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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for hmx4
Z-value: 1.36
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Transcription factors associated with hmx4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hmx4 | dr11_v1_chr1_-_40911332_40911332 | 0.14 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_14234076 Show fit | 13.06 |
ENSDART00000040049
|
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2 |
|
| chr13_+_22659153 Show fit | 11.57 |
ENSDART00000143906
ENSDART00000140472 ENSDART00000078877 ENSDART00000182469 |
synuclein, gamma a |
|
| chr1_-_14233815 Show fit | 11.34 |
ENSDART00000044896
|
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2 |
|
| chr20_-_29418620 Show fit | 10.81 |
ENSDART00000172634
|
ryanodine receptor 3 |
|
| chr2_-_21352101 Show fit | 10.71 |
ENSDART00000057021
|
hedgehog acyltransferase like, a |
|
| chr20_-_29420713 Show fit | 10.27 |
ENSDART00000147464
|
ryanodine receptor 3 |
|
| chr19_+_233143 Show fit | 10.04 |
ENSDART00000175273
|
synaptic Ras GTPase activating protein 1a |
|
| chr18_+_5549672 Show fit | 9.28 |
ENSDART00000184970
|
nicotinamide nucleotide transhydrogenase 2 |
|
| chr2_-_49978227 Show fit | 7.77 |
ENSDART00000142835
|
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b |
|
| chr1_-_25911292 Show fit | 7.74 |
ENSDART00000145012
|
ubiquitin specific peptidase 53b |
Network of associatons between targets according to the STRING database.
First level regulatory network of hmx4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 21.1 | GO:0051209 | release of sequestered calcium ion into cytosol(GO:0051209) |
| 3.6 | 10.7 | GO:0050748 | N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060) |
| 0.2 | 10.4 | GO:1901214 | regulation of neuron death(GO:1901214) |
| 0.1 | 9.7 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 9.7 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.2 | 9.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 2.3 | 9.3 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 0.2 | 8.2 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.2 | 7.9 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 1.0 | 7.8 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.8 | GO:0043005 | neuron projection(GO:0043005) |
| 0.5 | 21.3 | GO:0043679 | axon terminus(GO:0043679) |
| 3.0 | 21.1 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 14.8 | GO:0045202 | synapse(GO:0045202) |
| 0.1 | 14.1 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.2 | 10.5 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 10.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 9.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 7.9 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 7.8 | GO:0034703 | cation channel complex(GO:0034703) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 24.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 4.2 | 21.1 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763) |
| 0.1 | 20.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 18.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 15.8 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 13.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 3.9 | 11.6 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.0 | 11.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.8 | 10.8 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 9.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.2 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 4.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 3.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 3.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 3.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 2.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 2.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.1 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 5.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.4 | 5.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.5 | 4.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.3 | 4.3 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.2 | 4.1 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.2 | 3.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 3.6 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 3.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |