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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gcm2

Z-value: 0.72

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Transcription factors associated with gcm2

Gene Symbol Gene ID Gene Info
gcm2
ENSDARG00000045413 glial cells missing transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gcm2dr11_v1_chr24_-_8831866_88319120.028.7e-01Click!

Activity profile of gcm2 motif

Sorted Z-values of gcm2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_6158933 13.04 ENSDART00000021609
gad2
glutamate decarboxylase 2
chr18_-_21218851 9.68 ENSDART00000060160
calb2a
calbindin 2a
chr16_+_45571956 9.44 ENSDART00000143867
syngap1b
synaptic Ras GTPase activating protein 1b
chr1_-_20911297 9.05 ENSDART00000078271
cpe
carboxypeptidase E
chr5_-_23317477 7.72 ENSDART00000090171
nlgn3b
neuroligin 3b
chr6_-_13308813 6.90 ENSDART00000065372
kcnj3b
potassium inwardly-rectifying channel, subfamily J, member 3b
chr10_+_7182168 6.69 ENSDART00000172766
psd3l
pleckstrin and Sec7 domain containing 3, like
chr10_+_7182423 6.31 ENSDART00000186788
psd3l
pleckstrin and Sec7 domain containing 3, like
chr3_+_46724528 6.13 ENSDART00000181358
pde4a
phosphodiesterase 4A, cAMP-specific
chr19_-_8604429 5.91 ENSDART00000151165
trim46b
tripartite motif containing 46b
chr4_+_19534833 5.86 ENSDART00000140028
lrrc4.1
leucine rich repeat containing 4.1
chr17_+_8183393 5.64 ENSDART00000155957
tulp4b
tubby like protein 4b
chr17_-_35881841 5.13 ENSDART00000110040
sox11a
SRY (sex determining region Y)-box 11a
chr20_-_32110882 4.73 ENSDART00000030324
grm1a
glutamate receptor, metabotropic 1a
chr21_+_25068215 4.59 ENSDART00000167523
ENSDART00000189259
dixdc1b
DIX domain containing 1b
chr1_+_45323400 4.39 ENSDART00000148906
ENSDART00000132366
emp1
epithelial membrane protein 1
chr14_-_14746767 4.36 ENSDART00000183755
ENSDART00000190938
ogt.1
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
chr1_-_53756851 4.28 ENSDART00000122445
akt3b
v-akt murine thymoma viral oncogene homolog 3b
chr25_-_28443607 4.27 ENSDART00000157243
ptprz1a
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr6_-_46403475 4.26 ENSDART00000154148
camk1a
calcium/calmodulin-dependent protein kinase Ia
chr2_-_42871286 4.09 ENSDART00000087823
adcy8
adenylate cyclase 8 (brain)
chr12_+_29055143 4.01 ENSDART00000076322
gabrz
gamma-aminobutyric acid (GABA) A receptor, zeta
chr3_-_30061985 3.99 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr14_+_7140997 3.91 ENSDART00000170994
ENSDART00000129898
ctsf
cathepsin F
chr22_+_5176255 3.91 ENSDART00000092647
cers1
ceramide synthase 1
chr4_-_20081621 3.81 ENSDART00000024647
dennd6b
DENN/MADD domain containing 6B
chr5_-_21065094 3.73 ENSDART00000143785
si:dkey-13n15.2
si:dkey-13n15.2
chr6_+_42819337 3.65 ENSDART00000046498
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr23_+_40109353 3.54 ENSDART00000149249
ghrhrl
growth hormone releasing hormone receptor, like
chr17_+_37310663 3.50 ENSDART00000157122
elmsan1b
ELM2 and Myb/SANT-like domain containing 1b
chr22_-_20342260 3.46 ENSDART00000161610
ENSDART00000165667
tcf3b
transcription factor 3b
chr16_+_5678071 3.46 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
zgc:158689
chr12_+_29054907 3.45 ENSDART00000152936
gabrz
gamma-aminobutyric acid (GABA) A receptor, zeta
chr16_+_25407021 3.41 ENSDART00000187489
ENSDART00000086333
jarid2a
jumonji, AT rich interactive domain 2a
chr14_-_27289042 3.39 ENSDART00000159727
pcdh11
protocadherin 11
chr16_-_32671782 3.39 ENSDART00000123980
pnisr
PNN-interacting serine/arginine-rich protein
chr10_+_37145007 3.32 ENSDART00000131777
cuedc1a
CUE domain containing 1a
chr13_-_44285793 3.30 ENSDART00000167383
CABZ01069436.1

chr4_+_11384891 3.21 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr18_-_215698 3.20 ENSDART00000147430
tarsl2
threonyl-tRNA synthetase-like 2
chr5_-_34185115 3.20 ENSDART00000192771
fibcd1
fibrinogen C domain containing 1
chr24_+_25069609 3.11 ENSDART00000115165
amer2
APC membrane recruitment protein 2
chr16_-_22006996 3.10 ENSDART00000116114
si:dkey-71b5.7
si:dkey-71b5.7
chr6_-_55354004 3.00 ENSDART00000165911
pcif1
PDX1 C-terminal inhibiting factor 1
chr3_-_6768905 2.97 ENSDART00000193638
ENSDART00000123809
ENSDART00000189440
ENSDART00000188335
mast1b
microtubule associated serine/threonine kinase 1b
chr3_-_32299892 2.93 ENSDART00000181472
si:dkey-16p21.7
si:dkey-16p21.7
chr4_+_7888047 2.92 ENSDART00000104676
camk1da
calcium/calmodulin-dependent protein kinase 1Da
chr12_+_35011899 2.90 ENSDART00000153007
ENSDART00000153020
qki2
QKI, KH domain containing, RNA binding 2
chr15_+_33851280 2.83 ENSDART00000162308
inpp5ka
inositol polyphosphate-5-phosphatase Ka
chr18_+_43183749 2.75 ENSDART00000151166
nectin1b
nectin cell adhesion molecule 1b
chr21_+_349091 2.69 ENSDART00000183693
ZNF462
zinc finger protein 462
chr10_-_25852517 2.66 ENSDART00000191551
trpc4a
transient receptor potential cation channel, subfamily C, member 4a
chr21_+_21791799 2.62 ENSDART00000151759
neu3.1
sialidase 3 (membrane sialidase), tandem duplicate 1
chr9_-_3400727 2.54 ENSDART00000183979
ENSDART00000111386
dlx2a
distal-less homeobox 2a
chr20_+_28434196 2.53 ENSDART00000034245
dpf3
D4, zinc and double PHD fingers, family 3
chr2_-_9971609 2.50 ENSDART00000137924
ENSDART00000048655
ENSDART00000131613
zgc:55943
zgc:55943
chr3_-_9722603 2.46 ENSDART00000168234
crebbpb
CREB binding protein b
chr16_+_17763848 2.41 ENSDART00000149408
ENSDART00000148878
them4
thioesterase superfamily member 4
chr15_+_29123031 2.39 ENSDART00000133988
ENSDART00000060030
zgc:101731
zgc:101731
chr6_+_42818963 2.37 ENSDART00000184833
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr11_-_41132296 2.28 ENSDART00000162944
dnajc11b
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr17_-_35361322 2.26 ENSDART00000019617
rsad2
radical S-adenosyl methionine domain containing 2
chr22_+_5176693 2.25 ENSDART00000160927
cers1
ceramide synthase 1
chr16_-_32671998 2.18 ENSDART00000161395
pnisr
PNN-interacting serine/arginine-rich protein
chr19_+_4024443 2.18 ENSDART00000159215
ENSDART00000172204
meaf6
MYST/Esa1-associated factor 6
chr3_+_39759130 2.17 ENSDART00000185202
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr16_+_27564270 2.14 ENSDART00000140460
tmem67
transmembrane protein 67
chr1_+_26445615 2.12 ENSDART00000180810
g3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr14_-_2217285 2.12 ENSDART00000157949
ENSDART00000166150
ENSDART00000054891
ENSDART00000183268
pcdh2ab2
pcdh2ab2
protocadherin 2 alpha b2
protocadherin 2 alpha b2
chr16_+_12267672 2.08 ENSDART00000060037
zgc:92606
zgc:92606
chr14_+_21820034 1.96 ENSDART00000122739
ctbp1
C-terminal binding protein 1
chr3_-_26171668 1.80 ENSDART00000113890
rabep2
rabaptin, RAB GTPase binding effector protein 2
chr16_-_21903083 1.73 ENSDART00000165849
setdb1b
SET domain, bifurcated 1b
chr20_+_54333774 1.68 ENSDART00000144633
cipcb
CLOCK-interacting pacemaker b
chr21_-_43398457 1.67 ENSDART00000166530
ccni2
cyclin I family, member 2
chr1_+_26444986 1.63 ENSDART00000046376
g3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr2_+_8717155 1.62 ENSDART00000018114
ENSDART00000137872
ENSDART00000133037
usp33
ubiquitin specific peptidase 33
chr20_+_17739923 1.59 ENSDART00000024627
cdh2
cadherin 2, type 1, N-cadherin (neuronal)
chr1_-_26293203 1.56 ENSDART00000180140
cxxc4
CXXC finger 4
chr9_-_33608427 1.53 ENSDART00000100849
caska
calcium/calmodulin-dependent serine protein kinase a
chr20_+_43648369 1.53 ENSDART00000187930
ENSDART00000017269
parp1
poly (ADP-ribose) polymerase 1
chr13_+_31479814 1.48 ENSDART00000148112
lrrc9
leucine rich repeat containing 9
chr3_-_45298487 1.46 ENSDART00000102245
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr17_-_35278763 1.45 ENSDART00000063437
adam17a
ADAM metallopeptidase domain 17a
chr1_-_57172294 1.45 ENSDART00000063774
rac1l
Rac family small GTPase 1, like
chr20_+_48100261 1.43 ENSDART00000158604
xkr5a
XK related 5a
chr22_+_26703026 1.43 ENSDART00000158756
crebbpa
CREB binding protein a
chr10_+_45071603 1.35 ENSDART00000186505
ENSDART00000157573
camk2b2
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr5_+_18925367 1.35 ENSDART00000051621
pgam5
PGAM family member 5, serine/threonine protein phosphatase, mitochondrial
chr8_-_33381430 1.34 ENSDART00000190019
lmx1bb
LIM homeobox transcription factor 1, beta b
chr23_-_36446307 1.33 ENSDART00000136623
zgc:174906
zgc:174906
chr2_-_32505091 1.30 ENSDART00000141884
ENSDART00000056639
faim2a
Fas apoptotic inhibitory molecule 2a
chr7_-_71829649 1.30 ENSDART00000160449
cacnb2a
calcium channel, voltage-dependent, beta 2a
chr9_+_36356740 1.29 ENSDART00000139033
lrp1bb
low density lipoprotein receptor-related protein 1Bb
chr20_-_54435287 1.27 ENSDART00000148632
yy1b
YY1 transcription factor b
chr8_+_23521974 1.26 ENSDART00000188130
ENSDART00000129378
sema3gb
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr25_-_21156678 1.19 ENSDART00000156257
wnk1a
WNK lysine deficient protein kinase 1a
chr6_+_23010242 1.19 ENSDART00000113116
polg2
polymerase (DNA directed), gamma 2, accessory subunit
chr17_+_13099476 1.19 ENSDART00000012670
pnn
pinin, desmosome associated protein
chr21_+_17301790 1.19 ENSDART00000145057
tsc1b
TSC complex subunit 1b
chr6_+_15762647 1.16 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr5_+_70262153 1.15 ENSDART00000185309
znf618
zinc finger protein 618
chr1_+_34295925 1.11 ENSDART00000075584
kctd12.2
potassium channel tetramerisation domain containing 12.2
chr11_-_41130239 1.08 ENSDART00000173268
dnajc11b
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr23_+_5565261 1.08 ENSDART00000059307
ENSDART00000169904
smpd2a
sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase)
chr21_-_1799265 1.07 ENSDART00000066623
st8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr20_-_14012859 1.04 ENSDART00000152429
si:ch211-22i13.2
si:ch211-22i13.2
chr1_+_26626824 0.98 ENSDART00000158193
coro2a
coronin, actin binding protein, 2A
chr14_-_5677979 0.95 ENSDART00000182156
tlx2
T cell leukemia homeobox 2
chr11_-_2277081 0.93 ENSDART00000109026
znf740a
zinc finger protein 740a
chr10_-_5053589 0.93 ENSDART00000193579
tmem150c
transmembrane protein 150C
chr8_+_10350122 0.89 ENSDART00000186650
ENSDART00000098009
tbc1d22b
TBC1 domain family, member 22B
chr1_+_54043563 0.87 ENSDART00000149760
triobpa
TRIO and F-actin binding protein a
chr10_+_4095917 0.86 ENSDART00000114533
mn1a
meningioma 1a
chr24_-_21258945 0.85 ENSDART00000111025
boc
BOC cell adhesion associated, oncogene regulated
chr4_+_19127973 0.84 ENSDART00000136611
si:dkey-21o22.2
si:dkey-21o22.2
chr20_+_11731039 0.80 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr17_+_53250802 0.80 ENSDART00000143819
VASH1
vasohibin 1
chr12_+_49125510 0.79 ENSDART00000185804
FO704607.1

chr20_-_28433616 0.79 ENSDART00000169289
wdr21
WD repeat domain 21
chr19_+_7627070 0.78 ENSDART00000151078
ENSDART00000131324
pygo2
pygopus homolog 2 (Drosophila)
chr4_-_73411863 0.78 ENSDART00000171434
zgc:162958
zgc:162958
chr14_+_7898372 0.68 ENSDART00000159593
ube2d2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr14_-_33177935 0.68 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr1_+_44941031 0.68 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr10_+_44956660 0.64 ENSDART00000169225
ENSDART00000189298
il1b
interleukin 1, beta
chr13_-_43108693 0.62 ENSDART00000164439
si:ch211-106f21.1
si:ch211-106f21.1
chr13_+_2448251 0.61 ENSDART00000188361
arfgef3
ARFGEF family member 3
chr23_-_36823932 0.61 ENSDART00000142305
hipk1a
homeodomain interacting protein kinase 1a
chr4_-_760560 0.59 ENSDART00000103601
agbl5
ATP/GTP binding protein-like 5
chr20_+_26947800 0.58 ENSDART00000062066
si:dkey-177p2.6
si:dkey-177p2.6
chr5_+_69686368 0.58 ENSDART00000158237
znf1005
zinc finger protein 1005
chr17_-_25563847 0.55 ENSDART00000040032
rtn4ip1
reticulon 4 interacting protein 1
chr19_+_56351 0.54 ENSDART00000168334
col14a1b
collagen, type XIV, alpha 1b
chr1_-_51157660 0.52 ENSDART00000137172
jag1a
jagged 1a
chr23_-_22523303 0.51 ENSDART00000079019
spsb1
splA/ryanodine receptor domain and SOCS box containing 1
chr1_-_26292897 0.51 ENSDART00000112899
ENSDART00000185410
cxxc4
CXXC finger 4
chr1_+_2112726 0.45 ENSDART00000131714
ENSDART00000138396
mbnl2
muscleblind-like splicing regulator 2
chr23_+_4646194 0.44 ENSDART00000092344
LO017700.1

chr19_-_29302249 0.42 ENSDART00000188751
srfbp1
serum response factor binding protein 1
chr23_-_30960506 0.40 ENSDART00000142661
osbpl2a
oxysterol binding protein-like 2a
chr20_-_28433990 0.38 ENSDART00000182824
ENSDART00000193381
wdr21
WD repeat domain 21
chr13_+_43650632 0.37 ENSDART00000141024
zfyve21
zinc finger, FYVE domain containing 21
chr21_+_1380099 0.37 ENSDART00000184516
TCF4
transcription factor 4
chr4_+_76441823 0.35 ENSDART00000163932
si:dkey-16p6.1
si:dkey-16p6.1
chr23_+_27652906 0.34 ENSDART00000077931
wnt1
wingless-type MMTV integration site family, member 1
chr22_+_26703518 0.33 ENSDART00000187997
ENSDART00000166775
crebbpa
CREB binding protein a
chr17_-_43665366 0.32 ENSDART00000127945
egr2a
early growth response 2a
chr14_-_1963369 0.27 ENSDART00000125521
pcdh2g5
protocadherin 2 gamma 5
chr11_+_23760470 0.23 ENSDART00000175688
ENSDART00000121874
ENSDART00000086720
nfasca
neurofascin homolog (chicken) a
chr7_+_15266093 0.22 ENSDART00000124676
sv2ba
synaptic vesicle glycoprotein 2Ba
chr5_-_25572151 0.20 ENSDART00000144995
si:dkey-229d2.4
si:dkey-229d2.4
chr15_-_3976035 0.15 ENSDART00000168061
si:ch73-309g22.1
si:ch73-309g22.1
chr21_+_28535203 0.14 ENSDART00000184950
CR749775.2

chr1_+_418869 0.12 ENSDART00000152173
tpp2
tripeptidyl peptidase 2
chr19_-_47452874 0.12 ENSDART00000025931
tfap2e
transcription factor AP-2 epsilon
chr21_-_3452683 0.10 ENSDART00000009740
smad7
SMAD family member 7
chr1_+_17527342 0.08 ENSDART00000139702
ENSDART00000140076
ENSDART00000005593
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr16_+_33163858 0.08 ENSDART00000101943
rragca
Ras-related GTP binding Ca
chr15_-_41749364 0.07 ENSDART00000155464
ftr73
finTRIM family, member 73
chr14_-_413273 0.06 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr14_-_15699528 0.06 ENSDART00000161123
neurl1b
neuralized E3 ubiquitin protein ligase 1B
chr24_+_18299175 0.05 ENSDART00000140994
tpk1
thiamin pyrophosphokinase 1
chr25_-_18125769 0.04 ENSDART00000140484
kitlga
kit ligand a
chr22_+_9922301 0.03 ENSDART00000105924
blf
bloody fingers

Network of associatons between targets according to the STRING database.

First level regulatory network of gcm2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.4 9.7 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.9 2.8 GO:0044650 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.7 7.7 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.6 4.1 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.6 2.8 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.5 2.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.5 5.1 GO:0046548 retinal rod cell development(GO:0046548)
0.4 1.7 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.4 3.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 3.2 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.3 13.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 6.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.3 4.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.2 3.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 3.4 GO:0042407 cristae formation(GO:0042407)
0.2 2.6 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.2 3.1 GO:0007398 ectoderm development(GO:0007398)
0.2 9.4 GO:0036269 swimming behavior(GO:0036269) brain morphogenesis(GO:0048854)
0.2 0.6 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 1.7 GO:0021592 fourth ventricle development(GO:0021592)
0.2 4.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 2.2 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.1 1.1 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.1 1.7 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 1.2 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 1.4 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 1.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 6.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 4.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 2.9 GO:1990798 pancreas regeneration(GO:1990798)
0.1 7.3 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 1.1 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.1 0.6 GO:0035608 protein deglutamylation(GO:0035608)
0.1 2.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.2 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.1 2.7 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.3 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 7.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 5.6 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 2.5 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 0.8 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 2.9 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 2.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 1.2 GO:0010107 potassium ion import(GO:0010107)
0.1 1.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 1.5 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 13.6 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 9.1 GO:0016485 protein processing(GO:0016485)
0.1 0.8 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 2.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 4.2 GO:0016573 histone acetylation(GO:0016573)
0.0 2.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.1 GO:0021986 habenula development(GO:0021986)
0.0 1.4 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 0.6 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 4.0 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 2.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 1.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.1 GO:0097237 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.7 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 3.0 GO:0006338 chromatin remodeling(GO:0006338)
0.0 3.1 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 5.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.0 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.7 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.1 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229)
0.0 1.4 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 0.5 GO:0042462 eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.7 GO:0043195 terminal bouton(GO:0043195)
0.3 3.2 GO:0098982 GABA-ergic synapse(GO:0098982)
0.3 3.4 GO:0061617 MICOS complex(GO:0061617)
0.3 13.0 GO:0032587 ruffle membrane(GO:0032587)
0.2 1.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.2 7.5 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 3.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 9.6 GO:0048786 presynaptic active zone(GO:0048786)
0.1 2.1 GO:0036038 MKS complex(GO:0036038)
0.1 1.6 GO:0014704 intercalated disc(GO:0014704)
0.1 2.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 2.5 GO:0071565 nBAF complex(GO:0071565)
0.1 2.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 4.7 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 1.2 GO:0030057 desmosome(GO:0030057)
0.1 2.8 GO:0001726 ruffle(GO:0001726)
0.1 2.1 GO:0000421 autophagosome membrane(GO:0000421)
0.1 4.2 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 7.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.8 GO:0055037 recycling endosome(GO:0055037)
0.0 2.4 GO:0031201 SNARE complex(GO:0031201)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.1 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.7 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 3.8 GO:0005764 lysosome(GO:0005764)
0.0 0.4 GO:0030686 90S preribosome(GO:0030686)
0.0 19.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.6 GO:0030496 midbody(GO:0030496)
0.0 2.5 GO:0005911 cell-cell junction(GO:0005911)
0.0 3.6 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.8 6.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.7 3.0 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.7 4.4 GO:0097363 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.7 4.7 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.6 3.5 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.5 2.8 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.4 6.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 6.0 GO:0038191 neuropilin binding(GO:0038191)
0.4 9.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 3.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.3 2.2 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 7.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 6.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 2.6 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.2 7.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 1.7 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.2 3.2 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.2 8.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 2.2 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.2 4.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 1.5 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.1 2.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 4.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 2.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 3.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.6 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.2 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1 4.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) beta-catenin binding(GO:0008013)
0.1 0.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 3.7 GO:0000149 SNARE binding(GO:0000149)
0.0 2.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 13.0 GO:0005543 phospholipid binding(GO:0005543)
0.0 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 8.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.1 GO:0004788 thiamine diphosphokinase activity(GO:0004788) thiamine binding(GO:0030975)
0.0 1.6 GO:0045296 cadherin binding(GO:0045296)
0.0 2.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.6 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 2.5 GO:0042393 histone binding(GO:0042393)
0.0 2.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 9.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 9.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 3.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.9 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.1 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 1.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 13.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.5 9.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 2.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 4.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling