	ENSDART00000051448	serpina7 NCBI UniProt Show fit	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_+_28830388 Show fit	18.81	ENSDART00000149150	serpina7 NCBI UniProt Show fit	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr20_+_6142433 Show fit	18.45	ENSDART00000054084 ENSDART00000136986	ttr NCBI UniProt Show fit	transthyretin (prealbumin, amyloidosis type I)
chr5_+_28857969 Show fit	17.02	ENSDART00000149850	si:ch211-186e20.2 NCBI UniProt Show fit	si:ch211-186e20.2
chr11_+_13223625 Show fit	17.02	ENSDART00000161275	abcb11b NCBI UniProt Show fit	ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr21_-_1625976 Show fit	16.39	ENSDART00000066621	vmo1b NCBI UniProt Show fit	vitelline membrane outer layer 1 homolog b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	157.9	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.4	35.8	GO:0055113	epiboly involved in gastrulation with mouth forming second(GO:0055113)
6.9	20.8	GO:0006957	complement activation, alternative pathway(GO:0006957)
4.3	17.0	GO:0015722	canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
1.7	16.7	GO:0072337	modified amino acid transport(GO:0072337)
0.3	16.6	GO:0006414	translational elongation(GO:0006414)
2.3	16.2	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1	13.8	GO:0042157	lipoprotein metabolic process(GO:0042157)
0.2	13.7	GO:0006096	glycolytic process(GO:0006096)
1.9	13.6	GO:0045901	positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)

Showing 1 to 10 of 171 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	203.6	GO:0005615	extracellular space(GO:0005615)
6.9	20.8	GO:0044215	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0	20.6	GO:0005576	extracellular region(GO:0005576)
0.0	20.2	GO:0005783	endoplasmic reticulum(GO:0005783)
0.4	18.4	GO:0031941	filamentous actin(GO:0031941)
2.4	16.6	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
2.2	13.4	GO:0042612	MHC class I protein complex(GO:0042612)
0.1	12.9	GO:0016459	myosin complex(GO:0016459)
0.2	11.6	GO:0030173	integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.2	11.0	GO:0005643	nuclear pore(GO:0005643)

Showing 1 to 10 of 62 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	137.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.0	39.4	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.7	30.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.1	28.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	22.7	GO:0008289	lipid binding(GO:0008289)
0.0	18.6	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
4.6	18.5	GO:0070324	thyroid hormone binding(GO:0070324)
0.9	18.4	GO:0051393	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
4.3	17.0	GO:0015432	canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
2.3	13.7	GO:0004743	pyruvate kinase activity(GO:0004743)

Showing 1 to 10 of 104 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	37.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	32.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.0	16.5	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.4	13.4	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.2	12.0	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.2	7.2	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	6.4	PID P53 REGULATION PATHWAY	p53 pathway
0.4	4.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	4.4	ST GA13 PATHWAY	G alpha 13 Pathway
0.2	3.5	PID IGF1 PATHWAY	IGF1 pathway

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	34.5	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.2	31.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.1	23.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.9	18.5	REACTOME AMYLOIDS	Genes involved in Amyloids
1.1	16.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.5	13.6	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
2.7	13.4	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
1.0	13.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	11.0	REACTOME TRANSLATION	Genes involved in Translation
0.4	10.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling

Showing 1 to 10 of 42 entries

Results for foxa3

Z-value: 1.36

Motif logo

Transcription factors associated with foxa3

Activity-expression correlation:

Activity profile of foxa3 motif

Sorted Z-values of foxa3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: