ISMARA results: hoxa13a+hoxa13b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxa13a+hoxa13b

Z-value: 1.51

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Transcription factors associated with hoxa13a+hoxa13b

Gene Symbol	Gene ID	Gene Info
hoxa13b NCBI UniProt	ENSDARG00000036254	homeobox A13b
hoxa13a NCBI UniProt	ENSDARG00000100312	homeobox A13a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hoxa13a	dr11_v1_chr19_+_19729506_19729506	0.07	5.3e-01	Click!
hoxa13b	dr11_v1_chr16_+_20895904_20895904	0.01	9.6e-01	Click!

Activity profile of hoxa13a+hoxa13b motif

Sorted Z-values of hoxa13a+hoxa13b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_30611814 Show fit	11.55	ENSDART00000089803	slc8a1a NCBI UniProt Show fit	solute carrier family 8 (sodium/calcium exchanger), member 1a
chr2_-_24289641 Show fit	11.04	ENSDART00000128784 ENSDART00000123565 ENSDART00000141922 ENSDART00000184550 ENSDART00000191469	myh7l NCBI UniProt Show fit	myosin heavy chain 7-like
chr17_-_15382704 Show fit	9.02	ENSDART00000005313	zgc:85722 NCBI UniProt Show fit	zgc:85722
chr2_+_16781015 Show fit	7.95	ENSDART00000155147 ENSDART00000003845	tfa NCBI UniProt Show fit	transferrin-a
chr14_+_36738069 Show fit	7.83	ENSDART00000105590	tdo2a NCBI UniProt Show fit	tryptophan 2,3-dioxygenase a
chr2_+_16780643 Show fit	6.91	ENSDART00000125647 ENSDART00000108611 ENSDART00000181245 ENSDART00000163194	tfa NCBI UniProt Show fit	transferrin-a
chr16_-_21785261 Show fit	6.87	ENSDART00000078858	si:ch73-86n18.1 NCBI UniProt Show fit	si:ch73-86n18.1
chr23_+_7379728 Show fit	6.57	ENSDART00000012194	gata5 NCBI UniProt Show fit	GATA binding protein 5
chr21_-_2707768 Show fit	5.99	ENSDART00000165384	CABZ01101739.1 NCBI UniProt Show fit
chr21_-_25756119 Show fit	5.91	ENSDART00000002341	cldnc NCBI UniProt Show fit	claudin c

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa13a+hoxa13b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	14.6	GO:0019731	antibacterial humoral response(GO:0019731)
1.1	11.7	GO:0006032	chitin catabolic process(GO:0006032)
0.4	8.3	GO:1990035	calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
1.0	8.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.4	8.0	GO:0014823	response to activity(GO:0014823)
1.5	7.4	GO:1901842	regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2	7.2	GO:0006730	one-carbon metabolic process(GO:0006730)
1.6	6.6	GO:0048618	post-embryonic foregut morphogenesis(GO:0048618)
1.6	6.5	GO:0035994	response to muscle stretch(GO:0035994)
0.2	5.3	GO:0051084	'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084) chaperone mediated protein folding requiring cofactor(GO:0051085)

Showing 1 to 10 of 313 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	20.5	GO:0055037	recycling endosome(GO:0055037)
0.0	14.0	GO:0005739	mitochondrion(GO:0005739)
0.1	11.3	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	11.2	GO:0016459	myosin complex(GO:0016459)
0.6	8.4	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1	8.4	GO:0042383	sarcolemma(GO:0042383)
0.0	7.1	GO:0030133	transport vesicle(GO:0030133)
0.0	6.8	GO:0005764	lysosome(GO:0005764)
0.1	5.4	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.3	4.8	GO:0031306	intrinsic component of mitochondrial outer membrane(GO:0031306)

Showing 1 to 10 of 118 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.7	GO:0003924	GTPase activity(GO:0003924)
0.0	11.8	GO:0003774	motor activity(GO:0003774)
1.1	11.7	GO:0004568	chitinase activity(GO:0004568)
0.9	11.5	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
2.7	8.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.3	8.1	GO:0051087	chaperone binding(GO:0051087)
0.3	7.7	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.2	6.1	GO:0008307	structural constituent of muscle(GO:0008307)
0.3	5.5	GO:0005344	oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.4	5.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)

Showing 1 to 10 of 228 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	5.7	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.1	5.1	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.2	4.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	3.8	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	3.0	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	2.8	PID AP1 PATHWAY	AP-1 transcription factor network
0.4	2.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	2.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	1.9	PID RAC1 PATHWAY	RAC1 signaling pathway

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	9.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.3	6.8	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	6.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	5.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.3	4.6	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.1	4.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	4.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.4	3.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.4	3.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	3.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation

Showing 1 to 10 of 77 entries

Results for hoxa13a+hoxa13b

Z-value: 1.51

Motif logo

Transcription factors associated with hoxa13a+hoxa13b

Activity-expression correlation:

Activity profile of hoxa13a+hoxa13b motif

Sorted Z-values of hoxa13a+hoxa13b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa13a+hoxa13b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: