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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for foxd2_foxd5
Z-value: 1.94
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Transcription factors associated with foxd2_foxd5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxd2 | dr11_v1_chr8_+_19674369_19674369 | -0.48 | 1.2e-06 | Click! |
| foxd5 | dr11_v1_chr8_+_30452945_30452945 | -0.20 | 5.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxd2_foxd5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 69.0 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.2 | 67.9 | GO:0006914 | autophagy(GO:0006914) |
| 0.8 | 63.5 | GO:0007599 | hemostasis(GO:0007599) |
| 2.0 | 47.4 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 2.3 | 46.3 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 37.8 | GO:0008283 | cell proliferation(GO:0008283) |
| 11.7 | 35.1 | GO:0048785 | hatching gland development(GO:0048785) |
| 1.3 | 34.8 | GO:0035622 | intrahepatic bile duct development(GO:0035622) |
| 0.3 | 33.3 | GO:0072376 | complement activation(GO:0006956) protein activation cascade(GO:0072376) |
| 1.9 | 31.0 | GO:0006228 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 156.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 64.6 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 50.9 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 0.3 | 34.8 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.6 | 24.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 16.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 2.5 | 12.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 1.5 | 12.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 8.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.5 | 7.8 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 104.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 59.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 56.4 | GO:0005198 | structural molecule activity(GO:0005198) |
| 6.2 | 49.8 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.7 | 43.4 | GO:0042562 | hormone binding(GO:0042562) |
| 0.2 | 39.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 34.8 | GO:0019904 | protein domain specific binding(GO:0019904) |
| 5.9 | 29.7 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
| 1.0 | 28.9 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 3.4 | 27.6 | GO:0031419 | cobalamin binding(GO:0031419) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 93.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 67.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 52.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.8 | 33.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.9 | 25.4 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.4 | 8.4 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.2 | 6.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 6.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 6.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 5.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.3 | 65.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 5.9 | 58.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 2.8 | 58.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 5.9 | 47.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 1.7 | 40.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 2.0 | 35.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 1.5 | 31.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 3.2 | 25.3 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.9 | 22.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.9 | 16.5 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |