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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxb13a

Z-value: 0.41

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Transcription factors associated with hoxb13a

Gene Symbol Gene ID Gene Info
hoxb13a
ENSDARG00000056015 homeobox B13a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb13adr11_v1_chr3_+_23654233_236542330.093.7e-01Click!

Activity profile of hoxb13a motif

Sorted Z-values of hoxb13a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_18253111 4.59 ENSDART00000125984
mustn1b
musculoskeletal, embryonic nuclear protein 1b
chr17_-_15382704 2.98 ENSDART00000005313
zgc:85722
zgc:85722
chr20_+_40150612 2.84 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
trdn
triadin
chr11_-_30611814 2.33 ENSDART00000089803
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr12_+_41697664 2.29 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr5_-_46980651 2.08 ENSDART00000181022
ENSDART00000168038
edil3a
EGF-like repeats and discoidin I-like domains 3a
chr20_-_25709247 1.82 ENSDART00000146711
si:dkeyp-117h8.2
si:dkeyp-117h8.2
chr16_+_14002944 1.74 ENSDART00000059926
si:dkey-85k15.7
si:dkey-85k15.7
chr17_+_15788100 1.64 ENSDART00000027667
rragd
ras-related GTP binding D
chr7_-_30367650 1.47 ENSDART00000075519
aldh1a2
aldehyde dehydrogenase 1 family, member A2
chr16_-_563235 1.36 ENSDART00000016303
irx2a
iroquois homeobox 2a
chr20_+_29743904 1.35 ENSDART00000146366
ENSDART00000153154
kidins220b
kinase D-interacting substrate 220b
chr20_-_52338782 1.32 ENSDART00000109735
ENSDART00000132941
si:ch1073-287p18.1
si:ch1073-287p18.1
chr11_+_24314148 1.25 ENSDART00000171491
rem1
RAS (RAD and GEM)-like GTP-binding 1
chr17_-_7371564 1.20 ENSDART00000060336
rab32b
RAB32b, member RAS oncogene family
chr22_+_11857356 1.20 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr7_-_31781339 1.05 ENSDART00000142666
nap1l4b
nucleosome assembly protein 1-like 4b
chr16_-_27628994 1.02 ENSDART00000157407
nacad
NAC alpha domain containing
chr1_-_44940830 0.98 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
tmem176
transmembrane protein 176
chr18_+_44649804 0.95 ENSDART00000059063
ehd2b
EH-domain containing 2b
chr12_+_27704015 0.89 ENSDART00000153256
cacna1g
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr7_-_20865005 0.89 ENSDART00000190752
fis1
fission, mitochondrial 1
chr5_-_14390445 0.88 ENSDART00000026120
ap3m2
adaptor-related protein complex 3, mu 2 subunit
chr16_-_21785261 0.84 ENSDART00000078858
si:ch73-86n18.1
si:ch73-86n18.1
chr3_+_32443395 0.83 ENSDART00000188447
prr12b
proline rich 12b
chr25_+_28823952 0.80 ENSDART00000067072
nfybb
nuclear transcription factor Y, beta b
chr1_+_44941031 0.78 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr11_-_29623380 0.78 ENSDART00000162587
ENSDART00000193935
ENSDART00000191646
chd5
chromodomain helicase DNA binding protein 5
chr6_-_12644563 0.75 ENSDART00000153797
dock9b
dedicator of cytokinesis 9b
chr24_-_20808283 0.73 ENSDART00000143759
vipr1b
vasoactive intestinal peptide receptor 1b
chr2_-_40196547 0.64 ENSDART00000168098
ccl34a.3
chemokine (C-C motif) ligand 34a, duplicate 3
chr2_-_31735142 0.63 ENSDART00000130903
ralyl
RALY RNA binding protein like
chr10_+_39164638 0.63 ENSDART00000188997
CU633908.1

chr19_-_17526735 0.63 ENSDART00000189391
thrb
thyroid hormone receptor beta
chr12_-_3705862 0.62 ENSDART00000193864
ENSDART00000185857
CABZ01069040.1

chr7_-_8324927 0.61 ENSDART00000102535
f13a1b
coagulation factor XIII, A1 polypeptide b
chr17_-_23412705 0.60 ENSDART00000126995
si:ch211-149k12.3
si:ch211-149k12.3
chr21_-_27272657 0.60 ENSDART00000040754
ENSDART00000175009
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr2_-_31661609 0.60 ENSDART00000144383
si:ch211-106h4.9
si:ch211-106h4.9
chr17_-_45150763 0.59 ENSDART00000155043
ENSDART00000156786
ENSDART00000191147
tmed8
transmembrane p24 trafficking protein 8
chr15_+_11381532 0.59 ENSDART00000124172
si:ch73-321d9.2
si:ch73-321d9.2
chr20_+_34717403 0.55 ENSDART00000034252
pnocb
prepronociceptin b
chr23_+_35759843 0.55 ENSDART00000047082
gdap1l1
ganglioside induced differentiation associated protein 1-like 1
chr1_-_1627487 0.53 ENSDART00000166094
clic6
chloride intracellular channel 6
chr1_+_52481332 0.52 ENSDART00000074231
cldnd1b
claudin domain containing 1b
chr2_-_4070850 0.52 ENSDART00000159990
yme1l1b
YME1-like 1b
chr13_-_26799244 0.51 ENSDART00000036419
vrk2
vaccinia related kinase 2
chr14_-_24761132 0.50 ENSDART00000146299
slit3
slit homolog 3 (Drosophila)
chr13_+_22675802 0.50 ENSDART00000145538
ENSDART00000143312
zgc:193505
zgc:193505
chr23_+_30048849 0.49 ENSDART00000126027
uts2a
urotensin 2, alpha
chr10_-_22249444 0.49 ENSDART00000148831
fgf11b
fibroblast growth factor 11b
chr14_+_23184517 0.47 ENSDART00000181410
enox2
ecto-NOX disulfide-thiol exchanger 2
chr21_-_37733287 0.45 ENSDART00000157826
mpp1
membrane protein, palmitoylated 1
chr19_-_40776267 0.45 ENSDART00000189038
calcr
calcitonin receptor
chr9_+_2333550 0.44 ENSDART00000016417
atp5mc3a
ATP synthase membrane subunit c locus 3a
chr8_-_25120231 0.43 ENSDART00000147308
amigo1
adhesion molecule with Ig-like domain 1
chr23_+_13124085 0.42 ENSDART00000139475
samd10b
sterile alpha motif domain containing 10b
chr21_-_27273147 0.41 ENSDART00000143239
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr24_-_36238054 0.39 ENSDART00000155725
tmem241
transmembrane protein 241
chr3_+_60044780 0.38 ENSDART00000080437
zgc:113030
zgc:113030
chr6_+_45300746 0.37 ENSDART00000159176
BX942846.1

chr18_+_1154189 0.36 ENSDART00000135090
si:ch1073-75f15.2
si:ch1073-75f15.2
chr5_-_26181863 0.35 ENSDART00000098500
ccdc125
coiled-coil domain containing 125
chr23_-_24226533 0.34 ENSDART00000109134
plekhm2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr25_+_19106574 0.32 ENSDART00000067332
rlbp1b
retinaldehyde binding protein 1b
chr8_+_50953776 0.32 ENSDART00000013870
zgc:56596
zgc:56596
chr6_+_35362225 0.31 ENSDART00000133783
ENSDART00000102483
rgs4
regulator of G protein signaling 4
chr23_-_7799184 0.31 ENSDART00000190946
ENSDART00000165427
myt1b
myelin transcription factor 1b
chr12_-_7253270 0.31 ENSDART00000035762
ube2d1b
ubiquitin-conjugating enzyme E2D 1b
chr6_-_28222592 0.30 ENSDART00000131126
bcl6a
B-cell CLL/lymphoma 6a (zinc finger protein 51)
chr16_-_41717063 0.30 ENSDART00000084610
cep85
centrosomal protein 85
chr22_+_2390544 0.30 ENSDART00000147345
ENSDART00000133611
zgc:171435
zgc:171435
chr22_+_18187857 0.28 ENSDART00000166300
mef2b
myocyte enhancer factor 2b
chr17_-_11439815 0.27 ENSDART00000130105
psma3
proteasome subunit alpha 3
chr10_-_21953643 0.27 ENSDART00000188921
ENSDART00000193569
FO744833.2

chr7_-_40082053 0.27 ENSDART00000083719
ENSDART00000173687
shrprbck1r
sharpin and rbck1 related
chr23_+_31596441 0.26 ENSDART00000053534
tbpl1
TBP-like 1
chr18_-_9046805 0.26 ENSDART00000134224
grm3
glutamate receptor, metabotropic 3
chr19_-_5380770 0.24 ENSDART00000000221
krt91
keratin 91
chr22_-_13466246 0.23 ENSDART00000134035
cntnap5b
contactin associated protein-like 5b
chr13_-_49802194 0.20 ENSDART00000148722
b3galnt2
beta-1,3-N-acetylgalactosaminyltransferase 2
chr25_-_31739309 0.20 ENSDART00000098896
acot19
acyl-CoA thioesterase 19
chr23_-_19682971 0.16 ENSDART00000048891
zgc:193598
zgc:193598
chr17_-_52587598 0.14 ENSDART00000061497
si:ch211-173a9.6
si:ch211-173a9.6
chr20_-_48485354 0.13 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr25_+_25453221 0.12 ENSDART00000176822
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr19_+_42071033 0.11 ENSDART00000169067
ENSDART00000183436
nfyc
nuclear transcription factor Y, gamma
chr2_+_16597011 0.11 ENSDART00000160641
ENSDART00000125413
xrn1
5'-3' exoribonuclease 1
chr4_-_4387012 0.09 ENSDART00000191836
CU468826.3
Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr2_-_7711522 0.09 ENSDART00000163175
dcun1d1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr20_-_19511700 0.08 ENSDART00000040191
snx17
sorting nexin 17
chr17_+_31820401 0.07 ENSDART00000192607
ENSDART00000157490
eef1akmt2
EEF1A lysine methyltransferase 2
chr2_-_59145027 0.07 ENSDART00000128320
FO834803.1

chr5_+_27434601 0.06 ENSDART00000064701
loxl2b
lysyl oxidase-like 2b
chr22_+_2228919 0.05 ENSDART00000133475
znf1161
zinc finger protein 1161
chr5_+_37406358 0.04 ENSDART00000162811
klhl13
kelch-like family member 13
chr9_-_14683574 0.03 ENSDART00000144022
pard3bb
par-3 family cell polarity regulator beta b
chr10_-_7785930 0.03 ENSDART00000043961
ENSDART00000111058
mpx
myeloid-specific peroxidase
chr15_-_17406056 0.02 ENSDART00000146735
tubd1
tubulin, delta 1
chr8_+_10339869 0.01 ENSDART00000132253
tbc1d22b
TBC1 domain family, member 22B

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb13a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.6 GO:0035988 chondrocyte proliferation(GO:0035988)
0.4 1.5 GO:0061113 pancreas morphogenesis(GO:0061113)
0.3 2.3 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.3 1.3 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 0.6 GO:0046552 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.1 0.9 GO:0016559 peroxisome fission(GO:0016559) mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 2.3 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.5 GO:0007624 ultradian rhythm(GO:0007624)
0.1 0.3 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 1.4 GO:0035778 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014)
0.1 1.6 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 1.2 GO:0032438 melanosome organization(GO:0032438)
0.1 0.3 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.9 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.6 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.5 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.3 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.3 GO:1903729 regulation of plasma membrane organization(GO:1903729)
0.0 0.4 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 1.0 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.4 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.1 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.0 0.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.8 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 1.0 GO:0006612 protein targeting to membrane(GO:0006612)
0.0 1.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0007634 optokinetic behavior(GO:0007634)
0.0 0.4 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 1.0 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 2.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.9 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.2 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.3 GO:0042383 sarcolemma(GO:0042383)
0.0 1.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 2.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.6 GO:0043679 axon terminus(GO:0043679)
0.0 0.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.2 0.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.4 GO:0097643 amylin receptor activity(GO:0097643)
0.1 0.9 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.7 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 1.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 0.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 1.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.3 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 2.1 GO:0005178 integrin binding(GO:0005178)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0019894 kinesin binding(GO:0019894)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.6 GO:0017022 myosin binding(GO:0017022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.2 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling