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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for hoxa4a+hoxc3a
Z-value: 0.67
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Transcription factors associated with hoxa4a+hoxc3a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxa3a | dr11_v1_chr19_+_19777437_19777437 | 0.29 | 5.2e-03 | Click! |
| hoxc3a | dr11_v1_chr23_+_36106790_36106790 | -0.14 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_20110086 Show fit | 7.31 |
ENSDART00000054664
|
troponin C type 1b (slow) |
|
| chr19_-_5369486 Show fit | 4.42 |
ENSDART00000105004
|
keratin 17 |
|
| chr22_-_10459880 Show fit | 4.20 |
ENSDART00000064801
|
osteoglycin |
|
| chr5_-_71705191 Show fit | 3.79 |
ENSDART00000187767
|
adenylate kinase 1 |
|
| chr15_-_12011390 Show fit | 3.58 |
ENSDART00000187403
|
si:dkey-202l22.6 |
|
| chr4_+_73085993 Show fit | 3.54 |
ENSDART00000165749
|
si:ch73-170d6.2 |
|
| chr21_-_32060993 Show fit | 3.42 |
ENSDART00000131651
|
si:ch211-160j14.2 |
|
| chr11_-_1550709 Show fit | 3.24 |
ENSDART00000110097
|
si:ch73-303b9.1 |
|
| chr2_+_11205795 Show fit | 3.23 |
ENSDART00000019078
|
LIM homeobox 8a |
|
| chr15_-_46779934 Show fit | 3.22 |
ENSDART00000085136
|
chloride channel 2c |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxa4a+hoxc3a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.5 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 4.5 | GO:0031101 | fin regeneration(GO:0031101) |
| 0.1 | 4.1 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.2 | 3.8 | GO:2000344 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 3.2 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.1 | 3.2 | GO:0031102 | neuron projection regeneration(GO:0031102) |
| 0.8 | 3.1 | GO:0019242 | methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
| 0.1 | 3.1 | GO:0035567 | non-canonical Wnt signaling pathway(GO:0035567) |
| 0.6 | 3.0 | GO:0003210 | cardiac atrium formation(GO:0003210) |
| 0.1 | 3.0 | GO:0021884 | forebrain neuron development(GO:0021884) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.5 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 5.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 5.4 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 3.8 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 3.4 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 3.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 2.9 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 2.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 2.0 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 2.0 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.3 | 7.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.7 | 4.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 4.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 3.8 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.2 | 3.4 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.6 | 3.2 | GO:0009374 | biotin binding(GO:0009374) |
| 0.2 | 3.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.8 | 3.1 | GO:0004807 | triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929) |
| 0.2 | 3.1 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 4.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 2.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 1.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 1.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 1.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.2 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.2 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 2.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 2.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.2 | 1.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 1.9 | REACTOME BASE EXCISION REPAIR | Genes involved in Base Excision Repair |
| 0.0 | 1.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 1.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 1.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |