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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gmeb1

Z-value: 0.33

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Transcription factors associated with gmeb1

Gene Symbol Gene ID Gene Info
gmeb1
ENSDARG00000062060 glucocorticoid modulatory element binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gmeb1dr11_v1_chr19_+_16068445_160684450.405.3e-05Click!

Activity profile of gmeb1 motif

Sorted Z-values of gmeb1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_17676745 4.60 ENSDART00000030665
slc25a4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr5_-_30588539 2.28 ENSDART00000086686
ENSDART00000159163
ENSDART00000142958
c2cd2l
c2cd2-like
chr4_-_25485404 2.25 ENSDART00000041402
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr4_-_25485214 2.24 ENSDART00000159941
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr20_+_22666548 2.19 ENSDART00000147520
lnx1
ligand of numb-protein X 1
chr20_-_27381691 2.11 ENSDART00000010293
serpina10a
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a
chr11_+_35364445 1.16 ENSDART00000125766
camkvb
CaM kinase-like vesicle-associated b
chr4_+_23126558 1.01 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr3_-_16000168 0.92 ENSDART00000160628
nme3
NME/NM23 nucleoside diphosphate kinase 3
chr3_-_15999501 0.79 ENSDART00000160668
nme3
NME/NM23 nucleoside diphosphate kinase 3
chr12_+_11650146 0.74 ENSDART00000150191
waplb
WAPL cohesin release factor b
chr14_-_8795081 0.71 ENSDART00000106671
tgfb2l
transforming growth factor, beta 2, like
chr22_-_621609 0.63 ENSDART00000137264
ENSDART00000106636
srsf3b
serine/arginine-rich splicing factor 3b
chr25_+_34845115 0.62 ENSDART00000061996
tmem231
transmembrane protein 231
chr3_+_32933663 0.61 ENSDART00000112742
nbr1b
neighbor of brca1 gene 1b
chr22_-_621888 0.56 ENSDART00000135829
srsf3b
serine/arginine-rich splicing factor 3b
chr12_-_48374728 0.55 ENSDART00000153403
ENSDART00000188117
dnajb12b
DnaJ (Hsp40) homolog, subfamily B, member 12b
chr14_-_21932403 0.47 ENSDART00000054420
rad9a
RAD9 checkpoint clamp component A
chr14_-_31489410 0.43 ENSDART00000018347
cab39l1
calcium binding protein 39, like 1
chr23_-_9807546 0.43 ENSDART00000136740
ENSDART00000004474
mapre1b
microtubule-associated protein, RP/EB family, member 1b
chr9_+_16241656 0.36 ENSDART00000154326
si:ch211-261p9.4
si:ch211-261p9.4
chr16_+_23397785 0.34 ENSDART00000148961
s100a10b
S100 calcium binding protein A10b
chr6_-_11362871 0.32 ENSDART00000151125
pcnt
pericentrin
chr4_-_73825089 0.25 ENSDART00000174207
si:dkey-262g12.12
si:dkey-262g12.12
chr21_+_6397463 0.23 ENSDART00000136539
si:ch211-225g23.1
si:ch211-225g23.1
chr4_-_17642168 0.23 ENSDART00000007030
klhl42
kelch-like family, member 42
chr8_+_10305400 0.23 ENSDART00000172400
pim1
Pim-1 proto-oncogene, serine/threonine kinase
chr10_+_29137482 0.18 ENSDART00000178280
picalma
phosphatidylinositol binding clathrin assembly protein a
chr25_+_22281441 0.16 ENSDART00000089516
stoml1
stomatin (EPB72)-like 1
chr4_+_45148652 0.15 ENSDART00000150798
si:dkey-51d8.9
si:dkey-51d8.9
chr2_-_3045861 0.15 ENSDART00000105818
ENSDART00000187575
guk1a
guanylate kinase 1a
chr25_-_36044583 0.14 ENSDART00000073432
rbl2
retinoblastoma-like 2 (p130)
chr25_+_18711804 0.13 ENSDART00000011149
fam185a
family with sequence similarity 185, member A
chr10_+_39091716 0.13 ENSDART00000193072
si:ch73-1a9.4
si:ch73-1a9.4
chr9_-_306515 0.13 ENSDART00000166059
si:ch211-166e11.5
si:ch211-166e11.5
chr20_+_31287356 0.05 ENSDART00000007688
slc22a16
solute carrier family 22 (organic cation/carnitine transporter), member 16
chr5_+_6955900 0.03 ENSDART00000099417
CABZ01041962.1

chr21_-_8153165 0.02 ENSDART00000182580
CABZ01074363.1

Network of associatons between targets according to the STRING database.

First level regulatory network of gmeb1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0015860 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.3 4.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.7 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.2 1.0 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.1 1.7 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.5 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.0 2.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.5 GO:0051788 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.0 0.0 GO:0015695 organic cation transport(GO:0015695)
0.0 0.7 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 4.3 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.3 4.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0048306 calcium-dependent protein binding(GO:0048306)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.5 PID ATM PATHWAY ATM pathway
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 4.6 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 1.0 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.5 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress