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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxa1a+hoxb1b-1+hoxc1a

Z-value: 1.86

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Transcription factors associated with hoxa1a+hoxb1b-1+hoxc1a

Gene Symbol Gene ID Gene Info
hoxb1b-1
ENSDARG00000054033 homeobox B1b
hoxc1a
ENSDARG00000070337 homeobox C1a
hoxa1a
ENSDARG00000104307 homeobox A1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxc1adr11_v1_chr23_+_36178104_361781040.637.4e-12Click!
hoxa1adr11_v1_chr19_+_19786117_19786213-0.347.9e-04Click!
hoxb1bdr11_v1_chr12_+_27141140_271411400.132.1e-01Click!

Activity profile of hoxa1a+hoxb1b-1+hoxc1a motif

Sorted Z-values of hoxa1a+hoxb1b-1+hoxc1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_25916530 48.51 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr20_-_9462433 36.56 ENSDART00000152674
ENSDART00000040557
zgc:101840
zgc:101840
chr25_+_7461624 32.02 ENSDART00000170569
syt12
synaptotagmin XII
chr9_-_51370293 26.26 ENSDART00000084806
slc4a10b
solute carrier family 4, sodium bicarbonate transporter, member 10b
chr23_-_11870962 25.45 ENSDART00000143481
si:dkey-178k16.1
si:dkey-178k16.1
chr1_-_14258409 23.60 ENSDART00000079359
pde5aa
phosphodiesterase 5A, cGMP-specific, a
chr11_-_1131569 22.89 ENSDART00000173228
slc6a11b
solute carrier family 6 (neurotransmitter transporter), member 11b
chr9_+_34425736 21.33 ENSDART00000135147
si:ch211-218d20.15
si:ch211-218d20.15
chr15_-_27972474 19.96 ENSDART00000162753
CR391930.1

chr10_+_466926 18.97 ENSDART00000145220
arvcfa
ARVCF, delta catenin family member a
chr23_-_12015139 18.12 ENSDART00000110627
ENSDART00000193988
ENSDART00000184528
si:dkey-178k16.1
si:dkey-178k16.1
chr18_+_24919614 18.01 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr14_-_7888748 17.89 ENSDART00000166293
ppp3cb
protein phosphatase 3, catalytic subunit, beta isozyme
chr15_-_16704417 17.20 ENSDART00000155163
caln1
calneuron 1
chr4_+_21129752 16.63 ENSDART00000169764
syt1a
synaptotagmin Ia
chr3_+_29714775 16.36 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr22_-_600016 16.31 ENSDART00000086434
tmcc2
transmembrane and coiled-coil domain family 2
chr5_-_55600689 16.00 ENSDART00000013229
gnaq
guanine nucleotide binding protein (G protein), q polypeptide
chr17_+_8183393 15.60 ENSDART00000155957
tulp4b
tubby like protein 4b
chr16_+_46111849 15.26 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr23_-_12014931 14.80 ENSDART00000134652
si:dkey-178k16.1
si:dkey-178k16.1
chr16_-_13730152 14.23 ENSDART00000138772
ttyh1
tweety family member 1
chr21_-_43079161 13.94 ENSDART00000144151
jakmip2
janus kinase and microtubule interacting protein 2
chr10_-_26766780 13.91 ENSDART00000146666
mcf2b
MCF.2 cell line derived transforming sequence b
chr17_+_40684 13.50 ENSDART00000164231
CABZ01111555.1

chr14_+_19258702 12.80 ENSDART00000187087
ENSDART00000005738
slitrk2
SLIT and NTRK-like family, member 2
chr16_-_31188715 12.45 ENSDART00000058829
scrt1b
scratch family zinc finger 1b
chr13_+_35745572 12.37 ENSDART00000159690
gpr75
G protein-coupled receptor 75
chr23_+_21067684 12.32 ENSDART00000132066
kcnab2b
potassium voltage-gated channel, shaker-related subfamily, beta member 2 b
chr11_+_30817943 12.14 ENSDART00000150130
ENSDART00000159997
cacna1ab
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr4_+_74226447 11.76 ENSDART00000174336
ENSDART00000191455
ENSDART00000180062
ptprr
protein tyrosine phosphatase, receptor type, r
chr6_+_23752593 11.50 ENSDART00000164366
zgc:158654
zgc:158654
chr9_-_23217196 11.27 ENSDART00000083567
kif5c
kinesin family member 5C
chr4_+_11384891 11.26 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr5_+_65492183 11.25 ENSDART00000162804
si:dkey-21e5.1
si:dkey-21e5.1
chr16_-_13004166 11.10 ENSDART00000133735
cacng7b
calcium channel, voltage-dependent, gamma subunit 7b
chr6_-_31576397 11.00 ENSDART00000111837
raver2
ribonucleoprotein, PTB-binding 2
chr9_-_48296469 10.97 ENSDART00000058255
bbs5
Bardet-Biedl syndrome 5
chr14_-_1565317 10.85 ENSDART00000169496
CABZ01064248.1

chr17_-_6399920 10.83 ENSDART00000022010
hivep2b
human immunodeficiency virus type I enhancer binding protein 2b
chr12_+_41510492 10.69 ENSDART00000170976
ENSDART00000176164
kif5bb
kinesin family member 5B, b
chr11_-_1509773 10.45 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr9_+_11202552 10.35 ENSDART00000151931
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr17_+_19626479 10.26 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr3_+_37824268 10.14 ENSDART00000137038
asic2
acid-sensing (proton-gated) ion channel 2
chr14_+_2478994 9.70 ENSDART00000170538
CU929317.1

chr25_-_24074500 9.68 ENSDART00000040410
th
tyrosine hydroxylase
chr5_+_61301525 9.52 ENSDART00000128773
doc2b
double C2-like domains, beta
chr2_+_42872661 9.26 ENSDART00000036979
efr3a
EFR3 homolog A (S. cerevisiae)
chr18_+_24922125 8.87 ENSDART00000180385
rgma
repulsive guidance molecule family member a
chr20_-_32446406 8.84 ENSDART00000026635
nr2e1
nuclear receptor subfamily 2, group E, member 1
chr11_-_21528056 8.77 ENSDART00000181626
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr6_-_29105727 8.76 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr5_-_31689796 8.61 ENSDART00000184319
ENSDART00000190229
ENSDART00000186294
ENSDART00000170313
ENSDART00000147065
ENSDART00000134427
ENSDART00000098172
sh3glb2b
SH3-domain GRB2-like endophilin B2b
chr17_-_7436766 8.61 ENSDART00000162002
grm1b
glutamate receptor, metabotropic 1b
chr6_-_55585423 8.51 ENSDART00000157129
slc12a5a
solute carrier family 12 (potassium/chloride transporter), member 5a
chr10_+_39692241 8.48 ENSDART00000113414
kirrel3a
kirre like nephrin family adhesion molecule 3a
chr20_+_1088658 8.48 ENSDART00000162991
BX537249.1

chr4_+_4816695 8.32 ENSDART00000136962
slc13a4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr18_-_23875370 8.19 ENSDART00000130163
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr3_+_46628885 8.11 ENSDART00000006602
pde4a
phosphodiesterase 4A, cAMP-specific
chr6_-_16561536 8.09 ENSDART00000167295
unc80
unc-80 homolog (C. elegans)
chr17_+_51764310 8.07 ENSDART00000157171
si:ch211-168d23.3
si:ch211-168d23.3
chr17_-_20394566 7.97 ENSDART00000154667
sorcs3b
sortilin related VPS10 domain containing receptor 3b
chr22_+_3232925 7.86 ENSDART00000166754
CU929402.1

chr21_+_30194904 7.66 ENSDART00000137023
ENSDART00000078403
BRD8
si:ch211-59d17.3
chr5_-_52277643 7.63 ENSDART00000010757
rgmb
repulsive guidance molecule family member b
chr2_-_31754292 7.35 ENSDART00000192498
ralyl
RALY RNA binding protein like
chr6_-_13401133 7.31 ENSDART00000151206
fmnl2b
formin-like 2b
chr24_+_26039464 7.25 ENSDART00000131017
tnk2a
tyrosine kinase, non-receptor, 2a
chr7_+_31074636 7.16 ENSDART00000173805
tjp1a
tight junction protein 1a
chr20_+_26349002 6.84 ENSDART00000152842
syne1a
spectrin repeat containing, nuclear envelope 1a
chr23_-_333457 6.73 ENSDART00000114486
uhrf1bp1
UHRF1 binding protein 1
chr17_-_45009782 6.70 ENSDART00000123971
fam161b
family with sequence similarity 161, member B
chr19_-_45985989 6.64 ENSDART00000165897
si:ch211-153f2.3
si:ch211-153f2.3
chr12_-_33582382 6.62 ENSDART00000009794
ENSDART00000136617
tdrkh
tudor and KH domain containing
chr2_-_45630823 6.60 ENSDART00000183553
CR450720.1

chr21_+_43561650 6.59 ENSDART00000085071
gpr185a
G protein-coupled receptor 185 a
chr14_+_24215046 6.42 ENSDART00000079215
stc2a
stanniocalcin 2a
chr14_+_34547554 6.38 ENSDART00000074819
gabrp
gamma-aminobutyric acid (GABA) A receptor, pi
chr25_+_336503 6.36 ENSDART00000160395
CU929262.1

chr10_-_2527342 6.28 ENSDART00000184168
CU856539.1

chr17_-_26604946 6.15 ENSDART00000087062
fam149b1
family with sequence similarity 149, member B1
chr5_+_31959954 6.15 ENSDART00000142826
myo1hb
myosin IHb
chr12_+_38770654 6.06 ENSDART00000155367
kif19
kinesin family member 19
chr8_-_40464935 5.97 ENSDART00000040013
myl7
myosin, light chain 7, regulatory
chr12_+_39685485 5.80 ENSDART00000163403
LO017650.1

chr25_+_2668892 5.79 ENSDART00000122929
bbs4
Bardet-Biedl syndrome 4
chr19_+_42219165 5.39 ENSDART00000163192
CU896644.1

chr25_-_36827491 5.39 ENSDART00000170941
CU929365.1

chr20_+_27691307 5.17 ENSDART00000153299
si:dkey-1h6.8
si:dkey-1h6.8
chr18_-_16392448 5.07 ENSDART00000180253
mgat4c
mgat4 family, member C
chr18_-_23875219 4.93 ENSDART00000059976
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr19_+_13994563 4.90 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr18_-_18875308 4.89 ENSDART00000127182
arl2bp
ADP-ribosylation factor-like 2 binding protein
chr2_+_45354747 4.86 ENSDART00000083957
ENSDART00000135582
ENSDART00000160867
camsap2b
calmodulin regulated spectrin-associated protein family, member 2b
chr20_-_47550577 4.85 ENSDART00000187361
CABZ01053323.1

chr10_-_31175744 4.83 ENSDART00000191728
pknox2
pbx/knotted 1 homeobox 2
chr4_-_16641742 4.76 ENSDART00000180605
sinhcaf
SIN3-HDAC complex associated factor
chr8_-_22698651 4.73 ENSDART00000181411
iqsec2a
IQ motif and Sec7 domain 2a
chr3_+_15805917 4.66 ENSDART00000055834
phospho1
phosphatase, orphan 1
chr5_-_66028714 4.45 ENSDART00000022625
ENSDART00000164228
nrarpb
NOTCH regulated ankyrin repeat protein b
chr1_+_10221568 4.13 ENSDART00000152424
npy2rl
neuropeptide Y receptor Y2, like
chr17_-_26604549 4.11 ENSDART00000174773
fam149b1
family with sequence similarity 149, member B1
chr7_+_7151832 4.08 ENSDART00000109485
gal3st3
galactose-3-O-sulfotransferase 3
chr17_-_7060477 4.03 ENSDART00000081797
sash1b
SAM and SH3 domain containing 1b
chr16_+_14707960 4.01 ENSDART00000137912
col14a1a
collagen, type XIV, alpha 1a
chr5_-_52921532 3.94 ENSDART00000160566
CU695117.1

chr25_-_29987839 3.76 ENSDART00000154088
fam19a5b
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5b
chr8_-_44015210 3.69 ENSDART00000186879
ENSDART00000188965
ENSDART00000001313
ENSDART00000188902
ENSDART00000185935
ENSDART00000147869
rimbp2
rimbp2
RIMS binding protein 2
RIMS binding protein 2
chr18_-_18874921 3.60 ENSDART00000193332
arl2bp
ADP-ribosylation factor-like 2 binding protein
chr20_-_35841570 3.44 ENSDART00000037855
tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr2_-_16217344 3.36 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr3_+_18846488 3.24 ENSDART00000148133
tmem104
transmembrane protein 104
chr9_+_32073606 3.12 ENSDART00000184170
ENSDART00000180355
ENSDART00000110204
ENSDART00000123278
pikfyve
phosphoinositide kinase, FYVE finger containing
chr22_-_24984733 3.11 ENSDART00000142147
ENSDART00000187284
dnal4b
dynein, axonemal, light chain 4b
chr17_-_28097760 3.05 ENSDART00000149861
kdm1a
lysine (K)-specific demethylase 1a
chr12_-_1361517 2.99 ENSDART00000188297
LO018020.2

chr9_-_12652984 2.81 ENSDART00000052256
sumo3b
small ubiquitin-like modifier 3b
chr3_-_214709 2.76 ENSDART00000098311
CABZ01079818.1

chr4_-_17642168 2.74 ENSDART00000007030
klhl42
kelch-like family, member 42
chr8_+_6410933 2.69 ENSDART00000168789
lrrtm4l2
leucine rich repeat transmembrane neuronal 4 like 2
chr4_-_9191220 2.47 ENSDART00000156919
hcfc2
host cell factor C2
chr16_+_19033554 2.42 ENSDART00000182430
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
chr5_-_22544151 2.40 ENSDART00000006474
glra4b
glycine receptor, alpha 4b
chr13_-_32577386 2.20 ENSDART00000016535
kcns3a
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3a
chr14_-_24101897 2.06 ENSDART00000143695
cpeb4a
cytoplasmic polyadenylation element binding protein 4a
chr6_+_29791164 2.03 ENSDART00000017424
ptmaa
prothymosin, alpha a
chr7_-_72067475 1.91 ENSDART00000017763
LO018380.1

chr22_-_34937455 1.89 ENSDART00000169217
ENSDART00000188330
ENSDART00000165142
slit1b
slit homolog 1b (Drosophila)
chr1_+_43686251 1.89 ENSDART00000074604
ENSDART00000137791
cisd2
CDGSH iron sulfur domain 2
chr17_+_8754020 1.88 ENSDART00000105322
edrf1
erythroid differentiation regulatory factor 1
chr3_-_21118969 1.82 ENSDART00000129016
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr1_-_56717813 1.82 ENSDART00000159196
FO681314.1

chr8_-_51930826 1.74 ENSDART00000109785
cabin1
calcineurin binding protein 1
chr8_-_39739056 1.69 ENSDART00000147992
si:ch211-170d8.5
si:ch211-170d8.5
chr10_-_34976812 1.68 ENSDART00000170625
smad9
SMAD family member 9
chr5_-_16791223 1.65 ENSDART00000192744
atad1a
ATPase family, AAA domain containing 1a
chr24_+_27548474 1.64 ENSDART00000105774
ENSDART00000123368
ek1
eph-like kinase 1
chr15_+_42933236 1.63 ENSDART00000167763
slc8a2b
solute carrier family 8 (sodium/calcium exchanger), member 2b
chr4_-_14926637 1.62 ENSDART00000110199
prdm4
PR domain containing 4
chr23_+_27782071 1.62 ENSDART00000131379
kmt2d
lysine (K)-specific methyltransferase 2D
chr14_+_34952883 1.61 ENSDART00000182812
il12ba
interleukin 12Ba
chr4_-_71983381 1.61 ENSDART00000169130
ftr64
finTRIM family, member 64
chr21_-_3844322 1.56 ENSDART00000166652
st6galnac4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr17_-_49481672 1.54 ENSDART00000166394
fcf1
FCF1 rRNA-processing protein
chr24_+_34113424 1.54 ENSDART00000105572
gbx1
gastrulation brain homeobox 1
chr20_-_53624645 1.41 ENSDART00000083427
ENSDART00000152920
slc25a29
solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
chr11_+_3501669 1.36 ENSDART00000160808
pusl1
pseudouridylate synthase-like 1
chr6_-_14038804 1.29 ENSDART00000184606
ENSDART00000184609
etv5b
ets variant 5b
chr7_+_62080456 1.16 ENSDART00000092580
rbpjb
recombination signal binding protein for immunoglobulin kappa J region b
chr20_+_29587995 1.14 ENSDART00000153339
adam17b
ADAM metallopeptidase domain 17b
chr1_-_10577945 1.13 ENSDART00000179237
ENSDART00000040502
ENSDART00000186876
trpc5a
transient receptor potential cation channel, subfamily C, member 5a
chr22_+_35089031 1.09 ENSDART00000076040
srfa
serum response factor a
chr4_-_13626831 1.09 ENSDART00000173077
si:dkeyp-81f3.4
si:dkeyp-81f3.4
chr17_+_8754426 0.99 ENSDART00000185519
edrf1
erythroid differentiation regulatory factor 1
chr2_+_33541928 0.98 ENSDART00000162852
BX548164.1

chr15_+_15456536 0.95 ENSDART00000109004
ENSDART00000156835
zgc:174895
zgc:174895
chr7_+_13464878 0.91 ENSDART00000172969
dagla
diacylglycerol lipase, alpha
chr13_-_39736938 0.91 ENSDART00000141645
zgc:171482
zgc:171482
chr15_-_33304133 0.84 ENSDART00000186092
nbeab
neurobeachin b
chr6_+_19383267 0.79 ENSDART00000166549
mchr1a
melanin-concentrating hormone receptor 1a
chr18_-_23874929 0.78 ENSDART00000134910
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr1_+_20069535 0.76 ENSDART00000088653
prss12
protease, serine, 12 (neurotrypsin, motopsin)
chr13_-_36184476 0.69 ENSDART00000057185
map3k9
mitogen-activated protein kinase kinase kinase 9
chr3_-_1283247 0.63 ENSDART00000149814
tcf20
transcription factor 20
chr23_+_36178104 0.62 ENSDART00000103131
hoxc1a
homeobox C1a
chr11_+_33628104 0.58 ENSDART00000165318
thsd7bb
thrombospondin, type I, domain containing 7Bb
chr17_-_28749640 0.52 ENSDART00000000948
coch
coagulation factor C homolog, cochlin (Limulus polyphemus)
chr4_+_43408004 0.46 ENSDART00000150476
si:dkeyp-53e4.2
si:dkeyp-53e4.2
chr20_-_28842524 0.30 ENSDART00000046035
ENSDART00000139843
ENSDART00000129858
ENSDART00000137425
ENSDART00000135720
max
myc associated factor X
chr17_+_31914877 0.17 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr3_-_6417328 0.17 ENSDART00000160979
jpt1b
Jupiter microtubule associated homolog 1b
chr7_+_16835218 0.10 ENSDART00000173580
nav2a
neuron navigator 2a
chr12_+_48581588 0.06 ENSDART00000114996
CABZ01078415.1

chr13_-_11679486 0.04 ENSDART00000108694
si:ch211-195e19.1
si:ch211-195e19.1
chr15_+_15456910 0.02 ENSDART00000155708
zgc:174895
zgc:174895

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa1a+hoxb1b-1+hoxc1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 26.9 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
4.6 13.9 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
3.2 9.7 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
2.7 11.0 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
2.1 12.3 GO:0051969 regulation of transmission of nerve impulse(GO:0051969)
1.9 48.5 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
1.8 8.8 GO:2001223 negative regulation of neuron migration(GO:2001223)
1.6 27.5 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
1.6 11.3 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
1.4 5.8 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
1.2 32.0 GO:0060291 long-term synaptic potentiation(GO:0060291)
1.2 17.9 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
1.2 26.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.1 3.4 GO:0031642 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
1.1 26.3 GO:0015701 bicarbonate transport(GO:0015701)
1.1 11.3 GO:1904071 presynaptic active zone assembly(GO:1904071)
1.0 6.0 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005) atrial cardiac muscle cell development(GO:0055014)
1.0 65.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.7 15.8 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.7 11.6 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.7 8.5 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.7 7.2 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.5 19.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.5 8.5 GO:0055075 potassium ion homeostasis(GO:0055075)
0.5 3.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.5 1.9 GO:0010259 multicellular organism aging(GO:0010259)
0.4 3.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.4 8.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.4 4.9 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.4 4.4 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.4 1.4 GO:0006844 acyl carnitine transport(GO:0006844)
0.3 16.0 GO:0001508 action potential(GO:0001508)
0.3 12.3 GO:0060349 bone morphogenesis(GO:0060349)
0.3 2.1 GO:0002931 response to ischemia(GO:0002931)
0.3 43.3 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.3 1.2 GO:0072149 glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.3 9.5 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.3 2.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.3 1.5 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.2 1.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 1.6 GO:0051893 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.1 1.7 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 8.3 GO:0006814 sodium ion transport(GO:0006814)
0.1 6.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 15.3 GO:0006836 neurotransmitter transport(GO:0006836)
0.1 1.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 2.7 GO:1990798 pancreas regeneration(GO:1990798)
0.1 8.5 GO:0007416 synapse assembly(GO:0007416)
0.1 1.3 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 4.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.8 GO:0016925 protein sumoylation(GO:0016925)
0.1 12.8 GO:0021782 glial cell development(GO:0021782)
0.1 4.1 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.1 4.8 GO:0030336 negative regulation of cell migration(GO:0030336)
0.1 1.9 GO:0021602 cranial nerve morphogenesis(GO:0021602)
0.1 5.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 1.1 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 1.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 1.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 7.6 GO:0071772 BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773)
0.0 6.7 GO:0044782 cilium organization(GO:0044782)
0.0 0.7 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 14.5 GO:0055080 cation homeostasis(GO:0055080)
0.0 11.0 GO:0000377 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.3 GO:0048264 determination of ventral identity(GO:0048264)
0.0 6.1 GO:0007018 microtubule-based movement(GO:0007018)
0.0 9.0 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 21.8 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 1.0 GO:0071559 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.0 2.2 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.9 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.8 GO:0031638 zymogen activation(GO:0031638)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 16.6 GO:0042584 chromaffin granule membrane(GO:0042584)
3.0 17.9 GO:0005955 calcineurin complex(GO:0005955)
2.0 14.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
1.4 34.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.4 11.0 GO:0034464 BBSome(GO:0034464)
1.2 49.3 GO:0043679 axon terminus(GO:0043679)
1.1 11.3 GO:0098982 GABA-ergic synapse(GO:0098982)
1.1 12.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.7 36.1 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.5 4.0 GO:0005614 interstitial matrix(GO:0005614)
0.5 4.9 GO:0036449 microtubule minus-end(GO:0036449)
0.4 1.6 GO:0043514 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.4 8.8 GO:0044327 dendritic spine head(GO:0044327) phagocytic vesicle(GO:0045335)
0.4 4.8 GO:0016580 Sin3 complex(GO:0016580)
0.4 6.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 26.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 9.7 GO:0043204 perikaryon(GO:0043204)
0.2 16.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 15.3 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 8.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.2 32.0 GO:0070382 exocytic vesicle(GO:0070382)
0.2 17.3 GO:0005871 kinesin complex(GO:0005871)
0.2 8.5 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.2 6.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 12.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 7.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 6.1 GO:0005902 microvillus(GO:0005902)
0.1 11.4 GO:0034703 cation channel complex(GO:0034703)
0.1 2.4 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 7.2 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 7.2 GO:0005911 cell-cell junction(GO:0005911)
0.1 3.1 GO:0030286 dynein complex(GO:0030286)
0.0 10.3 GO:0070161 adherens junction(GO:0005912) anchoring junction(GO:0070161)
0.0 8.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 2.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 22.0 GO:0043005 neuron projection(GO:0043005)
0.0 2.8 GO:0045177 apical part of cell(GO:0045177)
0.0 6.7 GO:0005929 cilium(GO:0005929)
0.0 1.9 GO:0031968 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
16.2 48.5 GO:1903136 cuprous ion binding(GO:1903136)
3.0 17.9 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
1.9 26.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.8 34.5 GO:0015026 coreceptor activity(GO:0015026)
1.8 23.6 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
1.8 16.0 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
1.8 22.9 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
1.7 13.9 GO:0001972 retinoic acid binding(GO:0001972)
1.7 20.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
1.6 14.2 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.2 8.6 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
1.1 9.7 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
1.0 48.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.6 11.3 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.6 12.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.5 17.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.5 1.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.5 39.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 4.1 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.4 3.1 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.4 1.6 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.4 4.9 GO:0030507 spectrin binding(GO:0030507)
0.4 8.8 GO:0031267 small GTPase binding(GO:0031267)
0.4 1.4 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.3 11.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 8.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 1.0 GO:0003999 adenine phosphoribosyltransferase activity(GO:0003999)
0.3 12.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.3 10.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 2.0 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.3 6.8 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.3 2.4 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 0.8 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.2 4.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.2 1.6 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 19.0 GO:0045296 cadherin binding(GO:0045296)
0.2 6.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 2.8 GO:0031386 protein tag(GO:0031386)
0.2 7.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 9.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.6 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 12.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 3.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 3.1 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 0.9 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.7 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 5.1 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 11.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 39.8 GO:0003779 actin binding(GO:0003779)
0.1 1.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 11.8 GO:0019900 kinase binding(GO:0019900)
0.0 1.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.6 GO:0005179 hormone activity(GO:0005179)
0.0 6.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 23.4 GO:0003723 RNA binding(GO:0003723)
0.0 2.7 GO:0042802 identical protein binding(GO:0042802)
0.0 1.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 26.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 16.0 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
1.5 19.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.9 36.2 PID BMP PATHWAY BMP receptor signaling
0.7 9.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 13.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 3.4 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.7 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.3 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 16.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
1.1 17.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
1.0 34.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.9 9.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.4 4.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.3 1.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 3.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 8.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 8.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 13.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 5.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 1.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 3.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 3.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 3.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production