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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hivep1

Z-value: 0.95

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Transcription factors associated with hivep1

Gene Symbol Gene ID Gene Info
hivep1
ENSDARG00000103658 HIVEP zinc finger 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hivep1dr11_v1_chr19_-_3488860_3488860-0.619.0e-11Click!

Activity profile of hivep1 motif

Sorted Z-values of hivep1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_28830643 14.26 ENSDART00000051448
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr14_-_1454045 9.62 ENSDART00000161460
pmt
phosphoethanolamine methyltransferase
chr18_+_7073130 8.99 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
si:dkey-88e18.2
chr20_-_40754794 8.74 ENSDART00000187251
cx32.3
connexin 32.3
chr16_-_27749172 8.61 ENSDART00000145198
steap4
STEAP family member 4
chr5_+_28830388 8.61 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_-_36750068 8.08 ENSDART00000173388
abcc6b.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 1
chr9_-_43082945 8.05 ENSDART00000142257
ccdc141
coiled-coil domain containing 141
chr16_+_23403602 7.50 ENSDART00000159848
s100w
S100 calcium binding protein W
chr24_-_21689146 7.46 ENSDART00000105917
urad
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
chr2_-_37465517 7.25 ENSDART00000139983
si:dkey-57k2.6
si:dkey-57k2.6
chr24_+_26006730 6.74 ENSDART00000140384
ENSDART00000139184
ccl20b
chemokine (C-C motif) ligand 20b
chr15_-_36365840 6.57 ENSDART00000192926
si:dkey-23k10.3
si:dkey-23k10.3
chr5_-_42904329 6.31 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr17_+_51627209 6.03 ENSDART00000056886
zgc:113142
zgc:113142
chr6_+_54576520 5.92 ENSDART00000093199
ENSDART00000127519
ENSDART00000157142
tead3b
TEA domain family member 3 b
chr7_-_60831082 5.48 ENSDART00000073654
ENSDART00000136999
pcxb
pyruvate carboxylase b
chr18_-_5527050 5.46 ENSDART00000145400
ENSDART00000132498
ENSDART00000146209
zgc:153317
zgc:153317
chr13_-_25196758 5.44 ENSDART00000184722
adka
adenosine kinase a
chr16_-_25608453 5.42 ENSDART00000140140
zgc:110410
zgc:110410
chr16_+_46294337 5.41 ENSDART00000040769
nr2f5
nuclear receptor subfamily 2, group F, member 5
chr4_+_18806251 5.27 ENSDART00000138662
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr13_+_30692669 5.27 ENSDART00000187818
CR762483.1

chr19_-_24555935 5.10 ENSDART00000132660
ENSDART00000162801
polr3gla
polymerase (RNA) III (DNA directed) polypeptide G like a
chr7_-_19003504 4.94 ENSDART00000157618
HACD4
si:ch73-41h24.1
chr15_-_3736149 4.87 ENSDART00000182986
lpar6a
lysophosphatidic acid receptor 6a
chr14_+_1014109 4.74 ENSDART00000157945
f8
coagulation factor VIII, procoagulant component
chr3_-_58733718 4.72 ENSDART00000154603
si:ch73-281f12.4
si:ch73-281f12.4
chr25_+_34641536 4.67 ENSDART00000167033
CABZ01079011.1

chr9_-_813693 4.51 ENSDART00000174793
marco
macrophage receptor with collagenous structure
chr5_+_22579975 4.40 ENSDART00000080877
tnfsf10l4
tumor necrosis factor (ligand) superfamily, member 10 like 4
chr23_-_33738570 4.29 ENSDART00000131680
si:ch211-210c8.7
si:ch211-210c8.7
chr6_-_54815886 4.28 ENSDART00000180793
ENSDART00000007498
tnni1b
troponin I type 1b (skeletal, slow)
chr22_-_16180467 4.27 ENSDART00000171331
ENSDART00000185607
vcam1b
vascular cell adhesion molecule 1b
chr16_+_38394371 4.19 ENSDART00000137954
cd83
CD83 molecule
chr1_-_52447364 4.07 ENSDART00000140740
si:ch211-217k17.10
si:ch211-217k17.10
chr3_+_31662126 3.98 ENSDART00000113441
mylk5
myosin, light chain kinase 5
chr7_-_73717082 3.90 ENSDART00000164301
ENSDART00000082625
BX664721.2

chr3_-_49815223 3.88 ENSDART00000181208
gcgra
glucagon receptor a
chr8_-_20230559 3.82 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr16_-_40426837 3.82 ENSDART00000193690
plekhf2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr12_+_22576404 3.81 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr20_+_16881883 3.78 ENSDART00000130107
nfkbiaa
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr10_+_19596214 3.73 ENSDART00000183110
CABZ01059626.1

chr20_-_30376433 3.70 ENSDART00000190737
rps7
ribosomal protein S7
chr19_-_24555623 3.64 ENSDART00000176022
polr3gla
polymerase (RNA) III (DNA directed) polypeptide G like a
chr7_+_21275152 3.60 ENSDART00000173612
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr2_-_43583896 3.59 ENSDART00000161711
itgb1b
integrin, beta 1b
chr10_-_8079737 3.51 ENSDART00000059014
ENSDART00000179549
zgc:173443
si:ch211-251f6.6
zgc:173443
si:ch211-251f6.6
chr5_-_30984271 3.47 ENSDART00000051392
spns3
spinster homolog 3 (Drosophila)
chr8_-_18667693 3.45 ENSDART00000100516
stap2b
signal transducing adaptor family member 2b
chr25_-_14637660 3.45 ENSDART00000143666
nav2b
neuron navigator 2b
chr19_-_12404590 3.39 ENSDART00000103703
ftr56
finTRIM family, member 56
chr8_+_24745041 3.35 ENSDART00000148872
slc16a4
solute carrier family 16, member 4
chr23_+_26733232 3.26 ENSDART00000035080
zgc:158263
zgc:158263
chr5_+_9246458 3.25 ENSDART00000081772
susd1
sushi domain containing 1
chr11_-_279328 3.24 ENSDART00000066179
npffl
neuropeptide FF-amide peptide precursor like
chr3_+_56574623 3.24 ENSDART00000130877
rac1b
Rac family small GTPase 1b
chr10_-_41980797 3.16 ENSDART00000076575
rhof
ras homolog family member F
chr1_+_17892944 3.03 ENSDART00000013021
tlr3
toll-like receptor 3
chr20_+_23501535 3.01 ENSDART00000177922
ENSDART00000058532
palld
palladin, cytoskeletal associated protein
chr24_+_28525507 2.93 ENSDART00000191121
arhgap29a
Rho GTPase activating protein 29a
chr1_-_18585046 2.89 ENSDART00000147228
fam114a1
family with sequence similarity 114, member A1
chr14_+_16765992 2.85 ENSDART00000140061
sqstm1
sequestosome 1
chr19_-_3261019 2.81 ENSDART00000134407
si:ch211-133n4.12
si:ch211-133n4.12
chr6_-_442163 2.78 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
grap2b
GRB2-related adaptor protein 2b
chr19_-_7144548 2.72 ENSDART00000147177
ENSDART00000134850
psmb8a
psmb13a
proteasome subunit beta 8A
proteasome subunit beta 13a
chr6_-_46589726 2.64 ENSDART00000084334
ptgis
prostaglandin I2 (prostacyclin) synthase
chr13_+_40692804 2.64 ENSDART00000109822
hps1
Hermansky-Pudlak syndrome 1
chr15_-_18200358 2.64 ENSDART00000158569
si:ch211-247l8.8
si:ch211-247l8.8
chr8_-_12432604 2.58 ENSDART00000133350
ENSDART00000140699
ENSDART00000101174
traf1
TNF receptor-associated factor 1
chr16_+_23087326 2.57 ENSDART00000167518
ENSDART00000161087
efna3b
ephrin-A3b
chr2_-_24398324 2.48 ENSDART00000165226
zgc:154006
zgc:154006
chr16_-_25739331 2.45 ENSDART00000189455
bcl3
B cell CLL/lymphoma 3
chr19_+_7124337 2.41 ENSDART00000031380
tap2a
transporter associated with antigen processing, subunit type a
chr2_-_2642476 2.36 ENSDART00000124032
serbp1b
SERPINE1 mRNA binding protein 1b
chr6_-_39270851 2.33 ENSDART00000148839
arhgef25b
Rho guanine nucleotide exchange factor (GEF) 25b
chr5_+_9246018 2.33 ENSDART00000081769
ENSDART00000183189
susd1
sushi domain containing 1
chr16_-_25741225 2.32 ENSDART00000130641
bcl3
B cell CLL/lymphoma 3
chr24_-_21131607 2.29 ENSDART00000010126
zdhhc23b
zinc finger, DHHC-type containing 23b
chr7_-_28696556 2.23 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr13_-_25819825 2.21 ENSDART00000077612
rel
v-rel avian reticuloendotheliosis viral oncogene homolog
chr9_-_51563575 2.21 ENSDART00000167034
ENSDART00000148918
tank
TRAF family member-associated NFKB activator
chr10_+_5422575 2.20 ENSDART00000063093
auh
AU RNA binding protein/enoyl-CoA hydratase
chr8_+_52377516 2.17 ENSDART00000115398
arid5a
AT rich interactive domain 5A (MRF1-like)
chr15_+_25681044 2.17 ENSDART00000077853
hic1
hypermethylated in cancer 1
chr18_-_16924221 2.12 ENSDART00000122102
wee1
WEE1 G2 checkpoint kinase
chr3_+_25166805 2.11 ENSDART00000077493
TST
zgc:162544
chr12_-_4206869 2.10 ENSDART00000106572
si:dkey-32n7.9
si:dkey-32n7.9
chr12_+_17754859 2.09 ENSDART00000112119
bhlha15
basic helix-loop-helix family, member a15
chr22_+_28969071 2.06 ENSDART00000163427
pimr95
Pim proto-oncogene, serine/threonine kinase, related 95
chr20_+_43691208 2.04 ENSDART00000152976
ENSDART00000045185
lin9
lin-9 DREAM MuvB core complex component
chr6_-_436658 2.03 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr3_-_32079916 1.97 ENSDART00000040900
baxb
BCL2 associated X, apoptosis regulator b
chr4_+_38550788 1.94 ENSDART00000157412
si:ch211-209n20.1
si:ch211-209n20.1
chr3_+_6325895 1.92 ENSDART00000167386
ENSDART00000165000
zgc:136767
zgc:136767
chr3_+_22273123 1.91 ENSDART00000044157
scn4ab
sodium channel, voltage-gated, type IV, alpha, b
chr7_-_34262080 1.90 ENSDART00000183246
si:ch211-98n17.5
si:ch211-98n17.5
chr15_+_17251191 1.88 ENSDART00000156587
si:ch73-223p23.2
si:ch73-223p23.2
chr8_+_26410539 1.87 ENSDART00000168780
ifrd2
interferon-related developmental regulator 2
chr12_-_4835378 1.86 ENSDART00000172093
si:ch211-93e11.8
si:ch211-93e11.8
chr7_+_4384863 1.79 ENSDART00000042955
ENSDART00000134653
slc12a10.3
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3
chr2_+_111919 1.78 ENSDART00000149391
fggy
FGGY carbohydrate kinase domain containing
chr15_-_38202630 1.77 ENSDART00000183772
rhoga
ras homolog family member Ga
chr3_-_31619463 1.75 ENSDART00000124559
moto
minamoto
chr18_+_30567945 1.75 ENSDART00000078894
irf8
interferon regulatory factor 8
chr23_+_19606291 1.71 ENSDART00000139415
flnb
filamin B, beta (actin binding protein 278)
chr24_-_5911973 1.67 ENSDART00000077933
ENSDART00000077922
pimr64
Pim proto-oncogene, serine/threonine kinase, related 64
chr25_-_6557854 1.66 ENSDART00000181740
cspg4
chondroitin sulfate proteoglycan 4
chr11_-_21304452 1.63 ENSDART00000163008
RASSF5
si:dkey-85p17.3
chr16_+_11683548 1.62 ENSDART00000138000
si:dkey-250k15.7
si:dkey-250k15.7
chr8_-_25247284 1.60 ENSDART00000132697
gnat2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr4_-_12914163 1.60 ENSDART00000140002
ENSDART00000145917
ENSDART00000141355
ENSDART00000067135
msrb3
methionine sulfoxide reductase B3
chr10_+_37173029 1.59 ENSDART00000136510
ksr1a
kinase suppressor of ras 1a
chr2_-_36674005 1.58 ENSDART00000004899
ccnl1b
cyclin L1b
chr22_+_24378064 1.56 ENSDART00000180592
BX649608.2

chr7_+_32021982 1.56 ENSDART00000173848
mettl15
methyltransferase like 15
chr7_+_22585447 1.54 ENSDART00000149144
chrnb1l
cholinergic receptor, nicotinic, beta 1 (muscle) like
chr20_+_98179 1.54 ENSDART00000022725
si:ch1073-155h21.1
si:ch1073-155h21.1
chr11_+_40544269 1.54 ENSDART00000175424
ENSDART00000184673
mmel1
membrane metallo-endopeptidase-like 1
chr22_+_3184500 1.53 ENSDART00000176409
ENSDART00000160604
ftsj3
FtsJ RNA methyltransferase homolog 3
chr8_-_48704050 1.53 ENSDART00000163916
pimr182
Pim proto-oncogene, serine/threonine kinase, related 182
chr22_-_651719 1.52 ENSDART00000148692
apobec2a
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a
chr6_+_9175886 1.51 ENSDART00000165333
si:ch211-207l14.1
si:ch211-207l14.1
chr9_-_49978335 1.46 ENSDART00000170814
scn1a
sodium channel, voltage-gated, type I, alpha
chr2_+_30547018 1.39 ENSDART00000193747
ankrd33bb
ankyrin repeat domain 33Bb
chr6_-_131401 1.38 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr14_-_35883019 1.38 ENSDART00000112379
fam198b
family with sequence similarity 198, member B
chr11_-_8320868 1.36 ENSDART00000160570
si:ch211-247n2.1
si:ch211-247n2.1
chr14_+_14806692 1.34 ENSDART00000193050
fhdc2
FH2 domain containing 2
chr7_-_804515 1.34 ENSDART00000159359
rela
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr14_-_16807206 1.32 ENSDART00000157957
tcirg1b
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr16_+_35535375 1.31 ENSDART00000171675
cited4b
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b
chr19_+_41173386 1.28 ENSDART00000142773
asb4
ankyrin repeat and SOCS box containing 4
chr18_+_16053455 1.27 ENSDART00000189163
ENSDART00000188269
FO834850.1

chr8_-_48740953 1.27 ENSDART00000160805
pimr180
Pim proto-oncogene, serine/threonine kinase, related 180
chr19_+_43504480 1.26 ENSDART00000159421
BX649384.3

chr14_-_24081929 1.25 ENSDART00000158576
msx2a
muscle segment homeobox 2a
chr20_-_49657134 1.22 ENSDART00000151248
col12a1b
collagen, type XII, alpha 1b
chr13_+_21601149 1.21 ENSDART00000179369
sh2d4ba
SH2 domain containing 4Ba
chr1_-_59571758 1.20 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr7_+_16834679 1.16 ENSDART00000180481
ENSDART00000184585
ENSDART00000188749
nav2a
neuron navigator 2a
chr13_+_21600946 1.14 ENSDART00000144045
sh2d4ba
SH2 domain containing 4Ba
chr20_-_44055095 1.13 ENSDART00000125898
ENSDART00000082265
runx2b
runt-related transcription factor 2b
chr23_+_3594171 1.11 ENSDART00000159609
si:dkey-9l20.3
si:dkey-9l20.3
chr5_-_10007897 1.11 ENSDART00000109052
CR936408.1
Danio rerio uncharacterized LOC799523 (LOC799523), mRNA.
chr23_+_43849190 1.10 ENSDART00000017375
cnga1
cyclic nucleotide gated channel alpha 1
chr10_-_43844537 1.09 ENSDART00000114208
tlr8b
toll-like receptor 8b
chr9_+_35014728 1.08 ENSDART00000100700
gabpa
GA binding protein transcription factor, alpha subunit
chr12_+_28888975 1.07 ENSDART00000076362
phkg2
phosphorylase kinase, gamma 2 (testis)
chr15_-_16076399 1.06 ENSDART00000135658
ENSDART00000133755
ENSDART00000080413
srsf1a
serine/arginine-rich splicing factor 1a
chr20_-_41992878 1.05 ENSDART00000100967
si:dkeyp-114g9.1
si:dkeyp-114g9.1
chr3_-_27061637 1.04 ENSDART00000157126
atf7ip2
activating transcription factor 7 interacting protein 2
chr15_-_29510074 1.04 ENSDART00000184070
BX324227.3

chr15_-_37779978 1.02 ENSDART00000157202
si:dkey-42l23.3
si:dkey-42l23.3
chr6_-_6976096 1.02 ENSDART00000151822
ENSDART00000039443
ENSDART00000177960
tuba8l4
tubulin, alpha 8 like 4
chr9_-_32663496 1.02 ENSDART00000078384
gzm3.2
granzyme 3, tandem duplicate 2
chr9_-_23894392 1.01 ENSDART00000133417
asb18
ankyrin repeat and SOCS box containing 18
chr8_+_32722842 0.98 ENSDART00000147594
hmcn2
hemicentin 2
chr25_-_3347418 0.98 ENSDART00000082385
golt1bb
golgi transport 1Bb
chr19_-_3193912 0.96 ENSDART00000133159
si:ch211-133n4.6
si:ch211-133n4.6
chr22_-_6777976 0.94 ENSDART00000187946
CT583625.5

chr15_-_29534022 0.93 ENSDART00000182658
BX324227.2

chr8_-_45729758 0.91 ENSDART00000189329
BX088696.1

chr24_+_9003998 0.90 ENSDART00000179656
ENSDART00000191314
CR318624.2

chr2_+_20793982 0.90 ENSDART00000014785
prg4a
proteoglycan 4a
chr13_+_22717939 0.88 ENSDART00000188288
nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr15_-_28677725 0.87 ENSDART00000060255
blmh
bleomycin hydrolase
chr24_-_31422574 0.87 ENSDART00000158567
cngb3.1
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr2_-_50966124 0.87 ENSDART00000170470
ghrhra
growth hormone releasing hormone receptor a
chr11_-_36450770 0.86 ENSDART00000128889
zbtb40
zinc finger and BTB domain containing 40
chr9_+_35014513 0.85 ENSDART00000100701
gabpa
GA binding protein transcription factor, alpha subunit
chr5_-_29195063 0.85 ENSDART00000109926
man1b1b
mannosidase, alpha, class 1B, member 1b
chr7_-_17591007 0.84 ENSDART00000171023
CU672228.1

chr1_+_55279124 0.84 ENSDART00000152660
si:ch211-286b5.6
si:ch211-286b5.6
chr21_+_21357309 0.82 ENSDART00000079634
ENSDART00000146102
kcnk12l
potassium channel, subfamily K, member 12 like
chr17_-_13070602 0.81 ENSDART00000188311
ENSDART00000193428
CU469462.1

chr21_+_5257316 0.81 ENSDART00000184441
loxhd1a
lipoxygenase homology domains 1a
chr22_+_38301365 0.78 ENSDART00000137339
traf5
Tnf receptor-associated factor 5
chr24_+_25919809 0.78 ENSDART00000006615
map3k15
mitogen-activated protein kinase kinase kinase 15
chr18_+_40572294 0.76 ENSDART00000147003
si:ch211-132b12.2
si:ch211-132b12.2
chr14_-_30366196 0.76 ENSDART00000007022
pdgfrl
platelet-derived growth factor receptor-like
chr5_+_431994 0.76 ENSDART00000181692
ENSDART00000170350
thap1
THAP domain containing, apoptosis associated protein 1
chr7_+_38685654 0.75 ENSDART00000180003
syt13
synaptotagmin XIII
chr8_-_7475917 0.75 ENSDART00000082157
gata1b
GATA binding protein 1b
chr1_+_292545 0.74 ENSDART00000148261
cenpe
centromere protein E
chr25_-_27843066 0.73 ENSDART00000179684
ENSDART00000186000
ENSDART00000190065
asb15a
ankyrin repeat and SOCS box containing 15a
chr19_+_40250682 0.73 ENSDART00000102888
cdk6
cyclin-dependent kinase 6
chr20_+_16703050 0.73 ENSDART00000005244
kcnk13b
potassium channel, subfamily K, member 13b
chr3_+_34140507 0.72 ENSDART00000131802
si:dkey-204f11.64
si:dkey-204f11.64
chr23_-_31974060 0.71 ENSDART00000168087
BX927210.1

chr8_-_48741106 0.71 ENSDART00000164203
pimr180
Pim proto-oncogene, serine/threonine kinase, related 180
chr17_+_33313566 0.71 ENSDART00000045040
si:ch211-132f19.7
si:ch211-132f19.7
chr22_+_38767780 0.68 ENSDART00000149499
alpi.1
alkaline phosphatase, intestinal, tandem duplicate 1
chr19_+_43392446 0.66 ENSDART00000147290
yrk
Yes-related kinase
chr8_-_10949847 0.65 ENSDART00000123209
pqlc2
PQ loop repeat containing 2
chr12_-_37941733 0.64 ENSDART00000130167
CABZ01046949.1

chr9_-_12624622 0.63 ENSDART00000146535
tspearb
thrombospondin-type laminin G domain and EAR repeats b
chr5_+_37032038 0.61 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_-_53329704 0.60 ENSDART00000193895
exd1
exonuclease 3'-5' domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of hivep1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0019628 urate catabolic process(GO:0019628) urate metabolic process(GO:0046415)
2.2 8.6 GO:0015677 copper ion import(GO:0015677)
1.4 4.2 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468)
1.3 3.8 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
1.0 3.0 GO:0034138 chemokine production(GO:0032602) toll-like receptor 3 signaling pathway(GO:0034138)
1.0 2.9 GO:0035973 aggrephagy(GO:0035973)
0.9 5.4 GO:0044209 AMP salvage(GO:0044209)
0.7 2.6 GO:1903232 melanosome assembly(GO:1903232)
0.6 1.7 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.5 1.5 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.4 2.2 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.4 7.9 GO:0046686 response to cadmium ion(GO:0046686)
0.4 1.6 GO:0030091 protein repair(GO:0030091)
0.4 6.3 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.3 26.5 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.2 1.7 GO:0007141 male meiosis I(GO:0007141)
0.2 2.0 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.2 7.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.2 5.3 GO:0015701 bicarbonate transport(GO:0015701)
0.2 1.4 GO:0005513 detection of calcium ion(GO:0005513)
0.2 3.6 GO:0043114 regulation of vascular permeability(GO:0043114)
0.2 4.7 GO:0030168 platelet activation(GO:0030168)
0.2 5.9 GO:0035329 hippo signaling(GO:0035329)
0.2 2.6 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.2 5.4 GO:0032526 response to retinoic acid(GO:0032526)
0.2 5.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.2 3.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 1.6 GO:0050909 sensory perception of taste(GO:0050909)
0.1 1.0 GO:0090497 mesenchymal cell migration(GO:0090497)
0.1 0.5 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 5.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 4.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 6.0 GO:0019226 transmission of nerve impulse(GO:0019226)
0.1 0.9 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 3.8 GO:0051014 actin filament severing(GO:0051014)
0.1 0.7 GO:0043697 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 0.4 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.1 1.3 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 2.6 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 1.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 2.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 3.9 GO:0010906 regulation of cellular carbohydrate metabolic process(GO:0010675) regulation of glucose metabolic process(GO:0010906)
0.1 4.7 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 1.8 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 4.3 GO:0001946 lymphangiogenesis(GO:0001946)
0.1 1.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1 2.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 1.2 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.1 1.3 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1 1.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.6 GO:0046548 retinal rod cell development(GO:0046548)
0.1 0.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 2.5 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 3.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 2.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 2.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 3.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 4.8 GO:0048545 response to steroid hormone(GO:0048545)
0.0 0.3 GO:0061056 somatic motor neuron differentiation(GO:0021523) sclerotome development(GO:0061056)
0.0 1.1 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 2.1 GO:0035272 exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.0 1.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 3.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.9 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 3.9 GO:0006909 phagocytosis(GO:0006909)
0.0 1.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.7 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 2.9 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.4 GO:0021984 adenohypophysis development(GO:0021984)
0.0 7.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.1 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.7 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 2.1 GO:0009416 response to light stimulus(GO:0009416)
0.0 0.7 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 0.9 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 1.5 GO:0016485 protein processing(GO:0016485)
0.0 0.2 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.8 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0031085 BLOC-3 complex(GO:0031085)
0.4 2.9 GO:0016234 inclusion body(GO:0016234)
0.4 8.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.4 5.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 1.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.6 GO:1990923 PET complex(GO:1990923)
0.1 3.7 GO:0032040 small-subunit processome(GO:0032040)
0.1 4.3 GO:0005861 troponin complex(GO:0005861)
0.1 2.7 GO:0005839 proteasome core complex(GO:0005839)
0.1 3.5 GO:0000421 autophagosome membrane(GO:0000421)
0.1 3.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 4.2 GO:0019814 immunoglobulin complex(GO:0019814)
0.1 7.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 3.8 GO:0031901 early endosome membrane(GO:0031901)
0.1 2.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.8 GO:0001726 ruffle(GO:0001726)
0.0 0.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 6.8 GO:0010008 endosome membrane(GO:0010008)
0.0 5.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 6.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.2 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 36.9 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0031010 ISWI-type complex(GO:0031010)
0.0 2.6 GO:0016607 nuclear speck(GO:0016607)
0.0 1.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.0 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.2 GO:0000178 exosome (RNase complex)(GO:0000178)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.6 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
1.8 5.5 GO:0004736 pyruvate carboxylase activity(GO:0004736)
1.6 6.3 GO:0005153 interleukin-8 receptor binding(GO:0005153)
1.1 3.3 GO:0001729 ceramide kinase activity(GO:0001729)
1.1 5.4 GO:0004001 adenosine kinase activity(GO:0004001)
0.8 3.9 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.7 3.6 GO:0098639 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.5 1.5 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.3 4.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 3.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 5.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.3 2.2 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.3 1.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.2 27.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.1 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 3.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 7.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 1.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 1.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.2 1.8 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.2 5.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 5.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 7.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 2.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 4.7 GO:0051020 GTPase binding(GO:0051020)
0.1 3.5 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 5.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 2.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.8 GO:0004096 catalase activity(GO:0004096)
0.1 1.3 GO:0051117 ATPase binding(GO:0051117)
0.1 0.8 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 0.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 5.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 3.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 4.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 10.5 GO:0043492 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 0.9 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 2.6 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.1 1.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.6 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.1 0.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.6 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 3.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.0 GO:0004875 complement receptor activity(GO:0004875)
0.0 8.2 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.9 GO:0017046 peptide hormone binding(GO:0017046)
0.0 3.5 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 2.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 2.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 3.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.2 2.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 3.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 22.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.6 PID CONE PATHWAY Visual signal transduction: Cones
0.1 2.6 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 1.1 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 1.9 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.7 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 1.1 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.7 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.4 3.0 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.3 4.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 2.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 1.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 2.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 3.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.1 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 1.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 2.6 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 1.7 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.0 3.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis