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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxb1a+hoxb1b-2

Z-value: 1.30

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Transcription factors associated with hoxb1a+hoxb1b-2

Gene Symbol Gene ID Gene Info
hoxb1a
ENSDARG00000008174 homeobox B1a
hoxb1b-2
ENSDARG00000112663 homeobox B1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb1adr11_v1_chr3_+_23768898_237688980.151.6e-01Click!

Activity profile of hoxb1a+hoxb1b-2 motif

Sorted Z-values of hoxb1a+hoxb1b-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_36378494 33.28 ENSDART00000058503
gpm6aa
glycoprotein M6Aa
chr7_-_13381129 31.31 ENSDART00000164326
si:ch73-119p20.1
si:ch73-119p20.1
chr12_-_25916530 25.27 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr25_+_7461624 23.82 ENSDART00000170569
syt12
synaptotagmin XII
chr1_-_38709551 23.23 ENSDART00000128794
gpm6ab
glycoprotein M6Ab
chr4_+_21129752 22.43 ENSDART00000169764
syt1a
synaptotagmin Ia
chr3_+_29714775 21.88 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr1_-_20911297 19.33 ENSDART00000078271
cpe
carboxypeptidase E
chr25_-_13842618 18.38 ENSDART00000160258
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr4_+_26496489 18.16 ENSDART00000160652
iqsec3a
IQ motif and Sec7 domain 3a
chr7_-_52842007 17.71 ENSDART00000182710
map1aa
microtubule-associated protein 1Aa
chr23_-_11870962 17.63 ENSDART00000143481
si:dkey-178k16.1
si:dkey-178k16.1
chr14_-_7888748 17.56 ENSDART00000166293
ppp3cb
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_-_10220036 17.29 ENSDART00000134619
mpp2b
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr10_-_27049170 17.14 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr16_+_46111849 15.92 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr10_+_466926 15.35 ENSDART00000145220
arvcfa
ARVCF, delta catenin family member a
chr17_+_19626479 14.89 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr2_+_27010439 14.73 ENSDART00000030547
cdh7a
cadherin 7a
chr21_-_28920245 14.62 ENSDART00000132884
cxxc5a
CXXC finger protein 5a
chr1_-_8428736 14.30 ENSDART00000138435
ENSDART00000121823
syngr3b
synaptogyrin 3b
chr15_-_16704417 14.13 ENSDART00000155163
caln1
calneuron 1
chr3_+_37824268 14.07 ENSDART00000137038
asic2
acid-sensing (proton-gated) ion channel 2
chr22_-_13544244 14.05 ENSDART00000110136
cntnap5b
contactin associated protein-like 5b
chr18_+_28102620 13.91 ENSDART00000132342
kiaa1549lb
KIAA1549-like b
chr11_+_30817943 12.33 ENSDART00000150130
ENSDART00000159997
cacna1ab
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr17_-_20897250 11.57 ENSDART00000088106
ank3b
ankyrin 3b
chr22_-_600016 11.34 ENSDART00000086434
tmcc2
transmembrane and coiled-coil domain family 2
chr18_+_24922125 10.46 ENSDART00000180385
rgma
repulsive guidance molecule family member a
chr16_-_31188715 10.33 ENSDART00000058829
scrt1b
scratch family zinc finger 1b
chr2_+_29249204 10.08 ENSDART00000168957
cdh18a
cadherin 18, type 2a
chr24_+_32472155 9.89 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr17_-_7436766 9.80 ENSDART00000162002
grm1b
glutamate receptor, metabotropic 1b
chr16_-_37964325 9.15 ENSDART00000148801
mrap2a
melanocortin 2 receptor accessory protein 2a
chr20_-_35841570 9.12 ENSDART00000037855
tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr5_-_52277643 9.05 ENSDART00000010757
rgmb
repulsive guidance molecule family member b
chr8_-_39903803 8.88 ENSDART00000012391
cabp1a
calcium binding protein 1a
chr24_-_40009446 8.59 ENSDART00000087422
aoc1
amine oxidase, copper containing 1
chr3_-_35800221 8.40 ENSDART00000031390
caskin1
CASK interacting protein 1
chr11_-_27702778 8.31 ENSDART00000045942
ENSDART00000125352
phf2
PHD finger protein 2
chr4_+_4272622 8.18 ENSDART00000164810
ano2
anoctamin 2
chr14_+_34547554 7.72 ENSDART00000074819
gabrp
gamma-aminobutyric acid (GABA) A receptor, pi
chr9_+_35017702 7.51 ENSDART00000193640
gabpa
GA binding protein transcription factor, alpha subunit
chr22_+_3223489 7.50 ENSDART00000082011
lim2.2
lens intrinsic membrane protein 2.2
chr3_-_57744323 7.00 ENSDART00000101829
lgals3bpb
lectin, galactoside-binding, soluble, 3 binding protein b
chr17_+_51764310 6.24 ENSDART00000157171
si:ch211-168d23.3
si:ch211-168d23.3
chr6_-_13401133 6.20 ENSDART00000151206
fmnl2b
formin-like 2b
chr10_-_2527342 6.03 ENSDART00000184168
CU856539.1

chr1_+_34181581 5.85 ENSDART00000146042
epha6
eph receptor A6
chr17_-_20394566 5.67 ENSDART00000154667
sorcs3b
sortilin related VPS10 domain containing receptor 3b
chr2_-_16217344 5.58 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr2_+_25657958 5.48 ENSDART00000161407
tnika
TRAF2 and NCK interacting kinase a
chr2_+_2223837 5.46 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr2_+_25658112 5.32 ENSDART00000051234
tnika
TRAF2 and NCK interacting kinase a
chr3_+_15805917 5.23 ENSDART00000055834
phospho1
phosphatase, orphan 1
chr18_-_18875308 5.06 ENSDART00000127182
arl2bp
ADP-ribosylation factor-like 2 binding protein
chr5_-_37881345 4.76 ENSDART00000084819
arhgap35b
Rho GTPase activating protein 35b
chr8_-_44015210 4.53 ENSDART00000186879
ENSDART00000188965
ENSDART00000001313
ENSDART00000188902
ENSDART00000185935
ENSDART00000147869
rimbp2
rimbp2
RIMS binding protein 2
RIMS binding protein 2
chr7_+_7151832 4.50 ENSDART00000109485
gal3st3
galactose-3-O-sulfotransferase 3
chr17_-_20897407 4.49 ENSDART00000149481
ank3b
ankyrin 3b
chr18_-_18874921 4.24 ENSDART00000193332
arl2bp
ADP-ribosylation factor-like 2 binding protein
chr21_-_25395223 4.17 ENSDART00000016219
ppme1
protein phosphatase methylesterase 1
chr7_+_36898850 4.16 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr22_-_16997475 3.99 ENSDART00000090237
nfia
nuclear factor I/A
chr3_-_21062706 3.98 ENSDART00000155605
ENSDART00000153686
ENSDART00000157168
ENSDART00000156614
ENSDART00000155743
ENSDART00000156275
fam57ba
family with sequence similarity 57, member Ba
chr19_+_13994563 3.90 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr6_-_4214297 3.81 ENSDART00000191433
trak2
trafficking protein, kinesin binding 2
chr25_+_2668892 3.72 ENSDART00000122929
bbs4
Bardet-Biedl syndrome 4
chr16_-_1502699 3.60 ENSDART00000187189
sim1a
single-minded family bHLH transcription factor 1a
chr7_-_37547889 3.46 ENSDART00000193359
cylda
cylindromatosis (turban tumor syndrome), a
chr6_-_53143667 3.41 ENSDART00000079694
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr1_-_14258409 3.39 ENSDART00000079359
pde5aa
phosphodiesterase 5A, cGMP-specific, a
chr9_-_53537989 3.30 ENSDART00000114022
slitrk5b
SLIT and NTRK-like family, member 5b
chr25_-_35497055 3.24 ENSDART00000009271
slc5a12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr9_+_32073606 3.13 ENSDART00000184170
ENSDART00000180355
ENSDART00000110204
ENSDART00000123278
pikfyve
phosphoinositide kinase, FYVE finger containing
chr24_-_21713883 3.12 ENSDART00000081357
flt3
fms-related tyrosine kinase 3
chr3_-_6417328 3.07 ENSDART00000160979
jpt1b
Jupiter microtubule associated homolog 1b
chr10_+_1396940 2.92 ENSDART00000150096
gdnfa
glial cell derived neurotrophic factor a
chr9_+_21795917 2.90 ENSDART00000169069
rev1
REV1, polymerase (DNA directed)
chr4_-_17642168 2.87 ENSDART00000007030
klhl42
kelch-like family, member 42
chr3_-_21118969 2.82 ENSDART00000129016
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr14_-_26377044 2.63 ENSDART00000022236
emx3
empty spiracles homeobox 3
chr2_-_45630823 2.60 ENSDART00000183553
CR450720.1

chr10_-_31175744 2.42 ENSDART00000191728
pknox2
pbx/knotted 1 homeobox 2
chr3_-_55650771 2.39 ENSDART00000162413
axin2
axin 2 (conductin, axil)
chr18_+_40354998 2.35 ENSDART00000098791
ENSDART00000049171
sema6dl
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr8_+_6410933 2.10 ENSDART00000168789
lrrtm4l2
leucine rich repeat transmembrane neuronal 4 like 2
chr24_-_39518599 1.92 ENSDART00000145606
ENSDART00000031486
lyrm1
LYR motif containing 1
chr3_-_1283247 1.90 ENSDART00000149814
tcf20
transcription factor 20
chr19_-_867071 1.78 ENSDART00000122257
eomesa
eomesodermin homolog a
chr5_-_16791223 1.56 ENSDART00000192744
atad1a
ATPase family, AAA domain containing 1a
chr7_-_33350082 1.45 ENSDART00000008785
anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr10_+_32646402 1.42 ENSDART00000137244
zbtb21
zinc finger and BTB domain containing 21
chr14_-_24101897 1.38 ENSDART00000143695
cpeb4a
cytoplasmic polyadenylation element binding protein 4a
chr3_+_40409100 1.33 ENSDART00000103486
tnrc18
trinucleotide repeat containing 18
chr16_-_32582798 1.26 ENSDART00000137936
fbxl4
F-box and leucine-rich repeat protein 4
chr6_+_29791164 1.25 ENSDART00000017424
ptmaa
prothymosin, alpha a
chr23_+_27782071 1.24 ENSDART00000131379
kmt2d
lysine (K)-specific methyltransferase 2D
chr16_+_10422836 1.21 ENSDART00000161568
ino80e
INO80 complex subunit E
chr13_-_31829786 1.21 ENSDART00000138667
sertad4
SERTA domain containing 4
chr10_-_25591194 1.16 ENSDART00000131640
tiam1a
T cell lymphoma invasion and metastasis 1a
chr4_-_8014463 1.14 ENSDART00000036153
ccdc3a
coiled-coil domain containing 3a
chr10_+_37182626 1.11 ENSDART00000137636
ksr1a
kinase suppressor of ras 1a
chr24_+_34113424 1.06 ENSDART00000105572
gbx1
gastrulation brain homeobox 1
chr5_-_52921532 1.02 ENSDART00000160566
CU695117.1

chr24_+_39518774 0.90 ENSDART00000132939
dcun1d3
defective in cullin neddylation 1 domain containing 3
chr17_-_28101880 0.84 ENSDART00000149458
ENSDART00000149226
ENSDART00000085758
kdm1a
lysine (K)-specific demethylase 1a
chr3_-_55650417 0.83 ENSDART00000171441
axin2
axin 2 (conductin, axil)
chr1_+_26626824 0.82 ENSDART00000158193
coro2a
coronin, actin binding protein, 2A
chr22_+_35089031 0.76 ENSDART00000076040
srfa
serum response factor a
chr5_-_22544151 0.69 ENSDART00000006474
glra4b
glycine receptor, alpha 4b
chr2_+_10821127 0.62 ENSDART00000145770
ENSDART00000174629
ENSDART00000081094
glmna
glomulin, FKBP associated protein a
chr7_+_16835218 0.55 ENSDART00000173580
nav2a
neuron navigator 2a
chr5_+_31959954 0.52 ENSDART00000142826
myo1hb
myosin IHb
chr6_+_19383267 0.40 ENSDART00000166549
mchr1a
melanin-concentrating hormone receptor 1a
chr1_-_10577945 0.21 ENSDART00000179237
ENSDART00000040502
ENSDART00000186876
trpc5a
transient receptor potential cation channel, subfamily C, member 5a
chr1_+_26071869 0.18 ENSDART00000059264
mxd4
MAX dimerization protein 4
chr1_-_26071535 0.11 ENSDART00000185187
pdcd4a
programmed cell death 4a
chr17_-_50233493 0.09 ENSDART00000172266
fosaa
v-fos FBJ murine osteosarcoma viral oncogene homolog Aa
chr17_+_40684 0.09 ENSDART00000164231
CABZ01111555.1

chr10_+_7563755 0.09 ENSDART00000165877
purg
purine-rich element binding protein G
chr24_-_20016817 0.05 ENSDART00000082201
ENSDART00000189448
slc22a13b
solute carrier family 22 member 13b
chr11_+_2600612 0.04 ENSDART00000173442
dnajc14
DnaJ (Hsp40) homolog, subfamily C, member 14
chr11_-_20956309 0.02 ENSDART00000188659
CABZ01008739.1

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb1a+hoxb1b-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0031642 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
2.8 8.3 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
2.1 10.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
1.7 8.6 GO:0046677 response to antibiotic(GO:0046677)
1.3 23.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.2 17.6 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
1.1 40.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.1 26.8 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
1.0 22.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.0 23.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
1.0 2.9 GO:0060688 regulation of neurotransmitter uptake(GO:0051580) regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.9 3.7 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.8 9.1 GO:0034394 protein localization to cell surface(GO:0034394) energy homeostasis(GO:0097009)
0.8 16.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.7 2.9 GO:0070987 error-free translesion synthesis(GO:0070987)
0.7 9.3 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.7 17.7 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.7 11.3 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.6 3.8 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.6 23.8 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.6 1.8 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.6 3.5 GO:1990108 protein linear deubiquitination(GO:1990108)
0.5 17.1 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.4 32.4 GO:0021549 cerebellum development(GO:0021549)
0.4 18.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.4 3.4 GO:0035587 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.3 23.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.3 3.2 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.3 9.8 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.3 5.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.3 18.4 GO:0046328 regulation of JNK cascade(GO:0046328)
0.2 10.8 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098)
0.2 5.2 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.2 5.0 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.2 1.2 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.1 3.1 GO:0030183 B cell differentiation(GO:0030183)
0.1 19.3 GO:0016485 protein processing(GO:0016485)
0.1 2.9 GO:1990798 pancreas regeneration(GO:1990798)
0.1 15.9 GO:0006836 neurotransmitter transport(GO:0006836)
0.1 14.1 GO:0048545 response to steroid hormone(GO:0048545)
0.1 2.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 14.6 GO:0001947 heart looping(GO:0001947)
0.1 6.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 4.5 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.1 11.1 GO:0050769 positive regulation of neurogenesis(GO:0050769)
0.1 0.9 GO:0045116 protein neddylation(GO:0045116)
0.1 40.2 GO:0031175 neuron projection development(GO:0031175)
0.1 6.9 GO:0071772 BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773)
0.0 3.2 GO:0006814 sodium ion transport(GO:0006814)
0.0 1.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.5 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.4 GO:0006913 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 56.5 GO:0044295 axonal growth cone(GO:0044295)
4.5 22.4 GO:0042584 chromaffin granule membrane(GO:0042584)
2.9 17.6 GO:0005955 calcineurin complex(GO:0005955)
0.8 19.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 25.3 GO:0043679 axon terminus(GO:0043679)
0.6 23.7 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.6 14.3 GO:0031594 neuromuscular junction(GO:0031594)
0.4 24.8 GO:0016342 catenin complex(GO:0016342)
0.3 15.9 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 7.7 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 8.7 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.2 12.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 6.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.2 17.7 GO:0043025 neuronal cell body(GO:0043025)
0.2 23.8 GO:0070382 exocytic vesicle(GO:0070382)
0.1 8.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 1.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 20.9 GO:0036477 dendrite(GO:0030425) somatodendritic compartment(GO:0036477)
0.1 1.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 1.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 8.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 8.9 GO:0043235 receptor complex(GO:0043235)
0.0 5.3 GO:0005912 adherens junction(GO:0005912)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.5 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 25.3 GO:1903136 cuprous ion binding(GO:1903136)
2.9 17.6 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
2.3 9.1 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
1.7 8.6 GO:0008131 primary amine oxidase activity(GO:0008131)
1.4 9.8 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
1.2 14.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
1.0 14.6 GO:0008327 methyl-CpG binding(GO:0008327)
1.0 19.5 GO:0015026 coreceptor activity(GO:0015026)
1.0 46.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.8 3.2 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.7 19.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 2.9 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.5 8.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.5 4.5 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.4 12.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 40.2 GO:0045296 cadherin binding(GO:0045296)
0.4 21.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.3 5.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 3.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 7.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 3.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 3.8 GO:0050811 GABA receptor binding(GO:0050811)
0.2 1.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.4 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.1 0.8 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1 3.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 3.1 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 1.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.7 GO:0016933 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 2.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 4.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 1.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 17.1 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0097602 cullin family protein binding(GO:0097602)
0.0 2.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 3.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 4.0 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 2.1 GO:0042802 identical protein binding(GO:0042802)
0.0 10.4 GO:0046983 protein dimerization activity(GO:0046983)
0.0 11.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 4.8 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 17.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.5 19.5 PID BMP PATHWAY BMP receptor signaling
0.5 19.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 3.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 5.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 17.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.9 19.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 19.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.4 5.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.3 3.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 9.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 3.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 2.9 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements