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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for hnf1a
Z-value: 5.58
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Transcription factors associated with hnf1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf1a | dr11_v1_chr8_+_39802506_39802506 | 0.79 | 1.8e-21 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_23625351 Show fit | 217.40 |
ENSDART00000192588
ENSDART00000163423 |
complement factor H like 4 |
|
| chr1_+_10051763 Show fit | 206.15 |
ENSDART00000011701
|
fibrinogen beta chain |
|
| chr5_+_32345187 Show fit | 176.04 |
ENSDART00000147132
|
complement component 9 |
|
| chr5_+_28830643 Show fit | 153.92 |
ENSDART00000051448
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 |
|
| chr5_+_45677781 Show fit | 151.59 |
ENSDART00000163120
ENSDART00000126537 |
group-specific component (vitamin D binding protein) |
|
| chr5_+_28830388 Show fit | 142.20 |
ENSDART00000149150
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 |
|
| chr22_-_24757785 Show fit | 140.44 |
ENSDART00000078225
|
vitellogenin 5 |
|
| chr9_-_9982696 Show fit | 138.09 |
ENSDART00000192548
ENSDART00000125852 |
UDP glucuronosyltransferase 1 family a, b |
|
| chr5_+_28848870 Show fit | 137.09 |
ENSDART00000149563
|
zgc:174259 |
|
| chr5_+_28849155 Show fit | 133.52 |
ENSDART00000079090
|
zgc:174259 |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 1038.3 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 14.5 | 566.3 | GO:0032355 | response to estradiol(GO:0032355) |
| 15.0 | 209.9 | GO:0016556 | mRNA modification(GO:0016556) |
| 7.9 | 206.7 | GO:0051180 | vitamin transport(GO:0051180) |
| 13.7 | 206.2 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 3.2 | 194.6 | GO:0007596 | blood coagulation(GO:0007596) |
| 58.7 | 176.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.4 | 149.7 | GO:0009410 | response to xenobiotic stimulus(GO:0009410) |
| 19.3 | 134.9 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 1.1 | 129.9 | GO:0006979 | response to oxidative stress(GO:0006979) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 1489.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 708.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.3 | 264.5 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 68.7 | 206.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 58.7 | 176.0 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.2 | 128.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.6 | 109.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.8 | 105.0 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.2 | 104.5 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 89.1 | GO:0005829 | cytosol(GO:0005829) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 1038.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 79.1 | 553.4 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 6.2 | 361.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 1.1 | 254.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 3.0 | 209.9 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 50.5 | 151.6 | GO:0005499 | vitamin D binding(GO:0005499) |
| 6.7 | 146.6 | GO:0010181 | FMN binding(GO:0010181) |
| 27.7 | 138.3 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
| 0.9 | 120.7 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) |
| 33.9 | 101.7 | GO:0047291 | lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 309.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 12.1 | 206.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 4.3 | 129.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 3.1 | 109.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 2.6 | 91.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 4.6 | 91.2 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 3.4 | 72.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.9 | 58.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 55.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 2.8 | 38.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.2 | 279.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 18.7 | 206.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 1.0 | 183.2 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 1.1 | 156.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 5.3 | 149.6 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 6.8 | 130.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 1.7 | 129.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 31.2 | 124.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.7 | 109.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 8.3 | 82.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |