ISMARA results: hic1l+hic2

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hic1l+hic2

Z-value: 1.03

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Transcription factors associated with hic1l+hic2

Gene Symbol	Gene ID	Gene Info
hic1l NCBI UniProt	ENSDARG00000045660	hypermethylated in cancer 1 like
hic2 NCBI UniProt	ENSDARG00000100497	hypermethylated in cancer 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hic1l	dr11_v1_chr25_-_25575717_25575717	-0.80	9.4e-22	Click!
hic2	dr11_v1_chr10_+_3145707_3145707	-0.61	8.7e-11	Click!

Activity profile of hic1l+hic2 motif

Sorted Z-values of hic1l+hic2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_-_25612680 Show fit	21.57	ENSDART00000114167	si:ch211-12h2.8 NCBI UniProt Show fit	si:ch211-12h2.8
chr7_+_29952719 Show fit	18.70	ENSDART00000173737	tpma NCBI UniProt Show fit	alpha-tropomyosin
chr7_+_29952169 Show fit	18.53	ENSDART00000173540 ENSDART00000173940 ENSDART00000173906 ENSDART00000173772 ENSDART00000173506 ENSDART00000039657	tpma NCBI UniProt Show fit	alpha-tropomyosin
chr14_-_21064199 Show fit	12.84	ENSDART00000172099	si:dkey-74k8.3 NCBI UniProt Show fit	si:dkey-74k8.3
chr1_-_55810730 Show fit	9.76	ENSDART00000100551	zgc:136908 NCBI UniProt Show fit	zgc:136908
chr2_-_44255537 Show fit	9.18	ENSDART00000011188 ENSDART00000093298	atp1a2a NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit alpha 2
chr18_-_16123222 Show fit	7.93	ENSDART00000061189	sspn NCBI UniProt Show fit	sarcospan (Kras oncogene-associated gene)
chr3_+_24207243 Show fit	7.87	ENSDART00000023454 ENSDART00000136400	adsl NCBI UniProt Show fit	adenylosuccinate lyase
chr16_+_12836143 Show fit	7.87	ENSDART00000067741	cacng6b NCBI UniProt Show fit	calcium channel, voltage-dependent, gamma subunit 6b
chr25_-_31423493 Show fit	7.67	ENSDART00000027661	myod1 NCBI UniProt Show fit	myogenic differentiation 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hic1l+hic2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	37.2	GO:0061515	myeloid cell development(GO:0061515)
3.5	17.7	GO:0071480	response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
3.3	9.8	GO:0051230	mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
3.1	9.2	GO:0065001	specification of axis polarity(GO:0065001)
1.6	8.2	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.9	7.9	GO:0006167	AMP biosynthetic process(GO:0006167)
2.6	7.7	GO:0002074	extraocular skeletal muscle development(GO:0002074)
1.8	7.3	GO:0035630	bone mineralization involved in bone maturation(GO:0035630)
1.0	5.2	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.4	5.0	GO:0009251	polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)

Showing 1 to 10 of 70 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	38.9	GO:0005884	actin filament(GO:0005884)
0.1	10.7	GO:0005581	collagen trimer(GO:0005581)
2.4	9.8	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.2	8.2	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.2	5.2	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	5.2	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	4.6	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	4.5	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	4.2	GO:0034707	chloride channel complex(GO:0034707)
0.0	3.8	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)

Showing 1 to 10 of 25 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	36.0	GO:0042803	protein homodimerization activity(GO:0042803)
0.1	23.7	GO:0030246	carbohydrate binding(GO:0030246)
0.2	9.8	GO:0031593	polyubiquitin binding(GO:0031593)
0.9	9.2	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3	8.2	GO:0005246	calcium channel regulator activity(GO:0005246)
2.0	7.9	GO:0016842	amidine-lyase activity(GO:0016842)
1.1	7.7	GO:0070888	E-box binding(GO:0070888)
0.1	7.3	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.6	5.4	GO:0004096	catalase activity(GO:0004096)
1.3	5.2	GO:0004092	carnitine O-acetyltransferase activity(GO:0004092)

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.1	3.7	PID PLK1 PATHWAY	PLK1 signaling events
0.1	2.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	2.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.1	1.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.9	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.6	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	0.5	PID RAS PATHWAY	Regulation of Ras family activation

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	7.9	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2	6.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.5	5.7	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	4.6	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.5	3.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	2.7	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.2	2.4	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.1	2.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	2.0	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	2.0	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors

Showing 1 to 10 of 17 entries

Results for hic1l+hic2

Z-value: 1.03

Motif logo

Transcription factors associated with hic1l+hic2

Activity-expression correlation:

Activity profile of hic1l+hic2 motif

Sorted Z-values of hic1l+hic2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hic1l+hic2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: