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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for hnf4a+hnf4b
Z-value: 4.57
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Transcription factors associated with hnf4a+hnf4b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf4a | dr11_v1_chr23_+_25832689_25832689 | 0.90 | 4.9e-34 | Click! |
| CABZ01057488.1 | dr11_v1_chr7_+_69019851_69019851 | 0.88 | 6.9e-31 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_23913943 Show fit | 156.24 |
ENSDART00000175404
ENSDART00000129525 |
apolipoprotein A-IV b, tandem duplicate 1 |
|
| chr20_+_1412193 Show fit | 139.48 |
ENSDART00000064419
|
liver-enriched gene 1, tandem duplicate 1 |
|
| chr20_+_1398564 Show fit | 115.45 |
ENSDART00000002242
|
liver-enriched gene 1, tandem duplicate 2 |
|
| chr1_+_17900306 Show fit | 109.48 |
ENSDART00000089480
|
cytochrome P450, family 4, subfamily V, polypeptide 8 |
|
| chr15_-_26552393 Show fit | 101.89 |
ENSDART00000150152
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b |
|
| chr1_+_53374454 Show fit | 88.09 |
ENSDART00000038807
|
uncoupling protein 1 |
|
| chr15_-_26552652 Show fit | 87.13 |
ENSDART00000152336
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b |
|
| chr16_+_23923746 Show fit | 86.54 |
ENSDART00000137962
|
si:dkey-7f3.14 |
|
| chr17_-_30702411 Show fit | 86.30 |
ENSDART00000114358
|
zgc:194392 |
|
| chr19_+_9277327 Show fit | 85.66 |
ENSDART00000104623
ENSDART00000151164 |
si:rp71-15k1.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf4a+hnf4b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 317.0 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.4 | 218.0 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 13.9 | 139.5 | GO:1990402 | embryonic liver development(GO:1990402) |
| 3.2 | 116.3 | GO:0050821 | protein stabilization(GO:0050821) |
| 0.8 | 112.2 | GO:0055123 | digestive system development(GO:0055123) |
| 36.5 | 109.5 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 11.0 | 88.1 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 2.0 | 86.2 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 5.1 | 86.0 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 3.0 | 72.5 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 889.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 819.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.5 | 328.9 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 163.3 | GO:0015630 | microtubule cytoskeleton(GO:0015630) |
| 0.2 | 109.2 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.2 | 103.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 4.5 | 67.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.5 | 55.4 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 13.2 | 53.0 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 45.4 | GO:0005739 | mitochondrion(GO:0005739) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 297.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 4.2 | 245.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.3 | 197.1 | GO:0008289 | lipid binding(GO:0008289) |
| 29.1 | 116.3 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.9 | 109.5 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.2 | 104.9 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 0.4 | 101.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.0 | 88.6 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 22.0 | 88.1 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 7.8 | 86.0 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 116.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.5 | 112.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 64.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 49.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 17.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 12.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 12.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.3 | 11.1 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.3 | 6.7 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.4 | 4.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.6 | 180.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 6.4 | 76.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 1.1 | 71.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 8.4 | 66.8 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 7.2 | 57.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.6 | 52.9 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.3 | 49.6 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 2.7 | 48.5 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 7.7 | 46.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 4.3 | 34.6 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |