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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for insm1a+insm1b

Z-value: 0.50

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Transcription factors associated with insm1a+insm1b

Gene Symbol Gene ID Gene Info
ENSDARG00000053301 insulinoma-associated 1b
ENSDARG00000091756 insulinoma-associated 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
insm1bdr11_v1_chr17_+_41463942_414639420.065.5e-01Click!
insm1adr11_v1_chr20_-_48485354_484853540.056.0e-01Click!

Activity profile of insm1a+insm1b motif

Sorted Z-values of insm1a+insm1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_51830997 4.41 ENSDART00000163616
homer scaffolding protein 1b
chr3_-_49566364 3.78 ENSDART00000161507
zgc:153426
chr8_-_37391372 2.72 ENSDART00000190407
ENSDART00000009569
solute carrier family 12 (potassium/chloride transporter), member 5b
chr2_+_58221163 2.46 ENSDART00000157939

chr11_+_25619892 2.40 ENSDART00000146647
ENSDART00000033702
catechol-O-methyltransferase b
chr13_+_23176330 2.35 ENSDART00000168351
sorbin and SH3 domain containing 1
chr10_+_21801030 2.33 ENSDART00000160881
ENSDART00000187969
protocadherin 1 gamma 30
chr8_-_14484599 2.30 ENSDART00000057644
LIM homeobox 4
chr17_-_4318393 2.26 ENSDART00000167995
ENSDART00000153824
N-ethylmaleimide-sensitive factor attachment protein, beta a
chr7_+_23515966 2.25 ENSDART00000186893
ENSDART00000186189
zgc:109889
chr4_+_13733838 2.10 ENSDART00000067166
ENSDART00000133157
contactin 1b
chr15_-_33925851 1.94 ENSDART00000187807
ENSDART00000187780
myelin associated glycoprotein
chr7_+_73397283 1.84 ENSDART00000174390

chr4_-_5597802 1.79 ENSDART00000136229
vascular endothelial growth factor Ab
chr16_-_29458806 1.79 ENSDART00000047931
leucine rich repeat and Ig domain containing 4b
chr8_+_1082100 1.79 ENSDART00000149276
leucine zipper, putative tumor suppressor family member 3b
chr18_+_5137241 1.64 ENSDART00000159601
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr23_-_21797517 1.62 ENSDART00000110041
leucine rich repeat containing 38a
chr18_+_642889 1.60 ENSDART00000189007

chr12_+_11352630 1.52 ENSDART00000129495
si:rp71-19m20.1
chr7_-_41489997 1.52 ENSDART00000174300
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr17_-_52579709 1.47 ENSDART00000156806
ribosomal protein S6 kinase-like 1
chr3_-_6768905 1.42 ENSDART00000193638
ENSDART00000123809
ENSDART00000189440
ENSDART00000188335
microtubule associated serine/threonine kinase 1b
chr7_-_72423666 1.36 ENSDART00000191214
rabphilin 3A homolog (mouse), b
chr19_+_46158078 1.35 ENSDART00000183933
ENSDART00000164055
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr9_-_4598883 1.34 ENSDART00000171927
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr14_-_6402769 1.29 ENSDART00000121552
solute carrier family 44 (choline transporter), member 1b
chr12_-_4683325 1.28 ENSDART00000152771
si:ch211-255p10.3
chr9_-_1434484 1.27 ENSDART00000093412
oxysterol binding protein-like 6
chr18_+_50278858 1.26 ENSDART00000014582
si:dkey-105e17.1
chr18_+_48608366 1.26 ENSDART00000151229
potassium inwardly-rectifying channel, subfamily J, member 5
chr11_+_24620742 1.25 ENSDART00000182471
ENSDART00000048365
synaptotagmin VIb
chr17_+_45454943 1.24 ENSDART00000074838
potassium channel, subfamily K, member 3b
chr9_+_53719230 1.24 ENSDART00000165827
si:ch211-199f5.1
chr3_+_14388010 1.24 ENSDART00000171726
ENSDART00000165452
transmembrane protein 56b
chr13_+_40034176 1.23 ENSDART00000189797
golgin A7 family, member Bb
chr18_+_18612388 1.19 ENSDART00000186455
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr9_+_4429593 1.16 ENSDART00000184855

chr21_+_32332616 1.14 ENSDART00000154105
si:ch211-247j9.1
chr2_+_1202347 1.12 ENSDART00000075837

chr7_+_73649686 1.11 ENSDART00000185589
si:dkey-46i9.1
chr11_-_30352333 1.11 ENSDART00000030794
transmembrane protein 169a
chr17_+_9310259 1.11 ENSDART00000186158
ENSDART00000190329
neuronal PAS domain protein 3
chr10_-_41157135 1.10 ENSDART00000134851
AP2 associated kinase 1b
chr3_+_17346502 1.08 ENSDART00000187786
ENSDART00000131584
si:ch211-210g13.5
chr4_+_69577362 1.08 ENSDART00000160913
zinc finger protein 1030
chr23_+_16430559 1.07 ENSDART00000112436
neurotensin receptor 1 (high affinity)
chr4_+_7888047 1.06 ENSDART00000104676
calcium/calmodulin-dependent protein kinase 1Da
chr6_-_46875310 1.03 ENSDART00000154442
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr24_+_23959107 1.03 ENSDART00000180036
homogentisate 1,2-dioxygenase
chr19_+_9305964 1.00 ENSDART00000136241
si:ch73-15n24.1
chr24_-_33873451 0.99 ENSDART00000159840
acid-sensing (proton-gated) ion channel 1c
chr12_-_48992527 0.98 ENSDART00000169696
cadherin related family member 1
chr16_-_31686602 0.95 ENSDART00000170357
complement component 1, s subcomponent
chr22_-_881080 0.94 ENSDART00000185489
choline/ethanolamine phosphotransferase 1b
chr17_+_6793001 0.92 ENSDART00000030773
forkhead box O3A
chr3_+_20001608 0.90 ENSDART00000137944
ankyrin repeat and SOCS box containing 16
chr18_-_41211980 0.90 ENSDART00000171431
zinc finger and BTB domain containing 38
chr10_+_41549819 0.89 ENSDART00000114210

chr24_-_28306484 0.89 ENSDART00000148618
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr2_+_21486529 0.89 ENSDART00000047468
inhibin, beta Ab
chr15_-_37921998 0.87 ENSDART00000193597
ENSDART00000181443
ENSDART00000168790
si:dkey-238d18.5
chr5_-_10236599 0.86 ENSDART00000099834
si:ch73-42k18.1
chr8_-_49705058 0.85 ENSDART00000083760
FERM domain containing 3
chr22_+_15336752 0.85 ENSDART00000139070
sulfotransferase family 3, cytosolic sulfotransferase 2
chr4_+_40329524 0.85 ENSDART00000165722
zinc finger protein 993
chr5_+_57641554 0.85 ENSDART00000171309
ENSDART00000157992
ENSDART00000164742
crystallin, alpha B, b
chr9_-_29039506 0.82 ENSDART00000100744
transmembrane protein 177
chr14_-_4076480 0.81 ENSDART00000059231
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr9_+_38427572 0.80 ENSDART00000108860
zgc:136333
chr14_+_8174828 0.80 ENSDART00000167228
pleckstrin and Sec7 domain containing 2
chr9_-_42989297 0.80 ENSDART00000126871
titin, tandem duplicate 2
chr12_+_47280839 0.79 ENSDART00000187574
ryanodine receptor 2
chr10_+_44940693 0.79 ENSDART00000157515
cyclin and CBS domain divalent metal cation transport mediator 4a
chr14_-_28567845 0.76 ENSDART00000126095
preproinsulin b
chr19_+_1097393 0.75 ENSDART00000168218

chr9_-_41077934 0.73 ENSDART00000100342
ankyrin and armadillo repeat containing
chr15_-_47822597 0.72 ENSDART00000193236
ENSDART00000161391

chr20_+_1996202 0.71 ENSDART00000184143

chr7_-_72261721 0.69 ENSDART00000172229
RAS guanyl releasing protein 2
chr2_+_9536021 0.68 ENSDART00000187357

chr23_+_19594608 0.67 ENSDART00000134865
sarcolemma associated protein b
chr9_-_30160897 0.65 ENSDART00000143986
ABI family, member 3 (NESH) binding protein a
chr16_-_22729491 0.63 ENSDART00000189854
toll-like receptor 19
chr6_-_39051319 0.63 ENSDART00000155093
tensin 2b
chr21_+_21791799 0.63 ENSDART00000151759
sialidase 3 (membrane sialidase), tandem duplicate 1
chr12_+_47907277 0.62 ENSDART00000097714
thymus, brain and testes associated
chr13_-_49666615 0.62 ENSDART00000148083
translocase of outer mitochondrial membrane 20
chr19_-_19556778 0.61 ENSDART00000164060
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr25_-_28443607 0.61 ENSDART00000157243
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr13_+_18331509 0.60 ENSDART00000181918
zgc:110319
chr4_-_25908871 0.60 ENSDART00000066949
FYVE, RhoGEF and PH domain containing 6
chr7_+_31871830 0.58 ENSDART00000139899
myosin binding protein C, cardiac
chr22_-_23666504 0.56 ENSDART00000158665
complement factor H
chr15_+_31471808 0.56 ENSDART00000110078
odorant receptor, family C, subfamily 102, member 3
chr10_+_6383270 0.56 ENSDART00000170548
zgc:114200
chr4_-_61406364 0.56 ENSDART00000142592
zinc finger protein 1021
chr10_-_1180314 0.55 ENSDART00000114261
bone morphogenetic protein receptor, type IBb
chr5_-_37252111 0.54 ENSDART00000185110
leucine-rich repeats and calponin homology (CH) domain containing 2
chr3_-_7129057 0.52 ENSDART00000125947

chr8_+_41453691 0.52 ENSDART00000061144
actin related protein 2/3 complex, subunit 5-like, a
chr8_+_23521974 0.51 ENSDART00000188130
ENSDART00000129378
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr16_+_38337783 0.51 ENSDART00000135008
GA binding protein transcription factor, beta subunit 2b
chr2_-_16216568 0.51 ENSDART00000173758
Rho guanine nucleotide exchange factor (GEF) 4
chr14_+_8504410 0.50 ENSDART00000123364
vascular endothelial growth factor Ba
chr11_+_15821433 0.50 ENSDART00000191005

chr25_-_35113891 0.48 ENSDART00000190724
zgc:165555
chr23_+_12134839 0.46 ENSDART00000128551
ENSDART00000141204
tubulin tyrosine ligase-like family, member 9
chr5_+_50371951 0.46 ENSDART00000184488
ENSDART00000171295
SMC5-SMC6 complex localization factor 1
chr19_-_1411409 0.45 ENSDART00000159305
3-oxoacyl-ACP synthase, mitochondrial
chr18_+_40552620 0.44 ENSDART00000087699
si:ch211-132b12.1
chr7_+_22585447 0.42 ENSDART00000149144
cholinergic receptor, nicotinic, beta 1 (muscle) like
chr1_-_21599219 0.42 ENSDART00000148327
ADAMTS-like 7
chr2_-_51316187 0.41 ENSDART00000163362
ENSDART00000166871
ENSDART00000160262
polymeric immunoglobulin receptor-like 3.5
chr3_+_40672242 0.40 ENSDART00000188494

chr17_-_52609728 0.40 ENSDART00000103572
leucine rich repeat containing 74A
chr21_+_25660613 0.40 ENSDART00000134017
si:dkey-17e16.15
chr3_-_40051425 0.39 ENSDART00000146700
lethal giant larvae homolog 1 (Drosophila)
chr12_+_30368145 0.38 ENSDART00000153454
si:ch211-225b10.4
chr1_-_40341306 0.38 ENSDART00000190649
mastermind-like transcriptional coactivator 3
chr7_-_3470451 0.38 ENSDART00000173387
si:ch211-285c6.6
chr2_-_51454868 0.37 ENSDART00000172550
si:dkeyp-104b3.2
chr2_-_28682476 0.36 ENSDART00000190178
7-dehydrocholesterol reductase
chr10_-_40352250 0.35 ENSDART00000150821
trace amine associated receptor 20f
chr1_+_2112726 0.34 ENSDART00000131714
ENSDART00000138396
muscleblind-like splicing regulator 2
chr6_-_55354004 0.34 ENSDART00000165911
PDX1 C-terminal inhibiting factor 1
chr12_-_47774807 0.34 ENSDART00000193831

chr13_+_36680564 0.31 ENSDART00000136030
ENSDART00000006923
ATP synthase, H+ transporting, mitochondrial F0 complex subunit s
chr11_-_20956309 0.31 ENSDART00000188659

chr21_+_26612777 0.31 ENSDART00000142667
estrogen-related receptor alpha
chr23_-_22623115 0.30 ENSDART00000188049

chr13_-_36680531 0.29 ENSDART00000085298
L-2-hydroxyglutarate dehydrogenase
chr1_-_18803919 0.29 ENSDART00000020970
phosphoglucomutase 2
chr10_+_14210667 0.29 ENSDART00000138854
si:dkey-286h21.1
chr3_-_61592417 0.29 ENSDART00000155082
neuronal pentraxin 2a
chr3_+_55131289 0.28 ENSDART00000111585

chr6_-_10828880 0.28 ENSDART00000131458
ENSDART00000020261
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr9_+_29040425 0.28 ENSDART00000150201
si:ch73-116o1.2
chr23_-_25891426 0.28 ENSDART00000189907

chr18_+_17493859 0.26 ENSDART00000090754
si:dkey-102f14.5
chr3_+_55114097 0.26 ENSDART00000121686
hemoglobin beta embryonic-1.1
chr21_+_40261187 0.26 ENSDART00000142204
si:ch211-218m3.11
chr25_-_25575241 0.24 ENSDART00000150636
hypermethylated in cancer 1 like
chr25_-_13659249 0.22 ENSDART00000045488
casein kinase 2, alpha prime polypeptide b
chr11_-_42099645 0.22 ENSDART00000173312
abhydrolase domain containing 6a
chr25_+_16601839 0.21 ENSDART00000008986
ATPase H+ transporting V1 subunit E1a
chr1_+_12767318 0.20 ENSDART00000162652
protocadherin 10a
chr3_+_18437397 0.20 ENSDART00000136243
ENSDART00000184882
ENSDART00000135470
TBC1 domain family, member 16
chr1_+_56955349 0.20 ENSDART00000152758
si:ch211-1f22.10
chr7_-_17412559 0.19 ENSDART00000163020
novel immune-type receptor 3a
chr13_+_41819817 0.18 ENSDART00000185778

chr11_-_309420 0.18 ENSDART00000173185
POC1 centriolar protein A
chr13_-_50546634 0.18 ENSDART00000192127

chr13_+_13668991 0.17 ENSDART00000148266
Pim proto-oncogene, serine/threonine kinase, related 48
chr2_-_37098785 0.16 ENSDART00000003670
zgc:101744
chr22_+_344763 0.15 ENSDART00000181934

chr3_+_55122662 0.15 ENSDART00000128380
hemoglobin beta embryonic-1.2
chr14_+_42172677 0.13 ENSDART00000148544
protocadherin 18b
chr8_+_15251448 0.12 ENSDART00000063717
zgc:171480
chr21_-_30415524 0.12 ENSDART00000101036
GrpE-like 2, mitochondrial
chr19_-_24198139 0.11 ENSDART00000138864
ENSDART00000125350
perforin 1.7
chr25_-_19661198 0.11 ENSDART00000149641
ATPase plasma membrane Ca2+ transporting 1b
chr5_-_16274058 0.11 ENSDART00000090684
kringle containing transmembrane protein 1
chr25_-_21085661 0.11 ENSDART00000099355
proline rich 5a (renal)
chr6_+_9421279 0.10 ENSDART00000161036
kalirin RhoGEF kinase b
chr25_-_24046870 0.10 ENSDART00000047569
insulin-like growth factor 2b
chr25_-_25575717 0.10 ENSDART00000067138
hypermethylated in cancer 1 like
chr17_+_25197180 0.10 ENSDART00000148775
Rho guanine nucleotide exchange factor (GEF) 10
chr5_-_37044262 0.07 ENSDART00000166670
si:dkeyp-110c7.8
chr1_+_55452892 0.07 ENSDART00000122508

chr19_+_9032073 0.06 ENSDART00000127755
ash1 (absent, small, or homeotic)-like (Drosophila)
chr15_+_4988189 0.04 ENSDART00000142995
ENSDART00000062852
signal peptidase complex subunit 2
chr5_+_36932718 0.03 ENSDART00000037879
cone-rod homeobox
chr4_+_76466751 0.03 ENSDART00000164709
zgc:153116
chr3_+_12829566 0.02 ENSDART00000157672
si:ch211-8c17.2
chr24_-_10394277 0.01 ENSDART00000127568
ANKH inorganic pyrophosphate transport regulator a
chr4_-_17409533 0.00 ENSDART00000011943
phenylalanine hydroxylase

Network of associatons between targets according to the STRING database.

First level regulatory network of insm1a+insm1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.6 2.3 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.3 2.4 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.3 0.8 GO:0019695 choline metabolic process(GO:0019695)
0.2 2.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 2.3 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.2 1.1 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.2 1.5 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 2.2 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.0 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.8 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 0.6 GO:0003210 cardiac atrium formation(GO:0003210)
0.1 2.7 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 0.5 GO:0017145 stem cell division(GO:0017145)
0.1 0.6 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 0.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.6 GO:0007220 Notch receptor processing(GO:0007220)
0.1 1.3 GO:0006825 copper ion transport(GO:0006825)
0.1 0.6 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.8 GO:0048769 sarcomerogenesis(GO:0048769)
0.0 1.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.0 1.1 GO:1990798 pancreas regeneration(GO:1990798)
0.0 1.2 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.3 GO:0086009 membrane repolarization(GO:0086009)
0.0 1.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.8 GO:0030537 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.9 GO:0051923 sulfation(GO:0051923)
0.0 0.4 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.5 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.0 0.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.3 GO:0006558 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0 0.1 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.0 1.6 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.9 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.9 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.4 GO:0042446 hormone biosynthetic process(GO:0042446)
0.0 0.2 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.1 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.9 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 2.2 GO:0031209 SCAR complex(GO:0031209)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.1 1.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.6 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 6.2 GO:0014069 postsynaptic density(GO:0014069)
0.0 1.3 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.8 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.6 2.4 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.5 1.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.4 1.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.4 1.2 GO:0005252 open rectifier potassium channel activity(GO:0005252)
0.4 2.3 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.3 1.3 GO:0016531 copper chaperone activity(GO:0016531)
0.2 2.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 1.0 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.2 0.9 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.2 2.8 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 2.7 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 0.3 GO:0042165 neurotransmitter binding(GO:0042165) acetylcholine binding(GO:0042166)
0.1 1.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.3 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 1.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.6 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1 0.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.5 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.9 GO:0016208 AMP binding(GO:0016208)
0.0 1.1 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.4 GO:0045159 myosin II binding(GO:0045159)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.6 GO:0044325 ion channel binding(GO:0044325)
0.0 1.1 GO:0010857 calcium-dependent protein kinase activity(GO:0010857)
0.0 1.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.3 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.5 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 1.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.4 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 1.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.6 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.7 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 1.0 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK