ISMARA results: irf10+irf8+irf9

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irf10+irf8+irf9

Z-value: 2.37

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Transcription factors associated with irf10+irf8+irf9

Gene Symbol	Gene ID	Gene Info
irf9 NCBI UniProt	ENSDARG00000016457	interferon regulatory factor 9
irf10 NCBI UniProt	ENSDARG00000027658	interferon regulatory factor 10
irf8 NCBI UniProt	ENSDARG00000056407	interferon regulatory factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irf10	dr11_v1_chr23_+_642001_642052	0.74	1.1e-17	Click!
irf9	dr11_v1_chr12_+_13282797_13282807	0.51	1.1e-07	Click!
irf8	dr11_v1_chr18_+_30567945_30567945	0.43	1.2e-05	Click!

Activity profile of irf10+irf8+irf9 motif

Sorted Z-values of irf10+irf8+irf9 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_17776981 Show fit	31.11	ENSDART00000141693	ccl19b NCBI UniProt Show fit	chemokine (C-C motif) ligand 19b
chr7_+_25033924 Show fit	27.02	ENSDART00000170873	sb:cb1058 NCBI UniProt Show fit	sb:cb1058
chr19_-_7115229 Show fit	26.43	ENSDART00000001930	psmb13a NCBI UniProt Show fit	proteasome subunit beta 13a
chr1_-_7951002 Show fit	23.10	ENSDART00000138187	si:dkey-79f11.8 NCBI UniProt Show fit	si:dkey-79f11.8
chr15_+_13984879 Show fit	22.49	ENSDART00000159438	zgc:162730 NCBI UniProt Show fit	zgc:162730
chr5_+_13373593 Show fit	21.58	ENSDART00000051668 ENSDART00000183883	ccl19a.2 NCBI UniProt Show fit	chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr19_+_7115223 Show fit	21.39	ENSDART00000001359	psmb12 NCBI UniProt Show fit	proteasome subunit beta 12
chr19_-_325584 Show fit	21.34	ENSDART00000134266	gpd1c NCBI UniProt Show fit	glycerol-3-phosphate dehydrogenase 1c
chr2_+_20539402 Show fit	21.17	ENSDART00000129585	si:ch73-14h1.2 NCBI UniProt Show fit	si:ch73-14h1.2
chr16_+_29514473 Show fit	19.63	ENSDART00000034102	ctss2.2 NCBI UniProt Show fit	cathepsin S, ortholog 2, tandem duplicate 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irf10+irf8+irf9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	108.5	GO:0051603	proteolysis involved in cellular protein catabolic process(GO:0051603)
0.0	61.3	GO:0035556	intracellular signal transduction(GO:0035556)
1.9	60.4	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
1.3	52.7	GO:0071346	cellular response to interferon-gamma(GO:0071346)
0.3	29.8	GO:0017148	negative regulation of translation(GO:0017148)
1.5	25.7	GO:0048002	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) antigen processing and presentation of peptide antigen(GO:0048002)
4.9	24.3	GO:0071763	nuclear membrane organization(GO:0071763)
5.3	21.3	GO:0046168	NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.2	20.7	GO:0009612	response to mechanical stimulus(GO:0009612)
0.2	19.6	GO:0010506	regulation of autophagy(GO:0010506)

Showing 1 to 10 of 90 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	101.8	GO:0005615	extracellular space(GO:0005615)
0.3	92.7	GO:0005764	lysosome(GO:0005764)
2.2	60.4	GO:0005839	proteasome core complex(GO:0005839)
0.0	56.7	GO:0005829	cytosol(GO:0005829)
0.4	23.7	GO:0030426	growth cone(GO:0030426)
3.6	21.3	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5	16.7	GO:0043186	P granule(GO:0043186)
2.0	16.2	GO:0042611	MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613)
2.1	12.6	GO:0042612	MHC class I protein complex(GO:0042612)
0.1	12.4	GO:0016459	myosin complex(GO:0016459)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	97.0	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
1.2	52.7	GO:0048020	CCR chemokine receptor binding(GO:0048020)
2.8	52.4	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9	45.8	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1	39.0	GO:0005525	GTP binding(GO:0005525)
4.0	28.0	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.1	26.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	25.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0	24.6	GO:0008270	zinc ion binding(GO:0008270)
1.1	24.3	GO:0019894	kinesin binding(GO:0019894)

Showing 1 to 10 of 81 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	44.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.6	31.9	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.4	17.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	15.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.5	14.7	PID ENDOTHELIN PATHWAY	Endothelins
1.6	12.6	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	12.6	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.3	12.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.7	11.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.2	9.3	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	60.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.1	30.7	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.5	26.7	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
1.4	17.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
1.6	14.8	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	14.7	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
1.2	13.5	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
2.5	12.6	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.6	12.6	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.6	11.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade

Showing 1 to 10 of 24 entries

Results for irf10+irf8+irf9

Z-value: 2.37

Motif logo

Transcription factors associated with irf10+irf8+irf9

Activity-expression correlation:

Activity profile of irf10+irf8+irf9 motif

Sorted Z-values of irf10+irf8+irf9 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irf10+irf8+irf9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: