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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gli2a+gli3

Z-value: 0.87

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Transcription factors associated with gli2a+gli3

Gene Symbol Gene ID Gene Info
gli2a
ENSDARG00000025641 GLI family zinc finger 2a
gli3
ENSDARG00000052131 GLI family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gli3dr11_v1_chr24_-_11821505_11821505-0.721.5e-16Click!
gli2adr11_v1_chr9_+_37152564_37152564-0.414.2e-05Click!

Activity profile of gli2a+gli3 motif

Sorted Z-values of gli2a+gli3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_19845378 18.93 ENSDART00000139314
ENSDART00000132958
ENSDART00000147502
grhprb
glyoxylate reductase/hydroxypyruvate reductase b
chr16_+_52512025 18.67 ENSDART00000056095
fabp10a
fatty acid binding protein 10a, liver basic
chr22_-_24858042 15.53 ENSDART00000137998
ENSDART00000078216
ENSDART00000138378
vtg7
vitellogenin 7
chr22_-_24818066 11.39 ENSDART00000143443
vtg6
vitellogenin 6
chr25_-_17403598 10.97 ENSDART00000104216
cyp2x9
cytochrome P450, family 2, subfamily X, polypeptide 9
chr22_-_24791505 10.38 ENSDART00000136837
vtg4
vitellogenin 4
chr22_+_38173960 9.88 ENSDART00000010537
cp
ceruloplasmin
chr10_+_26747755 7.80 ENSDART00000100329
f9b
coagulation factor IXb
chr4_+_72797711 6.86 ENSDART00000190934
ENSDART00000163236
MYRFL
myelin regulatory factor-like
chr16_-_31644545 6.80 ENSDART00000181634
CR855311.5

chr10_+_28428222 6.14 ENSDART00000135003
si:ch211-222e20.4
si:ch211-222e20.4
chr3_-_18805225 6.13 ENSDART00000133471
ENSDART00000131758
msrb1a
methionine sulfoxide reductase B1a
chr18_-_14836600 5.75 ENSDART00000045232
mtss1la
metastasis suppressor 1-like a
chr22_-_188102 5.37 ENSDART00000125391
ENSDART00000170463
CABZ01052268.1

chr6_+_10094061 5.24 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr23_+_44374041 5.23 ENSDART00000136056
ephb4b
eph receptor B4b
chr10_+_19595009 5.09 ENSDART00000112276
zgc:173837
zgc:173837
chr4_-_75175407 5.05 ENSDART00000180125
CABZ01043953.1

chr4_-_77114795 4.53 ENSDART00000144849
CU467646.2

chr4_-_55785014 4.00 ENSDART00000181348
CT583728.24

chr4_-_55801210 4.00 ENSDART00000186943
CT583728.13

chr24_+_7828613 3.72 ENSDART00000135161
zgc:101569
zgc:101569
chr4_-_55829342 3.70 ENSDART00000185611
CT583728.26

chr13_-_865193 3.62 ENSDART00000187053
AL929536.7

chr13_+_24842857 3.50 ENSDART00000123866
dusp13a
dual specificity phosphatase 13a
chr13_-_38039871 3.46 ENSDART00000140645
CR456624.1

chr13_+_15682803 3.43 ENSDART00000188063
CR931980.1

chr21_-_30935262 3.40 ENSDART00000172390
stim1b
stromal interaction molecule 1b
chr13_-_40726865 3.26 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr5_-_25621386 3.25 ENSDART00000051565
cyp1d1
cytochrome P450, family 1, subfamily D, polypeptide 1
chr15_-_47812268 2.97 ENSDART00000190231
tomt
transmembrane O-methyltransferase
chr3_+_57991074 2.95 ENSDART00000076077
myadml2
myeloid-associated differentiation marker-like 2
chr3_+_23692462 2.92 ENSDART00000145934
hoxb7a
homeobox B7a
chr4_-_52165969 2.83 ENSDART00000171130
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr18_-_2639351 2.72 ENSDART00000168106
relt
RELT, TNF receptor
chr10_-_24868581 2.72 ENSDART00000193055
CABZ01058107.1

chr2_+_51783120 2.59 ENSDART00000177559
crygn1
crystallin, gamma N1
chr22_-_11714104 2.52 ENSDART00000145265
ENSDART00000063127
ENSDART00000183743
crygs1
crystallin, gamma S1
chr17_-_8562586 2.50 ENSDART00000154257
ENSDART00000157308
fzd3b
frizzled class receptor 3b
chr25_-_35106751 2.48 ENSDART00000180682
ENSDART00000073457
zgc:194989
zgc:194989
chr25_+_245438 2.47 ENSDART00000004689
zgc:92481
zgc:92481
chr19_-_46566430 2.38 ENSDART00000166668
ext1b
exostosin glycosyltransferase 1b
chr8_+_28467893 2.38 ENSDART00000189724
slc52a3
solute carrier family 52 (riboflavin transporter), member 3
chr6_-_10693111 2.37 ENSDART00000187206
ENSDART00000192319
dnah9l
dynein, axonemal, heavy polypeptide 9 like
chr5_+_51594209 2.37 ENSDART00000164668
ENSDART00000058403
ENSDART00000055857
ckmt2b
creatine kinase, mitochondrial 2b (sarcomeric)
chr13_+_3252950 2.35 ENSDART00000020671
prph2b
peripherin 2b (retinal degeneration, slow)
chr8_-_14484599 2.30 ENSDART00000057644
lhx4
LIM homeobox 4
chr3_+_56574623 2.21 ENSDART00000130877
rac1b
Rac family small GTPase 1b
chr5_-_23715861 2.21 ENSDART00000019992
gbgt1l1
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1
chr2_+_54086436 2.19 ENSDART00000174581
CU179656.1

chr13_+_31583034 2.12 ENSDART00000111763
six6a
SIX homeobox 6a
chr8_-_40075983 2.12 ENSDART00000141455
ggt1a
gamma-glutamyltransferase 1a
chr3_+_55131289 2.06 ENSDART00000111585
AL935210.1

chr5_-_15948833 2.05 ENSDART00000051649
ENSDART00000124467
xbp1
X-box binding protein 1
chr25_+_25085349 2.04 ENSDART00000192166
si:ch73-182e20.4
si:ch73-182e20.4
chr13_-_30150592 2.04 ENSDART00000143093
sar1ab
secretion associated, Ras related GTPase 1Ab
chr5_+_36439405 1.96 ENSDART00000102973
eda
ectodysplasin A
chr9_+_6587364 1.96 ENSDART00000122279
fhl2a
four and a half LIM domains 2a
chr15_+_1137337 1.95 ENSDART00000191508
p2ry13
purinergic receptor P2Y13
chr19_-_10631482 1.94 ENSDART00000129264
si:dkey-211g8.9
si:dkey-211g8.9
chr9_+_6587056 1.86 ENSDART00000193421
fhl2a
four and a half LIM domains 2a
chr25_-_3836597 1.86 ENSDART00000115154
si:ch211-247i17.1
si:ch211-247i17.1
chr9_-_1984604 1.84 ENSDART00000082339
hoxd12a
homeobox D12a
chr8_+_48558100 1.80 ENSDART00000166165
si:ch211-215j19.12
si:ch211-215j19.12
chr23_-_27875140 1.78 ENSDART00000143662
ankrd33aa
ankyrin repeat domain 33Aa
chr3_-_46410387 1.76 ENSDART00000156822
cdip1
cell death-inducing p53 target 1
chr16_+_20220225 1.75 ENSDART00000182208
colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr19_+_2546775 1.72 ENSDART00000148527
ENSDART00000097528
sp4
sp4 transcription factor
chr8_-_49207319 1.71 ENSDART00000022870
fam110a
family with sequence similarity 110, member A
chr13_-_12602920 1.67 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr18_+_33100606 1.59 ENSDART00000003907
si:ch211-229c8.13
si:ch211-229c8.13
chr8_+_46587593 1.58 ENSDART00000075125
tas1r2.1
taste receptor, type 1, member 2, tandem duplicate 1
chr3_+_55114097 1.54 ENSDART00000121686
hbbe1.1
hemoglobin beta embryonic-1.1
chr12_-_464007 1.53 ENSDART00000106669
dhrs7cb
dehydrogenase/reductase (SDR family) member 7Cb
chr5_-_10012971 1.52 ENSDART00000179421
CR936408.2

chr21_+_4320769 1.50 ENSDART00000168553
HTRA2 (1 of many)
si:dkey-84o3.4
chr10_+_5954787 1.48 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
map3k1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr4_+_9679840 1.46 ENSDART00000190889
BX901962.12

chr18_+_2585298 1.46 ENSDART00000166314
ENSDART00000162043
p2ry2.2
purinergic receptor P2Y2, tandem duplicate 2
chr10_-_36726188 1.45 ENSDART00000157262
pimr137
Pim proto-oncogene, serine/threonine kinase, related 137
chr3_+_55122662 1.43 ENSDART00000128380
hbbe1.2
hemoglobin beta embryonic-1.2
chr9_+_23770666 1.43 ENSDART00000182493
si:ch211-219a4.3
si:ch211-219a4.3
chr12_+_27117609 1.42 ENSDART00000076154
hoxb8b
homeobox B8b
chr19_+_7954679 1.39 ENSDART00000150909
si:dkey-266f7.10
si:dkey-266f7.10
chr23_+_18138589 1.39 ENSDART00000114983
fam19a4a
family with sequence similarity 19 (chemokine (C-C motif)-like), member A4a
chr10_-_22854758 1.38 ENSDART00000079449
and3
actinodin3
chr4_-_5831036 1.38 ENSDART00000166232
foxm1
forkhead box M1
chr17_-_51202339 1.38 ENSDART00000167117
si:ch1073-469d17.2
si:ch1073-469d17.2
chr17_-_34952562 1.38 ENSDART00000021128
kidins220a
kinase D-interacting substrate 220a
chr4_+_57881965 1.36 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr19_-_40192249 1.33 ENSDART00000051972
grn1
granulin 1
chr9_+_50007556 1.31 ENSDART00000175587
slc38a11
solute carrier family 38, member 11
chr25_+_25085526 1.30 ENSDART00000171627
si:ch73-182e20.4
si:ch73-182e20.4
chr1_+_51479128 1.30 ENSDART00000028018
meis1a
Meis homeobox 1 a
chr20_-_33959815 1.30 ENSDART00000133081
selp
selectin P
chr14_+_31509922 1.28 ENSDART00000124499
hprt1
hypoxanthine phosphoribosyltransferase 1
chr21_+_35327589 1.28 ENSDART00000145191
ENSDART00000132743
rars
arginyl-tRNA synthetase
chr18_+_5273953 1.28 ENSDART00000165073
slc12a1
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr22_-_37565348 1.26 ENSDART00000149482
ENSDART00000104478
fxr1
fragile X mental retardation, autosomal homolog 1
chr21_-_26520629 1.25 ENSDART00000142731
rce1b
Ras converting CAAX endopeptidase 1b
chr14_+_30774032 1.25 ENSDART00000139552
atl3
atlastin 3
chr24_+_17334682 1.24 ENSDART00000018868
pdia4
protein disulfide isomerase family A, member 4
chr11_+_14295011 1.18 ENSDART00000060226
si:ch211-262i1.4
si:ch211-262i1.4
chr5_-_72289648 1.18 ENSDART00000037691
tbx5a
T-box 5a
chr10_-_40448736 1.17 ENSDART00000137644
ENSDART00000168190
taar20p
trace amine associated receptor 20p
chr16_+_42667560 1.16 ENSDART00000023452
dpy19l1l
dpy-19-like 1, like (H. sapiens)
chr7_-_15413188 1.16 ENSDART00000185980
si:ch211-106j24.1
si:ch211-106j24.1
chr21_+_43402794 1.15 ENSDART00000185572
frmd7
FERM domain containing 7
chr20_+_2669017 1.15 ENSDART00000058777
slc35a1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr11_+_36355348 1.14 ENSDART00000145427
sypl2a
synaptophysin-like 2a
chr13_-_45201300 1.14 ENSDART00000074750
ENSDART00000180265
runx3
runt-related transcription factor 3
chr24_+_35827766 1.13 ENSDART00000144700
si:dkeyp-7a3.1
si:dkeyp-7a3.1
chr20_-_7000225 1.12 ENSDART00000100098
adcy1a
adenylate cyclase 1a
chr5_+_20437124 1.11 ENSDART00000159001
tmem119a
transmembrane protein 119a
chr6_-_43817761 1.11 ENSDART00000183945
foxp1b
forkhead box P1b
chr2_-_57707039 1.10 ENSDART00000097685
CABZ01060891.1

chr14_+_30774515 1.10 ENSDART00000191666
atl3
atlastin 3
chr22_-_12726556 1.08 ENSDART00000105776
fam207a
family with sequence similarity 207, member A
chr8_-_45729758 1.04 ENSDART00000189329
BX088696.1

chr15_-_38361787 1.01 ENSDART00000155758
trpc2a
transient receptor potential cation channel, subfamily C, member 2a
chr21_+_22985078 1.01 ENSDART00000156491
lpar6b
lysophosphatidic acid receptor 6b
chr23_+_12072980 1.00 ENSDART00000141646
edn3b
endothelin 3b
chr23_+_43834376 0.99 ENSDART00000148989
si:ch211-149b19.4
si:ch211-149b19.4
chr23_+_4414343 0.99 ENSDART00000081821
wnt7ab
wingless-type MMTV integration site family, member 7Ab
chr23_+_4414164 0.98 ENSDART00000192762
wnt7ab
wingless-type MMTV integration site family, member 7Ab
chr2_+_48638827 0.97 ENSDART00000163634
CR381673.2

chr20_-_38610360 0.96 ENSDART00000168783
ENSDART00000164638
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr1_-_470812 0.94 ENSDART00000192527
zgc:92518
zgc:92518
chr8_-_49201258 0.93 ENSDART00000114584
ENSDART00000142172
zgc:171501
zgc:171501
chr2_+_47718605 0.92 ENSDART00000189180
ENSDART00000148824
mbnl1
muscleblind-like splicing regulator 1
chr14_+_46020282 0.91 ENSDART00000190087
c1qtnf2
C1q and TNF related 2
chr12_+_34273240 0.89 ENSDART00000037904
socs3b
suppressor of cytokine signaling 3b
chr22_+_26600834 0.88 ENSDART00000157411
adcy9
adenylate cyclase 9
chr8_-_52859301 0.86 ENSDART00000162004
nr5a1a
nuclear receptor subfamily 5, group A, member 1a
chr14_+_34952883 0.85 ENSDART00000182812
il12ba
interleukin 12Ba
chr22_-_20814450 0.80 ENSDART00000089076
dot1l
DOT1-like histone H3K79 methyltransferase
chr16_-_30847192 0.79 ENSDART00000191106
ENSDART00000128158
ptk2ab
protein tyrosine kinase 2ab
chr6_+_7123980 0.79 ENSDART00000179738
ENSDART00000151311
si:ch211-237c6.4
si:ch211-237c6.4
chr8_+_29962635 0.78 ENSDART00000007640
ptch1
patched 1
chr14_+_24258562 0.78 ENSDART00000106074
ENSDART00000173227
chrm1a
cholinergic receptor, muscarinic 1a
chr5_-_38643188 0.77 ENSDART00000144972
si:ch211-271e10.1
si:ch211-271e10.1
chr17_-_4252221 0.77 ENSDART00000152020
gdf3
growth differentiation factor 3
chr6_-_15639087 0.76 ENSDART00000128940
ENSDART00000183092
mlpha
melanophilin a
chr13_-_50624173 0.75 ENSDART00000184181
vox
ventral homeobox
chr22_+_22438783 0.75 ENSDART00000147825
kif14
kinesin family member 14
chr16_-_4026265 0.74 ENSDART00000149339
si:ch211-175f12.2
si:ch211-175f12.2
chr14_-_29859067 0.74 ENSDART00000136380
sorbs2b
sorbin and SH3 domain containing 2b
chr13_-_31346392 0.74 ENSDART00000134343
rrp12
ribosomal RNA processing 12 homolog
chr20_+_15552657 0.73 ENSDART00000063912
jun
Jun proto-oncogene, AP-1 transcription factor subunit
chr8_-_7078575 0.72 ENSDART00000137413
si:ch73-233m11.2
si:ch73-233m11.2
chr11_+_440305 0.71 ENSDART00000082517
rab43
RAB43, member RAS oncogene family
chr14_-_41091667 0.71 ENSDART00000170042
drp2
dystrophin related protein 2
chr14_+_43554490 0.70 ENSDART00000060351
adra1bb
adrenoceptor alpha 1Bb
chr1_-_23370395 0.64 ENSDART00000143014
ENSDART00000126785
ENSDART00000159138
pds5a
PDS5 cohesin associated factor A
chr24_-_39354829 0.62 ENSDART00000169108
kcnj12a
potassium inwardly-rectifying channel, subfamily J, member 12a
chr10_-_44411032 0.62 ENSDART00000111509
CABZ01072096.1

chr23_+_20422661 0.61 ENSDART00000144047
ENSDART00000104336
tnnc2
troponin C type 2 (fast)
chr3_-_51109286 0.59 ENSDART00000172010
si:ch211-148f13.1
si:ch211-148f13.1
chr21_+_29227224 0.58 ENSDART00000013641
adra1ba
adrenoceptor alpha 1Ba
chr21_-_45073764 0.52 ENSDART00000181390
ENSDART00000063714
rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
chr2_+_44528255 0.49 ENSDART00000193834
pask
PAS domain containing serine/threonine kinase
chr1_-_53684005 0.49 ENSDART00000108906
xpo1a
exportin 1 (CRM1 homolog, yeast) a
chr6_-_8480815 0.48 ENSDART00000162300
rasal3
RAS protein activator like 3
chr24_+_18299175 0.48 ENSDART00000140994
tpk1
thiamin pyrophosphokinase 1
chr19_+_7424347 0.48 ENSDART00000004622
sf3b4
splicing factor 3b, subunit 4
chr4_+_5132951 0.44 ENSDART00000103279
ccnd2b
cyclin D2, b
chr4_-_17741513 0.42 ENSDART00000141680
mybpc1
myosin binding protein C, slow type
chr1_+_10129099 0.40 ENSDART00000187740
rbm46
RNA binding motif protein 46
chr17_+_6563307 0.39 ENSDART00000156454
adgrf3a
adhesion G protein-coupled receptor F3a
chr20_-_6131686 0.38 ENSDART00000145964
ENSDART00000086578
ENSDART00000164090
pum2
pumilio RNA-binding family member 2
chr21_+_10739846 0.37 ENSDART00000084011
cplx4a
complexin 4a
chr4_+_64921810 0.36 ENSDART00000157654
BX928743.1

chr10_-_1827225 0.35 ENSDART00000058627
epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr5_+_68878124 0.34 ENSDART00000139933
spaw
southpaw
chr6_-_10725847 0.33 ENSDART00000184567
sp3b
Sp3b transcription factor
chr22_-_10487490 0.27 ENSDART00000064798
aspn
asporin (LRR class 1)
chr7_-_2129076 0.26 ENSDART00000182385
si:cabz01007807.1
si:cabz01007807.1
chr20_-_25626693 0.19 ENSDART00000132247
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr16_-_7827517 0.17 ENSDART00000189975
tcaim
T cell activation inhibitor, mitochondrial
chr4_+_51347000 0.17 ENSDART00000161859
si:dkeyp-82b4.3
si:dkeyp-82b4.3
chr23_+_21424747 0.17 ENSDART00000135440
ENSDART00000104214
tas1r1
taste receptor, type 1, member 1
chr22_+_1751640 0.15 ENSDART00000162093
znf1169
zinc finger protein 1169
chr12_-_33746111 0.15 ENSDART00000127203
llgl2
lethal giant larvae homolog 2 (Drosophila)
chr8_-_18316482 0.13 ENSDART00000190156
rnf220b
ring finger protein 220b
chr17_+_30587333 0.12 ENSDART00000156500
nhsl1a
NHS-like 1a
chr23_-_41824460 0.12 ENSDART00000131235
GMEB2
si:ch73-302a13.2
chr12_+_18358082 0.08 ENSDART00000123315
si:dkey-7e14.3
si:dkey-7e14.3
chr7_+_6756273 0.08 ENSDART00000015873
sf3b2
splicing factor 3b, subunit 2
chr22_+_38762693 0.06 ENSDART00000015016
ENSDART00000150187
alpi.1
alkaline phosphatase, intestinal, tandem duplicate 1
chr17_+_6585333 0.04 ENSDART00000124293
adgrf3a
adhesion G protein-coupled receptor F3a
chr1_+_7956030 0.03 ENSDART00000159655
CR855320.1

Network of associatons between targets according to the STRING database.

First level regulatory network of gli2a+gli3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
1.0 39.4 GO:0032355 response to estradiol(GO:0032355)
0.7 3.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.7 2.0 GO:0048785 hatching gland development(GO:0048785)
0.6 9.0 GO:0006825 copper ion transport(GO:0006825)
0.5 2.0 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.5 3.4 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.4 1.3 GO:0032263 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
0.4 1.3 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.4 2.4 GO:0032218 riboflavin transport(GO:0032218)
0.4 1.2 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214) cardiac left ventricle formation(GO:0003218)
0.4 1.2 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.4 1.1 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.4 1.5 GO:0070257 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.3 5.7 GO:0097178 ruffle assembly(GO:0097178)
0.3 1.0 GO:0060584 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 1.3 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.2 11.0 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.2 2.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 0.8 GO:0034729 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.2 1.0 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 0.8 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 1.3 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.2 2.4 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 0.5 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229)
0.2 0.8 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 2.2 GO:0030259 lipid glycosylation(GO:0030259)
0.1 1.4 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.1 2.2 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 7.8 GO:0007596 blood coagulation(GO:0007596)
0.1 0.8 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.1 1.1 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.5 GO:0015671 oxygen transport(GO:0015671)
0.1 0.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 1.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.9 GO:0030325 adrenal gland development(GO:0030325)
0.1 0.8 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 2.4 GO:0003351 epithelial cilium movement(GO:0003351)
0.1 2.0 GO:0042476 odontogenesis(GO:0042476)
0.1 1.3 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 0.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.7 GO:0051597 response to methylmercury(GO:0051597)
0.0 1.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 5.1 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 2.3 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 3.6 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.3 GO:0035462 determination of left/right asymmetry in diencephalon(GO:0035462) determination of left/right asymmetry in nervous system(GO:0035545)
0.0 0.8 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 2.5 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.0 2.0 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 1.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.6 GO:0014823 response to activity(GO:0014823)
0.0 1.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 2.7 GO:0003407 neural retina development(GO:0003407)
0.0 0.4 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 0.7 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 0.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 1.3 GO:0009190 cyclic nucleotide biosynthetic process(GO:0009190)
0.0 1.1 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.9 GO:0097696 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.0 2.2 GO:0007601 visual perception(GO:0007601)
0.0 0.8 GO:0060042 retina morphogenesis in camera-type eye(GO:0060042)
0.0 1.3 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 4.1 GO:0045087 innate immune response(GO:0045087)
0.0 0.6 GO:1990573 potassium ion import across plasma membrane(GO:1990573)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:1902737 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.2 0.9 GO:0070743 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.1 1.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 2.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 7.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.4 GO:0030286 dynein complex(GO:0030286)
0.0 3.8 GO:0030018 Z disc(GO:0030018)
0.0 1.3 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 5.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.0 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 3.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.1 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.2 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 1.8 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 15.4 GO:0005615 extracellular space(GO:0005615)
0.0 4.7 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 18.9 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
5.3 37.3 GO:0045735 nutrient reservoir activity(GO:0045735)
3.1 18.7 GO:0032052 bile acid binding(GO:0032052)
1.5 6.1 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
1.1 3.3 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
1.1 3.3 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
1.0 5.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.7 3.0 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.7 9.9 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.6 2.4 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.4 1.3 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.4 2.4 GO:0032217 riboflavin transporter activity(GO:0032217)
0.3 1.0 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 5.2 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 2.1 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.2 0.9 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.2 0.8 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.2 2.4 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 11.0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.2 2.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 1.3 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.2 0.5 GO:0030975 thiamine diphosphokinase activity(GO:0004788) thiamine binding(GO:0030975)
0.2 2.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.3 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 2.0 GO:0005123 death receptor binding(GO:0005123)
0.1 3.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.5 GO:0031720 haptoglobin binding(GO:0031720)
0.1 1.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 1.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 2.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 5.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.0 11.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 1.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.3 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.9 GO:0017022 myosin binding(GO:0017022)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 1.7 GO:0008201 heparin binding(GO:0008201)
0.0 3.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.2 GO:0019901 protein kinase binding(GO:0019901)
0.0 1.8 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 1.3 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 9.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 0.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.9 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.2 2.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 2.0 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 0.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.5 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis