ISMARA results: foxa_foxa1

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for foxa_foxa1_foxa2

Z-value: 2.57

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Transcription factors associated with foxa_foxa1_foxa2

Gene Symbol	Gene ID	Gene Info
foxa NCBI UniProt	ENSDARG00000087094	forkhead box A sequence
foxa NCBI UniProt	ENSDARG00000110743	forkhead box A sequence
foxa NCBI UniProt	ENSDARG00000115019	forkhead box A sequence
foxa1 NCBI UniProt	ENSDARG00000102138	forkhead box A1
foxa2 NCBI UniProt	ENSDARG00000003411	forkhead box A2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
foxa2	dr11_v1_chr17_-_42568498_42568498	0.84	3.5e-26	Click!
foxa1	dr11_v1_chr17_+_10318071_10318071	0.58	1.2e-09	Click!
foxa	dr11_v1_chr14_-_33981544_33981544	0.08	4.3e-01	Click!

Activity profile of foxa_foxa1_foxa2 motif

Sorted Z-values of foxa_foxa1_foxa2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_6142433 Show fit	84.64	ENSDART00000054084 ENSDART00000136986	ttr NCBI UniProt Show fit	transthyretin (prealbumin, amyloidosis type I)
chr5_+_28830643 Show fit	68.08	ENSDART00000051448	serpina7 NCBI UniProt Show fit	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr16_+_23978978 Show fit	68.02	ENSDART00000058964 ENSDART00000135084	apoa2 NCBI UniProt Show fit	apolipoprotein A-II
chr22_-_36856405 Show fit	66.57	ENSDART00000029588	kng1 NCBI UniProt Show fit	kininogen 1
chr5_+_28830388 Show fit	63.86	ENSDART00000149150	serpina7 NCBI UniProt Show fit	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr2_+_10134345 Show fit	63.40	ENSDART00000100725	ahsg2 NCBI UniProt Show fit	alpha-2-HS-glycoprotein 2
chr5_+_28857969 Show fit	62.21	ENSDART00000149850	si:ch211-186e20.2 NCBI UniProt Show fit	si:ch211-186e20.2
chr16_-_54455573 Show fit	61.37	ENSDART00000075275	pklr NCBI UniProt Show fit	pyruvate kinase L/R
chr5_+_28848870 Show fit	59.80	ENSDART00000149563	zgc:174259 NCBI UniProt Show fit	zgc:174259
chr5_+_28849155 Show fit	58.15	ENSDART00000079090	zgc:174259 NCBI UniProt Show fit	zgc:174259

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa_foxa1_foxa2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.2	524.1	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
7.8	85.9	GO:0019731	antibacterial humoral response(GO:0019731)
8.5	84.6	GO:0072337	modified amino acid transport(GO:0072337)
3.2	77.9	GO:0009749	response to glucose(GO:0009749)
9.8	68.6	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.9	61.4	GO:0006096	glycolytic process(GO:0006096)
0.7	58.8	GO:0055113	epiboly involved in gastrulation with mouth forming second(GO:0055113)
3.6	57.6	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.7	47.8	GO:0007596	blood coagulation(GO:0007596)
13.8	41.3	GO:0010430	fatty acid omega-oxidation(GO:0010430)

Showing 1 to 10 of 172 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	625.5	GO:0005615	extracellular space(GO:0005615)
0.2	104.5	GO:0005576	extracellular region(GO:0005576)
0.8	84.2	GO:0055037	recycling endosome(GO:0055037)
1.7	76.1	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.1	50.7	GO:0005794	Golgi apparatus(GO:0005794)
2.7	40.4	GO:0005579	membrane attack complex(GO:0005579)
0.0	38.0	GO:0005783	endoplasmic reticulum(GO:0005783)
0.2	34.1	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
1.5	31.3	GO:0030127	COPII vesicle coat(GO:0030127)
4.0	27.9	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 61 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.0	465.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.6	141.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.1	125.3	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
21.2	84.6	GO:0070324	thyroid hormone binding(GO:0070324)
18.5	73.9	GO:0004373	glycogen (starch) synthase activity(GO:0004373)
10.2	61.4	GO:0004743	pyruvate kinase activity(GO:0004743)
0.1	41.7	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
10.3	41.3	GO:0070643	vitamin D 25-hydroxylase activity(GO:0070643)
0.8	37.5	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
1.3	35.7	GO:0004181	metallocarboxypeptidase activity(GO:0004181)

Showing 1 to 10 of 131 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	241.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
3.3	147.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
3.9	66.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	19.8	PID MTOR 4PATHWAY	mTOR signaling pathway
1.5	18.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.5	13.2	PID IGF1 PATHWAY	IGF1 pathway
0.6	10.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
1.3	10.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.3	7.4	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	2.6	PID E2F PATHWAY	E2F transcription factor network

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.1	92.0	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
3.7	84.6	REACTOME AMYLOIDS	Genes involved in Amyloids
1.6	72.9	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
6.8	68.0	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
4.4	66.6	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
3.5	62.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
4.2	54.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.9	54.1	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.8	38.1	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.5	35.1	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression

Showing 1 to 10 of 50 entries

Results for foxa_foxa1_foxa2

Z-value: 2.57

Motif logo

Transcription factors associated with foxa_foxa1_foxa2

Activity-expression correlation:

Activity profile of foxa_foxa1_foxa2 motif

Sorted Z-values of foxa_foxa1_foxa2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa_foxa1_foxa2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: