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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gli1+gli2b

Z-value: 1.07

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Transcription factors associated with gli1+gli2b

Gene Symbol Gene ID Gene Info
gli2b
ENSDARG00000020884 GLI family zinc finger 2b
gli1
ENSDARG00000101244 GLI family zinc finger 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gli2bdr11_v1_chr11_+_43661735_436617350.132.2e-01Click!
gli1dr11_v1_chr6_-_59505589_595055890.037.4e-01Click!

Activity profile of gli1+gli2b motif

Sorted Z-values of gli1+gli2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_20422661 22.11 ENSDART00000144047
ENSDART00000104336
tnnc2
troponin C type 2 (fast)
chr12_-_464007 15.53 ENSDART00000106669
dhrs7cb
dehydrogenase/reductase (SDR family) member 7Cb
chr7_+_29952719 14.89 ENSDART00000173737
tpma
alpha-tropomyosin
chr10_+_33171501 14.70 ENSDART00000159666
myl10
myosin, light chain 10, regulatory
chr7_+_29952169 14.49 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
tpma
alpha-tropomyosin
chr14_+_15331486 13.61 ENSDART00000172077
ENSDART00000183370
ENSDART00000182467
SPINK2
si:dkey-203a12.5
si:dkey-203a12.4
si:dkey-203a12.5
chr14_+_15543331 13.10 ENSDART00000167025
si:dkey-203a12.7
si:dkey-203a12.7
chr20_-_53996193 12.04 ENSDART00000004756
hsp90aa1.1
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr14_+_15257658 11.45 ENSDART00000161625
ENSDART00000193577
si:dkey-77g12.4
si:dkey-203a12.5
si:dkey-77g12.4
si:dkey-203a12.5
chr18_+_5547185 11.40 ENSDART00000193977
nnt2
nicotinamide nucleotide transhydrogenase 2
chr14_+_15495088 11.00 ENSDART00000165765
ENSDART00000188577
si:dkey-203a12.6
si:dkey-203a12.6
chr14_+_15597049 10.85 ENSDART00000159732
si:dkey-203a12.8
si:dkey-203a12.8
chr14_+_15231097 10.63 ENSDART00000172430
si:dkey-203a12.3
si:dkey-203a12.3
chr7_+_29951997 10.51 ENSDART00000173453
tpma
alpha-tropomyosin
chr4_-_17741513 10.16 ENSDART00000141680
mybpc1
myosin binding protein C, slow type
chr7_+_31871830 9.85 ENSDART00000139899
mybpc3
myosin binding protein C, cardiac
chr13_-_865193 9.77 ENSDART00000187053
AL929536.7

chr14_-_15171435 9.27 ENSDART00000159148
ENSDART00000166622
si:dkey-77g12.1
si:dkey-77g12.1
chr8_-_14121634 7.21 ENSDART00000184946
bgna
biglycan a
chr14_+_15430991 6.42 ENSDART00000158221
si:dkey-203a12.5
si:dkey-203a12.5
chr20_+_27194833 6.27 ENSDART00000150072
si:dkey-85n7.8
si:dkey-85n7.8
chr19_+_9004256 6.23 ENSDART00000186401
ENSDART00000091443
si:ch211-81a5.1
si:ch211-81a5.1
chr1_+_59090743 6.10 ENSDART00000100199
mfap4
microfibril associated protein 4
chr13_-_17723417 6.06 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr9_+_23770666 5.73 ENSDART00000182493
si:ch211-219a4.3
si:ch211-219a4.3
chr10_+_15224660 5.61 ENSDART00000137932
sh3bp2
SH3-domain binding protein 2
chr12_+_27462225 5.47 ENSDART00000105661
meox1
mesenchyme homeobox 1
chr13_+_228045 5.39 ENSDART00000161091
zgc:64201
zgc:64201
chr10_+_43188678 5.35 ENSDART00000012522
vcanb
versican b
chr12_-_26415499 5.28 ENSDART00000185779
synpo2lb
synaptopodin 2-like b
chr6_-_3982783 5.07 ENSDART00000171944
slc25a12
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr6_+_28796773 4.67 ENSDART00000168237
ENSDART00000163541
tp63
tumor protein p63
chr12_+_18358082 4.53 ENSDART00000123315
si:dkey-7e14.3
si:dkey-7e14.3
chr16_-_30885838 4.28 ENSDART00000131356
dennd3b
DENN/MADD domain containing 3b
chr23_+_26009266 4.24 ENSDART00000054025
si:dkey-78k11.9
si:dkey-78k11.9
chr20_-_54377933 4.11 ENSDART00000182664
entpd5b
ectonucleoside triphosphate diphosphohydrolase 5b
chr13_-_330004 4.09 ENSDART00000093149
ddx21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
chr2_+_58877162 3.87 ENSDART00000122174
CABZ01085658.1

chr16_-_43041324 3.67 ENSDART00000155445
ENSDART00000156836
ENSDART00000154945
si:dkey-7j14.6
si:dkey-7j14.6
chr15_-_34056733 3.64 ENSDART00000170130
ENSDART00000188272
VWDE
si:dkey-30e9.7
chr23_+_18779043 3.56 ENSDART00000158267
emp3b
epithelial membrane protein 3b
chr18_-_17485419 3.54 ENSDART00000018764
foxl1
forkhead box L1
chr25_+_30298377 3.53 ENSDART00000153622
C11orf96
chromosome 11 open reading frame 96
chr1_-_470812 3.53 ENSDART00000192527
zgc:92518
zgc:92518
chr1_+_59090583 3.53 ENSDART00000150658
mfap4
microfibril associated protein 4
chr10_-_34907477 3.50 ENSDART00000099604
sparta
spartin a
chr25_+_245438 3.48 ENSDART00000004689
zgc:92481
zgc:92481
chr17_+_30587333 3.43 ENSDART00000156500
nhsl1a
NHS-like 1a
chr1_+_57235896 3.40 ENSDART00000152621
si:dkey-27j5.7
si:dkey-27j5.7
chr13_-_39947335 3.39 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr22_-_3344613 3.26 ENSDART00000165600
tbxa2r
thromboxane A2 receptor
chr4_+_10721795 3.26 ENSDART00000136000
ENSDART00000067253
stab2
stabilin 2
chr11_+_24314148 2.97 ENSDART00000171491
rem1
RAS (RAD and GEM)-like GTP-binding 1
chr21_+_11560153 2.96 ENSDART00000065842
cd8a
CD8a molecule
chr21_+_261490 2.95 ENSDART00000177919
jak2a
Janus kinase 2a
chr22_+_26665422 2.91 ENSDART00000164994
adcy9
adenylate cyclase 9
chr5_-_51747278 2.86 ENSDART00000192232
lhfpl2b
LHFPL tetraspan subfamily member 2b
chr15_-_38129845 2.83 ENSDART00000057095
si:dkey-24p1.1
si:dkey-24p1.1
chr20_+_2669017 2.79 ENSDART00000058777
slc35a1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr19_+_49721 2.72 ENSDART00000160489
col14a1b
collagen, type XIV, alpha 1b
chr5_+_36439405 2.67 ENSDART00000102973
eda
ectodysplasin A
chr21_-_36948 2.65 ENSDART00000181230
JMY
junction mediating and regulatory protein, p53 cofactor
chr21_-_30415524 2.65 ENSDART00000101036
grpel2
GrpE-like 2, mitochondrial
chr16_-_13595027 2.64 ENSDART00000060004
ntd5
ntl-dependent gene 5
chr22_-_22147375 2.46 ENSDART00000149304
cdc34a
cell division cycle 34 homolog (S. cerevisiae) a
chr8_-_40327397 2.44 ENSDART00000074125
aplnra
apelin receptor a
chr13_-_9598320 2.40 ENSDART00000184613
cpxm1a
carboxypeptidase X (M14 family), member 1a
chr16_-_22930925 2.34 ENSDART00000133819
si:dkey-246i14.3
si:dkey-246i14.3
chr18_+_25653599 2.25 ENSDART00000007856
fkbp16
FK506 binding protein 16
chr12_+_34273240 2.24 ENSDART00000037904
socs3b
suppressor of cytokine signaling 3b
chr14_-_29859067 2.21 ENSDART00000136380
sorbs2b
sorbin and SH3 domain containing 2b
chr7_+_53156810 2.20 ENSDART00000189816
cdh29
cadherin 29
chr16_-_12784373 2.15 ENSDART00000080396
foxj2
forkhead box J2
chr22_+_38762693 2.14 ENSDART00000015016
ENSDART00000150187
alpi.1
alkaline phosphatase, intestinal, tandem duplicate 1
chr19_+_48060464 2.09 ENSDART00000123163
zgc:85936
zgc:85936
chr20_+_35484070 2.09 ENSDART00000026234
ENSDART00000141675
mep1a.2
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2
chr4_+_58016732 2.08 ENSDART00000165777
CT027609.1

chr25_-_34740627 2.07 ENSDART00000137665
frs2b
fibroblast growth factor receptor substrate 2b
chr10_-_39154594 2.06 ENSDART00000148825
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr10_-_15053507 2.06 ENSDART00000157446
ENSDART00000170441
CLDN23
si:ch211-95j8.5
chr3_-_9488350 2.05 ENSDART00000186707
FO904885.2

chr23_+_44049509 1.91 ENSDART00000102003
txk
TXK tyrosine kinase
chr21_+_45819662 1.86 ENSDART00000193362
ENSDART00000184255
pitx1
paired-like homeodomain 1
chr7_+_18075504 1.85 ENSDART00000173689
si:ch73-40a2.1
si:ch73-40a2.1
chr12_-_30338779 1.83 ENSDART00000192511
vwa2
von Willebrand factor A domain containing 2
chr8_+_29962635 1.82 ENSDART00000007640
ptch1
patched 1
chr3_+_19621034 1.79 ENSDART00000025358
itgb3a
integrin beta 3a
chr23_+_4414164 1.76 ENSDART00000192762
wnt7ab
wingless-type MMTV integration site family, member 7Ab
chr10_-_24391716 1.70 ENSDART00000141332
ENSDART00000100772
slc43a2b
solute carrier family 43 (amino acid system L transporter), member 2b
chr6_+_7123980 1.69 ENSDART00000179738
ENSDART00000151311
si:ch211-237c6.4
si:ch211-237c6.4
chr4_+_63253425 1.66 ENSDART00000193510
si:ch211-258f1.3
si:ch211-258f1.3
chr3_-_15444396 1.66 ENSDART00000104361
si:dkey-56d12.4
si:dkey-56d12.4
chr11_-_21304452 1.65 ENSDART00000163008
RASSF5
si:dkey-85p17.3
chr23_+_4414343 1.63 ENSDART00000081821
wnt7ab
wingless-type MMTV integration site family, member 7Ab
chrM_+_9735 1.59 ENSDART00000093613
mt-co3
cytochrome c oxidase III, mitochondrial
chr22_+_24389135 1.59 ENSDART00000157861
p3h2
prolyl 3-hydroxylase 2
chr14_-_33821515 1.57 ENSDART00000173218
vimr2
vimentin-related 2
chr6_-_436658 1.53 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr23_+_34005792 1.53 ENSDART00000132668
si:ch211-207e14.4
si:ch211-207e14.4
chr5_+_36513605 1.52 ENSDART00000013590
wnt11
wingless-type MMTV integration site family, member 11
chr15_-_43287515 1.51 ENSDART00000155103
prss16
protease, serine, 16 (thymus)
chr2_-_33993533 1.40 ENSDART00000140910
ENSDART00000077304
ptch2
patched 2
chr10_-_14488472 1.31 ENSDART00000101298
ENSDART00000138161
galt
galactose-1-phosphate uridylyltransferase
chr18_+_30567945 1.30 ENSDART00000078894
irf8
interferon regulatory factor 8
chr23_+_36052944 1.28 ENSDART00000103149
hoxc13a
homeobox C13a
chr4_+_5132951 1.24 ENSDART00000103279
ccnd2b
cyclin D2, b
chr3_+_34986837 1.24 ENSDART00000190341
smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr8_-_43847138 1.20 ENSDART00000148358
adgrd1
adhesion G protein-coupled receptor D1
chr25_-_35106751 1.18 ENSDART00000180682
ENSDART00000073457
zgc:194989
zgc:194989
chr4_-_11077872 1.12 ENSDART00000150566
BX784029.4

chr9_+_56194410 1.11 ENSDART00000168530
LO018176.1

chr25_-_3087556 1.11 ENSDART00000193249
best1
bestrophin 1
chr7_-_27037990 1.06 ENSDART00000173561
nucb2a
nucleobindin 2a
chr23_-_22130778 1.02 ENSDART00000079212
phc2a
polyhomeotic homolog 2a (Drosophila)
chr22_+_19522982 1.02 ENSDART00000192428
ENSDART00000190812
si:dkey-78l4.13
si:dkey-78l4.13
chr17_-_50331351 0.97 ENSDART00000149294
otofb
otoferlin b
chr10_+_5645887 0.97 ENSDART00000171426
pdzph1
PDZ and pleckstrin homology domains 1
chr4_-_72101234 0.95 ENSDART00000167048
slco1f1
solute carrier organic anion transporter family, member 1F1
chr19_-_6988837 0.94 ENSDART00000145741
ENSDART00000167640
znf384l
zinc finger protein 384 like
chr2_-_10896745 0.91 ENSDART00000114609
cdcp2
CUB domain containing protein 2
chr19_+_18493782 0.88 ENSDART00000160992
fkbp10a
FK506 binding protein 10a
chr6_-_10693111 0.88 ENSDART00000187206
ENSDART00000192319
dnah9l
dynein, axonemal, heavy polypeptide 9 like
chr21_-_41873065 0.87 ENSDART00000014538
endou2
endonuclease, polyU-specific 2
chr18_-_45617146 0.86 ENSDART00000146543
wt1b
wilms tumor 1b
chr14_-_45702721 0.85 ENSDART00000165727
si:dkey-226n24.1
si:dkey-226n24.1
chr18_+_22123072 0.84 ENSDART00000148177
si:ch73-186j5.2
si:ch73-186j5.2
chr9_-_46399611 0.81 ENSDART00000164914
ENSDART00000145931
lct
si:dkey-79p17.3
lactase
si:dkey-79p17.3
chr10_-_15910974 0.79 ENSDART00000148169
pip5k1ba
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr6_+_11850359 0.78 ENSDART00000109552
ENSDART00000188139
ENSDART00000181499
ENSDART00000178269
baz2ba
bromodomain adjacent to zinc finger domain, 2Ba
chr3_+_34121156 0.77 ENSDART00000174929
aldh3b1
aldehyde dehydrogenase 3 family, member B1
chr6_+_42918933 0.76 ENSDART00000064896
gnat1
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
chr20_-_25626693 0.75 ENSDART00000132247
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr19_+_7424347 0.74 ENSDART00000004622
sf3b4
splicing factor 3b, subunit 4
chr2_-_38337122 0.73 ENSDART00000076523
ENSDART00000187473
slc7a8b
solute carrier family 7 (amino acid transporter light chain, L system), member 8b
chr13_-_38039871 0.71 ENSDART00000140645
CR456624.1

chr3_-_8285123 0.70 ENSDART00000158699
ENSDART00000138588
trim35-9
tripartite motif containing 35-9
chr4_+_28997595 0.69 ENSDART00000133357
si:dkey-13e3.1
si:dkey-13e3.1
chr10_-_44411032 0.69 ENSDART00000111509
CABZ01072096.1

chr5_+_40224938 0.67 ENSDART00000142897
si:dkey-193c22.2
si:dkey-193c22.2
chr2_-_44199722 0.66 ENSDART00000140633
ENSDART00000145728
sdhc
succinate dehydrogenase complex, subunit C, integral membrane protein
chr7_+_4162994 0.64 ENSDART00000172800
si:ch211-63p21.1
si:ch211-63p21.1
chr11_+_14295011 0.64 ENSDART00000060226
si:ch211-262i1.4
si:ch211-262i1.4
chr10_-_40490647 0.63 ENSDART00000143660
taar20x
trace amine associated receptor 20x
chr17_-_8562586 0.60 ENSDART00000154257
ENSDART00000157308
fzd3b
frizzled class receptor 3b
chr19_-_34995629 0.58 ENSDART00000141704
si:rp71-45k5.2
si:rp71-45k5.2
chr1_-_21599219 0.57 ENSDART00000148327
adamtsl7
ADAMTS-like 7
chr10_-_40448736 0.55 ENSDART00000137644
ENSDART00000168190
taar20p
trace amine associated receptor 20p
chr5_-_17876709 0.51 ENSDART00000141978
si:dkey-112e17.1
si:dkey-112e17.1
chr11_+_30306606 0.51 ENSDART00000128276
ENSDART00000190222
ugt1b4
UDP glucuronosyltransferase 1 family, polypeptide B4
chr18_-_39636348 0.49 ENSDART00000129828
cyp19a1a
cytochrome P450, family 19, subfamily A, polypeptide 1a
chr13_+_31583034 0.45 ENSDART00000111763
six6a
SIX homeobox 6a
chr11_+_44300548 0.44 ENSDART00000191626
CABZ01100304.1

chr22_-_22340688 0.44 ENSDART00000105597
si:ch211-129c21.1
si:ch211-129c21.1
chr21_-_8370500 0.40 ENSDART00000055328
nek6
NIMA-related kinase 6
chr10_-_24391030 0.39 ENSDART00000180013
ENSDART00000177914
slc43a2b
solute carrier family 43 (amino acid system L transporter), member 2b
chr10_+_16036246 0.38 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lmnb1
lamin B1
chr4_-_11067331 0.37 ENSDART00000150871
si:dkey-21h14.15
si:dkey-21h14.15
chr8_-_7078575 0.37 ENSDART00000137413
si:ch73-233m11.2
si:ch73-233m11.2
chr22_+_31207799 0.37 ENSDART00000133267
grip2b
glutamate receptor interacting protein 2b
chr4_+_57881965 0.36 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr9_-_33749556 0.36 ENSDART00000149383
ndp
Norrie disease (pseudoglioma)
chr2_-_57707039 0.36 ENSDART00000097685
CABZ01060891.1

chr7_+_10701938 0.31 ENSDART00000158162
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr18_-_18587745 0.30 ENSDART00000191973
sf3b3
splicing factor 3b, subunit 3
chr5_+_66326004 0.30 ENSDART00000144351
malt1
MALT paracaspase 1
chr25_+_32473433 0.28 ENSDART00000152326
sqor
sulfide quinone oxidoreductase
chr2_+_30147504 0.27 ENSDART00000190947
kcnb2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr21_-_17037907 0.22 ENSDART00000101263
ube2g1b
ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast)
chr23_-_27152866 0.21 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr2_+_54086436 0.21 ENSDART00000174581
CU179656.1

chr24_-_17029374 0.21 ENSDART00000039267
ptgdsb.1
prostaglandin D2 synthase b, tandem duplicate 1
chr4_+_38170708 0.21 ENSDART00000168900
znf1071
zinc finger protein 1071
chr8_+_40573137 0.20 ENSDART00000184278
izumo1
izumo sperm-egg fusion 1
chr18_-_1143996 0.19 ENSDART00000189186
ENSDART00000136140
hcn4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr16_-_40373836 0.19 ENSDART00000134498
si:dkey-242e21.3
si:dkey-242e21.3
chr2_-_12242695 0.16 ENSDART00000158175
gpr158b
G protein-coupled receptor 158b
chr18_-_40753583 0.14 ENSDART00000026767
akt2
v-akt murine thymoma viral oncogene homolog 2
chr11_+_2855430 0.13 ENSDART00000172837
kif21b
kinesin family member 21B
chr2_+_42005217 0.11 ENSDART00000143562
gbp2
guanylate binding protein 2
chr24_+_39518774 0.10 ENSDART00000132939
dcun1d3
defective in cullin neddylation 1 domain containing 3
chr10_+_16036573 0.10 ENSDART00000188757
lmnb1
lamin B1
chr18_+_14529005 0.09 ENSDART00000186379
kcng4a
potassium voltage-gated channel, subfamily G, member 4a
chr17_-_722218 0.09 ENSDART00000160385
SLC25A29
solute carrier family 25 member 29
chr8_+_28469054 0.08 ENSDART00000062716
slc52a3
solute carrier family 52 (riboflavin transporter), member 3
chr24_+_3972260 0.05 ENSDART00000131753
pfkpa
phosphofructokinase, platelet a

Network of associatons between targets according to the STRING database.

First level regulatory network of gli1+gli2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.0 GO:1903428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
2.9 11.4 GO:0006740 NADPH regeneration(GO:0006740)
2.0 9.8 GO:0003210 cardiac atrium formation(GO:0003210)
1.1 3.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
1.1 22.1 GO:0014823 response to activity(GO:0014823)
0.8 3.3 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.6 6.9 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.6 2.4 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
0.6 9.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.6 3.0 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.6 4.7 GO:0048730 epidermis morphogenesis(GO:0048730)
0.5 5.5 GO:0061056 sclerotome development(GO:0061056)
0.5 5.1 GO:0015800 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.4 1.3 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.4 38.9 GO:0061515 myeloid cell development(GO:0061515)
0.3 6.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.3 1.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 4.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 3.3 GO:0045777 positive regulation of blood pressure(GO:0045777)
0.3 1.3 GO:0019388 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.2 4.1 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.2 1.4 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.2 5.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 2.8 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.2 0.5 GO:0030238 female sex determination(GO:0030237) male sex determination(GO:0030238)
0.1 2.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.2 GO:0003160 endocardium morphogenesis(GO:0003160)
0.1 0.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 1.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 10.2 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.1 6.3 GO:0006119 oxidative phosphorylation(GO:0006119)
0.1 1.8 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.9 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 2.2 GO:0007259 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.1 2.7 GO:0042476 odontogenesis(GO:0042476)
0.1 0.4 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.1 3.5 GO:0035138 pectoral fin morphogenesis(GO:0035138)
0.1 0.7 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1 1.2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 2.8 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 0.8 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 1.0 GO:0010996 response to auditory stimulus(GO:0010996)
0.1 0.4 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.1 3.4 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.1 0.8 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.1 3.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 1.8 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 1.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 2.1 GO:1904018 positive regulation of angiogenesis(GO:0045766) positive regulation of vasculature development(GO:1904018)
0.0 1.6 GO:0032963 collagen metabolic process(GO:0032963) multicellular organismal macromolecule metabolic process(GO:0044259)
0.0 1.5 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.9 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.1 GO:0046324 regulation of glucose import(GO:0046324)
0.0 2.9 GO:0009190 cyclic nucleotide biosynthetic process(GO:0009190)
0.0 0.4 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.9 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 2.4 GO:0016485 protein processing(GO:0016485)
0.0 1.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 1.3 GO:0031101 fin regeneration(GO:0031101)
0.0 0.8 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.2 GO:0035036 sperm-egg recognition(GO:0035036)
0.0 0.3 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 12.0 GO:0043209 myelin sheath(GO:0043209)
0.7 2.6 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.5 22.1 GO:0005861 troponin complex(GO:0005861)
0.4 7.9 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 39.9 GO:0005884 actin filament(GO:0005884)
0.3 6.1 GO:0046930 pore complex(GO:0046930)
0.1 0.7 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 5.3 GO:0030018 Z disc(GO:0030018)
0.0 1.0 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 2.2 GO:0016342 catenin complex(GO:0016342)
0.0 1.8 GO:0008305 integrin complex(GO:0008305)
0.0 2.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.8 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.3 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 47.5 GO:0005576 extracellular region(GO:0005576)
0.0 0.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 5.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.9 GO:0031514 motile cilium(GO:0031514)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
1.2 6.1 GO:0015288 porin activity(GO:0015288)
0.9 9.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.8 3.2 GO:0097108 hedgehog family protein binding(GO:0097108)
0.8 22.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 1.8 GO:0070051 fibrinogen binding(GO:0070051)
0.5 3.3 GO:0004960 thromboxane receptor activity(GO:0004960)
0.5 5.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.5 2.4 GO:0060182 apelin receptor activity(GO:0060182)
0.4 5.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.4 1.6 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.3 40.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.3 7.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 2.8 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.3 2.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 4.1 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.2 0.7 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.2 7.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 0.8 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.2 2.7 GO:0005123 death receptor binding(GO:0005123)
0.1 9.6 GO:0003823 antigen binding(GO:0003823)
0.1 1.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 1.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 4.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 4.9 GO:0005109 frizzled binding(GO:0005109)
0.1 1.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 3.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 2.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 5.6 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.0 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.8 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 2.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 2.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 3.1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 2.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 4.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 3.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.0 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.2 GO:0001972 retinoic acid binding(GO:0001972)
0.0 2.6 GO:0008201 heparin binding(GO:0008201)
0.0 0.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 2.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.8 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 2.7 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 8.3 GO:0016887 ATPase activity(GO:0016887)
0.0 1.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 1.1 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.2 GO:0030552 cAMP binding(GO:0030552)
0.0 2.5 GO:0008236 serine-type peptidase activity(GO:0008236) serine hydrolase activity(GO:0017171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.2 2.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 3.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 7.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 3.4 ST GA13 PATHWAY G alpha 13 Pathway
0.1 16.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.3 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 1.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 6.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.5 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 32.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.7 3.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.4 3.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 2.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 5.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 3.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 4.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.8 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 2.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 0.8 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins