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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gbx2

Z-value: 0.49

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Transcription factors associated with gbx2

Gene Symbol Gene ID Gene Info
gbx2
ENSDARG00000002933 gastrulation brain homeobox 2
gbx2
ENSDARG00000116377 gastrulation brain homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gbx2dr11_v1_chr6_+_16031189_160311890.736.7e-17Click!

Activity profile of gbx2 motif

Sorted Z-values of gbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_31821396 5.61 ENSDART00000077053
plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr3_-_21037840 4.40 ENSDART00000002393
rundc3aa
RUN domain containing 3Aa
chr7_-_58098814 4.20 ENSDART00000147287
ENSDART00000043984
ank2b
ankyrin 2b, neuronal
chr17_-_37214196 3.71 ENSDART00000128715
kif3cb
kinesin family member 3Cb
chr18_+_26895994 3.38 ENSDART00000098347
ch25hl1.2
cholesterol 25-hydroxylase like 1, tandem duplicate 2
chr1_-_18803919 3.37 ENSDART00000020970
pgm2
phosphoglucomutase 2
chr10_-_34741738 3.29 ENSDART00000163072
dclk1a
doublecortin-like kinase 1a
chr4_-_5019113 3.04 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr12_+_5977777 3.02 ENSDART00000152302
si:ch211-131k2.2
si:ch211-131k2.2
chr17_+_24318753 2.85 ENSDART00000064083
otx1
orthodenticle homeobox 1
chr13_+_733027 2.52 ENSDART00000149547
nrxn1b
neurexin 1b
chr1_+_40023640 2.49 ENSDART00000101623
lgi2b
leucine-rich repeat LGI family, member 2b
chr11_+_6819050 2.45 ENSDART00000104289
rab3ab
RAB3A, member RAS oncogene family, b
chr4_-_5018705 2.31 ENSDART00000154025
strip2
striatin interacting protein 2
chr18_+_16750080 2.30 ENSDART00000136320
rnf141
ring finger protein 141
chr8_+_21229718 2.25 ENSDART00000100222
cry1ba
cryptochrome circadian clock 1ba
chr10_+_43797130 2.15 ENSDART00000027242
nr2f1b
nuclear receptor subfamily 2, group F, member 1b
chr5_+_30624183 2.15 ENSDART00000141444
abcg4a
ATP-binding cassette, sub-family G (WHITE), member 4a
chr18_+_7639401 2.13 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr4_+_11384891 2.13 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr20_-_18382708 2.08 ENSDART00000170864
ENSDART00000166762
ENSDART00000191333
vipas39
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
chr1_+_18811679 2.00 ENSDART00000078610
slc25a51a
solute carrier family 25, member 51a
chr22_-_619711 1.96 ENSDART00000192778
srsf3b
serine/arginine-rich splicing factor 3b
chr21_-_43606502 1.91 ENSDART00000151030
si:ch73-362m14.4
si:ch73-362m14.4
chr15_-_10341048 1.89 ENSDART00000171013
tenm4
teneurin transmembrane protein 4
chr5_+_57773222 1.83 ENSDART00000135344
ppp2r1ba
protein phosphatase 2, regulatory subunit A, beta a
chr22_+_24157807 1.79 ENSDART00000159165
b3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr9_-_9671244 1.79 ENSDART00000018228
gsk3b
glycogen synthase kinase 3 beta
chr7_-_33684632 1.74 ENSDART00000130553
tle3b
transducin-like enhancer of split 3b
chr18_+_17537344 1.74 ENSDART00000025782
nup93
nucleoporin 93
chr16_+_5678071 1.72 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
zgc:158689
chr11_-_2632747 1.72 ENSDART00000008133
si:ch211-160o17.2
si:ch211-160o17.2
chr18_+_31057143 1.71 ENSDART00000164585
mvda
mevalonate (diphospho) decarboxylase a
chr18_-_16937008 1.68 ENSDART00000100117
ENSDART00000022640
ENSDART00000136541
znf143b
zinc finger protein 143b
chr11_+_24620742 1.68 ENSDART00000182471
ENSDART00000048365
syt6b
synaptotagmin VIb
chr16_-_36093776 1.66 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr12_-_35386910 1.60 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr2_-_23004286 1.60 ENSDART00000134664
ENSDART00000110373
ENSDART00000185833
ENSDART00000187235
znf414
mllt1b
zinc finger protein 414
MLLT1, super elongation complex subunit b
chr8_+_23105117 1.59 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr7_+_59677273 1.44 ENSDART00000039535
ENSDART00000132044
trmt44
tRNA methyltransferase 44 homolog
chr17_+_10593398 1.43 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr1_-_18811517 1.39 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr19_-_20430892 1.36 ENSDART00000111409
tbc1d5
TBC1 domain family, member 5
chr22_-_36530902 1.31 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr1_-_22512063 1.30 ENSDART00000031546
ENSDART00000190987
chrna6
cholinergic receptor, nicotinic, alpha 6
chr23_-_333457 1.28 ENSDART00000114486
uhrf1bp1
UHRF1 binding protein 1
chr14_+_35464994 1.25 ENSDART00000115307
si:ch211-203d1.3
si:ch211-203d1.3
chr17_+_49281597 1.23 ENSDART00000155599
zgc:113176
zgc:113176
chr23_+_4253957 1.21 ENSDART00000008761
arl6ip5b
ADP-ribosylation factor-like 6 interacting protein 5b
chr15_-_16177603 1.18 ENSDART00000156352
si:ch211-259g3.4
si:ch211-259g3.4
chr5_-_20123002 1.14 ENSDART00000026516
pxmp2
peroxisomal membrane protein 2
chr8_+_20140321 1.12 ENSDART00000012120
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr22_+_2417105 1.11 ENSDART00000106415
zgc:113220
zgc:113220
chr5_-_69923241 1.09 ENSDART00000187389
fktn
fukutin
chr8_+_23826985 1.08 ENSDART00000187430
mapk14a
mitogen-activated protein kinase 14a
chr10_-_32920690 1.06 ENSDART00000136245
cux1a
cut-like homeobox 1a
chr11_-_12158412 1.00 ENSDART00000147670
npepps
aminopeptidase puromycin sensitive
chr14_+_25816874 0.97 ENSDART00000005499
glra1
glycine receptor, alpha 1
chr6_+_3717613 0.95 ENSDART00000184330
ssb
Sjogren syndrome antigen B (autoantigen La)
chr24_-_25364775 0.95 ENSDART00000151915
ptchd1
patched domain containing 1
chr16_-_26296477 0.89 ENSDART00000157553
erfl1
Ets2 repressor factor like 1
chr15_-_11956981 0.88 ENSDART00000164163
si:dkey-202l22.3
si:dkey-202l22.3
chr11_+_24340166 0.88 ENSDART00000188719
rbm39a
RNA binding motif protein 39a
chr3_+_32118670 0.88 ENSDART00000055287
ENSDART00000111688
zgc:109934
zgc:109934
chr10_-_14929630 0.86 ENSDART00000121892
ENSDART00000044756
ENSDART00000128579
ENSDART00000147653
smad2
SMAD family member 2
chr8_+_18010568 0.85 ENSDART00000121984
ssbp3b
single stranded DNA binding protein 3b
chr23_+_42254960 0.81 ENSDART00000102980
zcchc11
zinc finger, CCHC domain containing 11
chr8_-_18010097 0.81 ENSDART00000122730
ENSDART00000133666
acot11b
acyl-CoA thioesterase 11b
chr24_+_33802528 0.74 ENSDART00000136040
ENSDART00000147499
ENSDART00000182322
atg9b
autophagy related 9B
chr16_+_54875530 0.67 ENSDART00000149795
nr0b2a
nuclear receptor subfamily 0, group B, member 2a
chr23_-_30727596 0.64 ENSDART00000060193
thap3
THAP domain containing, apoptosis associated protein 3
chr2_+_35240485 0.62 ENSDART00000179804
tnr
tenascin R (restrictin, janusin)
chr11_-_422484 0.58 ENSDART00000122253
znf831
zinc finger protein 831
chr17_+_51499789 0.57 ENSDART00000187701
CABZ01067581.1

chr19_-_15855427 0.55 ENSDART00000133059
cited4a
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr17_+_1496107 0.54 ENSDART00000187804
LO018430.1

chr22_+_9862466 0.53 ENSDART00000146864
si:dkey-253d23.3
si:dkey-253d23.3
chr22_+_9862243 0.49 ENSDART00000105942
si:dkey-253d23.3
si:dkey-253d23.3
chr20_-_7128612 0.47 ENSDART00000146755
ENSDART00000036871
si:ch211-121a2.4
si:ch211-121a2.4
chr6_-_42369186 0.34 ENSDART00000039868
usp4
ubiquitin specific peptidase 4 (proto-oncogene)
chr11_+_31323746 0.33 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr6_-_39218609 0.33 ENSDART00000133305
os9
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr11_-_6452444 0.32 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
larp6b
La ribonucleoprotein domain family, member 6b
chr7_+_53755054 0.28 ENSDART00000181629
neo1a
neogenin 1a
chr22_-_9861531 0.27 ENSDART00000193197
si:dkey-253d23.2
si:dkey-253d23.2
chr18_+_8833251 0.26 ENSDART00000143519
impdh1a
IMP (inosine 5'-monophosphate) dehydrogenase 1a
chr12_-_34713690 0.26 ENSDART00000180807
bahcc1b
BAH domain and coiled-coil containing 1b
chr25_-_20523927 0.25 ENSDART00000114448
si:ch211-269c21.2
si:ch211-269c21.2
chr24_-_33801668 0.25 ENSDART00000079202
abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr2_-_26720854 0.25 ENSDART00000148110
si:dkey-181m9.8
si:dkey-181m9.8
chr24_-_16904234 0.22 ENSDART00000192879
mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr7_+_20260172 0.21 ENSDART00000012450
dvl2
dishevelled segment polarity protein 2
chr8_+_8298439 0.17 ENSDART00000170566
srpk3
SRSF protein kinase 3
chr17_+_41302660 0.16 ENSDART00000059480
fosl2
fos-like antigen 2
chr6_+_9191981 0.10 ENSDART00000150916
zgc:112392
zgc:112392
chr9_+_55154414 0.05 ENSDART00000182924
ANOS1
anosmin 1
chr15_+_28355023 0.05 ENSDART00000122159
si:dkey-118k5.3
si:dkey-118k5.3
chr2_-_36918709 0.02 ENSDART00000084876
zgc:153654
zgc:153654
chr11_-_29768054 0.01 ENSDART00000079117
plekha3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr9_-_30555725 0.01 ENSDART00000079222
chaf1b
chromatin assembly factor 1, subunit B
chr12_+_22560067 0.00 ENSDART00000172066
polr2a
polymerase (RNA) II (DNA directed) polypeptide A

Network of associatons between targets according to the STRING database.

First level regulatory network of gbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.8 2.4 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.7 4.4 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.6 3.0 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.5 5.3 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.4 1.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.4 1.9 GO:0032289 central nervous system myelin formation(GO:0032289)
0.3 1.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.3 1.0 GO:0071361 cellular response to ethanol(GO:0071361)
0.2 1.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.2 2.1 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.2 1.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 2.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.2 1.1 GO:0040016 embryonic cleavage(GO:0040016) positive regulation of myoblast fusion(GO:1901741)
0.1 0.9 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 1.6 GO:0050779 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.1 2.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 1.8 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 1.9 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 3.4 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 2.2 GO:0035476 angioblast cell migration(GO:0035476)
0.1 2.1 GO:0033344 cholesterol efflux(GO:0033344)
0.1 0.2 GO:2000725 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.1 1.7 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 0.7 GO:0044805 late nucleophagy(GO:0044805)
0.1 0.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 1.7 GO:0007340 acrosome reaction(GO:0007340)
0.1 1.1 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 1.6 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 1.4 GO:0030488 tRNA methylation(GO:0030488)
0.0 3.4 GO:0006006 glucose metabolic process(GO:0006006)
0.0 1.0 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.7 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 0.9 GO:0050890 cognition(GO:0050890)
0.0 0.2 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.3 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.3 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 5.6 GO:0016042 lipid catabolic process(GO:0016042)
0.0 1.7 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 2.1 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.2 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 1.2 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 1.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.2 GO:0051051 negative regulation of transport(GO:0051051)
0.0 3.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.2 GO:0030315 T-tubule(GO:0030315)
0.2 2.1 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 1.9 GO:0031209 SCAR complex(GO:0031209)
0.1 1.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.7 GO:0034399 nuclear periphery(GO:0034399)
0.1 1.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 3.0 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.0 GO:0043204 perikaryon(GO:0043204)
0.0 2.1 GO:0055037 recycling endosome(GO:0055037)
0.0 4.1 GO:0070382 exocytic vesicle(GO:0070382)
0.0 2.0 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0031835 neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
0.5 3.4 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.5 1.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 1.7 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.3 3.4 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.3 1.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 4.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 1.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.8 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 2.1 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 0.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 1.0 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.1 GO:0016405 CoA-ligase activity(GO:0016405)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.2 GO:0030586 [methionine synthase] reductase activity(GO:0030586)
0.1 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.9 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.9 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 5.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 3.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.4 GO:0043492 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 1.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.9 GO:0003697 single-stranded DNA binding(GO:0003697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 0.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo