ISMARA results: irf5

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irf5

Z-value: 3.56

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Transcription factors associated with irf5

Gene Symbol	Gene ID	Gene Info
irf5 NCBI UniProt	ENSDARG00000045681	interferon regulatory factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irf5	dr11_v1_chr4_-_13613148_13613148	0.80	8.6e-22	Click!

Activity profile of irf5 motif

Sorted Z-values of irf5 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_2039511 Show fit	90.47	ENSDART00000160223	spint1a NCBI UniProt Show fit	serine peptidase inhibitor, Kunitz type 1 a
chr10_-_22150419 Show fit	57.52	ENSDART00000006173	cldn7b NCBI UniProt Show fit	claudin 7b
chr15_-_2640966 Show fit	56.23	ENSDART00000063320	cldne NCBI UniProt Show fit	claudin e
chr17_-_22552678 Show fit	53.50	ENSDART00000079401	si:ch211-125o16.4 NCBI UniProt Show fit	si:ch211-125o16.4
chr14_-_33277743 Show fit	52.94	ENSDART00000048130	stard14 NCBI UniProt Show fit	START domain containing 14
chr9_-_30264415 Show fit	50.37	ENSDART00000060150	mid1ip1a NCBI UniProt Show fit	MID1 interacting protein 1a
chr8_+_44475793 Show fit	44.04	ENSDART00000190118	si:ch73-211l2.3 NCBI UniProt Show fit	si:ch73-211l2.3
chr14_-_33278084 Show fit	43.14	ENSDART00000132850	stard14 NCBI UniProt Show fit	START domain containing 14
chr7_+_69187585 Show fit	42.01	ENSDART00000160499 ENSDART00000166258	marveld3 NCBI UniProt Show fit	MARVEL domain containing 3
chr15_-_33964897 Show fit	37.84	ENSDART00000172075 ENSDART00000158126 ENSDART00000160456	lsr NCBI UniProt Show fit	lipolysis stimulated lipoprotein receptor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irf5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	141.6	GO:0051604	protein maturation(GO:0051604)
2.3	90.5	GO:0030199	collagen fibril organization(GO:0030199)
0.1	61.4	GO:0006508	proteolysis(GO:0006508)
9.6	57.5	GO:0060876	semicircular canal formation(GO:0060876)
1.2	56.2	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
1.2	47.3	GO:0060972	left/right pattern formation(GO:0060972)
0.8	42.9	GO:0046890	regulation of lipid biosynthetic process(GO:0046890)
14.0	42.0	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.2	39.6	GO:0043484	regulation of RNA splicing(GO:0043484)
0.1	39.2	GO:0001525	angiogenesis(GO:0001525)

Showing 1 to 10 of 142 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	203.1	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1	157.7	GO:0005576	extracellular region(GO:0005576)
0.0	130.8	GO:0016021	integral component of membrane(GO:0016021)
0.4	83.2	GO:0005764	lysosome(GO:0005764)
1.0	74.3	GO:0031902	late endosome membrane(GO:0031902)
10.7	53.5	GO:0043034	costamere(GO:0043034)
0.5	37.7	GO:0005770	late endosome(GO:0005770)
0.1	32.0	GO:0005874	microtubule(GO:0005874)
0.3	31.2	GO:0005802	trans-Golgi network(GO:0005802)
0.0	28.1	GO:0005789	endoplasmic reticulum membrane(GO:0005789)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	201.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	163.8	GO:0008289	lipid binding(GO:0008289)
0.8	98.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	77.7	GO:0005198	structural molecule activity(GO:0005198)
0.5	66.7	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.3	64.4	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.7	46.2	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
6.7	33.5	GO:1990756	protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.7	28.6	GO:0005109	frizzled binding(GO:0005109)
0.7	26.4	GO:0004629	phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)

Showing 1 to 10 of 90 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	73.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	36.0	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.4	30.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	28.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.6	25.7	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.7	22.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.6	19.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
1.1	14.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.2	12.2	PID P73PATHWAY	p73 transcription factor network
1.4	11.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	46.4	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
1.3	37.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
1.0	28.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
4.8	24.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
1.8	22.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.5	20.7	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.9	20.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.6	19.5	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.5	19.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.5	18.7	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins

Showing 1 to 10 of 42 entries

Results for irf5

Z-value: 3.56

Motif logo

Transcription factors associated with irf5

Activity-expression correlation:

Activity profile of irf5 motif

Sorted Z-values of irf5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irf5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: