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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hic1l+hic2

Z-value: 1.03

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Transcription factors associated with hic1l+hic2

Gene Symbol Gene ID Gene Info
hic1l
ENSDARG00000045660 hypermethylated in cancer 1 like
hic2
ENSDARG00000100497 hypermethylated in cancer 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hic1ldr11_v1_chr25_-_25575717_25575717-0.809.4e-22Click!
hic2dr11_v1_chr10_+_3145707_3145707-0.618.7e-11Click!

Activity profile of hic1l+hic2 motif

Sorted Z-values of hic1l+hic2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_25612680 21.57 ENSDART00000114167
si:ch211-12h2.8
si:ch211-12h2.8
chr7_+_29952719 18.70 ENSDART00000173737
tpma
alpha-tropomyosin
chr7_+_29952169 18.53 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
tpma
alpha-tropomyosin
chr14_-_21064199 12.84 ENSDART00000172099
si:dkey-74k8.3
si:dkey-74k8.3
chr1_-_55810730 9.76 ENSDART00000100551
zgc:136908
zgc:136908
chr2_-_44255537 9.18 ENSDART00000011188
ENSDART00000093298
atp1a2a
ATPase Na+/K+ transporting subunit alpha 2
chr18_-_16123222 7.93 ENSDART00000061189
sspn
sarcospan (Kras oncogene-associated gene)
chr3_+_24207243 7.87 ENSDART00000023454
ENSDART00000136400
adsl
adenylosuccinate lyase
chr16_+_12836143 7.87 ENSDART00000067741
cacng6b
calcium channel, voltage-dependent, gamma subunit 6b
chr25_-_31423493 7.67 ENSDART00000027661
myod1
myogenic differentiation 1
chr3_+_23221047 7.28 ENSDART00000009393
col1a1a
collagen, type I, alpha 1a
chr19_+_14109348 7.18 ENSDART00000159015
zgc:175136
zgc:175136
chr5_-_57641257 6.70 ENSDART00000149282
hspb2
heat shock protein, alpha-crystallin-related, b2
chr18_-_50845804 5.66 ENSDART00000158517
PDPR
si:cabz01113374.3
chr10_+_15608326 5.31 ENSDART00000188770
zfand5b
zinc finger, AN1-type domain 5b
chr5_+_32815745 5.20 ENSDART00000181535
crata
carnitine O-acetyltransferase a
chr4_-_77551860 5.03 ENSDART00000188176
AL935186.6

chr24_-_29822913 5.02 ENSDART00000160929
aglb
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase b
chr14_-_21063977 4.82 ENSDART00000164373
si:dkey-74k8.3
si:dkey-74k8.3
chr8_+_38417461 4.79 ENSDART00000132718
nkx6.3
NK6 homeobox 3
chr13_-_7573670 4.67 ENSDART00000102538
pitx3
paired-like homeodomain 3
chr6_+_29402997 4.64 ENSDART00000104298
ndufb5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 5
chr3_+_23692462 4.43 ENSDART00000145934
hoxb7a
homeobox B7a
chr4_-_8030583 4.23 ENSDART00000113628
si:ch211-240l19.8
si:ch211-240l19.8
chr24_-_9989634 4.16 ENSDART00000115275
zgc:152652
zgc:152652
chr2_+_24936766 4.11 ENSDART00000025962
gyg1a
glycogenin 1a
chr14_+_6159162 4.05 ENSDART00000128638
bscl2l
Bernardinelli-Seip congenital lipodystrophy 2, like
chr5_-_69041102 3.77 ENSDART00000161561
ank1a
ankyrin 1, erythrocytic a
chr4_-_14915268 3.74 ENSDART00000067040
si:dkey-180p18.9
si:dkey-180p18.9
chr15_+_25158104 3.14 ENSDART00000128267
slc35f2l
info solute carrier family 35, member F2, like
chr21_+_5257018 3.08 ENSDART00000183100
ENSDART00000191525
loxhd1a
lipoxygenase homology domains 1a
chr11_-_16021424 3.07 ENSDART00000193291
ENSDART00000170731
ENSDART00000104107
zgc:173544
zgc:173544
chr23_-_27875140 2.97 ENSDART00000143662
ankrd33aa
ankyrin repeat domain 33Aa
chr8_+_15254564 2.93 ENSDART00000024433
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr21_-_22681534 2.89 ENSDART00000159233
gig2f
grass carp reovirus (GCRV)-induced gene 2f
chr4_-_8040436 2.89 ENSDART00000113033
si:ch211-240l19.6
si:ch211-240l19.6
chr10_-_8129175 2.88 ENSDART00000133921
ndufa9b
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9b
chr10_+_43188678 2.70 ENSDART00000012522
vcanb
versican b
chr4_-_25485404 2.67 ENSDART00000041402
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr25_+_16915974 2.59 ENSDART00000188923
zgc:77158
zgc:77158
chr23_-_1587955 2.57 ENSDART00000136037
fndc7b
fibronectin type III domain containing 7b
chr20_+_27003713 2.56 ENSDART00000153232
si:dkey-177p2.18
si:dkey-177p2.18
chr3_-_32170850 2.44 ENSDART00000055307
ENSDART00000157366
tnnt1
troponin T type 1 (skeletal, slow)
chr6_-_29402578 2.44 ENSDART00000115031
mrpl47
mitochondrial ribosomal protein L47
chr2_-_37889111 2.37 ENSDART00000168939
ENSDART00000098529
mbl2
mannose binding lectin 2
chr21_-_42876565 2.32 ENSDART00000126480
zmp:0000001268
zmp:0000001268
chr15_-_37779978 2.30 ENSDART00000157202
si:dkey-42l23.3
si:dkey-42l23.3
chr1_+_30723380 2.29 ENSDART00000127943
ENSDART00000062628
ENSDART00000127670
bora
bora, aurora kinase A activator
chr14_-_897874 2.26 ENSDART00000167395
rgs14a
regulator of G protein signaling 14a
chr25_+_36292465 2.25 ENSDART00000152649
bmb
brambleberry
chr2_+_30547018 2.21 ENSDART00000193747
ankrd33bb
ankyrin repeat domain 33Bb
chr15_-_17138640 2.07 ENSDART00000080777
mrpl28
mitochondrial ribosomal protein L28
chr23_-_31060350 2.06 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
si:ch211-197l9.5
chr5_-_28679135 2.04 ENSDART00000193585
tnc
tenascin C
chr7_+_16963091 2.00 ENSDART00000173770
nav2a
neuron navigator 2a
chr4_-_5597167 2.00 ENSDART00000132431
vegfab
vascular endothelial growth factor Ab
chr24_+_34806822 1.96 ENSDART00000148407
ENSDART00000188328
mchr2
melanin-concentrating hormone receptor 2
chr6_-_49634787 1.95 ENSDART00000188538
BX323459.1

chr8_-_14144707 1.94 ENSDART00000148061
si:dkey-6n6.1
si:dkey-6n6.1
chr11_+_12879635 1.94 ENSDART00000182515
ENSDART00000081296
si:dkey-11m19.5
si:dkey-11m19.5
chr13_+_31205439 1.93 ENSDART00000132326
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr13_-_9061944 1.87 ENSDART00000164186
ENSDART00000102051
si:dkey-112g5.12
si:dkey-112g5.12
chr6_+_13726844 1.82 ENSDART00000055833
wnt6a
wingless-type MMTV integration site family, member 6a
chr25_+_19681662 1.81 ENSDART00000104347
si:dkeyp-110c12.3
si:dkeyp-110c12.3
chr23_-_32404022 1.81 ENSDART00000156387
ENSDART00000155508
si:ch211-66i15.4
si:ch211-66i15.4
chr19_+_17642356 1.80 ENSDART00000176431
CR382334.1

chr2_-_25159309 1.77 ENSDART00000137290
si:dkey-223d7.6
si:dkey-223d7.6
chr25_-_3087556 1.73 ENSDART00000193249
best1
bestrophin 1
chr11_+_13032483 1.72 ENSDART00000108968
ptgfr
prostaglandin F receptor (FP)
chr8_-_38616712 1.72 ENSDART00000141827
si:ch211-198d23.1
si:ch211-198d23.1
chr22_+_7497319 1.71 ENSDART00000034564
CELA1 (1 of many)
zgc:92511
chr2_+_17181777 1.71 ENSDART00000112063
ptger4c
prostaglandin E receptor 4 (subtype EP4) c
chr16_-_25606889 1.69 ENSDART00000077447
ENSDART00000131528
zgc:110410
zgc:110410
chr16_-_41840668 1.67 ENSDART00000146150
si:dkey-199f5.4
si:dkey-199f5.4
chr21_+_13244450 1.66 ENSDART00000146062
specc1lb
sperm antigen with calponin homology and coiled-coil domains 1-like b
chr7_-_65236649 1.65 ENSDART00000185070
pkd1l2a
polycystic kidney disease 1 like 2a
chr8_-_53548145 1.62 ENSDART00000180665
parapinopsina
parapinopsin a
chr20_+_23185530 1.62 ENSDART00000142346
lrrc66
leucine rich repeat containing 66
chr6_+_40723554 1.61 ENSDART00000103833
slc26a6l
solute carrier family 26, member 6, like
chr25_-_7686201 1.61 ENSDART00000157267
ENSDART00000155094
si:ch211-286c4.6
si:ch211-286c4.6
chr8_+_46536893 1.60 ENSDART00000124023
pimr187
Pim proto-oncogene, serine/threonine kinase, related 187
chr9_-_19610436 1.59 ENSDART00000108697
fgf9
fibroblast growth factor 9
chr23_-_1144425 1.58 ENSDART00000098271
psmb11b
proteasome subunit beta11b
chr21_+_25375172 1.58 ENSDART00000078748
or132-5
odorant receptor, family H, subfamily 132, member 5
chr23_-_2037566 1.57 ENSDART00000191312
ENSDART00000127443
prdm5
PR domain containing 5
chr1_+_44992207 1.56 ENSDART00000172357
tmem132a
transmembrane protein 132A
chr6_-_57655030 1.53 ENSDART00000155438
cbfa2t2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr22_+_29009541 1.53 ENSDART00000169449
pimr97
Pim proto-oncogene, serine/threonine kinase, related 97
chr8_-_7475917 1.52 ENSDART00000082157
gata1b
GATA binding protein 1b
chr3_-_1387292 1.51 ENSDART00000163535
ddx47
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chr23_-_21797517 1.50 ENSDART00000110041
lrrc38a
leucine rich repeat containing 38a
chr2_+_30531726 1.49 ENSDART00000146518
ankrd33bb
ankyrin repeat domain 33Bb
chr18_+_33100606 1.48 ENSDART00000003907
si:ch211-229c8.13
si:ch211-229c8.13
chr5_+_39537195 1.47 ENSDART00000051256
fgf5
fibroblast growth factor 5
chr5_+_61738276 1.46 ENSDART00000186256
RASL10B
RAS like family 10 member B
chr25_-_16146851 1.44 ENSDART00000104043
dkk3b
dickkopf WNT signaling pathway inhibitor 3b
chr2_-_30912922 1.41 ENSDART00000141669
myl12.2
myosin, light chain 12, genome duplicate 2
chr14_-_448182 1.40 ENSDART00000180018
FAT4
FAT atypical cadherin 4
chr13_+_32148338 1.40 ENSDART00000188591
osr1
odd-skipped related transciption factor 1
chr1_+_30723677 1.38 ENSDART00000177900
bora
bora, aurora kinase A activator
chr16_-_41807397 1.38 ENSDART00000138577
si:dkey-199f5.7
si:dkey-199f5.7
chr13_-_37383625 1.38 ENSDART00000192888
ENSDART00000100322
ENSDART00000138934
kcnh5b
potassium voltage-gated channel, subfamily H (eag-related), member 5b
chr15_-_37425468 1.37 ENSDART00000059630
si:ch211-113j13.2
si:ch211-113j13.2
chr11_+_20057182 1.37 ENSDART00000184979
fezf2
FEZ family zinc finger 2
chr22_+_30137374 1.33 ENSDART00000187808
add3a
adducin 3 (gamma) a
chr8_+_18101608 1.32 ENSDART00000140941
glis1b
GLIS family zinc finger 1b
chr19_+_4463389 1.31 ENSDART00000168805
kcnk9
potassium channel, subfamily K, member 9
chr12_-_22524388 1.29 ENSDART00000020942
shbg
sex hormone-binding globulin
chr17_+_15845765 1.28 ENSDART00000130881
ENSDART00000074936
gabrr2a
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr18_+_20677090 1.28 ENSDART00000060243
cftr
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr21_-_26520629 1.26 ENSDART00000142731
rce1b
Ras converting CAAX endopeptidase 1b
chr22_-_5006119 1.23 ENSDART00000187998
rx1
retinal homeobox gene 1
chr2_-_23600821 1.21 ENSDART00000146217
BX677666.1

chr13_-_14926318 1.20 ENSDART00000142785
cdc25b
cell division cycle 25B
chr16_-_25606235 1.15 ENSDART00000192741
zgc:110410
zgc:110410
chr1_-_54425791 1.11 ENSDART00000039911
pkd1a
polycystic kidney disease 1a
chr2_-_37883256 1.10 ENSDART00000035685
hbl4
hexose-binding lectin 4
chr14_-_41535822 1.07 ENSDART00000149407
itga6l
integrin, alpha 6, like
chr12_+_28995942 1.06 ENSDART00000076334
valopb
vertebrate ancient long opsin b
chr7_-_38689562 1.05 ENSDART00000167209
aplnr2
apelin receptor 2
chr22_+_7742211 1.04 ENSDART00000140896
CELA1 (1 of many)
zgc:92511
chr21_+_18877130 1.04 ENSDART00000136893
si:dkey-65l23.2
si:dkey-65l23.2
chr5_-_10236599 1.03 ENSDART00000099834
si:ch73-42k18.1
si:ch73-42k18.1
chr17_+_53294228 1.02 ENSDART00000158172
si:ch1073-416d2.3
si:ch1073-416d2.3
chr13_+_21870269 1.01 ENSDART00000144612
zswim8
zinc finger, SWIM-type containing 8
chr5_-_57820873 0.98 ENSDART00000089961
sik2a
salt-inducible kinase 2a
chr20_+_48543492 0.96 ENSDART00000175480
LO018254.1

chr25_+_30238021 0.96 ENSDART00000123220
alkbh3
alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
chr4_+_54519511 0.95 ENSDART00000161653
znf974
zinc finger protein 974
chr3_-_61592417 0.90 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr10_+_44437080 0.90 ENSDART00000181517
ENSDART00000054153
denr
density-regulated protein
chr20_-_25481306 0.89 ENSDART00000182495
si:dkey-183n20.15
si:dkey-183n20.15
chr15_+_42626957 0.86 ENSDART00000154754
grik1b
glutamate receptor, ionotropic, kainate 1b
chr2_-_41942666 0.85 ENSDART00000075673
ebi3
Epstein-Barr virus induced 3
chr13_-_45811137 0.85 ENSDART00000190512
fndc5a
fibronectin type III domain containing 5a
chr15_-_7337148 0.83 ENSDART00000182568
SLC7A1 (1 of many)
high affinity cationic amino acid transporter 1
chr7_+_26172396 0.83 ENSDART00000173975
si:ch211-196f2.7
si:ch211-196f2.7
chr1_-_34685007 0.80 ENSDART00000157471
klf5a
Kruppel-like factor 5a
chr13_+_36633355 0.79 ENSDART00000135612
si:ch211-67f24.7
si:ch211-67f24.7
chr17_+_52823015 0.79 ENSDART00000160507
ENSDART00000186979
meis2a
Meis homeobox 2a
chr9_-_41817712 0.78 ENSDART00000182657
si:dkeyp-30e7.2
si:dkeyp-30e7.2
chr2_+_9536021 0.78 ENSDART00000187357
CU929379.1

chr15_-_13254480 0.75 ENSDART00000190499
zgc:172282
zgc:172282
chr25_-_27541621 0.74 ENSDART00000130678
spam1
sperm adhesion molecule 1
chr7_+_22981909 0.74 ENSDART00000122449
ccnb3
cyclin B3
chr5_-_6508250 0.72 ENSDART00000060535
crybb3
crystallin, beta B3
chr10_-_34867401 0.71 ENSDART00000145545
dclk1a
doublecortin-like kinase 1a
chr12_+_22680115 0.71 ENSDART00000152879
ablim2
actin binding LIM protein family, member 2
chr7_-_65191937 0.71 ENSDART00000173234
pkd1l2a
polycystic kidney disease 1 like 2a
chr6_+_8630355 0.69 ENSDART00000161749
ENSDART00000193976
tspeara
thrombospondin-type laminin G domain and EAR repeats a
chr7_-_30143092 0.68 ENSDART00000173636
frmd5
FERM domain containing 5
chr17_-_19344999 0.62 ENSDART00000138315
gsc
goosecoid
chr23_+_22293682 0.62 ENSDART00000187304
CR354612.1

chr16_-_53800047 0.61 ENSDART00000158047
znrf2b
zinc and ring finger 2b
chr11_-_6001845 0.59 ENSDART00000108628
ano8b
anoctamin 8b
chr12_-_20362041 0.58 ENSDART00000184145
ENSDART00000105952
aqp8a.2
aquaporin 8a, tandem duplicate 2
chr8_+_36570791 0.56 ENSDART00000145566
ENSDART00000180527
pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr8_-_1219815 0.55 ENSDART00000016800
ENSDART00000149969
znf367
zinc finger protein 367
chr15_-_28082310 0.54 ENSDART00000152620
dhrs13a.3
dehydrogenase/reductase (SDR family) member 13a, duplicate 3
chr12_+_5251647 0.54 ENSDART00000124097
plce1
phospholipase C, epsilon 1
chr17_+_27134806 0.54 ENSDART00000151901
rps6ka1
ribosomal protein S6 kinase a, polypeptide 1
chr8_+_35664152 0.53 ENSDART00000144520
si:dkeyp-14d3.1
si:dkeyp-14d3.1
chr21_+_10794914 0.52 ENSDART00000084035
znf532
zinc finger protein 532
chr9_+_38737924 0.50 ENSDART00000147652
kansl1l
KAT8 regulatory NSL complex subunit 1-like
chr10_-_12650259 0.48 ENSDART00000191567
CT990561.2

chr2_+_31475772 0.47 ENSDART00000130722
cacnb2b
calcium channel, voltage-dependent, beta 2b
chr23_-_6765653 0.46 ENSDART00000192310
FP102169.1

chr12_+_35654749 0.44 ENSDART00000169889
ENSDART00000167873
baiap2b
BAI1-associated protein 2b
chr11_+_4953964 0.44 ENSDART00000092552
ptprga
protein tyrosine phosphatase, receptor type, g a
chr8_+_8973425 0.42 ENSDART00000066107
bcap31
B cell receptor associated protein 31
chr9_-_33107237 0.42 ENSDART00000013918
casq2
calsequestrin 2
chr10_-_26179805 0.42 ENSDART00000174797
trim3b
tripartite motif containing 3b
chr23_+_2669 0.42 ENSDART00000011146
twist3
twist3
chr14_+_25464681 0.41 ENSDART00000067500
ENSDART00000187601
si:dkey-280e21.3
si:dkey-280e21.3
chr12_-_47580562 0.37 ENSDART00000153431
rgs7b
regulator of G protein signaling 7b
chr3_+_9588705 0.37 ENSDART00000172543
ENSDART00000104875
trap1
TNF receptor-associated protein 1
chr10_+_41199660 0.36 ENSDART00000125314
adrb3b
adrenoceptor beta 3b
chr19_-_2115040 0.36 ENSDART00000020497
snx13
sorting nexin 13
chr3_-_61065055 0.35 ENSDART00000074199
cacng1b
calcium channel, voltage-dependent, gamma subunit 1b
chr16_+_35594670 0.34 ENSDART00000163275
si:ch211-1i11.3
si:ch211-1i11.3
chr10_+_42691210 0.33 ENSDART00000193813
rhobtb2b
Rho-related BTB domain containing 2b
chr5_-_38121612 0.31 ENSDART00000159543
si:ch211-284e13.6
si:ch211-284e13.6
chr25_+_7229046 0.28 ENSDART00000149965
ENSDART00000041820
lingo1a
leucine rich repeat and Ig domain containing 1a
chr2_-_14798295 0.28 ENSDART00000143430
ENSDART00000145869
si:ch73-366i20.1
si:ch73-366i20.1
chr13_+_39297802 0.25 ENSDART00000133636
si:dkey-85a20.4
si:dkey-85a20.4
chr11_-_41220794 0.23 ENSDART00000192895
mrps16
mitochondrial ribosomal protein S16
chr15_-_11956981 0.23 ENSDART00000164163
si:dkey-202l22.3
si:dkey-202l22.3
chr2_-_14793343 0.22 ENSDART00000132264
si:ch73-366i20.1
si:ch73-366i20.1
chr22_-_3595439 0.19 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr20_+_51466046 0.18 ENSDART00000178065
tlr5b
toll-like receptor 5b
chr7_+_22982201 0.18 ENSDART00000134116
ccnb3
cyclin B3
chr13_-_33207367 0.17 ENSDART00000146138
ENSDART00000109667
ENSDART00000182741
trip11
thyroid hormone receptor interactor 11
chr21_+_21612214 0.17 ENSDART00000008099
b9d2
B9 domain containing 2
chr22_+_5123479 0.17 ENSDART00000111822
ENSDART00000081910
loxl5a
lysyl oxidase-like 5a
chr17_+_26657896 0.16 ENSDART00000152037
ttc7b
tetratricopeptide repeat domain 7B
chr6_-_426041 0.16 ENSDART00000162789
fam83fb
family with sequence similarity 83, member Fb
chr1_+_32791920 0.15 ENSDART00000109369
zgc:174320
zgc:174320
chr12_+_31729498 0.07 ENSDART00000188546
ENSDART00000182562
ENSDART00000186147
RNF157
si:dkey-49c17.3
chr5_-_54148271 0.07 ENSDART00000163034
arhgef15
Rho guanine nucleotide exchange factor (GEF) 15
chr16_+_35344031 0.06 ENSDART00000167140
si:dkey-34d22.1
si:dkey-34d22.1

Network of associatons between targets according to the STRING database.

First level regulatory network of hic1l+hic2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 17.7 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
3.3 9.8 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
3.1 9.2 GO:0065001 specification of axis polarity(GO:0065001)
2.6 7.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
1.8 7.3 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
1.6 8.2 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
1.0 5.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
1.0 2.9 GO:1901006 ubiquinone-6 metabolic process(GO:1901004) ubiquinone-6 biosynthetic process(GO:1901006)
0.9 7.9 GO:0006167 AMP biosynthetic process(GO:0006167)
0.7 2.0 GO:0045887 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.6 4.0 GO:0034389 lipid particle organization(GO:0034389)
0.6 1.7 GO:0097095 frontonasal suture morphogenesis(GO:0097095)
0.5 1.4 GO:0048389 intermediate mesoderm development(GO:0048389)
0.5 2.3 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.4 1.3 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.4 1.2 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.4 5.0 GO:0009251 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.4 37.2 GO:0061515 myeloid cell development(GO:0061515)
0.3 2.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.3 1.6 GO:0016037 light absorption(GO:0016037)
0.3 1.3 GO:0045730 respiratory burst(GO:0045730)
0.3 0.9 GO:0002188 translation reinitiation(GO:0002188)
0.3 0.9 GO:0044321 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.3 1.1 GO:0044246 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246)
0.3 1.6 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.3 3.7 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 2.7 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 1.4 GO:0021767 mammillary body development(GO:0021767)
0.2 4.7 GO:0021984 adenohypophysis development(GO:0021984)
0.2 2.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.0 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.1 1.5 GO:0061550 cranial ganglion development(GO:0061550)
0.1 0.4 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.1 0.4 GO:0010660 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 2.3 GO:0008354 germ cell migration(GO:0008354)
0.1 2.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 1.7 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 1.6 GO:0061647 histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.1 1.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 0.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 1.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.4 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1 2.4 GO:0032543 mitochondrial translation(GO:0032543)
0.1 2.7 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 0.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.0 1.3 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.7 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.5 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.2 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 1.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.9 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.6 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 1.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.6 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.0 1.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.2 GO:0036372 opsin transport(GO:0036372)
0.0 1.9 GO:0003341 cilium movement(GO:0003341)
0.0 0.5 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 1.6 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.2 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 1.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.0 GO:1902667 regulation of axon guidance(GO:1902667)
0.0 0.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.2 8.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 38.9 GO:0005884 actin filament(GO:0005884)
0.3 2.6 GO:0031526 brush border membrane(GO:0031526)
0.3 1.9 GO:0036156 inner dynein arm(GO:0036156)
0.2 5.2 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 10.7 GO:0005581 collagen trimer(GO:0005581)
0.1 0.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 4.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 4.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.0 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 4.2 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.4 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 2.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.6 GO:0005839 proteasome core complex(GO:0005839)
0.0 5.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.5 GO:0044545 NSL complex(GO:0044545)
0.0 3.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.3 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.1 GO:0008305 integrin complex(GO:0008305)
0.0 2.0 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.2 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 7.9 GO:0016842 amidine-lyase activity(GO:0016842)
1.3 5.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
1.3 5.0 GO:0004133 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
1.1 7.7 GO:0070888 E-box binding(GO:0070888)
0.9 9.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.9 2.6 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.6 5.4 GO:0004096 catalase activity(GO:0004096)
0.5 2.0 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.5 2.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.5 1.9 GO:0070052 collagen V binding(GO:0070052)
0.3 2.6 GO:0008515 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.3 8.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 1.4 GO:0039706 co-receptor binding(GO:0039706)
0.3 36.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.2 1.0 GO:0060182 apelin receptor activity(GO:0060182)
0.2 9.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 2.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 1.1 GO:0004960 thromboxane receptor activity(GO:0004960)
0.2 2.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.9 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 2.4 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.3 GO:0004875 complement receptor activity(GO:0004875)
0.1 3.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.6 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 0.4 GO:0051380 norepinephrine binding(GO:0051380)
0.1 23.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.6 GO:0015250 water channel activity(GO:0015250)
0.1 1.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 2.0 GO:0042923 neuropeptide binding(GO:0042923)
0.1 0.7 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 2.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 7.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.3 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.5 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 1.8 GO:0005109 frizzled binding(GO:0005109)
0.0 4.2 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 2.1 GO:0042562 hormone binding(GO:0042562)
0.0 2.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.5 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 4.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 1.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.3 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.2 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.9 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.5 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.4 PID FGF PATHWAY FGF signaling pathway
0.0 0.6 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.9 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.5 3.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.5 5.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3 1.7 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.2 1.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 2.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 6.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 4.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 2.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins