ISMARA results: gata1b+gata2a

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gata1b+gata2a

Z-value: 2.65

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Transcription factors associated with gata1b+gata2a

Gene Symbol	Gene ID	Gene Info
gata1b NCBI UniProt	ENSDARG00000059130	GATA binding protein 1b
gata2a NCBI UniProt	ENSDARG00000059327	GATA binding protein 2a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
gata1b	dr11_v1_chr8_-_7474997_7474997	-0.51	1.8e-07	Click!
gata2a	dr11_v1_chr11_-_3865472_3865472	-0.36	3.0e-04	Click!

Activity profile of gata1b+gata2a motif

Sorted Z-values of gata1b+gata2a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_+_7379728 Show fit	68.30	ENSDART00000012194	gata5 NCBI UniProt Show fit	GATA binding protein 5
chr5_-_64168415 Show fit	50.35	ENSDART00000048395	cmlc1 NCBI UniProt Show fit	cardiac myosin light chain-1
chr2_-_51794472 Show fit	43.86	ENSDART00000186652	BX908782.3 NCBI UniProt Show fit
chr2_-_24289641 Show fit	42.06	ENSDART00000128784 ENSDART00000123565 ENSDART00000141922 ENSDART00000184550 ENSDART00000191469	myh7l NCBI UniProt Show fit	myosin heavy chain 7-like
chr16_-_36834505 Show fit	37.15	ENSDART00000141275 ENSDART00000139588 ENSDART00000041993	pnp4b NCBI UniProt Show fit	purine nucleoside phosphorylase 4b
chr13_+_10945337 Show fit	36.80	ENSDART00000091845	abcg5 NCBI UniProt Show fit	ATP-binding cassette, sub-family G (WHITE), member 5
chr8_-_40464935 Show fit	36.39	ENSDART00000040013	myl7 NCBI UniProt Show fit	myosin, light chain 7, regulatory
chr25_-_28674739 Show fit	36.27	ENSDART00000067073	lrrc10 NCBI UniProt Show fit	leucine rich repeat containing 10
chr2_+_4207209 Show fit	35.39	ENSDART00000157903 ENSDART00000166476	gata6 NCBI UniProt Show fit	GATA binding protein 6
chr18_-_42830563 Show fit	30.70	ENSDART00000191488	ttc36 NCBI UniProt Show fit	tetratricopeptide repeat domain 36

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1b+gata2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
21.5	128.9	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
20.7	103.7	GO:0001773	myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
2.4	65.5	GO:0042632	cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
1.0	51.4	GO:0018298	protein-chromophore linkage(GO:0018298)
3.7	47.5	GO:0061026	cardiac muscle tissue regeneration(GO:0061026)
0.3	31.7	GO:0071466	cellular response to xenobiotic stimulus(GO:0071466)
1.0	29.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	29.0	GO:0006508	proteolysis(GO:0006508)
3.4	27.5	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.5	27.4	GO:0003333	amino acid transmembrane transport(GO:0003333)

Showing 1 to 10 of 115 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	74.5	GO:0005615	extracellular space(GO:0005615)
0.1	66.8	GO:0009986	cell surface(GO:0009986)
0.3	55.1	GO:0030017	sarcomere(GO:0030017)
0.0	44.6	GO:0005829	cytosol(GO:0005829)
0.3	40.4	GO:0016459	myosin complex(GO:0016459)
0.1	33.3	GO:0005667	transcription factor complex(GO:0005667)
0.6	30.3	GO:0031941	filamentous actin(GO:0031941)
2.0	26.2	GO:0042627	chylomicron(GO:0042627)
1.7	20.6	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	18.9	GO:0005813	centrosome(GO:0005813)

Showing 1 to 10 of 47 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	128.5	GO:0008270	zinc ion binding(GO:0008270)
0.5	71.1	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.5	53.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	43.2	GO:0005509	calcium ion binding(GO:0005509)
3.2	42.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.2	40.4	GO:0003774	motor activity(GO:0003774)
0.1	40.0	GO:0003779	actin binding(GO:0003779)
0.2	37.8	GO:0005125	cytokine activity(GO:0005125)
4.1	37.1	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
1.5	30.3	GO:0051371	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)

Showing 1 to 10 of 111 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	62.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	30.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
1.4	24.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
2.3	18.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	17.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	15.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	14.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.7	11.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	9.1	PID FGF PATHWAY	FGF signaling pathway
0.2	8.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	103.7	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
5.5	65.5	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
1.1	27.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
1.6	24.6	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.4	20.9	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
2.6	17.9	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.9	17.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	13.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.2	12.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.3	11.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

Showing 1 to 10 of 36 entries

Results for gata1b+gata2a

Z-value: 2.65

Motif logo

Transcription factors associated with gata1b+gata2a

Activity-expression correlation:

Activity profile of gata1b+gata2a motif

Sorted Z-values of gata1b+gata2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1b+gata2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: