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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hmbox1a+zgc:91944

Z-value: 1.27

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Transcription factors associated with hmbox1a+zgc:91944

Gene Symbol Gene ID Gene Info
hmbox1a
ENSDARG00000027082 homeobox containing 1a
zgc
ENSDARG00000035887 91944
hmbox1a
ENSDARG00000109287 homeobox containing 1 b
zgc
ENSDARG00000114642 91944

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zgc:91944dr11_v1_chr19_-_32600823_32600868-0.631.4e-11Click!
hmbox1adr11_v1_chr17_-_16324565_16324565-0.454.9e-06Click!
CABZ01078261.1dr11_v1_chr20_+_49787584_49787584-0.196.6e-02Click!

Activity profile of hmbox1a+zgc:91944 motif

Sorted Z-values of hmbox1a+zgc:91944 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_31891110 13.53 ENSDART00000173883
mybpc3
myosin binding protein C, cardiac
chr7_-_71758307 12.65 ENSDART00000161067
ENSDART00000165253
myom1b
myomesin 1b
chr2_+_55982300 12.26 ENSDART00000183903
nmrk2
nicotinamide riboside kinase 2
chr15_-_17074393 11.29 ENSDART00000155526
si:ch211-24o10.6
si:ch211-24o10.6
chr14_+_21222287 11.23 ENSDART00000159905
si:ch211-175m2.4
si:ch211-175m2.4
chr7_+_41295974 10.88 ENSDART00000173568
ENSDART00000173544
si:dkey-86l18.10
si:dkey-86l18.10
chr14_+_11458044 10.77 ENSDART00000186425
si:ch211-153b23.5
si:ch211-153b23.5
chr7_-_71758613 10.37 ENSDART00000166724
myom1b
myomesin 1b
chr4_+_72798545 10.02 ENSDART00000181727
MYRFL
myelin regulatory factor-like
chr1_+_10051763 9.91 ENSDART00000011701
fgb
fibrinogen beta chain
chr20_-_30377221 9.70 ENSDART00000126229
rps7
ribosomal protein S7
chr13_+_8840772 9.69 ENSDART00000059321
epcam
epithelial cell adhesion molecule
chr19_-_40192249 9.53 ENSDART00000051972
grn1
granulin 1
chr2_-_42128714 9.47 ENSDART00000047055
trim55a
tripartite motif containing 55a
chr20_+_15015557 9.46 ENSDART00000039345
myoc
myocilin
chr21_-_45920 9.29 ENSDART00000040422
bhmt
betaine-homocysteine methyltransferase
chr7_+_19016023 9.03 ENSDART00000185212
CU972454.5

chr19_+_9295244 8.86 ENSDART00000132255
ENSDART00000144299
si:ch73-15n24.1
si:ch73-15n24.1
chr4_+_20566371 8.35 ENSDART00000127576
BX248410.1

chr24_-_11076400 8.21 ENSDART00000003195
chmp4c
charged multivesicular body protein 4C
chr18_-_46354269 8.19 ENSDART00000010813
foxa3
forkhead box A3
chr7_+_35075847 8.16 ENSDART00000193469
ENSDART00000037346
ctrb1
chymotrypsinogen B1
chr7_+_69841017 8.15 ENSDART00000169107
FO818704.1

chr15_-_39971756 7.99 ENSDART00000063789
rps5
ribosomal protein S5
chr5_-_42904329 7.68 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr13_-_21672131 7.48 ENSDART00000067537
elovl6l
ELOVL family member 6, elongation of long chain fatty acids like
chr21_-_32036597 7.43 ENSDART00000114964
zgc:165573
zgc:165573
chr12_-_26538823 7.36 ENSDART00000143213
acsf2
acyl-CoA synthetase family member 2
chr17_+_33375469 7.25 ENSDART00000032827
zgc:162964
zgc:162964
chr16_+_31921812 7.20 ENSDART00000176928
ENSDART00000193733
rps9
ribosomal protein S9
chr7_-_38790341 6.98 ENSDART00000159884
si:dkey-23n7.10
si:dkey-23n7.10
chr19_-_5669122 6.92 ENSDART00000112211
si:ch211-264f5.2
si:ch211-264f5.2
chr25_-_13188214 6.87 ENSDART00000187298
si:ch211-147m6.1
si:ch211-147m6.1
chr13_-_37620091 6.84 ENSDART00000135875
ENSDART00000193270
ENSDART00000018064
zgc:152791
zgc:152791
chr8_+_30699429 6.82 ENSDART00000005345
upb1
ureidopropionase, beta
chr23_-_14766902 6.76 ENSDART00000168113
gss
glutathione synthetase
chr8_-_47152001 6.62 ENSDART00000163922
ENSDART00000110512
ENSDART00000024320
ybx1
Y box binding protein 1
chr25_+_13205878 6.50 ENSDART00000162319
ENSDART00000162283
si:ch211-147m6.2
si:ch211-147m6.2
chr21_-_22730832 6.22 ENSDART00000101797
fbxo40.1
F-box protein 40, tandem duplicate 1
chr10_+_439692 6.21 ENSDART00000147740
zdhhc8a
zinc finger, DHHC-type containing 8a
chr8_+_44759576 6.19 ENSDART00000132115
si:ch1073-459j12.1
si:ch1073-459j12.1
chr9_-_98982 6.12 ENSDART00000147882
lims2
LIM and senescent cell antigen-like domains 2
chr22_-_23590069 6.10 ENSDART00000172067
f13b
coagulation factor XIII, B polypeptide
chr12_+_13244149 6.01 ENSDART00000186984
ENSDART00000105896
atp2a1l
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr1_-_513762 5.92 ENSDART00000148162
ENSDART00000144606
trmt10c
tRNA methyltransferase 10C, mitochondrial RNase P subunit
chr8_+_39724138 5.80 ENSDART00000009323
pla2g1b
phospholipase A2, group IB (pancreas)
chr8_+_14890821 5.80 ENSDART00000190966
soat1
sterol O-acyltransferase 1
chr8_+_47100863 5.73 ENSDART00000114811
arhgef16
Rho guanine nucleotide exchange factor (GEF) 16
chr2_+_2470687 5.70 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr5_-_34964830 5.61 ENSDART00000133170
arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr10_-_44008241 5.55 ENSDART00000137686
acads
acyl-CoA dehydrogenase short chain
chr20_+_53577502 5.55 ENSDART00000126983
myh6
myosin, heavy chain 6, cardiac muscle, alpha
chr15_+_6459847 5.55 ENSDART00000157250
ENSDART00000065824
bace2
beta-site APP-cleaving enzyme 2
chr22_-_23706771 5.53 ENSDART00000159771
cfhl1
complement factor H like 1
chr16_-_17699111 5.51 ENSDART00000108581
si:dkey-17m8.1
si:dkey-17m8.1
chr2_+_55984788 5.46 ENSDART00000183599
nmrk2
nicotinamide riboside kinase 2
chr23_-_11130683 5.45 ENSDART00000181189
cntn3a.2
contactin 3a, tandem duplicate 2
chr10_-_1726148 5.45 ENSDART00000187527
gal3st1b
galactose-3-O-sulfotransferase 1b
chr6_-_40581376 5.40 ENSDART00000185412
tspo
translocator protein
chr3_-_44059902 5.33 ENSDART00000158485
ENSDART00000159088
ENSDART00000165628
il4r.1
interleukin 4 receptor, tandem duplicate 1
chr20_-_1378514 5.29 ENSDART00000181830
scara5
scavenger receptor class A, member 5 (putative)
chr17_+_5985933 5.25 ENSDART00000190844
zgc:194275
zgc:194275
chr16_+_40560622 5.16 ENSDART00000038294
tp53inp1
tumor protein p53 inducible nuclear protein 1
chr24_-_23675446 5.14 ENSDART00000066644
hnf4g
hepatocyte nuclear factor 4, gamma
chr11_-_1400507 5.12 ENSDART00000173029
ENSDART00000172953
ENSDART00000111140
rpl29
ribosomal protein L29
chr19_+_31585917 5.05 ENSDART00000132182
gmnn
geminin, DNA replication inhibitor
chr11_-_40504170 4.95 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr8_+_53064920 4.89 ENSDART00000164823
nadka
NAD kinase a
chr1_+_44395976 4.88 ENSDART00000159686
ENSDART00000189905
ENSDART00000025145
unc93b1
unc-93 homolog B1, TLR signaling regulator
chr2_-_2957970 4.87 ENSDART00000162505
si:ch1073-82l19.1
si:ch1073-82l19.1
chr19_+_31585341 4.86 ENSDART00000052185
gmnn
geminin, DNA replication inhibitor
chr17_+_30591287 4.84 ENSDART00000154243
si:dkey-190l8.2
si:dkey-190l8.2
chr3_+_22335030 4.82 ENSDART00000055676
zgc:103564
zgc:103564
chr12_+_10631266 4.79 ENSDART00000161455
csf3a
colony stimulating factor 3 (granulocyte) a
chr12_-_49151326 4.71 ENSDART00000153244
bub3
BUB3 mitotic checkpoint protein
chr2_-_21438492 4.64 ENSDART00000046098
plcd1b
phospholipase C, delta 1b
chr18_-_20458840 4.40 ENSDART00000177125
kif23
kinesin family member 23
chr3_-_36708503 4.38 ENSDART00000166896
myh11b
myosin, heavy chain 11b, smooth muscle
chr7_-_16194952 4.33 ENSDART00000173739
btr04
bloodthirsty-related gene family, member 4
chr7_-_16195144 4.32 ENSDART00000173492
btr04
bloodthirsty-related gene family, member 4
chr1_-_9641845 4.30 ENSDART00000121490
ENSDART00000159411
ugt5b2
ugt5b3
UDP glucuronosyltransferase 5 family, polypeptide B2
UDP glucuronosyltransferase 5 family, polypeptide B3
chr10_-_1725699 4.30 ENSDART00000183555
gal3st1b
galactose-3-O-sulfotransferase 1b
chr1_+_7540978 4.25 ENSDART00000147770
mylz3
myosin, light polypeptide 3, skeletal muscle
chr15_-_34892664 4.24 ENSDART00000153787
ENSDART00000099721
rnf183
ring finger protein 183
chr3_-_34054081 4.22 ENSDART00000151590
ighv1-2
immunoglobulin heavy variable 1-2
chr3_+_39540014 4.21 ENSDART00000074848
zgc:165423
zgc:165423
chr18_+_5454341 4.21 ENSDART00000192649
dtwd1
DTW domain containing 1
chr19_+_31044487 4.14 ENSDART00000143494
ankmy2b
ankyrin repeat and MYND domain containing 2b
chr4_+_76705830 4.10 ENSDART00000064312
ms4a17a.7
membrane-spanning 4-domains, subfamily A, member 17A.7
chr21_+_5635420 4.08 ENSDART00000168158
shroom3
shroom family member 3
chr21_-_22474362 4.07 ENSDART00000169659
myo5b
myosin VB
chr7_+_17443567 3.99 ENSDART00000060383
nitr2b
novel immune-type receptor 2b
chr17_-_25382367 3.97 ENSDART00000162306
ENSDART00000165282
lck
LCK proto-oncogene, Src family tyrosine kinase
chr8_+_30664077 3.95 ENSDART00000138750
adora2aa
adenosine A2a receptor a
chr22_+_19366866 3.93 ENSDART00000137301
si:dkey-21e2.12
si:dkey-21e2.12
chr7_-_69121896 3.87 ENSDART00000130227
crispld2
cysteine-rich secretory protein LCCL domain containing 2
chr23_+_41679586 3.81 ENSDART00000067662
CU914487.1

chr6_+_11990733 3.81 ENSDART00000151075
baz2ba
bromodomain adjacent to zinc finger domain, 2Ba
chr2_+_49713592 3.78 ENSDART00000189624
BX323861.3

chr3_-_23512285 3.74 ENSDART00000159151
BX682558.1

chr13_+_8693410 3.73 ENSDART00000138448
ttc7a
tetratricopeptide repeat domain 7A
chr24_-_9979342 3.72 ENSDART00000138576
ENSDART00000191206
zgc:171977
zgc:171977
chr9_+_48088031 3.71 ENSDART00000073870
si:ch73-54b5.2
si:ch73-54b5.2
chr20_-_33512275 3.71 ENSDART00000185959
paplnb
papilin b, proteoglycan-like sulfated glycoprotein
chr16_+_54829574 3.69 ENSDART00000148392
pabpc1a
poly(A) binding protein, cytoplasmic 1a
chr19_-_47276297 3.67 ENSDART00000141437
sdc2
syndecan 2
chr11_-_12233 3.61 ENSDART00000173352
ENSDART00000173009
ENSDART00000102293
myg1
melanocyte proliferating gene 1
chr14_+_48862987 3.59 ENSDART00000167810
zgc:154054
zgc:154054
chr18_+_35130416 3.52 ENSDART00000151595
si:ch211-195m9.3
si:ch211-195m9.3
chr6_-_40657653 3.52 ENSDART00000154359
ppil1
peptidylprolyl isomerase (cyclophilin)-like 1
chr8_-_51578926 3.46 ENSDART00000190625
ankrd39
ankyrin repeat domain 39
chr21_+_23108420 3.41 ENSDART00000192394
ENSDART00000088459
htr3b
5-hydroxytryptamine (serotonin) receptor 3B
chr8_+_20140321 3.39 ENSDART00000012120
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr21_+_33459524 3.39 ENSDART00000053205
cd74b
CD74 molecule, major histocompatibility complex, class II invariant chain b
chr10_+_38610741 3.38 ENSDART00000126444
mmp13a
matrix metallopeptidase 13a
chr8_+_43852743 3.28 ENSDART00000186485
AL808129.2

chr17_+_6563307 3.28 ENSDART00000156454
adgrf3a
adhesion G protein-coupled receptor F3a
chr22_-_17611742 3.19 ENSDART00000144031
gpx4a
glutathione peroxidase 4a
chr8_-_45728620 3.18 ENSDART00000188795
BX088696.1

chr21_-_26558268 3.17 ENSDART00000065390
CR631122.1

chr10_-_26202766 3.14 ENSDART00000136393
fhdc3
FH2 domain containing 3
chr19_+_823945 3.13 ENSDART00000142287
ppp1r18
protein phosphatase 1, regulatory subunit 18
chr24_-_12958668 3.12 ENSDART00000178982
FITM1 (1 of many)
Danio rerio fat storage inducing transmembrane protein 1 (LOC792443), mRNA.
chr9_-_34986827 3.12 ENSDART00000137862
si:ch211-160b11.4
si:ch211-160b11.4
chr24_-_29868151 3.10 ENSDART00000184802
aglb
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase b
chr16_+_11834516 3.09 ENSDART00000146611
cxcr3.3
chemokine (C-X-C motif) receptor 3, tandem duplicate 3
chr8_-_22273819 3.06 ENSDART00000121513
nphp4
nephronophthisis 4
chr9_+_22657221 3.05 ENSDART00000101765
si:dkey-189g17.2
si:dkey-189g17.2
chr4_+_76509294 3.04 ENSDART00000099899
ms4a17a.17
membrane-spanning 4-domains, subfamily A, member 17A.17
chr5_-_61624693 2.98 ENSDART00000141323
si:dkey-261j4.4
si:dkey-261j4.4
chr2_-_37743834 2.97 ENSDART00000088040
ENSDART00000191057
myo9b
myosin IXb
chr22_+_19218733 2.96 ENSDART00000183212
ENSDART00000133595
si:dkey-21e2.7
si:dkey-21e2.7
chr12_+_3723650 2.91 ENSDART00000179922
ENSDART00000152482
ENSDART00000108771
pagr1
PAXIP1 associated glutamate-rich protein 1
chr19_-_33370271 2.90 ENSDART00000132628
nkd3l
naked cuticle homolog 3, like
chr5_-_67799617 2.90 ENSDART00000192117
eif4e1b
eukaryotic translation initiation factor 4E family member 1B
chr10_-_26196383 2.89 ENSDART00000192925
fhdc3
FH2 domain containing 3
chr13_-_21660203 2.88 ENSDART00000100925
mxtx1
mix-type homeobox gene 1
chr18_-_502722 2.87 ENSDART00000185757
sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
chr2_-_24061575 2.87 ENSDART00000089234
slc12a7a
solute carrier family 12 (potassium/chloride transporter), member 7a
chr3_-_31254379 2.86 ENSDART00000189376
apnl
actinoporin-like protein
chr12_-_20665164 2.85 ENSDART00000105352
gip
gastric inhibitory polypeptide
chr6_+_4160579 2.84 ENSDART00000105278
ENSDART00000187932
ENSDART00000111817
trim25l
tripartite motif containing 25, like
chr7_+_2849020 2.83 ENSDART00000168695
BX004857.1

chr7_+_53199763 2.83 ENSDART00000160097
cdh28
cadherin 28
chr15_-_23814330 2.81 ENSDART00000153843
si:ch211-167j9.5
si:ch211-167j9.5
chr10_+_29259882 2.81 ENSDART00000180606
sytl2a
synaptotagmin-like 2a
chr18_+_33009828 2.80 ENSDART00000160100
olfcj1
olfactory receptor C family, j1
chr14_-_29858883 2.79 ENSDART00000141034
sorbs2b
sorbin and SH3 domain containing 2b
chr1_-_11372456 2.73 ENSDART00000144164
ENSDART00000141238
sdk1b
sidekick cell adhesion molecule 1b
chr20_+_53522059 2.73 ENSDART00000147570
pak6b
p21 protein (Cdc42/Rac)-activated kinase 6b
chr11_+_42474694 2.73 ENSDART00000056048
ENSDART00000184710
si:ch1073-165f9.2
si:ch1073-165f9.2
chr18_+_33132266 2.72 ENSDART00000151623
si:ch211-229c8.14
si:ch211-229c8.14
chr13_+_15190677 2.71 ENSDART00000142240
ENSDART00000129045
mavs
mitochondrial antiviral signaling protein
chr12_-_2993095 2.71 ENSDART00000152316
si:dkey-202c14.3
si:dkey-202c14.3
chr3_+_49043917 2.69 ENSDART00000158212
zgc:92161
zgc:92161
chr13_-_18548729 2.65 ENSDART00000187686
BX908770.1

chr8_+_3530761 2.64 ENSDART00000081272
gcn1
GCN1 eIF2 alpha kinase activator homolog
chr5_-_11809404 2.62 ENSDART00000132564
nf2a
neurofibromin 2a (merlin)
chr20_+_3934516 2.62 ENSDART00000165732
clec11a
C-type lectin domain containing 11A
chr16_-_42004544 2.62 ENSDART00000034544
caspa
caspase a
chr14_+_16151636 2.56 ENSDART00000159352
polr1a
polymerase (RNA) I polypeptide A
chr19_-_3781405 2.56 ENSDART00000170609
btr19
bloodthirsty-related gene family, member 19
chr5_+_36439405 2.54 ENSDART00000102973
eda
ectodysplasin A
chr3_-_55147731 2.50 ENSDART00000155871
ENSDART00000109016
ENSDART00000122904
hbae3
hemoglobin alpha embryonic-3
chr4_+_74929427 2.45 ENSDART00000174082
nup50
nucleoporin 50
chr22_-_23000815 2.44 ENSDART00000137111
ptprc
protein tyrosine phosphatase, receptor type, C
chr12_-_33359052 2.43 ENSDART00000135943
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr12_+_45677293 2.42 ENSDART00000152850
ENSDART00000153047
si:ch73-111m19.2
si:ch73-111m19.2
chr21_+_40287100 2.41 ENSDART00000032154
or115-5
odorant receptor, family F, subfamily 115, member 5
chr9_+_20519846 2.41 ENSDART00000109680
ENSDART00000142220
vtcn1
V-set domain containing T cell activation inhibitor 1
chr7_+_65261576 2.40 ENSDART00000169566
bco1
beta-carotene oxygenase 1
chr8_+_471342 2.40 ENSDART00000167205
nudt12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr14_-_29859067 2.40 ENSDART00000136380
sorbs2b
sorbin and SH3 domain containing 2b
chr16_+_16529748 2.38 ENSDART00000029579
ccdc12
coiled-coil domain containing 12
chr22_-_36770649 2.34 ENSDART00000169442
acy1
aminoacylase 1
chr2_+_2503396 2.34 ENSDART00000168418
crhr2
corticotropin releasing hormone receptor 2
chr23_+_43950674 2.33 ENSDART00000167813
corin
corin, serine peptidase
chr8_+_26254903 2.32 ENSDART00000113763
slc26a6
solute carrier family 26, member 6
chr25_+_25085349 2.32 ENSDART00000192166
si:ch73-182e20.4
si:ch73-182e20.4
chr22_+_19407531 2.32 ENSDART00000141060
si:dkey-78l4.2
si:dkey-78l4.2
chr6_-_43780751 2.32 ENSDART00000188257
foxp1b
forkhead box P1b
chr19_+_45962016 2.30 ENSDART00000169710
utp23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr1_-_58505626 2.30 ENSDART00000171304
si:ch73-236c18.8
si:ch73-236c18.8
chr18_-_44331041 2.28 ENSDART00000168619
prdm10
PR domain containing 10
chr14_-_36320506 2.28 ENSDART00000074639
egf
epidermal growth factor
chr21_+_43404945 2.28 ENSDART00000142234
frmd7
FERM domain containing 7
chr24_-_7587401 2.27 ENSDART00000093163
galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr18_-_21170264 2.27 ENSDART00000175265
BX571884.1

chr17_+_17861681 2.27 ENSDART00000123311
ism2a
isthmin 2a
chr2_-_43191465 2.25 ENSDART00000025254
crema
cAMP responsive element modulator a
chr20_+_46371458 2.24 ENSDART00000152912
adgrg11
adhesion G protein-coupled receptor G11
chr5_-_26893310 2.24 ENSDART00000126669
lman2lb
lectin, mannose-binding 2-like b
chr7_-_15257120 2.24 ENSDART00000173048
ENSDART00000190735
si:dkey-172h23.2
si:dkey-172h23.2
chr13_+_40635844 2.20 ENSDART00000137310
hpse2
heparanase 2
chr1_+_54037077 2.20 ENSDART00000109386
triobpa
TRIO and F-actin binding protein a
chr8_+_23439340 2.19 ENSDART00000109932
ENSDART00000185469
foxp3b
forkhead box P3b
chr13_-_226109 2.19 ENSDART00000161705
ENSDART00000172744
ENSDART00000163902
ENSDART00000158208
rtn4b
reticulon 4b
chr25_+_16356083 2.19 ENSDART00000125925
ENSDART00000125444
tead1a
TEA domain family member 1a
chr14_+_23709134 2.19 ENSDART00000191162
ENSDART00000179754
ENSDART00000054266
gnpda1
glucosamine-6-phosphate deaminase 1
chr16_+_32152612 2.18 ENSDART00000008880
gprc6a
G protein-coupled receptor, class C, group 6, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of hmbox1a+zgc:91944

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0048785 hatching gland development(GO:0048785)
2.7 13.5 GO:0003210 cardiac atrium formation(GO:0003210)
2.2 6.6 GO:1900364 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)
1.8 7.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.7 6.8 GO:0006750 glutathione biosynthetic process(GO:0006750)
1.6 4.9 GO:0034154 toll-like receptor 3 signaling pathway(GO:0034138) toll-like receptor 7 signaling pathway(GO:0034154)
1.4 9.7 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
1.4 5.6 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
1.4 6.8 GO:0019482 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
1.3 5.3 GO:0002532 production of molecular mediator involved in inflammatory response(GO:0002532)
1.2 3.7 GO:0097435 fibril organization(GO:0097435)
1.2 5.9 GO:0090646 mitochondrial tRNA processing(GO:0090646)
1.1 3.4 GO:0010934 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081) myeloid leukocyte cytokine production(GO:0061082) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
1.1 3.2 GO:0019364 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
1.0 8.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.0 4.1 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.9 5.6 GO:0055014 atrial cardiac muscle cell development(GO:0055014)
0.9 3.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.9 3.5 GO:1904353 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.8 5.3 GO:0070207 protein homotrimerization(GO:0070207)
0.7 2.2 GO:0006041 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.7 2.9 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.7 4.9 GO:0006741 NADP biosynthetic process(GO:0006741)
0.7 6.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.7 3.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.7 9.9 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.6 5.8 GO:0034434 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.6 4.4 GO:0040016 embryonic cleavage(GO:0040016)
0.6 9.3 GO:0009086 methionine biosynthetic process(GO:0009086)
0.6 3.0 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.6 9.5 GO:0001952 regulation of cell-matrix adhesion(GO:0001952)
0.5 2.2 GO:0021557 oculomotor nerve development(GO:0021557)
0.5 2.7 GO:0098586 cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) cellular response to virus(GO:0098586)
0.5 5.6 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.5 11.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.5 7.7 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.5 2.9 GO:0051883 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.5 1.9 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.5 1.4 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.4 1.7 GO:0071632 optomotor response(GO:0071632)
0.4 5.8 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.4 0.8 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.4 2.3 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.4 8.2 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.4 2.9 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.3 8.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 3.1 GO:0042214 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.3 1.7 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.3 2.3 GO:0006203 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.3 4.8 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.3 1.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3 0.5 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839) myoblast migration(GO:0051451)
0.3 3.9 GO:0060325 face morphogenesis(GO:0060325)
0.3 5.5 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.2 9.7 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.2 1.2 GO:0046639 negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T cell differentiation(GO:0045581) regulation of T-helper cell differentiation(GO:0045622) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of alpha-beta T cell differentiation(GO:0046639) regulation of T-helper 17 type immune response(GO:2000316) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) regulation of T-helper 17 cell lineage commitment(GO:2000328) negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.2 1.4 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 4.4 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.2 3.1 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.2 6.8 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.2 4.7 GO:0045841 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) negative regulation of mitotic metaphase/anaphase transition(GO:0045841) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.2 5.5 GO:0070593 dendrite self-avoidance(GO:0070593)
0.2 2.2 GO:0007608 sensory perception of smell(GO:0007608)
0.2 2.6 GO:0009303 rRNA transcription(GO:0009303)
0.2 9.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.2 0.9 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.2 1.2 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.2 1.7 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.2 1.9 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.2 0.5 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.2 4.1 GO:0001843 neural tube closure(GO:0001843)
0.2 0.8 GO:0039703 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.2 1.3 GO:1990845 adaptive thermogenesis(GO:1990845)
0.2 3.4 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.2 3.4 GO:0048246 macrophage chemotaxis(GO:0048246)
0.2 2.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 1.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 1.5 GO:0034394 protein localization to cell surface(GO:0034394)
0.1 1.7 GO:0007172 signal complex assembly(GO:0007172)
0.1 2.1 GO:0014823 response to activity(GO:0014823)
0.1 0.5 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.1 0.4 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1 23.0 GO:0006936 muscle contraction(GO:0006936)
0.1 2.5 GO:0015671 oxygen transport(GO:0015671)
0.1 8.1 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.1 3.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.5 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.1 0.4 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.1 1.3 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.0 GO:0035065 regulation of histone acetylation(GO:0035065)
0.1 7.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.7 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.1 7.1 GO:0006400 tRNA modification(GO:0006400)
0.1 2.5 GO:0042476 odontogenesis(GO:0042476)
0.1 2.6 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.1 2.2 GO:0001757 somite specification(GO:0001757)
0.1 0.9 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.1 2.5 GO:0035329 hippo signaling(GO:0035329)
0.1 1.7 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.2 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 5.2 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.1 0.6 GO:0071385 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.1 5.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 4.6 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 1.5 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 3.0 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 4.3 GO:0006694 steroid biosynthetic process(GO:0006694)
0.1 2.4 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.1 4.2 GO:0006413 translational initiation(GO:0006413)
0.0 4.9 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.3 GO:0006517 protein deglycosylation(GO:0006517)
0.0 1.0 GO:0006298 mismatch repair(GO:0006298)
0.0 2.7 GO:0010842 retina layer formation(GO:0010842)
0.0 9.4 GO:0006914 autophagy(GO:0006914)
0.0 0.5 GO:0045022 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.3 GO:0044211 CTP salvage(GO:0044211)
0.0 2.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 2.0 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 2.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 3.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.4 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.1 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 7.4 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 2.7 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 0.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 2.3 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.0 0.6 GO:0016233 telomere capping(GO:0016233)
0.0 0.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 3.8 GO:0006364 rRNA processing(GO:0006364)
0.0 0.5 GO:0006265 DNA topological change(GO:0006265)
0.0 0.5 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 4.8 GO:0007601 visual perception(GO:0007601)
0.0 5.3 GO:0045087 innate immune response(GO:0045087)
0.0 9.4 GO:0016567 protein ubiquitination(GO:0016567)
0.0 2.5 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.6 GO:0032392 DNA geometric change(GO:0032392) DNA duplex unwinding(GO:0032508)
0.0 0.2 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 1.8 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.0 1.1 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 19.7 GO:0006508 proteolysis(GO:0006508)
0.0 4.0 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 2.3 GO:0051216 cartilage development(GO:0051216)
0.0 2.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 1.6 GO:0006260 DNA replication(GO:0006260)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0005577 fibrinogen complex(GO:0005577)
1.1 6.6 GO:0070062 extracellular exosome(GO:0070062)
1.1 23.0 GO:0031430 M band(GO:0031430)
1.0 2.9 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.7 5.9 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.7 4.2 GO:0005845 mRNA cap binding complex(GO:0005845)
0.7 2.6 GO:0061702 inflammasome complex(GO:0061702)
0.6 8.2 GO:0000815 ESCRT III complex(GO:0000815)
0.5 24.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 4.7 GO:0045171 intercellular bridge(GO:0045171)
0.4 1.7 GO:0017177 glucosidase II complex(GO:0017177)
0.4 3.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 4.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.3 1.0 GO:0030689 Noc complex(GO:0030689)
0.3 9.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 0.8 GO:0032301 MutSalpha complex(GO:0032301)
0.2 6.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 2.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 2.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.2 2.4 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.2 2.9 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 0.5 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 5.6 GO:0016605 PML body(GO:0016605)
0.1 1.0 GO:0032300 mismatch repair complex(GO:0032300)
0.1 17.0 GO:0016459 myosin complex(GO:0016459)
0.1 7.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 4.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.9 GO:0032040 small-subunit processome(GO:0032040)
0.1 3.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 13.0 GO:0005925 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.1 3.4 GO:0035869 ciliary transition zone(GO:0035869)
0.1 4.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.3 GO:0044545 NSL complex(GO:0044545)
0.1 5.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.5 GO:0070695 FHF complex(GO:0070695)
0.1 0.6 GO:0030914 STAGA complex(GO:0030914)
0.1 4.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 8.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 6.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 4.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.8 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0070847 core mediator complex(GO:0070847)
0.0 10.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 4.5 GO:0000776 kinetochore(GO:0000776)
0.0 18.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 5.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.4 GO:0005643 nuclear pore(GO:0005643)
0.0 0.6 GO:0070187 telosome(GO:0070187)
0.0 1.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 2.8 GO:0009986 cell surface(GO:0009986)
0.0 0.9 GO:0005839 proteasome core complex(GO:0005839)
0.0 3.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.8 GO:0043596 nuclear replication fork(GO:0043596)
0.0 10.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 5.2 GO:0005764 lysosome(GO:0005764)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 39.2 GO:0005576 extracellular region(GO:0005576)
0.0 1.1 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.5 GO:0045495 pole plasm(GO:0045495)
0.0 1.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 17.7 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
2.5 7.4 GO:0047760 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
1.9 7.7 GO:0005153 interleukin-8 receptor binding(GO:0005153)
1.5 5.9 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
1.4 5.8 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
1.4 6.8 GO:0043295 glutathione binding(GO:0043295)
1.2 13.5 GO:0032036 myosin heavy chain binding(GO:0032036)
1.1 5.5 GO:0008432 JUN kinase binding(GO:0008432)
1.1 9.7 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.9 6.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.9 9.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.8 3.1 GO:0004133 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.7 2.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.6 3.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.6 3.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.6 2.9 GO:0031769 glucagon receptor binding(GO:0031769)
0.5 3.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.5 4.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.5 2.9 GO:0030331 estrogen receptor binding(GO:0030331)
0.4 2.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 1.7 GO:0001596 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.4 3.4 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.4 6.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.4 1.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.4 1.6 GO:0034511 U3 snoRNA binding(GO:0034511)
0.4 9.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.4 2.3 GO:0008832 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.4 6.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4 2.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.3 17.5 GO:0019843 rRNA binding(GO:0019843)
0.3 3.1 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.3 2.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.3 3.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.3 2.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.3 1.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.3 5.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 0.8 GO:0032137 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.3 3.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 4.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.3 3.4 GO:0016405 CoA-ligase activity(GO:0016405)
0.2 1.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.2 5.8 GO:0004623 phospholipase A2 activity(GO:0004623)
0.2 1.5 GO:0031779 melanocortin receptor binding(GO:0031779)
0.2 1.7 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 2.3 GO:0004046 aminoacylase activity(GO:0004046)
0.2 2.5 GO:0031720 haptoglobin binding(GO:0031720)
0.2 2.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 2.6 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.2 1.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 2.2 GO:0005537 mannose binding(GO:0005537)
0.2 1.9 GO:0005000 vasopressin receptor activity(GO:0005000)
0.2 2.5 GO:0005123 death receptor binding(GO:0005123)
0.2 5.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 3.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 1.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 1.2 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.2 0.5 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 1.3 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 4.9 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 29.3 GO:0019900 kinase binding(GO:0019900)
0.1 8.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 4.6 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 7.0 GO:0000146 microfilament motor activity(GO:0000146)
0.1 10.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 2.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 24.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 5.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 2.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 8.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 5.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 16.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 5.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 1.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 2.3 GO:0017046 peptide hormone binding(GO:0017046)
0.1 2.6 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 1.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 2.3 GO:0005112 Notch binding(GO:0005112)
0.1 3.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 4.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 5.3 GO:0019955 cytokine binding(GO:0019955)
0.1 4.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.2 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 1.0 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.3 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 11.9 GO:0003774 motor activity(GO:0003774)
0.1 4.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 1.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 21.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 7.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 4.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 3.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 7.0 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 4.9 GO:0008083 growth factor activity(GO:0008083)
0.0 2.8 GO:0045296 cadherin binding(GO:0045296)
0.0 1.8 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.1 GO:0008905 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.0 2.2 GO:0016597 amino acid binding(GO:0016597)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 2.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 16.3 GO:0005102 receptor binding(GO:0005102)
0.0 2.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 5.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 2.2 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 2.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.8 ST JAK STAT PATHWAY Jak-STAT Pathway
0.6 9.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 3.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 8.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 12.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 6.2 PID AURORA B PATHWAY Aurora B signaling
0.2 6.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 5.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 7.9 PID P73PATHWAY p73 transcription factor network
0.1 2.4 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 1.6 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 2.1 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.8 PID FGF PATHWAY FGF signaling pathway
0.1 8.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 3.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID MYC PATHWAY C-MYC pathway
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.8 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
1.3 16.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.3 4.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.2 8.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.9 6.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.7 13.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.6 2.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.6 6.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.6 9.9 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.5 24.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.5 6.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.5 9.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 1.6 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.4 5.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 8.2 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 5.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.3 6.2 REACTOME KINESINS Genes involved in Kinesins
0.3 2.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 2.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 5.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.7 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 1.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 3.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 2.3 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.2 2.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 3.3 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 1.8 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.7 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 2.6 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 4.1 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 3.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.8 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.1 3.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 5.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 6.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.8 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 3.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.0 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 2.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 1.3 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.