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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gsx1

Z-value: 1.16

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Transcription factors associated with gsx1

Gene Symbol Gene ID Gene Info
gsx1
ENSDARG00000035735 GS homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gsx1dr11_v1_chr5_-_67911111_67911111-0.806.9e-22Click!

Activity profile of gsx1 motif

Sorted Z-values of gsx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_28445052 26.34 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr25_+_31276842 18.41 ENSDART00000187238
tnni2a.4
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr21_-_23110841 14.87 ENSDART00000147896
ENSDART00000003076
ENSDART00000184925
ENSDART00000190386
usp28
ubiquitin specific peptidase 28
chr12_+_3078221 14.77 ENSDART00000148835
ENSDART00000149427
sgca
sarcoglycan, alpha
chr7_+_20503344 11.18 ENSDART00000157699
si:dkey-19b23.12
si:dkey-19b23.12
chr15_+_46357080 11.03 ENSDART00000155571
ENSDART00000156541
wu:fb18f06
wu:fb18f06
chr9_-_6372535 10.36 ENSDART00000149189
ecrg4a
esophageal cancer related gene 4a
chr22_-_10121880 9.91 ENSDART00000002348
rdh5
retinol dehydrogenase 5 (11-cis/9-cis)
chr24_-_40744672 9.64 ENSDART00000160672
CU633479.1

chr6_-_46941245 9.15 ENSDART00000037875
igfn1.1
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 1
chr6_+_41191482 8.90 ENSDART00000000877
opn1mw3
opsin 1 (cone pigments), medium-wave-sensitive, 3
chr2_-_23768818 8.42 ENSDART00000148685
ENSDART00000191167
xirp1
xin actin binding repeat containing 1
chr5_-_33287691 8.42 ENSDART00000004238
rpl7a
ribosomal protein L7a
chr6_-_3982783 8.33 ENSDART00000171944
slc25a12
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr22_-_10586191 8.19 ENSDART00000148418
si:dkey-42i9.16
si:dkey-42i9.16
chr15_+_46356879 8.16 ENSDART00000154388
wu:fb18f06
wu:fb18f06
chr7_+_17816006 8.15 ENSDART00000080834
eml3
echinoderm microtubule associated protein like 3
chr5_+_27897504 8.03 ENSDART00000130936
adam28
ADAM metallopeptidase domain 28
chr8_-_23612462 8.02 ENSDART00000025024
slc38a5b
solute carrier family 38, member 5b
chr15_-_23376541 7.83 ENSDART00000078570
c1qtnf5
C1q and TNF related 5
chr8_+_23738122 7.65 ENSDART00000062983
rpl10a
ribosomal protein L10a
chr8_-_18537866 7.58 ENSDART00000148802
ENSDART00000148962
ENSDART00000149506
nexn
nexilin (F actin binding protein)
chr2_-_51511494 7.43 ENSDART00000161392
ENSDART00000160877
si:ch211-9d9.8
si:ch211-9d9.8
chr17_+_8799451 7.43 ENSDART00000189814
ENSDART00000191577
tonsl
tonsoku-like, DNA repair protein
chr9_-_21918963 7.40 ENSDART00000090782
lmo7a
LIM domain 7a
chr13_+_29238850 7.19 ENSDART00000026000
myofl
myoferlin like
chr24_-_37640705 7.11 ENSDART00000066583
zgc:112496
zgc:112496
chr2_+_33326522 7.10 ENSDART00000056655
klf17
Kruppel-like factor 17
chr6_-_46861676 7.01 ENSDART00000188712
ENSDART00000190148
igfn1.3
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr24_-_2450597 6.76 ENSDART00000188080
ENSDART00000093331
rreb1a
ras responsive element binding protein 1a
chr11_+_24703108 6.58 ENSDART00000159173
gpr25
G protein-coupled receptor 25
chr7_+_20344222 6.49 ENSDART00000141186
ENSDART00000139274
ponzr1
plac8 onzin related protein 1
chr17_+_16046132 6.32 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
chr6_-_40581376 6.16 ENSDART00000185412
tspo
translocator protein
chr19_+_43297546 6.07 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr17_+_16046314 5.49 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr21_-_7035599 5.40 ENSDART00000139777
si:ch211-93g21.1
si:ch211-93g21.1
chr24_+_19415124 5.37 ENSDART00000186931
sulf1
sulfatase 1
chr2_+_20793982 5.32 ENSDART00000014785
prg4a
proteoglycan 4a
chr8_+_11425048 5.30 ENSDART00000018739
tjp2b
tight junction protein 2b (zona occludens 2)
chr22_+_19366866 5.18 ENSDART00000137301
si:dkey-21e2.12
si:dkey-21e2.12
chr23_+_44374041 5.14 ENSDART00000136056
ephb4b
eph receptor B4b
chr18_-_6982499 5.07 ENSDART00000101525
si:dkey-266m15.6
si:dkey-266m15.6
chr21_-_40174647 5.06 ENSDART00000183738
ENSDART00000076840
ENSDART00000145109
slco2b1
solute carrier organic anion transporter family, member 2B1
chr10_-_21362320 5.01 ENSDART00000189789
avd
avidin
chr12_+_20352400 4.99 ENSDART00000066383
hbae5
hemoglobin, alpha embryonic 5
chr2_-_23778180 4.93 ENSDART00000136782
si:dkey-24c2.7
si:dkey-24c2.7
chr16_-_24605969 4.79 ENSDART00000163305
ENSDART00000167121
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr15_-_37104165 4.59 ENSDART00000165867
zmp:0000001114
zmp:0000001114
chr7_+_17816470 4.55 ENSDART00000173807
eml3
echinoderm microtubule associated protein like 3
chr7_+_2236317 4.54 ENSDART00000075859
zgc:172065
zgc:172065
chr12_+_10631266 4.51 ENSDART00000161455
csf3a
colony stimulating factor 3 (granulocyte) a
chr14_+_22022441 4.49 ENSDART00000149121
clcf1
cardiotrophin-like cytokine factor 1
chr10_+_16584382 4.49 ENSDART00000112039
CR790388.1

chr16_-_28878080 4.47 ENSDART00000149501
si:dkey-239n17.4
si:dkey-239n17.4
chr13_+_35637048 4.39 ENSDART00000085037
thbs2a
thrombospondin 2a
chr15_-_43284021 4.38 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr6_-_39024538 4.37 ENSDART00000165839
tns2b
tensin 2b
chr4_-_51460013 4.34 ENSDART00000193382
CR628395.1

chr25_+_32755485 4.22 ENSDART00000162188
etfa
electron-transfer-flavoprotein, alpha polypeptide
chr22_+_20427170 4.18 ENSDART00000136744
foxq2
forkhead box Q2
chr12_+_32199651 4.13 ENSDART00000153027
si:ch211-277e21.1
si:ch211-277e21.1
chr5_-_16472719 4.12 ENSDART00000162071
piwil2
piwi-like RNA-mediated gene silencing 2
chr15_-_41457898 4.12 ENSDART00000188847
nlrc9
NLR family CARD domain containing 9
chr20_+_38458084 4.07 ENSDART00000020153
ENSDART00000135912
coq8a
coenzyme Q8A
chr3_+_32112004 4.01 ENSDART00000105272
zgc:173593
zgc:173593
chr14_-_21959712 3.97 ENSDART00000021417
p2rx3a
purinergic receptor P2X, ligand-gated ion channel, 3a
chr10_-_21362071 3.87 ENSDART00000125167
avd
avidin
chr8_+_21353878 3.85 ENSDART00000056420
alas2
aminolevulinate, delta-, synthase 2
chr18_+_2228737 3.82 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr14_+_33329761 3.79 ENSDART00000161138
sowahd
sosondowah ankyrin repeat domain family d
chr8_+_54274355 3.75 ENSDART00000067639
TMCC1 (1 of many)
transmembrane and coiled-coil domain family 1
chr15_-_25518084 3.68 ENSDART00000158594
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr15_-_19705707 3.67 ENSDART00000047643
sytl2b
synaptotagmin-like 2b
chr8_-_25336589 3.64 ENSDART00000009682
atp5pb
ATP synthase peripheral stalk-membrane subunit b
chr19_-_82504 3.57 ENSDART00000027864
ENSDART00000160560
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr20_-_40755614 3.56 ENSDART00000061247
cx32.3
connexin 32.3
chr10_+_40633990 3.51 ENSDART00000190489
ENSDART00000139474
si:ch211-238p8.31
si:ch211-238p8.31
chr11_-_2478374 3.49 ENSDART00000173205
si:ch73-267c23.10
si:ch73-267c23.10
chr1_-_58505626 3.47 ENSDART00000171304
si:ch73-236c18.8
si:ch73-236c18.8
chr12_-_18577983 3.47 ENSDART00000193262
zdhhc4
zinc finger, DHHC-type containing 4
chr15_-_1822548 3.40 ENSDART00000082026
ENSDART00000180230
mmp28
matrix metallopeptidase 28
chr12_+_48803098 3.28 ENSDART00000074768
ppifb
peptidylprolyl isomerase Fb
chr5_-_44286987 3.27 ENSDART00000184112
si:ch73-337l15.2
si:ch73-337l15.2
chr11_+_45323455 3.26 ENSDART00000189249
mafgb
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr3_+_32129632 3.24 ENSDART00000174522
zgc:109934
zgc:109934
chr12_-_33770299 3.24 ENSDART00000189849
llgl2
lethal giant larvae homolog 2 (Drosophila)
chr20_+_10723292 3.19 ENSDART00000152805
si:ch211-182e10.4
si:ch211-182e10.4
chr9_+_41156818 3.18 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr15_+_5293785 3.11 ENSDART00000163157
or121-1
odorant receptor, family E, subfamily 121, member 1
chr24_+_6107901 3.04 ENSDART00000156419
si:ch211-37e10.2
si:ch211-37e10.2
chr16_-_17347727 3.03 ENSDART00000144392
zyx
zyxin
chr11_+_36665359 2.96 ENSDART00000166144
si:ch211-11c3.9
si:ch211-11c3.9
chr4_-_42408339 2.91 ENSDART00000172612
si:ch211-59d8.3
si:ch211-59d8.3
chr4_+_43246676 2.89 ENSDART00000187588
si:dkey-29j8.1
si:dkey-29j8.1
chr20_-_52902693 2.89 ENSDART00000166115
ENSDART00000161050
ctsbb
cathepsin Bb
chr7_-_7764287 2.88 ENSDART00000173021
ENSDART00000113131
intu
inturned planar cell polarity protein
chr10_+_31646020 2.86 ENSDART00000115251
esama
endothelial cell adhesion molecule a
chr14_+_7377552 2.84 ENSDART00000142158
ENSDART00000141471
hars
histidyl-tRNA synthetase
chr19_+_10339538 2.84 ENSDART00000151808
ENSDART00000151235
rcvrn3
recoverin 3
chr4_+_52356485 2.81 ENSDART00000170639
zgc:173705
zgc:173705
chr1_+_47178529 2.77 ENSDART00000158432
ENSDART00000074450
ENSDART00000137448
morc3b
MORC family CW-type zinc finger 3b
chr21_-_22827548 2.75 ENSDART00000079161
angptl5
angiopoietin-like 5
chr24_-_6078222 2.73 ENSDART00000146830
apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr10_+_40756352 2.67 ENSDART00000156210
ENSDART00000144576
taar19f
trace amine associated receptor 19f
chr20_-_23426339 2.62 ENSDART00000004625
zar1
zygote arrest 1
chr6_+_52891947 2.61 ENSDART00000174159
BX649282.3

chr21_+_42708621 2.60 ENSDART00000158392
si:ch1073-204b8.1
si:ch1073-204b8.1
chr11_-_45138857 2.60 ENSDART00000166501
cant1b
calcium activated nucleotidase 1b
chr8_+_37527575 2.58 ENSDART00000147239
or135-1
odorant receptor, family H, subfamily 135, member 1
chr8_+_25034544 2.57 ENSDART00000123300
ngrn
neugrin, neurite outgrowth associated
chr1_+_55239160 2.57 ENSDART00000152318
si:ch211-286b5.2
si:ch211-286b5.2
chr3_-_29941357 2.52 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr17_+_53425037 2.52 ENSDART00000154983
fabp10b
fatty acid binding protein 10b, liver basic
chr15_+_34988148 2.52 ENSDART00000076269
ccdc105
coiled-coil domain containing 105
chr4_-_71210030 2.51 ENSDART00000186473
si:ch211-205a14.7
si:ch211-205a14.7
chr8_-_52229462 2.50 ENSDART00000185949
ENSDART00000051825
tcf7l1b
transcription factor 7 like 1b
chr17_+_2162916 2.46 ENSDART00000103775
pak6a
p21 protein (Cdc42/Rac)-activated kinase 6a
chr1_-_9123465 2.46 ENSDART00000081337
ndufab1a
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1a
chr4_+_57194439 2.46 ENSDART00000075265
si:dkey-16p6.4
si:dkey-16p6.4
chr21_-_32060993 2.45 ENSDART00000131651
si:ch211-160j14.2
si:ch211-160j14.2
chr17_-_48944465 2.44 ENSDART00000154110
si:ch1073-80i24.3
si:ch1073-80i24.3
chr16_-_16761164 2.42 ENSDART00000135872
si:dkey-27n14.1
si:dkey-27n14.1
chr7_+_1467863 2.41 ENSDART00000173433
emc4
ER membrane protein complex subunit 4
chr12_+_16168342 2.41 ENSDART00000079326
ENSDART00000170024
lrp2b
low density lipoprotein receptor-related protein 2b
chr15_-_4969525 2.39 ENSDART00000157223
lipt2
lipoyl(octanoyl) transferase 2
chr10_+_40660772 2.34 ENSDART00000148007
taar19l
trace amine associated receptor 19l
chr18_+_619619 2.29 ENSDART00000159846
prtga
protogenin homolog a (Gallus gallus)
chr11_+_14284866 2.29 ENSDART00000163729
si:ch211-262i1.3
si:ch211-262i1.3
chr25_+_5068442 2.22 ENSDART00000097522
parvg
parvin, gamma
chr20_-_9095105 2.21 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr20_+_25879826 2.19 ENSDART00000018519
zgc:153896
zgc:153896
chr3_-_32169754 2.19 ENSDART00000179010
tnnt1
troponin T type 1 (skeletal, slow)
chr23_+_11285662 2.18 ENSDART00000111028
chl1a
cell adhesion molecule L1-like a
chr7_+_48667081 2.16 ENSDART00000083473
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr23_-_41965557 2.15 ENSDART00000144183
slc1a7b
solute carrier family 1 (glutamate transporter), member 7b
chr2_-_38256589 2.12 ENSDART00000173064
si:ch211-14a17.10
si:ch211-14a17.10
chr21_-_17296789 2.12 ENSDART00000192180
gfi1b
growth factor independent 1B transcription repressor
chr3_+_32553714 2.10 ENSDART00000165638
pax10
paired box 10
chr10_+_2799285 2.09 ENSDART00000030709
pnx
posterior neuron-specific homeobox
chr15_+_1796313 2.06 ENSDART00000126253
fam124b
family with sequence similarity 124B
chr8_-_17167819 2.01 ENSDART00000135042
ENSDART00000143920
mrps36
mitochondrial ribosomal protein S36
chr17_+_46818521 1.98 ENSDART00000156022
pimr14
Pim proto-oncogene, serine/threonine kinase, related 14
chr2_-_22927958 1.96 ENSDART00000141621
myo7bb
myosin VIIBb
chr21_+_45717930 1.92 ENSDART00000164315
ddx46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr23_+_404975 1.91 ENSDART00000181336
CU929146.1

chr2_+_19578446 1.89 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr8_+_48484455 1.88 ENSDART00000122737
PRDM16
si:ch211-263k4.2
chr13_+_2625150 1.88 ENSDART00000164177
plpp4
phospholipid phosphatase 4
chr8_+_8936912 1.88 ENSDART00000135958
si:dkey-83k24.5
si:dkey-83k24.5
chr8_+_30112655 1.86 ENSDART00000099027
fancc
Fanconi anemia, complementation group C
chr22_+_10660140 1.84 ENSDART00000105835
ENSDART00000038511
tusc2b
tumor suppressor candidate 2b
chr10_+_40774215 1.83 ENSDART00000131493
taar19b
trace amine associated receptor 19b
chr21_-_45077429 1.82 ENSDART00000187268
ENSDART00000191003
rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
chr22_+_14836040 1.82 ENSDART00000180951
gtpbp1l
GTP binding protein 1, like
chr12_+_23912074 1.80 ENSDART00000152864
svila
supervillin a
chr25_+_2415131 1.78 ENSDART00000162210
zmp:0000000932
zmp:0000000932
chr19_+_1688727 1.76 ENSDART00000115136
ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr17_-_45386546 1.75 ENSDART00000182647
tmem206
transmembrane protein 206
chr6_-_35046735 1.75 ENSDART00000143649
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr15_+_36309070 1.71 ENSDART00000157034
gmnc
geminin coiled-coil domain containing
chr3_+_46635527 1.71 ENSDART00000153971
si:dkey-248g21.1
si:dkey-248g21.1
chr15_+_9053059 1.71 ENSDART00000012039
ppm1na
protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative)
chr13_+_27232848 1.68 ENSDART00000138043
rin2
Ras and Rab interactor 2
chr5_-_8907819 1.67 ENSDART00000188523
adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr3_-_16719244 1.60 ENSDART00000055859
pold1
polymerase (DNA directed), delta 1, catalytic subunit
chrM_+_9735 1.55 ENSDART00000093613
mt-co3
cytochrome c oxidase III, mitochondrial
chr24_+_12835935 1.55 ENSDART00000114762
nanog
nanog homeobox
chr21_+_30746348 1.54 ENSDART00000050172
trpc2b
transient receptor potential cation channel, subfamily C, member 2b
chr23_-_31913069 1.53 ENSDART00000135526
mtfr2
mitochondrial fission regulator 2
chr14_+_45675306 1.50 ENSDART00000105461
rom1b
retinal outer segment membrane protein 1b
chr7_+_38509333 1.47 ENSDART00000153482
slc7a9
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr21_+_25777425 1.42 ENSDART00000021620
cldnd
claudin d
chr7_+_756942 1.40 ENSDART00000152224
zgc:63470
zgc:63470
chr11_+_39107131 1.38 ENSDART00000105140
zgc:112255
zgc:112255
chr10_-_25217347 1.38 ENSDART00000036906
kpna7
karyopherin alpha 7 (importin alpha 8)
chr4_-_9891874 1.33 ENSDART00000067193
adm2a
adrenomedullin 2a
chr10_+_6884627 1.33 ENSDART00000125262
ENSDART00000121729
ENSDART00000105384
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr4_-_16833518 1.31 ENSDART00000179867
ldhba
lactate dehydrogenase Ba
chr7_+_69653981 1.26 ENSDART00000090165
frem1a
Fras1 related extracellular matrix 1a
chr14_+_34490445 1.20 ENSDART00000132193
ENSDART00000148044
wnt8a
wingless-type MMTV integration site family, member 8a
chr21_+_43404945 1.19 ENSDART00000142234
frmd7
FERM domain containing 7
chr3_+_13624815 1.18 ENSDART00000161451
pglyrp6
peptidoglycan recognition protein 6
chr21_+_4313039 1.13 ENSDART00000141146
HTRA2 (1 of many)
si:dkey-84o3.4
chr9_+_54695981 1.10 ENSDART00000183605
rab9a
RAB9A, member RAS oncogene family
chr2_-_59285085 1.10 ENSDART00000131880
ftr34
finTRIM family, member 34
chr16_-_43344859 1.08 ENSDART00000058680
psma2
proteasome subunit alpha 2
chr16_+_13818743 1.07 ENSDART00000090191
flcn
folliculin
chr20_+_39457598 1.04 ENSDART00000140931
ENSDART00000156176
pimr128
Pim proto-oncogene, serine/threonine kinase, related 128
chr7_-_17816175 1.01 ENSDART00000091272
ENSDART00000173757
ecsit
ECSIT signalling integrator
chr20_+_12830448 1.01 ENSDART00000164754
BX547930.4

chr16_+_31804590 0.98 ENSDART00000167321
wnt4b
wingless-type MMTV integration site family, member 4b
chr24_+_1023839 0.96 ENSDART00000082526
zgc:111976
zgc:111976
chr17_-_23416897 0.95 ENSDART00000163391
si:ch211-149k12.3
si:ch211-149k12.3
chr8_+_45334255 0.92 ENSDART00000126848
ENSDART00000134161
ENSDART00000142322
ENSDART00000145011
ENSDART00000183560
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr4_+_9177997 0.90 ENSDART00000057254
ENSDART00000154614
nfyba
nuclear transcription factor Y, beta a
chr20_-_47188966 0.89 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr22_+_35275468 0.89 ENSDART00000189516
ENSDART00000181572
ENSDART00000165353
ENSDART00000185352
rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr18_-_43884044 0.89 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr3_-_58046319 0.84 ENSDART00000155968
si:ch211-256e16.10
si:ch211-256e16.10

Network of associatons between targets according to the STRING database.

First level regulatory network of gsx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 26.3 GO:0052576 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
3.5 10.4 GO:0070314 G1 to G0 transition(GO:0070314)
2.4 7.1 GO:0048785 hatching gland development(GO:0048785)
2.0 8.0 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
1.7 9.9 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
1.1 7.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
1.1 4.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.8 8.3 GO:0015800 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.8 2.4 GO:2000376 oxygen metabolic process(GO:0072592) regulation of oxygen metabolic process(GO:2000374) positive regulation of oxygen metabolic process(GO:2000376)
0.7 5.4 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.6 3.2 GO:0008594 photoreceptor cell morphogenesis(GO:0008594) negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.6 4.5 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.6 1.9 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.6 4.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.6 6.5 GO:0061333 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.6 13.4 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.5 2.5 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.5 11.5 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.5 3.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.4 3.5 GO:0009217 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.4 1.7 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.4 20.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.4 1.2 GO:0021512 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.4 1.6 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.4 1.2 GO:0016045 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
0.4 1.8 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.4 5.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.4 7.4 GO:0031297 replication fork processing(GO:0031297)
0.3 2.4 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.3 4.0 GO:0033198 response to ATP(GO:0033198)
0.3 1.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.3 0.6 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3 2.5 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.3 3.3 GO:0070301 necrotic cell death(GO:0070265) cellular response to hydrogen peroxide(GO:0070301) programmed necrotic cell death(GO:0097300)
0.3 0.9 GO:0090219 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.3 1.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3 4.5 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.3 7.2 GO:0007520 myoblast fusion(GO:0007520)
0.3 2.2 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 2.8 GO:0036368 cone photoresponse recovery(GO:0036368)
0.3 8.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.2 1.7 GO:0061635 regulation of protein complex stability(GO:0061635)
0.2 5.0 GO:0015671 oxygen transport(GO:0015671)
0.2 5.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 2.9 GO:0014823 response to activity(GO:0014823)
0.2 2.2 GO:0050909 sensory perception of taste(GO:0050909)
0.2 3.5 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.2 8.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 2.9 GO:0070527 platelet aggregation(GO:0070527)
0.2 6.2 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.2 0.8 GO:0046103 adenosine catabolic process(GO:0006154) inosine metabolic process(GO:0046102) inosine biosynthetic process(GO:0046103)
0.2 1.1 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 3.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.7 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 2.1 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.1 2.9 GO:0060173 limb development(GO:0060173)
0.1 1.9 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 2.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.8 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.9 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.5 GO:0098586 cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) cellular response to virus(GO:0098586)
0.1 3.4 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 4.4 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.1 3.8 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.1 9.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 4.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 1.7 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 1.1 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 3.2 GO:0007259 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.1 1.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 1.5 GO:0006828 manganese ion transport(GO:0006828)
0.1 4.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 0.7 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 2.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.7 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 2.0 GO:0043648 dicarboxylic acid metabolic process(GO:0043648)
0.0 1.8 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.8 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 1.0 GO:0051784 negative regulation of mitotic nuclear division(GO:0045839) negative regulation of nuclear division(GO:0051784)
0.0 7.4 GO:0030155 regulation of cell adhesion(GO:0030155)
0.0 0.6 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 1.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 1.6 GO:0060968 regulation of gene silencing(GO:0060968)
0.0 2.6 GO:0017148 negative regulation of translation(GO:0017148)
0.0 2.1 GO:0030218 erythrocyte differentiation(GO:0030218)
0.0 0.4 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 7.5 GO:0060041 retina development in camera-type eye(GO:0060041)
0.0 2.5 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 1.3 GO:0033334 fin morphogenesis(GO:0033334) appendage morphogenesis(GO:0035107)
0.0 9.2 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.0 1.9 GO:0001756 somitogenesis(GO:0001756)
0.0 5.6 GO:0006281 DNA repair(GO:0006281)
0.0 4.9 GO:0046777 protein autophosphorylation(GO:0046777)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 14.8 GO:0016012 sarcoglycan complex(GO:0016012)
1.1 7.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.8 4.1 GO:1990923 PET complex(GO:1990923)
0.7 2.0 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.5 20.6 GO:0005861 troponin complex(GO:0005861)
0.4 5.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 1.2 GO:0097189 apoptotic body(GO:0097189)
0.3 1.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 6.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.3 16.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 2.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 3.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 0.6 GO:0032301 MutSalpha complex(GO:0032301)
0.2 4.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.2 8.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 12.7 GO:0072686 mitotic spindle(GO:0072686)
0.2 1.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 1.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.9 GO:0015030 Cajal body(GO:0015030)
0.1 3.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 12.8 GO:0016324 apical plasma membrane(GO:0016324)
0.1 3.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 2.3 GO:0043186 P granule(GO:0043186)
0.1 1.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 7.6 GO:0030018 Z disc(GO:0030018)
0.1 2.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 6.7 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 6.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 5.4 GO:0005795 Golgi stack(GO:0005795)
0.1 1.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 8.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 10.6 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 7.3 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 13.8 GO:0005739 mitochondrion(GO:0005739)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.0 13.9 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 26.3 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
1.8 8.9 GO:0009374 biotin binding(GO:0009374)
1.3 6.6 GO:0060182 apelin receptor activity(GO:0060182)
1.3 3.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.8 2.5 GO:0000035 acyl binding(GO:0000035)
0.8 8.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.8 2.4 GO:0033819 lipoyl(octanoyl) transferase activity(GO:0033819)
0.7 8.3 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.6 3.5 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.5 4.1 GO:0034584 piRNA binding(GO:0034584)
0.4 5.1 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.4 5.0 GO:0031720 haptoglobin binding(GO:0031720)
0.4 1.2 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.3 1.7 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.3 4.0 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.3 5.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 2.4 GO:0032977 membrane insertase activity(GO:0032977)
0.2 5.1 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 0.6 GO:0032356 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.2 3.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 5.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 1.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 8.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.2 4.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.6 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 3.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 4.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 6.2 GO:0008013 beta-catenin binding(GO:0008013)
0.1 14.9 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 7.7 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 2.8 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.8 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 1.8 GO:0045159 myosin II binding(GO:0045159)
0.1 0.8 GO:0043394 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 15.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.5 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 1.9 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 0.8 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.4 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.1 5.7 GO:0003724 RNA helicase activity(GO:0003724)
0.1 2.2 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 1.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 4.2 GO:0009055 electron carrier activity(GO:0009055)
0.1 1.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 11.2 GO:0005125 cytokine activity(GO:0005125)
0.0 4.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.7 GO:0030145 manganese ion binding(GO:0030145)
0.0 4.4 GO:0008201 heparin binding(GO:0008201)
0.0 9.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.0 6.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 7.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 2.4 GO:0042562 hormone binding(GO:0042562)
0.0 3.5 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 7.4 GO:0042393 histone binding(GO:0042393)
0.0 0.4 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 6.6 GO:0008017 microtubule binding(GO:0008017)
0.0 3.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 3.0 GO:0042802 identical protein binding(GO:0042802)
0.0 9.7 GO:0003779 actin binding(GO:0003779)
0.0 2.2 GO:0015293 symporter activity(GO:0015293)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.9 PID CONE PATHWAY Visual signal transduction: Cones
0.4 8.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 3.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 7.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 14.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.9 PID BARD1 PATHWAY BARD1 signaling events
0.1 8.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.3 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.3 8.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 3.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 3.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 2.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 16.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 2.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 4.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.9 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.7 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 0.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere