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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for foxo3a

Z-value: 0.76

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Transcription factors associated with foxo3a

Gene Symbol Gene ID Gene Info
foxo3a
ENSDARG00000023058 forkhead box O3A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxo3adr11_v1_chr17_+_6793001_67930010.593.4e-10Click!

Activity profile of foxo3a motif

Sorted Z-values of foxo3a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_36378494 11.98 ENSDART00000058503
gpm6aa
glycoprotein M6Aa
chr14_-_25599002 7.43 ENSDART00000040955
slc25a48
solute carrier family 25, member 48
chr19_+_10396042 6.61 ENSDART00000028048
ENSDART00000151735
necap1
NECAP endocytosis associated 1
chr12_-_13886952 6.29 ENSDART00000110503
adam11
ADAM metallopeptidase domain 11
chr6_+_48618512 6.25 ENSDART00000111190
FAM19A3
si:dkey-238f9.1
chr11_+_18873619 5.60 ENSDART00000176141
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr1_-_28749604 4.89 ENSDART00000148522
GK3P
zgc:172295
chr13_+_1100197 4.84 ENSDART00000139560
ppp3r1a
protein phosphatase 3, regulatory subunit B, alpha a
chr8_-_25011157 4.75 ENSDART00000078795
ahcyl1
adenosylhomocysteinase-like 1
chr3_-_28258462 4.70 ENSDART00000191573
rbfox1
RNA binding fox-1 homolog 1
chr19_+_2275019 4.67 ENSDART00000136138
itgb8
integrin, beta 8
chr3_+_19207176 4.39 ENSDART00000087803
rln3a
relaxin 3a
chr25_-_11088839 4.23 ENSDART00000154748
sv2bb
synaptic vesicle glycoprotein 2Bb
chr7_+_47287307 4.19 ENSDART00000114669
dpy19l3
dpy-19 like C-mannosyltransferase 3
chr24_-_6678640 4.16 ENSDART00000042478
enkur
enkurin, TRPC channel interacting protein
chr3_-_26191960 4.11 ENSDART00000113843
ypel3
yippee-like 3
chr4_-_4256300 4.01 ENSDART00000103319
ENSDART00000150279
cd9b
CD9 molecule b
chr14_-_48939560 4.00 ENSDART00000021736
scocb
short coiled-coil protein b
chr1_-_6494384 3.86 ENSDART00000109356
klf7a
Kruppel-like factor 7a
chr6_-_52156427 3.83 ENSDART00000082821
rims4
regulating synaptic membrane exocytosis 4
chr18_+_1703984 3.83 ENSDART00000114010
slitrk3a
SLIT and NTRK-like family, member 3a
chr24_+_17007407 3.68 ENSDART00000110652
zfx
zinc finger protein, X-linked
chr3_-_51912019 3.67 ENSDART00000149914
aatka
apoptosis-associated tyrosine kinase a
chr1_-_9277986 3.65 ENSDART00000146065
ENSDART00000114876
ENSDART00000132812
ubn1
ubinuclein 1
chr3_+_54168007 3.51 ENSDART00000109894
olfm2a
olfactomedin 2a
chr9_+_17971935 3.44 ENSDART00000149736
akap11
A kinase (PRKA) anchor protein 11
chr5_+_36611128 3.43 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr16_-_32671782 3.41 ENSDART00000123980
pnisr
PNN-interacting serine/arginine-rich protein
chr15_+_8043751 3.34 ENSDART00000193701
cadm2b
cell adhesion molecule 2b
chr20_+_30445971 3.32 ENSDART00000153150
myt1la
myelin transcription factor 1-like, a
chr1_+_16127825 3.31 ENSDART00000122503
tusc3
tumor suppressor candidate 3
chr19_-_28367413 3.22 ENSDART00000079092
si:dkey-261i16.5
si:dkey-261i16.5
chr21_-_42202792 3.22 ENSDART00000124708
gabra6b
gamma-aminobutyric acid (GABA) A receptor, alpha 6b
chr14_-_34044369 3.11 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr20_+_6142433 3.08 ENSDART00000054084
ENSDART00000136986
ttr
transthyretin (prealbumin, amyloidosis type I)
chr1_+_41886830 3.02 ENSDART00000185887
ENSDART00000084735
si:dkey-37g12.1
si:dkey-37g12.1
chr19_+_9344171 2.88 ENSDART00000133447
ENSDART00000104622
si:ch211-288g17.4
si:ch211-288g17.4
chr8_+_26432677 2.87 ENSDART00000078369
ENSDART00000131925
zgc:136971
zgc:136971
chr19_-_12965020 2.86 ENSDART00000128975
slc25a32a
solute carrier family 25 (mitochondrial folate carrier), member 32a
chr15_+_14856307 2.83 ENSDART00000167213
diabloa
diablo, IAP-binding mitochondrial protein a
chr15_-_31498123 2.76 ENSDART00000153665
si:dkey-1m11.6
si:dkey-1m11.6
chr8_+_21225064 2.62 ENSDART00000129210
cry1ba
cryptochrome circadian clock 1ba
chr4_+_5741733 2.58 ENSDART00000110243
pou3f2a
POU class 3 homeobox 2a
chr20_+_40457599 2.57 ENSDART00000017553
serinc1
serine incorporator 1
chr8_+_10823069 2.55 ENSDART00000081341
mapk13
mitogen-activated protein kinase 13
chr24_-_25004553 2.55 ENSDART00000080997
ENSDART00000136860
zdhhc20b
zinc finger, DHHC-type containing 20b
chr9_+_29603649 2.54 ENSDART00000140477
mcf2lb
mcf.2 cell line derived transforming sequence-like b
chr16_+_25011994 2.52 ENSDART00000157312
znf1035
zinc finger protein 1035
chr12_+_27213733 2.50 ENSDART00000133048
nbr1a
neighbor of brca1 gene 1a
chr19_-_12967986 2.50 ENSDART00000151064
slc25a32a
solute carrier family 25 (mitochondrial folate carrier), member 32a
chr22_-_7129631 2.48 ENSDART00000171359
asic1b
acid-sensing (proton-gated) ion channel 1b
chr16_-_32671998 2.47 ENSDART00000161395
pnisr
PNN-interacting serine/arginine-rich protein
chr16_-_22251414 2.46 ENSDART00000158500
ENSDART00000179998
atp8b2
ATPase phospholipid transporting 8B2
chr20_-_39273987 2.35 ENSDART00000127173
clu
clusterin
chr12_+_12112384 2.29 ENSDART00000152431
grid1b
glutamate receptor, ionotropic, delta 1b
chr13_+_29926094 2.29 ENSDART00000057528
cuedc2
CUE domain containing 2
chr11_+_6819050 2.28 ENSDART00000104289
rab3ab
RAB3A, member RAS oncogene family, b
chr15_-_5165013 2.24 ENSDART00000081653
or126-7
odorant receptor, family E, subfamily 126, member 7
chr5_-_38384289 2.21 ENSDART00000135260
mink1
misshapen-like kinase 1
chr10_-_36633882 2.20 ENSDART00000077161
ENSDART00000137688
rsf1b.1
rsf1b.1
remodeling and spacing factor 1b, tandem duplicate 1
remodeling and spacing factor 1b, tandem duplicate 1
chr10_-_20669635 2.14 ENSDART00000131361
kcnip3b
Kv channel interacting protein 3b, calsenilin
chr21_+_32339158 2.10 ENSDART00000161723
si:ch211-247j9.1
si:ch211-247j9.1
chr13_+_29925397 2.06 ENSDART00000123482
cuedc2
CUE domain containing 2
chr3_-_20063671 2.05 ENSDART00000056614
ENSDART00000126915
ubtf
upstream binding transcription factor, RNA polymerase I
chr1_+_45969240 2.04 ENSDART00000042086
arhgef7b
Rho guanine nucleotide exchange factor (GEF) 7b
chr23_-_33680265 1.99 ENSDART00000138416
tfcp2
transcription factor CP2
chr25_+_7494181 1.98 ENSDART00000165005
cat
catalase
chr9_+_13229585 1.98 ENSDART00000154879
ENSDART00000141705
carf
calcium responsive transcription factor
chr15_+_16897554 1.93 ENSDART00000154679
ypel2b
yippee-like 2b
chr4_-_14926637 1.89 ENSDART00000110199
prdm4
PR domain containing 4
chr9_-_16877456 1.83 ENSDART00000161105
ENSDART00000160869
fbxl3a
F-box and leucine-rich repeat protein 3a
chr8_+_17869225 1.73 ENSDART00000080079
slc44a5b
solute carrier family 44, member 5b
chr24_-_18659147 1.72 ENSDART00000166039
zgc:66014
zgc:66014
chr6_-_18698456 1.69 ENSDART00000166587
rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr11_-_44409856 1.61 ENSDART00000162886
il1rapl1b
interleukin 1 receptor accessory protein-like 1b
chr11_-_18323059 1.57 ENSDART00000182590
SFMBT1
Scm like with four mbt domains 1
chr23_-_12158685 1.54 ENSDART00000135035
fam217b
family with sequence similarity 217, member B
chr24_+_14240196 1.53 ENSDART00000124740
ncoa2
nuclear receptor coactivator 2
chr5_+_15495351 1.50 ENSDART00000111646
ENSDART00000114446
suds3
SDS3 homolog, SIN3A corepressor complex component
chr9_-_10532591 1.48 ENSDART00000175269
thsd7ba
thrombospondin, type I, domain containing 7Ba
chr6_-_12270226 1.44 ENSDART00000180473
pkp4
plakophilin 4
chr3_-_45308394 1.43 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr1_+_45839927 1.43 ENSDART00000148086
ENSDART00000180413
ENSDART00000048191
ENSDART00000179047
map2k7
mitogen-activated protein kinase kinase 7
chr15_+_23784842 1.43 ENSDART00000192889
ENSDART00000138375
ift20
intraflagellar transport 20 homolog (Chlamydomonas)
chr14_-_30960470 1.42 ENSDART00000129989
si:ch211-191o15.6
si:ch211-191o15.6
chr6_-_40922971 1.39 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr13_+_5978809 1.38 ENSDART00000102563
ENSDART00000121598
phf10
PHD finger protein 10
chr21_+_32338897 1.35 ENSDART00000110137
si:ch211-247j9.1
si:ch211-247j9.1
chr2_+_9061885 1.34 ENSDART00000028906
pigk
phosphatidylinositol glycan anchor biosynthesis, class K
chr3_+_27786601 1.33 ENSDART00000086994
nat15
N-acetyltransferase 15 (GCN5-related, putative)
chr17_+_24718272 1.33 ENSDART00000007271
mtfr1l
mitochondrial fission regulator 1-like
chr25_+_17920668 1.28 ENSDART00000093358
borcs5
BLOC-1 related complex subunit 5
chr20_+_25904199 1.22 ENSDART00000016864
slc35f6
solute carrier family 35, member F6
chr18_-_26675699 1.21 ENSDART00000113280
FRMD5
si:ch211-69m14.1
chr10_-_8197049 1.21 ENSDART00000129467
dhx29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr4_-_14926106 1.17 ENSDART00000147629
prdm4
PR domain containing 4
chr4_-_14207471 1.17 ENSDART00000015134
twf1b
twinfilin actin-binding protein 1b
chr14_-_33177935 1.15 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr12_-_16452200 1.15 ENSDART00000037601
rpp30
ribonuclease P/MRP 30 subunit
chr3_+_55031685 1.13 ENSDART00000132587
mpg
N-methylpurine DNA glycosylase
chr18_-_14337450 1.13 ENSDART00000061435
hsbp1b
heat shock factor binding protein 1b
chr17_+_44756247 1.12 ENSDART00000153773
cipca
CLOCK-interacting pacemaker a
chr9_-_16876474 1.11 ENSDART00000185450
fbxl3a
F-box and leucine-rich repeat protein 3a
chr8_+_40081403 1.11 ENSDART00000138036
lrrc75ba
leucine rich repeat containing 75Ba
chr10_+_2529037 1.10 ENSDART00000123467
zmp:0000001301
zmp:0000001301
chr17_-_9962578 1.08 ENSDART00000021942
eapp
e2f-associated phosphoprotein
chr22_+_30335936 1.08 ENSDART00000059923
mxi1
max interactor 1, dimerization protein
chr8_-_25716074 1.07 ENSDART00000007482
tspy
testis specific protein, Y-linked
chr8_+_53204027 1.02 ENSDART00000135353
CFAP74
cilia and flagella associated protein 74
chr19_-_10324182 1.01 ENSDART00000151352
ENSDART00000151162
ENSDART00000023571
u2af2b
U2 small nuclear RNA auxiliary factor 2b
chr5_+_24063046 1.00 ENSDART00000051548
ENSDART00000133355
ENSDART00000142268
gps2
G protein pathway suppressor 2
chr9_-_3400727 1.00 ENSDART00000183979
ENSDART00000111386
dlx2a
distal-less homeobox 2a
chr20_-_211920 0.97 ENSDART00000104790
znf292b
zinc finger protein 292b
chr20_-_39273505 0.96 ENSDART00000153114
clu
clusterin
chr7_+_24023653 0.95 ENSDART00000141165
tinf2
TERF1 (TRF1)-interacting nuclear factor 2
chr5_-_28679135 0.95 ENSDART00000193585
tnc
tenascin C
chr7_-_28696556 0.93 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr6_-_12172424 0.92 ENSDART00000109344
tanc1a
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr13_-_50247689 0.91 ENSDART00000034541
gpatch11
G patch domain containing 11
chr12_-_22509069 0.88 ENSDART00000179755
ENSDART00000109707
neurl4
neuralized E3 ubiquitin protein ligase 4
chr9_-_12885201 0.87 ENSDART00000124957
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr21_+_33172526 0.85 ENSDART00000183532
arl3l1
ADP-ribosylation factor-like 3, like 1
chr8_+_7778770 0.85 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr7_-_28611145 0.85 ENSDART00000054366
scube2
signal peptide, CUB domain, EGF-like 2
chr6_-_32045951 0.83 ENSDART00000016629
ENSDART00000139055
efcab7
EF-hand calcium binding domain 7
chr1_-_16394814 0.80 ENSDART00000013024
fgf20a
fibroblast growth factor 20a
chr22_-_4769140 0.79 ENSDART00000165235
calr3a
calreticulin 3a
chr3_+_24458899 0.79 ENSDART00000156655
cbx6b
chromobox homolog 6b
chr9_+_13230214 0.79 ENSDART00000017932
ENSDART00000179850
carf
calcium responsive transcription factor
chr16_+_49647402 0.76 ENSDART00000015694
ENSDART00000132547
rab5ab
RAB5A, member RAS oncogene family, b
chr23_-_24226533 0.74 ENSDART00000109134
plekhm2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr7_+_38278860 0.74 ENSDART00000016265
lrp3
low density lipoprotein receptor-related protein 3
chr17_-_14966384 0.74 ENSDART00000105064
txndc16
thioredoxin domain containing 16
chr21_-_32301109 0.74 ENSDART00000139890
clk4b
CDC-like kinase 4b
chr13_+_45980163 0.73 ENSDART00000074547
ENSDART00000005195
bsdc1
BSD domain containing 1
chr20_+_19562383 0.73 ENSDART00000103798
nme6
NME/NM23 nucleoside diphosphate kinase 6
chr16_-_12496632 0.72 ENSDART00000019941
slc2a3b
solute carrier family 2 (facilitated glucose transporter), member 3b
chr9_+_50600355 0.71 ENSDART00000187567
fign
fidgetin
chr5_+_28271412 0.71 ENSDART00000031727
vamp8
vesicle-associated membrane protein 8 (endobrevin)
chr23_+_22785375 0.70 ENSDART00000142085
rerea
arginine-glutamic acid dipeptide (RE) repeats a
chr24_+_33589667 0.69 ENSDART00000152097
dnah5l
dynein, axonemal, heavy chain 5 like
chr13_+_28854438 0.66 ENSDART00000193407
ENSDART00000189554
CU639469.1

chr13_+_24834199 0.63 ENSDART00000101274
zgc:153981
zgc:153981
chr17_+_14965570 0.63 ENSDART00000066604
gpr137c
G protein-coupled receptor 137c
chr5_-_51998708 0.61 ENSDART00000097194
serinc5
serine incorporator 5
chr7_-_28549361 0.61 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
st5
suppression of tumorigenicity 5
chr2_+_44615153 0.60 ENSDART00000156523
yeats2
YEATS domain containing 2
chr5_-_68058168 0.60 ENSDART00000177026
rnf167
ring finger protein 167
chr20_-_35470891 0.60 ENSDART00000152993
ENSDART00000016090
pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr2_-_17492486 0.59 ENSDART00000189464
kdm4ab
lysine (K)-specific demethylase 4A, genome duplicate b
chr11_+_18612421 0.55 ENSDART00000110621
ncoa3
nuclear receptor coactivator 3
chr19_+_1878500 0.53 ENSDART00000113392
ggcta
gamma-glutamylcyclotransferase a
chr16_-_31445781 0.49 ENSDART00000056551
csnk2a1
casein kinase 2, alpha 1 polypeptide
chr15_+_20543770 0.47 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr4_-_68913650 0.47 ENSDART00000184297
si:dkey-264f17.5
si:dkey-264f17.5
chr22_-_28777374 0.46 ENSDART00000188206
si:dkeyp-34c12.1
si:dkeyp-34c12.1
chr4_-_22472653 0.45 ENSDART00000066903
ENSDART00000130072
ENSDART00000123369
kmt2e
lysine (K)-specific methyltransferase 2E
chr1_-_30689004 0.43 ENSDART00000018827
dachc
dachshund c
chr25_+_17920361 0.42 ENSDART00000185644
borcs5
BLOC-1 related complex subunit 5
chr15_+_19990068 0.42 ENSDART00000154033
ENSDART00000054428
zgc:112083
zgc:112083
chr19_-_10656667 0.41 ENSDART00000081379
ENSDART00000151456
ENSDART00000143271
ENSDART00000182126
olah
oleoyl-ACP hydrolase
chr15_+_23657051 0.41 ENSDART00000078336
klc3
kinesin light chain 3
chr16_-_36748374 0.40 ENSDART00000133310
pik3r4
phosphoinositide-3-kinase, regulatory subunit 4
chr21_-_11855828 0.38 ENSDART00000081666
ube2r2
ubiquitin-conjugating enzyme E2R 2
chr4_-_6809323 0.38 ENSDART00000099467
ifrd1
interferon-related developmental regulator 1
chr7_+_72279584 0.37 ENSDART00000172021
tollip
toll interacting protein
chr5_-_18046053 0.36 ENSDART00000144898
rnf215
ring finger protein 215
chr9_+_23895711 0.35 ENSDART00000034686
cops8
COP9 signalosome subunit 8
chr12_-_35105670 0.35 ENSDART00000153034
si:ch73-127m5.2
si:ch73-127m5.2
chr19_+_1688727 0.34 ENSDART00000115136
ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr9_+_34089156 0.34 ENSDART00000000005
ccdc80
coiled-coil domain containing 80
chr6_-_9565526 0.33 ENSDART00000151470
map3k2
mitogen-activated protein kinase kinase kinase 2
chr16_+_42829735 0.27 ENSDART00000014956
polr3glb
polymerase (RNA) III (DNA directed) polypeptide G like b
chr2_-_17492080 0.24 ENSDART00000024302
kdm4ab
lysine (K)-specific demethylase 4A, genome duplicate b
chr19_-_379750 0.24 ENSDART00000102725
tnfaip8l2a
tumor necrosis factor, alpha-induced protein 8-like 2a
chr3_+_53116172 0.19 ENSDART00000115117
brd4
bromodomain containing 4
chr20_-_9428021 0.17 ENSDART00000025330
rdh14b
retinol dehydrogenase 14b
chr4_-_8040436 0.16 ENSDART00000113033
si:ch211-240l19.6
si:ch211-240l19.6
chr3_-_13546610 0.15 ENSDART00000159647
amdhd2
amidohydrolase domain containing 2
chr1_+_8984068 0.14 ENSDART00000122568
tlr2
toll-like receptor 2
chr10_+_42589707 0.13 ENSDART00000075269
fgfr1b
fibroblast growth factor receptor 1b
chr5_-_54672763 0.11 ENSDART00000159009
spag8
sperm associated antigen 8
chr16_-_44900306 0.10 ENSDART00000058380
rbm42
RNA binding motif protein 42
chr8_+_8973425 0.07 ENSDART00000066107
bcap31
B cell receptor associated protein 31
chr1_-_8917902 0.05 ENSDART00000137900
grin2ab
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
chr5_-_20446082 0.02 ENSDART00000051607
ISCU (1 of many)
si:ch211-191d15.2
chr13_-_42400647 0.00 ENSDART00000043069
march5
membrane-associated ring finger (C3HC4) 5

Network of associatons between targets according to the STRING database.

First level regulatory network of foxo3a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.4 GO:0006844 acyl carnitine transport(GO:0006844)
1.4 4.2 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.9 2.8 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.8 4.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.8 2.3 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.7 2.0 GO:0071896 protein localization to adherens junction(GO:0071896)
0.6 3.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.6 3.5 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.6 4.0 GO:0061635 regulation of protein complex stability(GO:0061635)
0.6 2.8 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.4 1.4 GO:0035790 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.4 2.5 GO:0070207 protein homotrimerization(GO:0070207)
0.3 1.6 GO:0016322 neuron remodeling(GO:0016322)
0.3 0.9 GO:0045887 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.3 3.1 GO:0072337 modified amino acid transport(GO:0072337)
0.3 1.1 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.3 0.8 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.2 1.2 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.2 1.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 1.7 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 3.1 GO:0001964 startle response(GO:0001964)
0.2 1.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.2 3.8 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.2 3.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.2 1.0 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 0.9 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 2.5 GO:0015693 magnesium ion transport(GO:0015693)
0.1 4.7 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 3.2 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.1 2.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 1.2 GO:0032387 negative regulation of intracellular transport(GO:0032387) mitochondrial outer membrane permeabilization(GO:0097345)
0.1 2.0 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.1 3.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.7 GO:0070254 mucus secretion(GO:0070254)
0.1 0.4 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 4.7 GO:0021854 hypothalamus development(GO:0021854)
0.1 0.8 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 3.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 1.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.8 GO:0046850 regulation of bone remodeling(GO:0046850)
0.1 0.7 GO:0032418 lysosome localization(GO:0032418)
0.1 2.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 1.4 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 0.2 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.1 0.6 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 0.8 GO:0042694 muscle cell fate specification(GO:0042694)
0.1 0.5 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 3.3 GO:1901214 regulation of neuron death(GO:1901214)
0.1 3.3 GO:0007338 single fertilization(GO:0007338)
0.0 0.7 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.0 0.7 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 3.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.5 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.1 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.0 1.3 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.5 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 4.2 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 1.1 GO:0014029 neural crest formation(GO:0014029)
0.0 1.1 GO:0006284 base-excision repair(GO:0006284)
0.0 3.5 GO:0014032 neural crest cell development(GO:0014032)
0.0 2.3 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 1.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 2.1 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 3.3 GO:0021782 glial cell development(GO:0021782)
0.0 0.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 16.6 GO:0031175 neuron projection development(GO:0031175)
0.0 0.4 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.8 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.7 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 2.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.9 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 12.0 GO:0044295 axonal growth cone(GO:0044295)
0.7 2.2 GO:0031213 RSF complex(GO:0031213)
0.4 1.7 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.4 4.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.3 3.3 GO:0042583 chromaffin granule(GO:0042583)
0.3 1.2 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.2 1.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 0.4 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.2 3.1 GO:0031209 SCAR complex(GO:0031209)
0.2 0.8 GO:0098842 postsynaptic early endosome(GO:0098842)
0.2 2.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 6.6 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 3.8 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.1 5.9 GO:0048786 presynaptic active zone(GO:0048786)
0.1 4.7 GO:0008305 integrin complex(GO:0008305)
0.1 4.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 3.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 4.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.0 GO:0070187 telosome(GO:0070187)
0.1 1.5 GO:0070822 Sin3-type complex(GO:0070822)
0.1 0.7 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.6 GO:0044306 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.0 5.5 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.3 GO:0089701 U2AF(GO:0089701)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 3.5 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 2.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.6 GO:0030141 secretory granule(GO:0030141)
0.0 2.3 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.0 GO:0030027 lamellipodium(GO:0030027)
0.0 7.4 GO:0005743 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.9 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.4 GO:0005912 adherens junction(GO:0005912)
0.0 1.2 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.4 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
1.8 5.4 GO:0008517 folic acid transporter activity(GO:0008517)
1.6 4.7 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
1.0 3.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.8 3.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.5 1.6 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.5 2.5 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.4 3.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.3 1.4 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 2.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 3.2 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.2 2.0 GO:0004096 catalase activity(GO:0004096)
0.2 3.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 4.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 3.3 GO:0051787 misfolded protein binding(GO:0051787)
0.1 2.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 3.4 GO:0051018 protein kinase A binding(GO:0051018)
0.1 1.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 4.7 GO:0005178 integrin binding(GO:0005178)
0.1 3.8 GO:0044325 ion channel binding(GO:0044325)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.1 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.1 0.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.8 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.7 GO:0019894 kinesin binding(GO:0019894)
0.0 0.3 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 2.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 4.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 4.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 8.1 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 4.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 3.2 GO:0060090 binding, bridging(GO:0060090)
0.0 0.4 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 2.8 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 2.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 2.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 1.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 2.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 3.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 0.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.0 PID FOXO PATHWAY FoxO family signaling
0.0 3.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 6.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.4 3.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.4 2.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 2.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.1 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 4.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.4 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 3.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.3 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 3.1 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.1 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.5 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 2.1 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling