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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hnf1ba+hnf1bb

Z-value: 5.50

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Transcription factors associated with hnf1ba+hnf1bb

Gene Symbol Gene ID Gene Info
hnf1ba
ENSDARG00000006615 HNF1 homeobox Ba
hnf1bb
ENSDARG00000022295 HNF1 homeobox Bb
hnf1ba
ENSDARG00000115522 HNF1 homeobox Ba

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf1bbdr11_v1_chr21_+_38817785_388178430.867.1e-29Click!
hnf1badr11_v1_chr15_-_16012963_160129630.835.1e-25Click!

Activity profile of hnf1ba+hnf1bb motif

Sorted Z-values of hnf1ba+hnf1bb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_10051763 199.00 ENSDART00000011701
fgb
fibrinogen beta chain
chr5_+_32345187 197.99 ENSDART00000147132
c9
complement component 9
chr20_-_40750953 168.28 ENSDART00000061256
cx28.9
connexin 28.9
chr20_+_23440632 155.92 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr22_-_23748284 148.80 ENSDART00000162005
cfhl2
complement factor H like 2
chr5_+_28830388 147.64 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr6_+_60055168 147.38 ENSDART00000008752
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_+_1486822 147.20 ENSDART00000132500
c8a
complement component 8, alpha polypeptide
chr2_+_1487118 146.41 ENSDART00000147283
c8a
complement component 8, alpha polypeptide
chr15_+_28202170 138.66 ENSDART00000077736
vtna
vitronectin a
chr5_+_45677781 137.25 ENSDART00000163120
ENSDART00000126537
gc
group-specific component (vitamin D binding protein)
chr5_+_28830643 134.57 ENSDART00000051448
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr2_-_41942666 130.62 ENSDART00000075673
ebi3
Epstein-Barr virus induced 3
chr20_-_40754794 129.88 ENSDART00000187251
cx32.3
connexin 32.3
chr20_+_10538025 129.74 ENSDART00000129762
serpina1l
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr22_-_23668356 128.29 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
cfh
complement factor H
chr22_-_23706771 123.20 ENSDART00000159771
cfhl1
complement factor H like 1
chr5_+_28848870 120.61 ENSDART00000149563
zgc:174259
zgc:174259
chr14_+_38654300 119.25 ENSDART00000148938
ENSDART00000150107
rnasel3
ribonuclease like 3
chr5_+_28849155 117.41 ENSDART00000079090
zgc:174259
zgc:174259
chr22_-_24880824 114.87 ENSDART00000061165
vtg2
vitellogenin 2
chr22_-_24738188 114.82 ENSDART00000050238
vtg1
vitellogenin 1
chr22_-_24791505 113.27 ENSDART00000136837
vtg4
vitellogenin 4
chr10_+_21867307 111.28 ENSDART00000126629
cbln17
cerebellin 17
chr2_-_5466708 105.94 ENSDART00000136682
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
chr3_-_16760923 105.74 ENSDART00000055855
aspdh
aspartate dehydrogenase domain containing
chr20_+_10544100 102.72 ENSDART00000113927
serpina1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr2_-_5475910 102.41 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
proca
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr13_+_23988442 99.51 ENSDART00000010918
agt
angiotensinogen
chr24_-_17039638 99.13 ENSDART00000048823
c8g
complement component 8, gamma polypeptide
chr21_+_38002879 96.32 ENSDART00000065183
cldn2
claudin 2
chr23_+_28770225 94.67 ENSDART00000132179
ENSDART00000142273
masp2
mannan-binding lectin serine peptidase 2
chr16_+_26777473 94.60 ENSDART00000188870
cdh17
cadherin 17, LI cadherin (liver-intestine)
chr23_+_25856541 93.62 ENSDART00000145426
ENSDART00000028236
hnf4a
hepatocyte nuclear factor 4, alpha
chr5_+_28858345 92.60 ENSDART00000111180
si:ch211-186e20.2
si:ch211-186e20.2
chr22_-_23781083 92.04 ENSDART00000166563
ENSDART00000170458
ENSDART00000166158
ENSDART00000171246
cfhl3
complement factor H like 3
chr16_-_22294265 89.53 ENSDART00000124718
aqp10a
aquaporin 10a
chr1_-_12126535 88.19 ENSDART00000164817
ENSDART00000015251
mttp
microsomal triglyceride transfer protein
chr12_-_6177894 82.72 ENSDART00000152292
a1cf
apobec1 complementation factor
chr10_+_25726694 82.07 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr20_-_40755614 81.84 ENSDART00000061247
cx32.3
connexin 32.3
chr22_-_24757785 81.62 ENSDART00000078225
vtg5
vitellogenin 5
chr22_-_24818066 77.02 ENSDART00000143443
vtg6
vitellogenin 6
chr23_+_26491931 76.03 ENSDART00000190124
ENSDART00000132905
si:ch73-206d17.1
si:ch73-206d17.1
chr5_-_42904329 70.66 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr8_+_30699429 70.42 ENSDART00000005345
upb1
ureidopropionase, beta
chr10_-_17159761 69.83 ENSDART00000080449
slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr6_+_10094061 69.31 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr11_-_37997419 69.01 ENSDART00000102870
slc41a1
solute carrier family 41 (magnesium transporter), member 1
chr5_-_12063381 68.27 ENSDART00000026749
nipsnap1
nipsnap homolog 1 (C. elegans)
chr7_-_4296771 66.66 ENSDART00000128855
cbln11
cerebellin 11
chr13_-_40726865 65.23 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr14_+_32430982 63.20 ENSDART00000017179
ENSDART00000123382
ENSDART00000075593
f9a
coagulation factor IXa
chr9_+_21151138 62.59 ENSDART00000133903
hao2
hydroxyacid oxidase 2 (long chain)
chr8_+_15254564 58.91 ENSDART00000024433
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr2_+_26647472 58.40 ENSDART00000145415
ENSDART00000157409
ttpa
tocopherol (alpha) transfer protein
chr22_+_16555939 58.03 ENSDART00000012604
pdzk1ip1
PDZK1 interacting protein 1
chr23_-_20345473 54.37 ENSDART00000140935
si:rp71-17i16.6
si:rp71-17i16.6
chr3_+_26734162 54.03 ENSDART00000114552
si:dkey-202l16.5
si:dkey-202l16.5
chr6_+_30456788 53.97 ENSDART00000121492
FP236735.1

chr2_-_127945 52.40 ENSDART00000056453
igfbp1b
insulin-like growth factor binding protein 1b
chr6_-_59563597 51.98 ENSDART00000166311
INHBE
inhibin beta E subunit
chr24_-_4765740 51.08 ENSDART00000121576
cpb1
carboxypeptidase B1 (tissue)
chr5_+_1877464 49.39 ENSDART00000050658
zgc:101699
zgc:101699
chr25_+_23280220 49.10 ENSDART00000153940
ptprjb.1
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr3_-_16250527 47.35 ENSDART00000146699
ENSDART00000141181
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr9_+_29994439 45.70 ENSDART00000012447
tmem30c
transmembrane protein 30C
chr8_-_53490376 45.61 ENSDART00000158789
chdh
choline dehydrogenase
chr12_-_3940768 44.86 ENSDART00000134292
zgc:92040
zgc:92040
chr7_-_35066457 43.08 ENSDART00000058067
zgc:112160
zgc:112160
chr2_-_43635777 41.58 ENSDART00000148633
itgb1b.1
integrin, beta 1b.1
chr25_-_37191929 40.21 ENSDART00000128108
urahb
urate (5-hydroxyiso-) hydrolase b
chr5_+_57480014 40.06 ENSDART00000135520
si:ch211-202f5.3
si:ch211-202f5.3
chr16_+_11623956 38.52 ENSDART00000137788
cxcr3.1
chemokine (C-X-C motif) receptor 3, tandem duplicate 1
chr7_-_29534001 38.31 ENSDART00000124028
anxa2b
annexin A2b
chr1_+_12178215 38.26 ENSDART00000090380
stra6l
STRA6-like
chr11_-_40647190 35.63 ENSDART00000173217
ENSDART00000173276
ENSDART00000147264
fam213b
family with sequence similarity 213, member B
chr20_-_25481306 32.58 ENSDART00000182495
si:dkey-183n20.15
si:dkey-183n20.15
chr4_+_18804317 30.99 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr21_+_39941184 29.39 ENSDART00000133604
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr6_+_41039166 28.89 ENSDART00000125659
entpd8
ectonucleoside triphosphate diphosphohydrolase 8
chr5_-_30620625 28.40 ENSDART00000098273
tcnl
transcobalamin like
chr4_-_56954002 26.23 ENSDART00000160934
si:dkey-269o24.1
si:dkey-269o24.1
chr11_-_45152912 26.13 ENSDART00000167540
ENSDART00000173050
ENSDART00000170795
afmid
arylformamidase
chr21_+_39941559 24.46 ENSDART00000189718
ENSDART00000160875
ENSDART00000135235
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr11_-_45152702 24.15 ENSDART00000168066
afmid
arylformamidase
chr22_+_21317597 23.26 ENSDART00000132605
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr8_+_17869225 22.12 ENSDART00000080079
slc44a5b
solute carrier family 44, member 5b
chr20_-_23440955 21.73 ENSDART00000153386
slc10a4
solute carrier family 10, member 4
chr16_-_42894628 21.55 ENSDART00000045600
hfe2
hemochromatosis type 2
chr4_-_12766418 21.49 ENSDART00000024312
dera
deoxyribose-phosphate aldolase (putative)
chr13_-_23666579 20.78 ENSDART00000192457
ENSDART00000179777
map3k21
mitogen-activated protein kinase kinase kinase 21
chr17_-_17948587 20.77 ENSDART00000090447
hhipl1
HHIP-like 1
chr9_-_8314028 20.38 ENSDART00000102739
si:ch211-145c1.1
si:ch211-145c1.1
chr6_-_43027828 19.93 ENSDART00000149637
glyctk
glycerate kinase
chr7_+_27317174 19.23 ENSDART00000193058
sox6
SRY (sex determining region Y)-box 6
chr5_+_37854685 18.92 ENSDART00000051222
ENSDART00000185283
ins
preproinsulin
chr23_+_27740788 18.80 ENSDART00000053871
dhh
desert hedgehog
chr5_+_44846434 18.12 ENSDART00000145299
ENSDART00000136521
kank1a
KN motif and ankyrin repeat domains 1a
chr14_+_2487672 17.70 ENSDART00000170629
ENSDART00000123063
fgf18a
fibroblast growth factor 18a
chr16_+_11603096 16.92 ENSDART00000146286
si:dkey-11o1.3
si:dkey-11o1.3
chr12_+_5209822 16.82 ENSDART00000152610
SLC35G1
si:ch211-197g18.2
chr6_-_43028270 16.55 ENSDART00000149092
ENSDART00000149559
glyctk
glycerate kinase
chr9_+_28232522 16.15 ENSDART00000031761
fzd5
frizzled class receptor 5
chr25_+_4091067 16.10 ENSDART00000104926
eps8l2
EPS8 like 2
chr9_+_30720048 14.55 ENSDART00000146115
klf12b
Kruppel-like factor 12b
chr4_+_7827261 13.92 ENSDART00000129568
phyh
phytanoyl-CoA 2-hydroxylase
chr17_-_50233493 13.32 ENSDART00000172266
fosaa
v-fos FBJ murine osteosarcoma viral oncogene homolog Aa
chr5_+_9428876 13.00 ENSDART00000081791
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr4_-_5317006 12.07 ENSDART00000150867
si:ch211-214j24.15
si:ch211-214j24.15
chr16_-_9675982 11.22 ENSDART00000113724
mal2
mal, T cell differentiation protein 2 (gene/pseudogene)
chr23_+_27740592 10.82 ENSDART00000137875
dhh
desert hedgehog
chr19_-_15229421 10.67 ENSDART00000055619
phactr4a
phosphatase and actin regulator 4a
chr2_+_17055069 10.24 ENSDART00000115078
thpo
thrombopoietin
chr10_+_25369859 10.13 ENSDART00000047541
bach1b
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr6_-_25180438 10.00 ENSDART00000159696
lrrc8db
leucine rich repeat containing 8 VRAC subunit Db
chr25_-_27541621 9.84 ENSDART00000130678
spam1
sperm adhesion molecule 1
chr23_-_29394505 9.70 ENSDART00000017728
pgd
phosphogluconate dehydrogenase
chr15_+_29283981 9.38 ENSDART00000099895
rap1gap2a
RAP1 GTPase activating protein 2a
chr23_+_33752275 8.25 ENSDART00000007260
si:ch211-210c8.6
si:ch211-210c8.6
chr20_-_42534504 8.20 ENSDART00000132310
rfx6
regulatory factor X, 6
chr25_-_3759322 7.61 ENSDART00000088077
zgc:158398
zgc:158398
chr10_+_25369254 7.60 ENSDART00000164375
bach1b
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr5_+_45921234 7.32 ENSDART00000134355
ankdd1b
ankyrin repeat and death domain containing 1B
chr8_+_23391263 7.12 ENSDART00000149687
si:dkey-16n15.6
si:dkey-16n15.6
chr10_-_41664427 7.02 ENSDART00000150213
ggt1b
gamma-glutamyltransferase 1b
chr13_+_43050562 6.76 ENSDART00000016602
cdh23
cadherin-related 23
chr5_+_45322734 6.73 ENSDART00000084411
adamts3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr22_+_17261801 5.87 ENSDART00000192978
ENSDART00000193187
ENSDART00000179953
ENSDART00000134798
tdrd5
tudor domain containing 5
chr4_-_32179699 5.55 ENSDART00000124106
ENSDART00000158835
si:dkey-72l17.6
si:dkey-72l17.6
chr6_-_29515709 5.36 ENSDART00000180205
pex5la
peroxisomal biogenesis factor 5-like a
chr18_+_13182528 5.34 ENSDART00000166298
zgc:56622
zgc:56622
chr6_+_54221654 5.23 ENSDART00000128456
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr2_+_35880600 5.13 ENSDART00000004277
lamc1
laminin, gamma 1
chr6_-_43283122 4.66 ENSDART00000186022
frmd4ba
FERM domain containing 4Ba
chr3_+_19446997 4.60 ENSDART00000079352
zgc:123297
zgc:123297
chr7_-_17412559 4.35 ENSDART00000163020
nitr3a
novel immune-type receptor 3a
chr22_-_26005894 3.99 ENSDART00000105088
pdgfaa
platelet-derived growth factor alpha polypeptide a
chr2_-_16216568 3.68 ENSDART00000173758
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr19_-_3876877 3.53 ENSDART00000163711
thrap3b
thyroid hormone receptor associated protein 3b
chr8_+_23390844 3.41 ENSDART00000184556
si:dkey-16n15.6
si:dkey-16n15.6
chr7_+_27059330 3.16 ENSDART00000173919
plekha7b
pleckstrin homology domain containing, family A member 7b
chr7_-_72277269 2.94 ENSDART00000161914
ENSDART00000183927
slc35c1
solute carrier family 35 (GDP-fucose transporter), member C1
chr11_+_575665 2.86 ENSDART00000122133
mkrn2os.1
MKRN2 opposite strand, tandem duplicate 1
chr15_+_25156121 2.62 ENSDART00000189709
slc35f2l
info solute carrier family 35, member F2, like
chr4_+_45484774 2.59 ENSDART00000150573
si:dkey-256i11.6
si:dkey-256i11.6
chr4_+_54798291 2.41 ENSDART00000165113
ENSDART00000109624
si:dkeyp-82b4.6
si:dkeyp-82b4.6
chr6_+_7977611 2.23 ENSDART00000112290
palm3
paralemmin 3
chr14_-_26411918 2.22 ENSDART00000020582
tmed9
transmembrane p24 trafficking protein 9
chr24_+_35787629 2.17 ENSDART00000136721
si:dkeyp-7a3.1
si:dkeyp-7a3.1
chr18_+_33353271 2.07 ENSDART00000099142
v2rh13
vomeronasal 2 receptor, h13
chr24_-_21913426 2.04 ENSDART00000081178
c1qtnf9
C1q and TNF related 9
chr5_-_67661102 2.02 ENSDART00000013605
zbtb20
zinc finger and BTB domain containing 20
chr22_-_26100282 1.90 ENSDART00000166075
pdgfaa
platelet-derived growth factor alpha polypeptide a
chr5_-_30715225 1.84 ENSDART00000016758
ftr82
finTRIM family, member 82
chr13_-_18835254 1.40 ENSDART00000147579
ENSDART00000146795
lzts2a
leucine zipper, putative tumor suppressor 2a
chr2_+_32846602 1.20 ENSDART00000056649
tmem53
transmembrane protein 53
chr13_+_31205439 1.14 ENSDART00000132326
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr21_-_37027252 0.96 ENSDART00000076483
zgc:77151
zgc:77151
chr8_+_26293673 0.87 ENSDART00000144977
mgll
monoglyceride lipase
chr15_+_25156382 0.87 ENSDART00000171092
slc35f2l
info solute carrier family 35, member F2, like
chr19_+_28256076 0.67 ENSDART00000133354
irx4b
iroquois homeobox 4b
chr1_+_26667872 0.50 ENSDART00000152803
ENSDART00000152144
ENSDART00000152785
ENSDART00000152393
hemgn
hemogen
chr5_-_19394440 0.26 ENSDART00000163771
foxn4
forkhead box N4
chr18_+_2554666 0.13 ENSDART00000167218
p2ry2.1
purinergic receptor P2Y2, tandem duplicate 1
chr19_-_18418763 0.06 ENSDART00000167271
zgc:112966
zgc:112966

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf1ba+hnf1bb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
66.0 198.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
43.5 130.6 GO:0033210 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
36.8 147.4 GO:0071548 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
19.1 114.9 GO:0050764 regulation of phagocytosis(GO:0050764)
15.2 45.6 GO:0019695 choline metabolic process(GO:0019695)
14.1 70.4 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
13.9 69.3 GO:0035434 copper ion transmembrane transport(GO:0035434)
13.3 199.0 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
11.1 156.0 GO:0009435 NAD biosynthetic process(GO:0009435)
11.0 88.2 GO:0001579 medium-chain fatty acid transport(GO:0001579)
11.0 944.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
10.5 293.6 GO:0019835 cytolysis(GO:0019835)
10.4 93.6 GO:0070365 hepatocyte differentiation(GO:0070365)
10.4 393.7 GO:0032355 response to estradiol(GO:0032355)
9.0 44.9 GO:0010133 proline catabolic process to glutamate(GO:0010133)
7.7 38.3 GO:0030299 intestinal cholesterol absorption(GO:0030299)
7.7 38.3 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
7.5 180.2 GO:0051180 vitamin transport(GO:0051180)
6.3 69.0 GO:0010960 magnesium ion homeostasis(GO:0010960)
5.9 94.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
5.9 82.7 GO:0016556 mRNA modification(GO:0016556)
5.4 119.2 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
5.0 70.7 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
4.8 52.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
4.7 18.9 GO:0048521 positive regulation of epithelial cell differentiation(GO:0030858) negative regulation of behavior(GO:0048521) negative regulation of feeding behavior(GO:2000252)
4.5 271.6 GO:0007596 blood coagulation(GO:0007596)
4.2 29.6 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
2.7 8.2 GO:0061178 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
2.7 16.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
2.2 11.2 GO:0045056 transcytosis(GO:0045056)
2.1 49.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
2.0 49.1 GO:0048844 artery morphogenesis(GO:0048844)
2.0 13.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
1.9 94.7 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
1.9 28.9 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
1.9 19.2 GO:0060612 adipose tissue development(GO:0060612)
1.8 21.5 GO:0046386 deoxyribonucleotide catabolic process(GO:0009264) deoxyribose phosphate catabolic process(GO:0046386)
1.7 40.2 GO:0006144 purine nucleobase metabolic process(GO:0006144)
1.6 41.6 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
1.6 21.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.5 10.7 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.4 6.8 GO:0035678 neuromast hair cell morphogenesis(GO:0035678)
1.3 31.0 GO:0015701 bicarbonate transport(GO:0015701)
1.2 5.9 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.9 20.8 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.9 23.3 GO:0000187 activation of MAPK activity(GO:0000187)
0.8 9.7 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.8 9.8 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.7 2.2 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.6 2.9 GO:0072530 purine-containing compound transmembrane transport(GO:0072530)
0.6 5.9 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.5 5.4 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.5 10.2 GO:0002574 thrombocyte differentiation(GO:0002574)
0.5 51.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.5 94.6 GO:0048793 pronephros development(GO:0048793)
0.4 16.1 GO:0048794 swim bladder development(GO:0048794)
0.4 5.1 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.4 90.0 GO:0006814 sodium ion transport(GO:0006814)
0.4 38.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.3 5.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.2 115.9 GO:0006955 immune response(GO:0006955)
0.2 17.7 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.2 1.4 GO:0051013 microtubule severing(GO:0051013)
0.1 33.5 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.1 49.4 GO:0030097 hemopoiesis(GO:0030097)
0.1 9.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0070257 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.0 6.7 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
66.3 199.0 GO:0005577 fibrinogen complex(GO:0005577)
66.0 198.0 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
19.6 293.6 GO:0005579 membrane attack complex(GO:0005579)
2.0 5.9 GO:0033391 chromatoid body(GO:0033391)
1.8 101.4 GO:0016342 catenin complex(GO:0016342)
1.4 62.9 GO:0032587 ruffle membrane(GO:0032587)
1.1 1551.2 GO:0005615 extracellular space(GO:0005615)
1.0 9.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.8 99.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.8 155.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 43.4 GO:0005604 basement membrane(GO:0005604)
0.6 385.1 GO:0005576 extracellular region(GO:0005576)
0.5 57.9 GO:0005802 trans-Golgi network(GO:0005802)
0.4 58.4 GO:0005770 late endosome(GO:0005770)
0.4 53.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 36.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 11.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 187.7 GO:0005739 mitochondrion(GO:0005739)
0.1 10.7 GO:0030027 lamellipodium(GO:0030027)
0.1 51.4 GO:0005794 Golgi apparatus(GO:0005794)
0.1 3.5 GO:0016592 mediator complex(GO:0016592)
0.0 64.7 GO:0005829 cytosol(GO:0005829)
0.0 254.5 GO:0016021 integral component of membrane(GO:0016021)
0.0 1.4 GO:0030496 midbody(GO:0030496)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
71.7 501.6 GO:0045735 nutrient reservoir activity(GO:0045735)
45.8 137.3 GO:0005499 vitamin D binding(GO:0005499)
22.4 89.5 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
22.0 88.2 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
21.7 65.2 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
21.5 128.7 GO:0005412 glucose:sodium symporter activity(GO:0005412)
17.7 70.7 GO:0005153 interleukin-8 receptor binding(GO:0005153)
16.8 50.3 GO:0004061 arylformamidase activity(GO:0004061)
13.9 69.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
11.2 44.9 GO:0004657 proline dehydrogenase activity(GO:0004657)
9.6 38.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
9.1 36.5 GO:0008887 glycerate kinase activity(GO:0008887)
8.3 41.6 GO:0098634 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
8.1 944.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
5.1 138.7 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
4.8 52.4 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
4.5 49.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
3.9 147.4 GO:0030145 manganese ion binding(GO:0030145)
3.6 21.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
3.5 130.6 GO:0017046 peptide hormone binding(GO:0017046)
3.4 105.7 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
3.4 53.9 GO:0042910 xenobiotic transporter activity(GO:0042910)
3.3 29.6 GO:0005113 patched binding(GO:0005113)
3.0 62.6 GO:0010181 FMN binding(GO:0010181)
2.9 38.3 GO:0055102 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
2.6 47.4 GO:0033691 sialic acid binding(GO:0033691)
2.3 20.8 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
2.2 17.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
2.1 40.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
1.9 51.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.8 409.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.7 28.9 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
1.7 95.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
1.2 21.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
1.2 119.2 GO:0004540 ribonuclease activity(GO:0004540)
1.2 82.7 GO:0003727 single-stranded RNA binding(GO:0003727)
1.1 5.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.0 16.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.9 92.2 GO:0045296 cadherin binding(GO:0045296)
0.9 70.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.8 7.0 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.8 9.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.7 11.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.7 20.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.7 23.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.7 93.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.7 58.4 GO:0019842 vitamin binding(GO:0019842)
0.7 5.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.7 53.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.7 5.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.6 10.7 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.4 55.3 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.2 27.5 GO:0005179 hormone activity(GO:0005179)
0.1 27.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 121.6 GO:0005102 receptor binding(GO:0005102)
0.1 83.3 GO:0005198 structural molecule activity(GO:0005198)
0.1 6.8 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 2.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 1.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 9.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.2 GO:0030246 carbohydrate binding(GO:0030246)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
11.7 199.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
6.5 130.6 PID IL27 PATHWAY IL27-mediated signaling events
5.9 259.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
3.9 595.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.2 23.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
1.1 16.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.6 21.6 PID BMP PATHWAY BMP receptor signaling
0.6 91.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.4 5.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 2.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
49.1 147.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
32.1 128.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
29.8 685.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
18.1 199.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
10.7 96.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
8.8 88.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
8.8 70.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
6.5 52.0 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
5.9 112.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
5.5 137.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
3.9 50.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
2.9 63.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
2.9 45.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
2.1 69.8 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
1.8 23.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
1.6 102.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
1.3 69.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
1.3 99.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.8 44.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.5 82.7 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.2 5.2 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.2 5.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 6.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 3.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 9.7 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates