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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irf6

Z-value: 0.50

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Transcription factors associated with irf6

Gene Symbol Gene ID Gene Info
irf6
ENSDARG00000101986 interferon regulatory factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf6dr11_v1_chr22_+_1170294_11702950.686.8e-14Click!

Activity profile of irf6 motif

Sorted Z-values of irf6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_22552678 10.11 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr16_+_19637384 5.36 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
macc1
metastasis associated in colon cancer 1
chr4_-_17669881 4.48 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr19_-_15420678 4.47 ENSDART00000151454
ENSDART00000027697
serinc2
serine incorporator 2
chr18_+_44532370 4.19 ENSDART00000086952
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr7_+_69187585 4.12 ENSDART00000160499
ENSDART00000166258
marveld3
MARVEL domain containing 3
chr17_-_30666037 3.34 ENSDART00000156509
alkal2b
ALK and LTK ligand 2b
chr18_+_44532668 3.06 ENSDART00000140672
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr14_+_33329420 3.03 ENSDART00000171090
ENSDART00000164062
sowahd
sosondowah ankyrin repeat domain family d
chr18_+_44532199 3.02 ENSDART00000135386
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr7_+_19482877 2.92 ENSDART00000077868
si:ch211-212k18.7
si:ch211-212k18.7
chr14_+_33329761 2.91 ENSDART00000161138
sowahd
sosondowah ankyrin repeat domain family d
chr18_+_44532883 2.75 ENSDART00000121994
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr2_-_37140423 2.73 ENSDART00000144220
tspan37
tetraspanin 37
chr9_+_23765587 2.34 ENSDART00000145120
si:ch211-219a4.3
si:ch211-219a4.3
chr7_+_19483277 1.75 ENSDART00000173750
si:ch211-212k18.7
si:ch211-212k18.7
chr18_+_17624295 1.70 ENSDART00000151865
ENSDART00000190408
ENSDART00000189204
ENSDART00000188894
ENSDART00000033762
ENSDART00000193471
nlrc5
NLR family, CARD domain containing 5
chr23_-_30045661 1.67 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr9_-_23765480 1.54 ENSDART00000027212
si:ch211-219a4.6
si:ch211-219a4.6
chr20_-_3911546 1.21 ENSDART00000169787
cnksr3
cnksr family member 3
chr21_-_22543611 1.13 ENSDART00000177084
myo5b
myosin VB
chr16_+_27383717 0.88 ENSDART00000132329
ENSDART00000136256
stx17
syntaxin 17
chr8_-_27687095 0.68 ENSDART00000086946
mov10b.1
Moloney leukemia virus 10b, tandem duplicate 1
chr10_+_28160265 0.64 ENSDART00000022484
rnft1
ring finger protein, transmembrane 1
chr15_-_21702317 0.54 ENSDART00000155824
IL4I1
si:dkey-40g16.6
chr2_-_26620803 0.43 ENSDART00000003946
ENSDART00000126826
tmem59
transmembrane protein 59
chr9_+_34089156 0.41 ENSDART00000000005
ccdc80
coiled-coil domain containing 80
chr16_+_26601364 0.08 ENSDART00000087537
epb41l4b
erythrocyte membrane protein band 4.1 like 4B

Network of associatons between targets according to the STRING database.

First level regulatory network of irf6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.6 3.3 GO:0070375 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.3 1.7 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.3 1.1 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 0.7 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.6 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.1 13.0 GO:0008544 epidermis development(GO:0008544)
0.1 10.1 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.9 GO:0097352 autophagosome maturation(GO:0097352)
0.0 4.9 GO:0010506 regulation of autophagy(GO:0010506)
0.0 5.4 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.0 3.3 GO:0072594 establishment of protein localization to organelle(GO:0072594)
0.0 0.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 10.1 GO:0043034 costamere(GO:0043034)
0.1 4.7 GO:0031902 late endosome membrane(GO:0031902)
0.0 4.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.7 GO:0043186 P granule(GO:0043186)
0.0 4.9 GO:0005764 lysosome(GO:0005764)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.3 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.2 0.7 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.1 13.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.1 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins