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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irf5

Z-value: 3.56

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Transcription factors associated with irf5

Gene Symbol Gene ID Gene Info
irf5
ENSDARG00000045681 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf5dr11_v1_chr4_-_13613148_136131480.808.6e-22Click!

Activity profile of irf5 motif

Sorted Z-values of irf5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_2039511 90.47 ENSDART00000160223
spint1a
serine peptidase inhibitor, Kunitz type 1 a
chr10_-_22150419 57.52 ENSDART00000006173
cldn7b
claudin 7b
chr15_-_2640966 56.23 ENSDART00000063320
cldne
claudin e
chr17_-_22552678 53.50 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr14_-_33277743 52.94 ENSDART00000048130
stard14
START domain containing 14
chr9_-_30264415 50.37 ENSDART00000060150
mid1ip1a
MID1 interacting protein 1a
chr8_+_44475793 44.04 ENSDART00000190118
si:ch73-211l2.3
si:ch73-211l2.3
chr14_-_33278084 43.14 ENSDART00000132850
stard14
START domain containing 14
chr7_+_69187585 42.01 ENSDART00000160499
ENSDART00000166258
marveld3
MARVEL domain containing 3
chr15_-_33964897 37.84 ENSDART00000172075
ENSDART00000158126
ENSDART00000160456
lsr
lipolysis stimulated lipoprotein receptor
chr23_-_29556844 37.71 ENSDART00000138021
rbp7a
retinol binding protein 7a, cellular
chr17_+_30894431 37.29 ENSDART00000127996
degs2
delta(4)-desaturase, sphingolipid 2
chr18_+_44532370 36.97 ENSDART00000086952
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr24_-_26310854 34.21 ENSDART00000080113
apodb
apolipoprotein Db
chr7_+_19483277 33.80 ENSDART00000173750
si:ch211-212k18.7
si:ch211-212k18.7
chr5_-_29531948 33.51 ENSDART00000098360
arrdc1a
arrestin domain containing 1a
chr7_+_49681040 30.73 ENSDART00000176372
ENSDART00000192172
rassf7b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr10_+_15064433 30.08 ENSDART00000179978
parm1
prostate androgen-regulated mucin-like protein 1
chr19_-_15420678 29.69 ENSDART00000151454
ENSDART00000027697
serinc2
serine incorporator 2
chr22_-_17688868 29.28 ENSDART00000012336
ENSDART00000147070
tjp3
tight junction protein 3
chr20_+_26683933 29.28 ENSDART00000139852
ENSDART00000077751
foxq1b
forkhead box Q1b
chr16_+_19637384 29.19 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
macc1
metastasis associated in colon cancer 1
chr12_+_23424108 28.32 ENSDART00000077732
bambia
BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a
chr20_-_26551210 26.82 ENSDART00000077715
si:dkey-25e12.3
si:dkey-25e12.3
chr2_-_21438492 26.37 ENSDART00000046098
plcd1b
phospholipase C, delta 1b
chr21_-_25295087 26.10 ENSDART00000087910
ENSDART00000147860
st14b
suppression of tumorigenicity 14 (colon carcinoma) b
chr7_+_19482877 25.97 ENSDART00000077868
si:ch211-212k18.7
si:ch211-212k18.7
chr4_-_11580948 25.71 ENSDART00000049066
net1
neuroepithelial cell transforming 1
chr4_-_17669881 25.46 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr3_+_21200763 25.39 ENSDART00000067841
zgc:112038
zgc:112038
chr20_+_6535176 25.10 ENSDART00000054652
si:ch211-191a24.4
si:ch211-191a24.4
chr16_-_41990421 24.21 ENSDART00000055921
pycard
PYD and CARD domain containing
chr1_+_58332000 23.93 ENSDART00000145234
ggt1l2.1
gamma-glutamyltransferase 1 like 2.1
chr18_+_44532668 23.68 ENSDART00000140672
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr18_+_44532199 23.48 ENSDART00000135386
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr6_+_49771626 23.38 ENSDART00000134207
ctsz
cathepsin Z
chr14_+_33329420 23.03 ENSDART00000171090
ENSDART00000164062
sowahd
sosondowah ankyrin repeat domain family d
chr6_+_49771372 22.99 ENSDART00000063251
ctsz
cathepsin Z
chr18_+_44532883 22.50 ENSDART00000121994
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr16_+_29492937 22.15 ENSDART00000011497
ctsk
cathepsin K
chr23_-_31266586 21.22 ENSDART00000139746
si:dkey-261l7.2
si:dkey-261l7.2
chr20_+_6535438 20.81 ENSDART00000145763
si:ch211-191a24.4
si:ch211-191a24.4
chr12_+_17154655 20.73 ENSDART00000028003
ankrd22
ankyrin repeat domain 22
chr21_-_22543611 20.73 ENSDART00000177084
myo5b
myosin VB
chr24_-_34680956 20.01 ENSDART00000171009
ctnna1
catenin (cadherin-associated protein), alpha 1
chr23_+_2666944 19.90 ENSDART00000192861
CABZ01057928.1

chr7_-_26579465 19.61 ENSDART00000173820
si:dkey-62k3.6
si:dkey-62k3.6
chr2_-_37140423 19.45 ENSDART00000144220
tspan37
tetraspanin 37
chr5_-_37959874 19.27 ENSDART00000031719
mpzl2b
myelin protein zero-like 2b
chr5_+_66326004 19.13 ENSDART00000144351
malt1
MALT paracaspase 1
chr11_-_7261717 19.07 ENSDART00000128959
zgc:113223
zgc:113223
chr5_-_12587053 18.97 ENSDART00000162780
vsig10
V-set and immunoglobulin domain containing 10
chr1_+_38153944 18.66 ENSDART00000135666
galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr5_-_26187097 18.12 ENSDART00000137027
ccdc125
coiled-coil domain containing 125
chr10_-_15879569 18.07 ENSDART00000136789
tjp2a
tight junction protein 2a (zona occludens 2)
chr3_-_40976288 17.93 ENSDART00000193553
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr14_+_22076596 17.89 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
slc43a1a
solute carrier family 43 (amino acid system L transporter), member 1a
chr1_-_7570181 17.60 ENSDART00000103588
mxa
myxovirus (influenza) resistance A
chr10_+_5060191 17.45 ENSDART00000145908
ENSDART00000122397
carm1l
coactivator-associated arginine methyltransferase 1, like
chr16_-_45152169 17.24 ENSDART00000171452
si:ch73-343g19.4
si:ch73-343g19.4
chr14_+_16345003 17.07 ENSDART00000003040
ENSDART00000165193
itln3
intelectin 3
chr9_+_3055566 17.05 ENSDART00000189906
ENSDART00000175891
ENSDART00000093021
ppp1r9ala
protein phosphatase 1 regulatory subunit 9A-like A
chr7_-_20103384 15.96 ENSDART00000052902
acap1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr19_-_7690975 15.50 ENSDART00000151384
si:dkey-204a24.10
si:dkey-204a24.10
chr18_+_45666489 15.09 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr3_-_40976463 14.98 ENSDART00000128450
ENSDART00000018676
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr3_-_29941357 14.98 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr9_+_23765587 14.89 ENSDART00000145120
si:ch211-219a4.3
si:ch211-219a4.3
chr9_+_41156818 14.81 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr22_+_19218733 14.59 ENSDART00000183212
ENSDART00000133595
si:dkey-21e2.7
si:dkey-21e2.7
chr14_+_33329761 14.20 ENSDART00000161138
sowahd
sosondowah ankyrin repeat domain family d
chr11_+_37251825 14.18 ENSDART00000169804
il17rc
interleukin 17 receptor C
chr19_+_14113886 14.08 ENSDART00000169343
kdf1b
keratinocyte differentiation factor 1b
chr3_+_32125452 13.96 ENSDART00000110396
zgc:194125
zgc:194125
chr7_-_67214972 13.87 ENSDART00000156861
swap70a
switching B cell complex subunit SWAP70a
chr14_+_32918484 13.82 ENSDART00000105721
lnx2b
ligand of numb-protein X 2b
chr16_+_35595312 13.81 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr20_+_36806398 13.70 ENSDART00000153317
abracl
ABRA C-terminal like
chr3_+_25191467 13.68 ENSDART00000156956
ENSDART00000154799
il2rb
interleukin 2 receptor, beta
chr17_-_30666037 13.66 ENSDART00000156509
alkal2b
ALK and LTK ligand 2b
chr3_+_32571929 13.65 ENSDART00000151025
si:ch73-248e21.1
si:ch73-248e21.1
chr15_-_29162193 13.64 ENSDART00000138449
ENSDART00000099885
xaf1
XIAP associated factor 1
chr7_-_19614916 13.58 ENSDART00000169029
zgc:194655
zgc:194655
chr23_+_42346799 13.30 ENSDART00000159985
ENSDART00000172144
cyp2aa11
cytochrome P450, family 2, subfamily AA, polypeptide 11
chr23_+_642001 13.22 ENSDART00000030643
ENSDART00000124850
irf10
interferon regulatory factor 10
chr3_+_29941777 13.21 ENSDART00000113889
ifi35
interferon-induced protein 35
chr4_+_12931763 13.18 ENSDART00000016382
wif1
wnt inhibitory factor 1
chr5_+_50913357 12.89 ENSDART00000092938
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr9_-_39968820 12.86 ENSDART00000100311
IKZF2
si:zfos-1425h8.1
chr10_+_4046448 12.77 ENSDART00000123086
ENSDART00000052268
pitpnb
phosphatidylinositol transfer protein, beta
chr23_+_642395 12.53 ENSDART00000186995
irf10
interferon regulatory factor 10
chr16_+_42772678 12.40 ENSDART00000155575
si:ch211-135n15.2
si:ch211-135n15.2
chr1_+_58290933 12.24 ENSDART00000140536
si:dkey-222h21.6
si:dkey-222h21.6
chr15_-_40175894 12.09 ENSDART00000156632
si:ch211-281l24.3
si:ch211-281l24.3
chr22_-_30973791 11.99 ENSDART00000104728
ssuh2.2
ssu-2 homolog, tandem duplicate 2
chr14_-_1432875 11.90 ENSDART00000164408
ENSDART00000159774
zgc:152774
zgc:152774
chr4_-_77557279 11.73 ENSDART00000180113
AL935186.10

chr3_+_32139666 11.70 ENSDART00000109791
zgc:92066
zgc:92066
chr10_+_35358675 11.69 ENSDART00000193263
si:dkey-259j3.5
si:dkey-259j3.5
chr10_-_2971407 11.56 ENSDART00000132526
marveld2a
MARVEL domain containing 2a
chr1_-_29747702 11.33 ENSDART00000133225
ENSDART00000189670
spp2
secreted phosphoprotein 2
chr25_+_19720228 11.27 ENSDART00000181804
mxd
myxovirus (influenza virus) resistance D
chr2_-_41861040 11.21 ENSDART00000045763
keap1a
kelch-like ECH-associated protein 1a
chr25_+_16646113 11.19 ENSDART00000110426
cecr2
cat eye syndrome chromosome region, candidate 2
chr2_-_24554416 11.18 ENSDART00000052061
cnn2
calponin 2
chr12_-_23658888 11.13 ENSDART00000088319
map3k8
mitogen-activated protein kinase kinase kinase 8
chr5_+_58455488 11.09 ENSDART00000038602
ENSDART00000127958
slc37a2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr14_-_28001986 11.09 ENSDART00000054115
tsc22d3
TSC22 domain family, member 3
chr25_+_28862660 10.87 ENSDART00000154681
si:ch211-106e7.2
si:ch211-106e7.2
chr16_+_46497149 10.80 ENSDART00000135151
ENSDART00000058324
rpz4
rapunzel 4
chr6_+_48348415 10.79 ENSDART00000064826
mov10a
Mov10 RISC complex RNA helicase a
chr3_+_25999477 10.62 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr23_-_30045661 10.61 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr5_-_30382925 10.51 ENSDART00000125381
gig2o
grass carp reovirus (GCRV)-induced gene 2o
chr15_+_11883804 10.50 ENSDART00000163255
gpr184
G protein-coupled receptor 184
chr22_-_11648094 10.49 ENSDART00000191791
dpp4
dipeptidyl-peptidase 4
chr12_-_33805366 10.31 ENSDART00000030566
galk1
galactokinase 1
chr10_+_2742499 10.17 ENSDART00000122847
grk5
G protein-coupled receptor kinase 5
chr14_-_33585809 10.12 ENSDART00000023540
sash3
SAM and SH3 domain containing 3
chr25_-_12809361 10.11 ENSDART00000162750
ca5a
carbonic anhydrase Va
chr8_-_27687095 10.05 ENSDART00000086946
mov10b.1
Moloney leukemia virus 10b, tandem duplicate 1
chr5_-_69716501 9.80 ENSDART00000158956
mob1a
MOB kinase activator 1A
chr7_+_13995792 9.61 ENSDART00000091470
furina
furin (paired basic amino acid cleaving enzyme) a
chr13_+_30692669 9.58 ENSDART00000187818
CR762483.1

chr2_+_47927026 9.47 ENSDART00000143023
ftr25
finTRIM family, member 25
chr11_-_42472941 9.47 ENSDART00000166624
arf4b
ADP-ribosylation factor 4b
chr24_+_11334733 9.47 ENSDART00000147552
ENSDART00000143171
si:dkey-12l12.1
si:dkey-12l12.1
chr8_+_45361775 9.41 ENSDART00000015193
chmp4bb
charged multivesicular body protein 4Bb
chr6_-_1777831 9.31 ENSDART00000167390
zgc:113442
zgc:113442
chr4_+_8569199 9.30 ENSDART00000165181
wnt5b
wingless-type MMTV integration site family, member 5b
chr9_+_23003208 9.13 ENSDART00000021060
eaf2
ELL associated factor 2
chr4_-_68563862 8.92 ENSDART00000182970
BX548011.2

chr4_-_20222182 8.86 ENSDART00000132464
gsap
gamma-secretase activating protein
chr11_+_10909183 8.65 ENSDART00000064860
rbms1a
RNA binding motif, single stranded interacting protein 1a
chr7_-_24149670 8.62 ENSDART00000005884
mmp14a
matrix metallopeptidase 14a (membrane-inserted)
chr23_-_29553430 8.44 ENSDART00000157773
ENSDART00000126384
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr2_-_55797318 8.41 ENSDART00000158147
calr3b
calreticulin 3b
chr18_+_27337994 8.38 ENSDART00000136172
si:dkey-29p10.4
si:dkey-29p10.4
chr22_-_17474583 8.27 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr16_+_33144306 8.25 ENSDART00000101953
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr15_+_25452092 8.21 ENSDART00000009545
pak4
p21 protein (Cdc42/Rac)-activated kinase 4
chr10_+_2587234 8.09 ENSDART00000126937
wu:fb59d01
wu:fb59d01
chr17_+_1627379 8.09 ENSDART00000184050
LO018432.1

chr2_-_47870649 8.05 ENSDART00000142854
ftr05
finTRIM family, member 5
chr9_-_23765480 8.05 ENSDART00000027212
si:ch211-219a4.6
si:ch211-219a4.6
chr7_+_19615056 8.05 ENSDART00000124752
ENSDART00000190297
si:ch211-212k18.15
si:ch211-212k18.15
chr21_+_43253538 7.97 ENSDART00000179940
ENSDART00000164806
ENSDART00000147026
shroom1
shroom family member 1
chr5_+_21922534 7.76 ENSDART00000148092
si:ch73-92i20.1
si:ch73-92i20.1
chr13_+_24263049 7.72 ENSDART00000135992
ENSDART00000088005
abcb10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr11_-_13107106 7.71 ENSDART00000184477
elovl1b
ELOVL fatty acid elongase 1b
chr24_+_22731228 7.70 ENSDART00000146733
si:dkey-225k4.1
si:dkey-225k4.1
chr3_+_32135037 7.59 ENSDART00000110490
BX511021.1

chr22_-_30678518 7.51 ENSDART00000138282
si:dkey-42l16.1
si:dkey-42l16.1
chr22_-_17474781 7.51 ENSDART00000186817
si:ch211-197g15.8
si:ch211-197g15.8
chr3_+_36127287 7.42 ENSDART00000058605
ENSDART00000182500
scpep1
serine carboxypeptidase 1
chr18_+_17624295 7.33 ENSDART00000151865
ENSDART00000190408
ENSDART00000189204
ENSDART00000188894
ENSDART00000033762
ENSDART00000193471
nlrc5
NLR family, CARD domain containing 5
chr18_+_45708744 7.21 ENSDART00000077341
depdc7
DEP domain containing 7
chr12_-_27242498 7.11 ENSDART00000152609
ENSDART00000152170
si:dkey-11c5.11
si:dkey-11c5.11
chr2_-_13333932 7.06 ENSDART00000150238
ENSDART00000168258
si:dkey-185p13.1
vps4b
si:dkey-185p13.1
vacuolar protein sorting 4b homolog B (S. cerevisiae)
chr16_-_30903930 7.05 ENSDART00000143996
dennd3b
DENN/MADD domain containing 3b
chr8_+_29986265 7.01 ENSDART00000148258
ptch1
patched 1
chr18_+_40467719 7.00 ENSDART00000087647
ugt5c2
UDP glucuronosyltransferase 5 family, polypeptide C2
chr4_+_76509294 6.95 ENSDART00000099899
ms4a17a.17
membrane-spanning 4-domains, subfamily A, member 17A.17
chr24_-_26885897 6.87 ENSDART00000180512
fndc3bb
fibronectin type III domain containing 3Bb
chr13_+_15182149 6.81 ENSDART00000193644
ENSDART00000134421
ENSDART00000086281
mavs
mitochondrial antiviral signaling protein
chr3_-_29508959 6.76 ENSDART00000055408
cyth4a
cytohesin 4a
chr15_-_33818872 6.75 ENSDART00000158325
n4bp2l2
NEDD4 binding protein 2-like 2
chr15_-_31067589 6.73 ENSDART00000060157
lgals9l3
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3
chr6_-_18400548 6.59 ENSDART00000179797
ENSDART00000164891
trim25
tripartite motif containing 25
chr12_-_41759686 6.49 ENSDART00000172175
ENSDART00000165152
ppp2r2d
protein phosphatase 2, regulatory subunit B, delta
chr6_-_35401282 6.43 ENSDART00000127612
rgs5a
regulator of G protein signaling 5a
chr5_+_35561607 6.36 ENSDART00000098022
ar
androgen receptor
chr22_+_38049130 6.36 ENSDART00000097533
wwtr1
WW domain containing transcription regulator 1
chr15_-_17071328 6.26 ENSDART00000122617
si:ch211-24o10.6
si:ch211-24o10.6
chr25_+_20272145 6.23 ENSDART00000109605
si:dkey-219c3.2
si:dkey-219c3.2
chr18_-_16922905 6.21 ENSDART00000187165
wee1
WEE1 G2 checkpoint kinase
chr24_+_37688729 6.14 ENSDART00000137017
h3f3d
H3 histone, family 3D
chr16_-_25829779 6.06 ENSDART00000086301
irge4
immunity-related GTPase family, e4
chr5_+_57442271 6.06 ENSDART00000097395
prpf4
PRP4 pre-mRNA processing factor 4 homolog (yeast)
chr25_+_5983430 6.06 ENSDART00000074814
ppib
peptidylprolyl isomerase B (cyclophilin B)
chr23_-_45501177 6.02 ENSDART00000150103
col24a1
collagen type XXIV alpha 1
chr3_+_24189804 5.99 ENSDART00000134723
prr15la
proline rich 15-like a
chr2_-_6115688 5.98 ENSDART00000081663
prdx1
peroxiredoxin 1
chr6_-_33916756 5.95 ENSDART00000137447
ENSDART00000138488
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr24_+_7782313 5.90 ENSDART00000111090
ptprh
protein tyrosine phosphatase, receptor type, h
chr22_+_24623936 5.87 ENSDART00000160924
mcoln2
mucolipin 2
chr12_+_27243059 5.80 ENSDART00000066269
arl4d
ADP-ribosylation factor-like 4D
chr15_-_21702317 5.74 ENSDART00000155824
IL4I1
si:dkey-40g16.6
chr11_+_42478184 5.69 ENSDART00000089963
zgc:110286
zgc:110286
chr12_-_35936329 5.61 ENSDART00000166634
rnf213b
ring finger protein 213b
chr3_-_55650771 5.60 ENSDART00000162413
axin2
axin 2 (conductin, axil)
chr23_+_44349252 5.38 ENSDART00000097644
ephb4b
eph receptor B4b
chr25_-_774350 5.36 ENSDART00000166321
ENSDART00000160386
IRAK4
interleukin 1 receptor associated kinase 4
chr6_-_49983329 5.29 ENSDART00000113083
asip1
agouti signaling protein 1
chr17_+_34805897 5.28 ENSDART00000137090
ENSDART00000077626
id2a
inhibitor of DNA binding 2a
chr3_+_3046909 5.28 ENSDART00000122435
BX004816.2

chr13_+_22863516 5.21 ENSDART00000113082
ENSDART00000189200
hnrnph3
heterogeneous nuclear ribonucleoprotein H3 (2H9)
chr18_+_37015185 5.21 ENSDART00000191305
sipa1l3
signal-induced proliferation-associated 1 like 3
chr21_+_19844195 5.17 ENSDART00000065674
ENSDART00000157188
fybb
FYN binding protein b
chr22_+_336256 5.17 ENSDART00000019155
btg2
B-cell translocation gene 2

Network of associatons between targets according to the STRING database.

First level regulatory network of irf5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.0 42.0 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
10.0 30.1 GO:0051973 positive regulation of telomerase activity(GO:0051973)
9.6 57.5 GO:0060876 semicircular canal formation(GO:0060876)
5.2 20.7 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
3.7 11.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
3.1 9.4 GO:0044878 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
3.0 23.9 GO:0031179 peptide modification(GO:0031179)
2.9 29.3 GO:0030104 water homeostasis(GO:0030104)
2.8 14.1 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
2.7 13.4 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) cellular response to virus(GO:0098586)
2.7 37.3 GO:0034311 diol metabolic process(GO:0034311)
2.3 90.5 GO:0030199 collagen fibril organization(GO:0030199)
2.3 13.7 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
2.2 17.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
2.0 10.0 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
2.0 17.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.9 15.0 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
1.8 5.3 GO:0043455 regulation of secondary metabolic process(GO:0043455)
1.5 6.0 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.5 10.3 GO:0006012 galactose metabolic process(GO:0006012)
1.4 25.7 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
1.4 18.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
1.3 6.7 GO:0035739 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
1.3 5.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
1.3 6.4 GO:0007618 mating(GO:0007618) male gonad development(GO:0008584)
1.3 6.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.2 47.3 GO:0060972 left/right pattern formation(GO:0060972)
1.2 56.2 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
1.2 7.3 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
1.2 4.8 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.1 5.6 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.1 11.2 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
1.1 28.3 GO:0030168 platelet activation(GO:0030168)
1.1 34.2 GO:0007568 aging(GO:0007568)
1.0 3.1 GO:0006751 glutathione catabolic process(GO:0006751)
1.0 17.4 GO:0018216 peptidyl-arginine methylation(GO:0018216)
1.0 9.1 GO:0014812 muscle cell migration(GO:0014812)
1.0 6.0 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
1.0 8.9 GO:0042987 beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
1.0 10.6 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.9 13.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.9 18.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.9 7.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.8 141.6 GO:0051604 protein maturation(GO:0051604)
0.8 4.8 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.8 5.3 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.8 42.9 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.7 4.9 GO:0014028 notochord formation(GO:0014028)
0.7 13.6 GO:0046849 bone remodeling(GO:0046849)
0.7 11.2 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.6 6.5 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.6 19.5 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.6 1.8 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.6 4.8 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.6 6.0 GO:0019430 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.6 19.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.5 4.3 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.5 20.9 GO:0048794 swim bladder development(GO:0048794)
0.5 8.8 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.5 7.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.5 17.3 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.5 37.8 GO:0007492 endoderm development(GO:0007492)
0.5 3.4 GO:0044030 regulation of DNA methylation(GO:0044030)
0.5 1.9 GO:1904103 regulation of convergent extension involved in gastrulation(GO:1904103)
0.5 7.0 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.4 4.0 GO:0044090 positive regulation of vacuole organization(GO:0044090)
0.4 13.7 GO:2001236 regulation of extrinsic apoptotic signaling pathway(GO:2001236)
0.4 12.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.4 2.0 GO:0055071 manganese ion homeostasis(GO:0055071)
0.4 2.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.4 13.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.4 1.2 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.4 11.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.4 4.9 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.4 7.1 GO:0042476 odontogenesis(GO:0042476)
0.4 3.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.4 22.1 GO:0060348 bone development(GO:0060348)
0.3 2.8 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.3 20.0 GO:0001894 tissue homeostasis(GO:0001894)
0.3 2.7 GO:0061316 canonical Wnt signaling pathway involved in heart development(GO:0061316) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.3 2.0 GO:0030242 pexophagy(GO:0030242)
0.3 4.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.3 16.0 GO:0007259 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.3 2.2 GO:0016266 O-glycan processing(GO:0016266)
0.3 26.4 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.3 4.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.3 4.7 GO:0097352 autophagosome maturation(GO:0097352)
0.3 3.5 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.3 1.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.3 13.3 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.3 1.5 GO:0016559 peroxisome fission(GO:0016559)
0.2 3.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.2 10.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 39.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.2 10.8 GO:0035194 posttranscriptional gene silencing(GO:0016441) posttranscriptional gene silencing by RNA(GO:0035194)
0.2 5.0 GO:0048920 neuromast primordium migration(GO:0048883) posterior lateral line neuromast primordium migration(GO:0048920)
0.2 21.7 GO:0010506 regulation of autophagy(GO:0010506)
0.2 8.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.2 11.2 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.2 6.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 21.1 GO:0001756 somitogenesis(GO:0001756)
0.2 18.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 27.9 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.2 12.8 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.2 4.8 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.2 4.8 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.2 29.2 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.2 34.6 GO:0072594 establishment of protein localization to organelle(GO:0072594)
0.2 3.4 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.2 8.1 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.2 6.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 6.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 8.2 GO:0002573 myeloid leukocyte differentiation(GO:0002573)
0.1 11.6 GO:0007605 sensory perception of sound(GO:0007605)
0.1 3.6 GO:0006458 'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084) chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 1.4 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 2.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.1 4.5 GO:0009880 embryonic pattern specification(GO:0009880)
0.1 3.8 GO:0030301 cholesterol transport(GO:0030301)
0.1 39.2 GO:0001525 angiogenesis(GO:0001525)
0.1 11.4 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.1 3.1 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082)
0.1 1.4 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 5.2 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 6.7 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.1 3.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 7.7 GO:0030218 erythrocyte differentiation(GO:0030218) erythrocyte homeostasis(GO:0034101)
0.1 3.2 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.1 2.4 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 4.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 61.4 GO:0006508 proteolysis(GO:0006508)
0.1 1.0 GO:0031297 replication fork processing(GO:0031297)
0.1 15.9 GO:0032970 regulation of actin filament-based process(GO:0032970)
0.0 0.4 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 1.8 GO:0045786 negative regulation of cell cycle(GO:0045786)
0.0 0.8 GO:0050821 protein stabilization(GO:0050821)
0.0 5.9 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 6.5 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 3.5 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 53.5 GO:0043034 costamere(GO:0043034)
6.1 24.2 GO:0061702 inflammasome complex(GO:0061702)
2.9 11.6 GO:0061689 tricellular tight junction(GO:0061689)
2.0 6.0 GO:0005592 collagen type XI trimer(GO:0005592)
1.7 10.5 GO:0031258 lamellipodium membrane(GO:0031258)
1.7 203.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
1.6 11.2 GO:0016234 inclusion body(GO:0016234)
1.4 26.4 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
1.1 9.1 GO:0032783 ELL-EAF complex(GO:0032783)
1.1 20.0 GO:0030057 desmosome(GO:0030057)
1.0 74.3 GO:0031902 late endosome membrane(GO:0031902)
1.0 4.8 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.9 11.2 GO:0031010 ISWI-type complex(GO:0031010)
0.8 3.1 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.7 4.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.7 2.0 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.6 11.6 GO:0042555 MCM complex(GO:0042555)
0.6 20.8 GO:0043186 P granule(GO:0043186)
0.5 37.7 GO:0005770 late endosome(GO:0005770)
0.5 8.0 GO:0043296 apical junction complex(GO:0043296)
0.5 1.4 GO:1990879 CST complex(GO:1990879)
0.4 1.2 GO:0070545 PeBoW complex(GO:0070545)
0.4 83.2 GO:0005764 lysosome(GO:0005764)
0.3 6.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.3 5.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 13.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 31.2 GO:0005802 trans-Golgi network(GO:0005802)
0.2 3.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.2 6.1 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.2 8.6 GO:0031012 extracellular matrix(GO:0031012)
0.2 4.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 3.4 GO:0000792 heterochromatin(GO:0000792)
0.2 6.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 11.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 1.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 22.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 3.2 GO:0030686 90S preribosome(GO:0030686)
0.1 13.2 GO:0016459 myosin complex(GO:0016459)
0.1 13.5 GO:0014069 postsynaptic density(GO:0014069)
0.1 32.0 GO:0005874 microtubule(GO:0005874)
0.1 157.7 GO:0005576 extracellular region(GO:0005576)
0.1 4.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 4.7 GO:0031201 SNARE complex(GO:0031201)
0.1 14.1 GO:0030054 cell junction(GO:0030054)
0.0 28.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.4 GO:0048786 presynaptic active zone(GO:0048786)
0.0 5.2 GO:0005794 Golgi apparatus(GO:0005794)
0.0 9.9 GO:0005730 nucleolus(GO:0005730)
0.0 12.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 7.0 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 4.9 GO:0005768 endosome(GO:0005768)
0.0 130.8 GO:0016021 integral component of membrane(GO:0016021)
0.0 5.2 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 9.8 GO:0005886 plasma membrane(GO:0005886)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.8 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
6.7 33.5 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
3.7 11.1 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
2.7 23.9 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
2.5 17.4 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
2.3 13.7 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
1.8 12.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
1.8 12.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
1.8 7.0 GO:0097108 hedgehog family protein binding(GO:0097108)
1.7 24.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
1.6 19.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
1.5 9.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
1.5 7.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
1.2 4.8 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
1.2 14.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
1.1 24.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
1.1 4.3 GO:0016453 C-acetyltransferase activity(GO:0016453)
1.0 10.6 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.9 201.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.9 6.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.8 98.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 13.6 GO:0031386 protein tag(GO:0031386)
0.8 4.8 GO:0051185 coenzyme transporter activity(GO:0051185)
0.8 3.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.8 6.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.8 5.3 GO:0031779 melanocortin receptor binding(GO:0031779)
0.7 17.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.7 5.9 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.7 26.4 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.7 46.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.7 28.6 GO:0005109 frizzled binding(GO:0005109)
0.7 6.7 GO:0016936 galactoside binding(GO:0016936)
0.6 2.6 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.6 7.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.6 7.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.6 10.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.6 8.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.6 1.8 GO:0009041 uridylate kinase activity(GO:0009041)
0.5 25.7 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.5 66.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.4 2.0 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.4 20.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.4 6.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.4 4.9 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.4 7.9 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4 10.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 2.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.3 1.7 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.3 6.2 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.3 2.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.3 1.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 4.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 64.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.3 1.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3 2.4 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.3 3.4 GO:0016405 CoA-ligase activity(GO:0016405)
0.3 15.6 GO:0031072 heat shock protein binding(GO:0031072)
0.2 5.4 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 3.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 163.8 GO:0008289 lipid binding(GO:0008289)
0.2 4.5 GO:0070411 I-SMAD binding(GO:0070411)
0.2 12.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 8.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 10.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 0.8 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 2.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 6.0 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 1.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 14.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 8.4 GO:0051082 unfolded protein binding(GO:0051082)
0.1 77.7 GO:0005198 structural molecule activity(GO:0005198)
0.1 22.1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.1 4.8 GO:0000049 tRNA binding(GO:0000049)
0.1 19.6 GO:0042802 identical protein binding(GO:0042802)
0.1 1.8 GO:0002039 p53 binding(GO:0002039)
0.1 3.4 GO:0035064 methylated histone binding(GO:0035064)
0.1 18.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 13.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 25.0 GO:0051015 actin filament binding(GO:0051015)
0.1 6.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 4.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 3.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 6.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 25.3 GO:0005525 GTP binding(GO:0005525)
0.0 1.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 5.9 GO:0042393 histone binding(GO:0042393)
0.0 5.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 5.4 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 11.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
1.1 14.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.9 36.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.7 22.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.6 19.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.6 25.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.6 6.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 73.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 9.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.4 10.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.4 30.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 5.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 6.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.3 8.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 4.5 PID ALK2 PATHWAY ALK2 signaling events
0.3 7.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.3 3.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 6.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 3.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.2 28.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 12.2 PID P73PATHWAY p73 transcription factor network
0.2 1.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 7.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.2 6.0 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.2 4.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 6.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 3.2 PID AURORA B PATHWAY Aurora B signaling
0.1 3.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.6 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 3.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 1.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.4 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 24.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.8 22.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
1.6 46.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
1.3 37.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
1.1 11.7 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.0 13.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
1.0 28.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.0 10.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.9 20.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.9 5.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.9 11.1 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.8 10.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.8 8.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.8 16.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.8 10.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.6 19.5 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.5 4.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 4.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.5 20.7 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.5 6.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.5 2.4 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.5 18.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.5 19.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.4 7.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.4 4.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.4 1.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 12.8 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.3 8.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 12.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 4.2 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.2 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 7.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 10.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 4.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 4.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 6.9 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 2.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint