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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for hnf1ba+hnf1bb
Z-value: 5.50
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Transcription factors associated with hnf1ba+hnf1bb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf1bb | dr11_v1_chr21_+_38817785_38817843 | 0.86 | 7.1e-29 | Click! |
| hnf1ba | dr11_v1_chr15_-_16012963_16012963 | 0.83 | 5.1e-25 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_10051763 Show fit | 199.00 |
ENSDART00000011701
|
fibrinogen beta chain |
|
| chr5_+_32345187 Show fit | 197.99 |
ENSDART00000147132
|
complement component 9 |
|
| chr20_-_40750953 Show fit | 168.28 |
ENSDART00000061256
|
connexin 28.9 |
|
| chr20_+_23440632 Show fit | 155.92 |
ENSDART00000180685
ENSDART00000042820 |
si:dkey-90m5.4 |
|
| chr22_-_23748284 Show fit | 148.80 |
ENSDART00000162005
|
complement factor H like 2 |
|
| chr5_+_28830388 Show fit | 147.64 |
ENSDART00000149150
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 |
|
| chr6_+_60055168 Show fit | 147.38 |
ENSDART00000008752
|
phosphoenolpyruvate carboxykinase 1 (soluble) |
|
| chr2_+_1486822 Show fit | 147.20 |
ENSDART00000132500
|
complement component 8, alpha polypeptide |
|
| chr2_+_1487118 Show fit | 146.41 |
ENSDART00000147283
|
complement component 8, alpha polypeptide |
|
| chr15_+_28202170 Show fit | 138.66 |
ENSDART00000077736
|
vitronectin a |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf1ba+hnf1bb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.0 | 944.8 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 10.4 | 393.7 | GO:0032355 | response to estradiol(GO:0032355) |
| 10.5 | 293.6 | GO:0019835 | cytolysis(GO:0019835) |
| 4.5 | 271.6 | GO:0007596 | blood coagulation(GO:0007596) |
| 13.3 | 199.0 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 66.0 | 198.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 7.5 | 180.2 | GO:0051180 | vitamin transport(GO:0051180) |
| 11.1 | 156.0 | GO:0009435 | NAD biosynthetic process(GO:0009435) |
| 36.8 | 147.4 | GO:0071548 | glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548) |
| 43.5 | 130.6 | GO:0033210 | leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 1551.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 385.1 | GO:0005576 | extracellular region(GO:0005576) |
| 19.6 | 293.6 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 254.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 66.3 | 199.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 66.0 | 198.0 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.2 | 187.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.8 | 155.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.8 | 101.4 | GO:0016342 | catenin complex(GO:0016342) |
| 0.8 | 99.4 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 944.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 71.7 | 501.6 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 1.8 | 409.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 3.9 | 147.4 | GO:0030145 | manganese ion binding(GO:0030145) |
| 5.1 | 138.7 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 45.8 | 137.3 | GO:0005499 | vitamin D binding(GO:0005499) |
| 3.5 | 130.6 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 21.5 | 128.7 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.1 | 121.6 | GO:0005102 | receptor binding(GO:0005102) |
| 1.2 | 119.2 | GO:0004540 | ribonuclease activity(GO:0004540) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 595.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 5.9 | 259.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 11.7 | 199.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 6.5 | 130.6 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.6 | 91.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.2 | 23.3 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.6 | 21.6 | PID BMP PATHWAY | BMP receptor signaling |
| 1.1 | 16.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.4 | 5.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 3.7 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 29.8 | 685.4 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 18.1 | 199.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 49.1 | 147.4 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 5.5 | 137.3 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 32.1 | 128.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 5.9 | 112.5 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 1.6 | 102.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.3 | 99.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 10.7 | 96.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 8.8 | 88.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |