ISMARA results: irf1b+irf2+irf2a

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irf1b+irf2+irf2a

Z-value: 3.75

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Transcription factors associated with irf1b+irf2+irf2a

Gene Symbol	Gene ID	Gene Info
irf2a NCBI UniProt	ENSDARG00000007387	interferon regulatory factor 2a
irf2 NCBI UniProt	ENSDARG00000040465	interferon regulatory factor 2
irf1b NCBI UniProt	ENSDARG00000043249	interferon regulatory factor 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irf2	dr11_v1_chr14_-_4121052_4121052	0.86	1.2e-28	Click!
irf1b	dr11_v1_chr21_+_45627775_45627775	0.77	1.1e-19	Click!
irf2a	dr11_v1_chr1_+_39865748_39865753	-0.10	3.5e-01	Click!

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_22675475 Show fit	59.33	ENSDART00000134423	ponzr3 NCBI UniProt Show fit	plac8 onzin related protein 3
chr19_-_7115229 Show fit	54.45	ENSDART00000001930	psmb13a NCBI UniProt Show fit	proteasome subunit beta 13a
chr13_+_13681681 Show fit	48.09	ENSDART00000057825	cfd NCBI UniProt Show fit	complement factor D (adipsin)
chr19_+_7115223 Show fit	44.64	ENSDART00000001359	psmb12 NCBI UniProt Show fit	proteasome subunit beta 12
chr13_+_22675802 Show fit	43.82	ENSDART00000145538 ENSDART00000143312	zgc:193505 NCBI UniProt Show fit	zgc:193505
chr9_+_30387930 Show fit	40.34	ENSDART00000112827	si:dkey-18p12.4 NCBI UniProt Show fit	si:dkey-18p12.4
chr10_-_22095505 Show fit	39.66	ENSDART00000140210	ponzr10 NCBI UniProt Show fit	plac8 onzin related protein 10
chr9_-_45601103 Show fit	38.94	ENSDART00000180465	agr1 NCBI UniProt Show fit	anterior gradient 1
chr10_+_17776981 Show fit	37.07	ENSDART00000141693	ccl19b NCBI UniProt Show fit	chemokine (C-C motif) ligand 19b
chr16_+_23487051 Show fit	35.88	ENSDART00000145496	icn2 NCBI UniProt Show fit	ictacalcin 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.5	142.7	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1	94.7	GO:0016567	protein ubiquitination(GO:0016567)
0.0	84.4	GO:0035556	intracellular signal transduction(GO:0035556)
0.6	58.7	GO:0017148	negative regulation of translation(GO:0017148)
1.3	54.4	GO:0071346	cellular response to interferon-gamma(GO:0071346)
5.2	52.2	GO:1900407	regulation of cellular response to oxidative stress(GO:1900407)
16.0	48.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.5	46.4	GO:0009612	response to mechanical stimulus(GO:0009612)
0.4	45.8	GO:0017038	protein import(GO:0017038)
4.3	43.0	GO:0051601	exocyst localization(GO:0051601)

Showing 1 to 10 of 172 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	205.6	GO:0005615	extracellular space(GO:0005615)
5.1	142.7	GO:0005839	proteasome core complex(GO:0005839)
0.4	123.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	86.9	GO:0005764	lysosome(GO:0005764)
0.1	72.6	GO:0005829	cytosol(GO:0005829)
0.0	66.6	GO:0016021	integral component of membrane(GO:0016021)
0.2	58.9	GO:0000151	ubiquitin ligase complex(GO:0000151)
4.9	39.3	GO:0042613	MHC class II protein complex(GO:0042613)
1.4	38.3	GO:0000145	exocyst(GO:0000145)
0.1	33.1	GO:0005938	cell cortex(GO:0005938)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	177.6	GO:0008270	zinc ion binding(GO:0008270)
6.2	118.7	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2	97.2	GO:0005525	GTP binding(GO:0005525)
1.8	93.9	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3	74.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.5	69.1	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
2.4	65.8	GO:0048306	calcium-dependent protein binding(GO:0048306)
1.6	61.8	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
1.2	54.4	GO:0048020	CCR chemokine receptor binding(GO:0048020)
10.6	53.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)

Showing 1 to 10 of 133 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	53.6	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
4.7	38.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	27.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	23.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.9	19.9	PID ENDOTHELIN PATHWAY	Endothelins
0.3	18.3	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
2.2	17.9	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.7	17.8	PID NECTIN PATHWAY	Nectin adhesion pathway
2.2	17.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.0	16.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	75.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
4.4	56.6	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
1.5	44.9	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
3.5	42.0	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
4.7	38.0	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.7	27.4	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
2.4	24.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
4.5	22.5	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.8	18.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.5	17.9	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide

Showing 1 to 10 of 51 entries

Results for irf1b+irf2+irf2a

Z-value: 3.75

Motif logo

Transcription factors associated with irf1b+irf2+irf2a

Activity-expression correlation:

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: