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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for gata3
Z-value: 2.02
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Transcription factors associated with gata3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gata3 | dr11_v1_chr4_-_25064510_25064510 | 0.15 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_49159207 Show fit | 75.81 |
ENSDART00000041942
|
tetraspanin 2a |
|
| chr20_+_9828769 Show fit | 47.25 |
ENSDART00000160480
ENSDART00000053844 ENSDART00000080691 |
syntaxin binding protein 6 (amisyn), like |
|
| chr16_-_29437373 Show fit | 42.97 |
ENSDART00000148405
|
si:ch211-113g11.6 |
|
| chr7_+_13382852 Show fit | 32.95 |
ENSDART00000166318
|
diacylglycerol lipase, alpha |
|
| chr21_-_43079161 Show fit | 32.30 |
ENSDART00000144151
|
janus kinase and microtubule interacting protein 2 |
|
| chr15_+_40008370 Show fit | 29.99 |
ENSDART00000063783
|
integral membrane protein 2Ca |
|
| chr19_-_32710922 Show fit | 29.57 |
ENSDART00000004034
|
hippocalcin |
|
| chr12_+_5189776 Show fit | 28.71 |
ENSDART00000081298
|
leucine-rich, glioma inactivated 1b |
|
| chr9_-_35557397 Show fit | 28.10 |
ENSDART00000100681
|
neural cell adhesion molecule 2 |
|
| chr7_-_13381129 Show fit | 27.00 |
ENSDART00000164326
|
si:ch73-119p20.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of gata3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 48.6 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.2 | 48.0 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.7 | 42.3 | GO:1902668 | negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668) |
| 8.2 | 32.9 | GO:0098921 | endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921) |
| 0.4 | 31.8 | GO:0021549 | cerebellum development(GO:0021549) |
| 7.5 | 30.0 | GO:1903019 | negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) negative regulation of glycoprotein metabolic process(GO:1903019) |
| 1.1 | 29.8 | GO:0031114 | regulation of microtubule depolymerization(GO:0031114) |
| 0.7 | 29.6 | GO:0048854 | brain morphogenesis(GO:0048854) |
| 6.9 | 27.5 | GO:0006867 | asparagine transport(GO:0006867) |
| 5.3 | 26.6 | GO:0009052 | pentose-phosphate shunt, non-oxidative branch(GO:0009052) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 124.8 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 106.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 59.3 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 1.7 | 48.5 | GO:0000145 | exocyst(GO:0000145) |
| 1.2 | 46.7 | GO:0043679 | axon terminus(GO:0043679) |
| 0.5 | 41.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.5 | 40.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.8 | 32.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 31.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 5.8 | 23.2 | GO:0097268 | cytoophidium(GO:0097268) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 63.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.9 | 48.9 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.4 | 43.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.7 | 42.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 3.0 | 32.9 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 30.2 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.2 | 30.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 29.3 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 4.6 | 27.5 | GO:0015182 | L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182) |
| 5.2 | 25.9 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 33.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 1.0 | 23.4 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.6 | 19.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.7 | 17.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.8 | 11.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 11.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 10.6 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.2 | 9.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.7 | 8.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.7 | 8.7 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 32.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.0 | 24.8 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 2.4 | 24.0 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 1.3 | 22.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 1.1 | 11.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 1.1 | 10.8 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 1.0 | 10.7 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 10.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.4 | 9.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.4 | 9.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |