ISMARA results: ikzf2

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for ikzf2

Z-value: 1.02

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Transcription factors associated with ikzf2

Gene Symbol	Gene ID	Gene Info
ikzf2 NCBI UniProt	ENSDARG00000069111	IKAROS family zinc finger 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IKZF2	dr11_v1_chr9_-_40014339_40014339	0.75	2.2e-18	Click!

Activity profile of ikzf2 motif

Sorted Z-values of ikzf2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_30921246 Show fit	19.31	ENSDART00000076850	cldni NCBI UniProt Show fit	claudin i
chr3_+_39540014 Show fit	13.54	ENSDART00000074848	zgc:165423 NCBI UniProt Show fit	zgc:165423
chr20_+_46040666 Show fit	13.03	ENSDART00000060744	si:dkey-7c18.24 NCBI UniProt Show fit	si:dkey-7c18.24
chr6_-_33075576 Show fit	10.00	ENSDART00000154017	si:dkey-170g13.2 NCBI UniProt Show fit	si:dkey-170g13.2
chr16_-_31976269 Show fit	9.04	ENSDART00000139664	styk1 NCBI UniProt Show fit	serine/threonine/tyrosine kinase 1
chr25_-_8602437 Show fit	8.86	ENSDART00000171200	rhcgb NCBI UniProt Show fit	Rh family, C glycoprotein b
chr1_+_1689775 Show fit	8.85	ENSDART00000048828	atp1a1a.4 NCBI UniProt Show fit	ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 4
chr18_-_17485419 Show fit	8.28	ENSDART00000018764	foxl1 NCBI UniProt Show fit	forkhead box L1
chr12_-_8070969 Show fit	7.89	ENSDART00000020995	tmem26b NCBI UniProt Show fit	transmembrane protein 26b
chr18_+_7591381 Show fit	7.66	ENSDART00000136313	si:dkeyp-1h4.6 NCBI UniProt Show fit	si:dkeyp-1h4.6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ikzf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	19.3	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.3	9.9	GO:0044243	collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.2	9.1	GO:0048247	lymphocyte chemotaxis(GO:0048247)
1.8	8.9	GO:0097272	ammonia homeostasis(GO:0097272)
0.1	8.2	GO:0060395	SMAD protein signal transduction(GO:0060395)
0.4	7.6	GO:0030007	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.4	7.5	GO:0034625	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3	7.2	GO:1903845	negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1	6.8	GO:0048916	posterior lateral line development(GO:0048916)
0.1	6.7	GO:0006937	regulation of muscle contraction(GO:0006937)

Showing 1 to 10 of 159 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	19.1	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0	13.8	GO:0005764	lysosome(GO:0005764)
0.0	9.7	GO:0000139	Golgi membrane(GO:0000139)
0.0	8.2	GO:0031012	extracellular matrix(GO:0031012)
0.3	7.0	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.0	6.9	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.4	6.3	GO:0005869	dynactin complex(GO:0005869)
0.3	6.2	GO:0045180	basal cortex(GO:0045180)
0.4	5.9	GO:0002102	podosome(GO:0002102)
0.0	5.9	GO:0030017	sarcomere(GO:0030017)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	16.8	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	12.2	GO:0005198	structural molecule activity(GO:0005198)
0.0	11.7	GO:0005525	GTP binding(GO:0005525)
0.1	9.3	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.2	9.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.9	8.9	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.4	8.9	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.0	8.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	7.6	GO:0051015	actin filament binding(GO:0051015)
0.4	7.5	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)

Showing 1 to 10 of 114 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.4	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.2	7.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	6.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	4.4	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.2	4.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	3.8	PID BCR 5PATHWAY	BCR signaling pathway
0.2	3.7	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	3.4	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.1	2.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	2.6	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	7.3	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1	6.6	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.6	6.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.3	6.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	4.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	3.8	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.5	3.5	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	3.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6	3.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	3.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 42 entries

Results for ikzf2

Z-value: 1.02

Motif logo

Transcription factors associated with ikzf2

Activity-expression correlation:

Activity profile of ikzf2 motif

Sorted Z-values of ikzf2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ikzf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: