ISMARA results: hoxa9a+hoxa9b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxa9a+hoxa9b

Z-value: 1.39

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Transcription factors associated with hoxa9a+hoxa9b

Gene Symbol	Gene ID	Gene Info
hoxa9b NCBI UniProt	ENSDARG00000056819	homeobox A9b
hoxa9a NCBI UniProt	ENSDARG00000105013	homeobox A9a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hoxa9b	dr11_v1_chr16_+_20915319_20915319	0.46	2.6e-06	Click!
hoxa9a	dr11_v1_chr19_+_19750101_19750223	0.31	2.7e-03	Click!

Activity profile of hoxa9a+hoxa9b motif

Sorted Z-values of hoxa9a+hoxa9b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr24_+_38301080 Show fit	38.21	ENSDART00000105672	mybpc2b NCBI UniProt Show fit	myosin binding protein C, fast type b
chr7_+_39386982 Show fit	22.52	ENSDART00000146702	tnni2b.2 NCBI UniProt Show fit	troponin I type 2b (skeletal, fast), tandem duplicate 2
chr3_+_32526263 Show fit	21.54	ENSDART00000150897	si:ch73-367p23.2 NCBI UniProt Show fit	si:ch73-367p23.2
chr5_-_32274383 Show fit	19.41	ENSDART00000122889	myhz1.3 NCBI UniProt Show fit	myosin, heavy polypeptide 1.3, skeletal muscle
chr8_+_6576940 Show fit	16.80	ENSDART00000138135	vsig8b NCBI UniProt Show fit	V-set and immunoglobulin domain containing 8b
chr6_-_46875310 Show fit	16.64	ENSDART00000154442	igfn1.3 NCBI UniProt Show fit	immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr6_+_55032439 Show fit	16.52	ENSDART00000164232 ENSDART00000158845 ENSDART00000157584 ENSDART00000026359 ENSDART00000122794 ENSDART00000183742	mybphb NCBI UniProt Show fit	myosin binding protein Hb
chr3_+_33300522 Show fit	15.83	ENSDART00000114023	hspb9 NCBI UniProt Show fit	heat shock protein, alpha-crystallin-related, 9
chr19_-_10425140 Show fit	15.10	ENSDART00000145319	si:ch211-171h4.3 NCBI UniProt Show fit	si:ch211-171h4.3
chr5_+_32206378 Show fit	14.77	ENSDART00000126873 ENSDART00000051361	myhz2 NCBI UniProt Show fit	myosin, heavy polypeptide 2, fast muscle specific

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa9a+hoxa9b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	39.2	GO:0060537	muscle tissue development(GO:0060537)
0.5	22.5	GO:0003009	skeletal muscle contraction(GO:0003009)
3.7	18.7	GO:0003210	cardiac atrium formation(GO:0003210)
0.0	17.3	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.1	17.2	GO:0030198	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
2.3	16.1	GO:0060017	parathyroid gland development(GO:0060017)
0.3	15.1	GO:0000187	activation of MAPK activity(GO:0000187)
0.7	14.8	GO:0014823	response to activity(GO:0014823)
0.4	14.4	GO:0030199	collagen fibril organization(GO:0030199)
0.1	13.5	GO:0048706	embryonic skeletal system development(GO:0048706)

Showing 1 to 10 of 191 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	60.0	GO:0031012	extracellular matrix(GO:0031012)
0.4	45.1	GO:0016459	myosin complex(GO:0016459)
0.1	24.4	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.2	23.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5	22.5	GO:0005861	troponin complex(GO:0005861)
0.2	17.6	GO:0030018	Z disc(GO:0030018)
0.4	15.7	GO:0000421	autophagosome membrane(GO:0000421)
0.0	14.4	GO:0005615	extracellular space(GO:0005615)
0.1	14.0	GO:0016324	apical plasma membrane(GO:0016324)
0.2	13.9	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)

Showing 1 to 10 of 75 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	24.4	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	19.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.7	18.7	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	18.6	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	17.4	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	17.2	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	16.3	GO:0005179	hormone activity(GO:0005179)
0.0	15.8	GO:0005198	structural molecule activity(GO:0005198)
0.5	15.7	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
1.5	15.5	GO:0051373	telethonin binding(GO:0031433) FATZ binding(GO:0051373)

Showing 1 to 10 of 145 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	30.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	14.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	11.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.1	8.8	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	8.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	8.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	7.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	7.2	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	7.0	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	6.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors

Showing 1 to 10 of 28 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.3	14.4	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.5	11.1	REACTOME AMYLOIDS	Genes involved in Amyloids
0.7	9.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.8	8.0	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.6	7.3	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	7.3	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.3	7.0	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	6.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	5.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction

Showing 1 to 10 of 45 entries

Results for hoxa9a+hoxa9b

Z-value: 1.39

Motif logo

Transcription factors associated with hoxa9a+hoxa9b

Activity-expression correlation:

Activity profile of hoxa9a+hoxa9b motif

Sorted Z-values of hoxa9a+hoxa9b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa9a+hoxa9b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: