ISMARA results: hoxb6a+hoxb6b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxb6a+hoxb6b

Z-value: 6.59

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Transcription factors associated with hoxb6a+hoxb6b

Gene Symbol	Gene ID	Gene Info
hoxb6a NCBI UniProt	ENSDARG00000010630	homeobox B6a
hoxb6b NCBI UniProt	ENSDARG00000026513	homeobox B6b
hoxb6b NCBI UniProt	ENSDARG00000111786	homeobox B6b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hoxb6b	dr11_v1_chr12_+_27127139_27127139	0.51	1.1e-07	Click!
hoxb6a	dr11_v1_chr3_+_23703704_23703704	0.23	2.4e-02	Click!

Activity profile of hoxb6a+hoxb6b motif

Sorted Z-values of hoxb6a+hoxb6b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_25916530 Show fit	78.82	ENSDART00000186386	sncgb NCBI UniProt Show fit	synuclein, gamma b (breast cancer-specific protein 1)
chr8_-_49431939 Show fit	75.54	ENSDART00000011453 ENSDART00000088240 ENSDART00000114173	sypb NCBI UniProt Show fit	synaptophysin b
chr9_-_32753535 Show fit	68.04	ENSDART00000060006	olig2 NCBI UniProt Show fit	oligodendrocyte lineage transcription factor 2
chr20_+_34915945 Show fit	66.28	ENSDART00000153064	snap25a NCBI UniProt Show fit	synaptosomal-associated protein, 25a
chr2_-_54387550 Show fit	62.83	ENSDART00000097388	napgb NCBI UniProt Show fit	N-ethylmaleimide-sensitive factor attachment protein, gamma b
chr10_-_17745345 Show fit	61.74	ENSDART00000132690 ENSDART00000135376	si:dkey-200l5.4 NCBI UniProt Show fit	si:dkey-200l5.4
chr21_-_21373242 Show fit	57.87	ENSDART00000079629	ppm1nb NCBI UniProt Show fit	protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative)
chr22_-_13851297 Show fit	57.34	ENSDART00000080306	s100b NCBI UniProt Show fit	S100 calcium binding protein, beta (neural)
chr4_-_7212875 Show fit	57.06	ENSDART00000161297	lrrn3b NCBI UniProt Show fit	leucine rich repeat neuronal 3b
chr5_-_29643930 Show fit	56.90	ENSDART00000161250	grin1b NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb6a+hoxb6b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	462.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9	457.5	GO:0031175	neuron projection development(GO:0031175)
1.0	288.5	GO:0099536	synaptic signaling(GO:0099536)
1.0	245.4	GO:0043547	positive regulation of GTPase activity(GO:0043547)
2.3	211.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
3.5	170.2	GO:0007019	microtubule depolymerization(GO:0007019)
2.3	155.0	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)
5.5	149.1	GO:0016082	synaptic vesicle priming(GO:0016082)
16.3	146.8	GO:0051965	positive regulation of synapse assembly(GO:0051965)
6.3	143.9	GO:0071542	dopaminergic neuron differentiation(GO:0071542)

Showing 1 to 10 of 519 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	658.6	GO:0005634	nucleus(GO:0005634)
1.3	551.7	GO:0043005	neuron projection(GO:0043005)
4.6	346.7	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3	319.7	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
6.3	278.1	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
6.9	234.5	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
2.3	217.8	GO:0008021	synaptic vesicle(GO:0008021)
1.8	214.4	GO:0045211	postsynaptic membrane(GO:0045211)
4.7	198.5	GO:0030426	growth cone(GO:0030426)
1.6	185.1	GO:0014069	postsynaptic density(GO:0014069)

Showing 1 to 10 of 202 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	405.2	GO:0005509	calcium ion binding(GO:0005509)
0.2	396.6	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
9.6	385.5	GO:0017075	syntaxin-1 binding(GO:0017075)
0.7	283.0	GO:0003712	transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.9	281.0	GO:0015631	tubulin binding(GO:0015631)
18.2	273.1	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.7	235.5	GO:0005096	GTPase activator activity(GO:0005096)
14.4	201.1	GO:0008503	benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.6	200.5	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.6	194.0	GO:0003924	GTPase activity(GO:0003924)

Showing 1 to 10 of 375 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.0	84.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
1.7	74.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
2.2	65.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
1.2	54.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
1.7	48.6	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.8	45.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.3	44.9	ST G ALPHA I PATHWAY	G alpha i Pathway
2.0	44.1	PID NETRIN PATHWAY	Netrin-mediated signaling events
2.0	42.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
1.5	42.1	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
13.5	202.9	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
16.0	79.9	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
5.7	79.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
5.4	65.3	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
1.1	59.0	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.8	57.6	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
7.7	53.8	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
5.7	51.3	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
3.2	45.4	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
1.3	44.2	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events

Showing 1 to 10 of 106 entries

Results for hoxb6a+hoxb6b

Z-value: 6.59

Motif logo

Transcription factors associated with hoxb6a+hoxb6b

Activity-expression correlation:

Activity profile of hoxb6a+hoxb6b motif

Sorted Z-values of hoxb6a+hoxb6b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb6a+hoxb6b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: