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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irx1b+irx4a+irx4b

Z-value: 0.50

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Transcription factors associated with irx1b+irx4a+irx4b

Gene Symbol Gene ID Gene Info
irx4a
ENSDARG00000035648 iroquois homeobox 4a
irx4b
ENSDARG00000036051 iroquois homeobox 4b
irx1b
ENSDARG00000056594 iroquois homeobox 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx1bdr11_v1_chr19_-_28130658_28130658-0.702.9e-15Click!
irx4bdr11_v1_chr19_+_28116410_28116410-0.534.8e-08Click!
irx4adr11_v1_chr16_-_383664_383664-0.472.0e-06Click!

Activity profile of irx1b+irx4a+irx4b motif

Sorted Z-values of irx1b+irx4a+irx4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_50147948 10.46 ENSDART00000149010
hp
haptoglobin
chr20_+_23440632 9.90 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr5_+_66170479 7.45 ENSDART00000172117
gldc
glycine dehydrogenase (decarboxylating)
chr13_+_2908764 5.92 ENSDART00000162362
wu:fj16a03
wu:fj16a03
chr23_+_19701587 5.38 ENSDART00000104425
dnase1l1
deoxyribonuclease I-like 1
chr7_+_56577522 5.13 ENSDART00000149130
ENSDART00000149624
hp
haptoglobin
chr7_+_56577906 4.28 ENSDART00000184023
hp
haptoglobin
chr18_+_22109379 3.76 ENSDART00000147230
zgc:158868
zgc:158868
chr1_-_7951002 2.93 ENSDART00000138187
si:dkey-79f11.8
si:dkey-79f11.8
chr24_-_25098719 2.87 ENSDART00000193651
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr5_-_35159379 2.42 ENSDART00000144105
fcho2
FCH domain only 2
chr3_-_402714 2.30 ENSDART00000134062
ENSDART00000105659
mhc1zja
major histocompatibility complex class I ZJA
chr11_+_14284866 2.18 ENSDART00000163729
si:ch211-262i1.3
si:ch211-262i1.3
chr13_-_43149063 2.04 ENSDART00000099601
vsir
V-set immunoregulatory receptor
chr20_-_23440955 1.93 ENSDART00000153386
slc10a4
solute carrier family 10, member 4
chr25_-_29072162 1.91 ENSDART00000169269
arid3b
AT rich interactive domain 3B (BRIGHT-like)
chr3_-_34100700 1.84 ENSDART00000151628
ighv6-1
immunoglobulin heavy variable 6-1
chr21_-_45871866 1.64 ENSDART00000161716
larp1
La ribonucleoprotein domain family, member 1
chr20_-_27190393 1.56 ENSDART00000149024
btbd7
BTB (POZ) domain containing 7
chr6_-_43262400 1.40 ENSDART00000156267
frmd4ba
FERM domain containing 4Ba
chr16_-_45398408 1.20 ENSDART00000004052
rgl2
ral guanine nucleotide dissociation stimulator-like 2
chr19_+_3653976 1.19 ENSDART00000125673
nedd9
neural precursor cell expressed, developmentally down-regulated 9
chr8_+_26410197 1.14 ENSDART00000145836
ENSDART00000053447
ifrd2
interferon-related developmental regulator 2
chr17_-_5352924 1.14 ENSDART00000167275
supt3h
SPT3 homolog, SAGA and STAGA complex component
chr23_+_40275400 1.05 ENSDART00000184259
fam46ab
family with sequence similarity 46, member Ab
chr15_+_37331585 1.02 ENSDART00000170715
zgc:171592
zgc:171592
chr2_-_7185460 0.98 ENSDART00000092078
rc3h1b
ring finger and CCCH-type domains 1b
chr2_-_13333932 0.82 ENSDART00000150238
ENSDART00000168258
si:dkey-185p13.1
vps4b
si:dkey-185p13.1
vacuolar protein sorting 4b homolog B (S. cerevisiae)
chr10_+_45345574 0.80 ENSDART00000166085
ppiab
peptidylprolyl isomerase Ab (cyclophilin A)
chr1_+_53919110 0.76 ENSDART00000020680
nup133
nucleoporin 133
chr16_-_44709832 0.65 ENSDART00000156784
si:ch211-151m7.6
si:ch211-151m7.6
chr15_-_41734639 0.62 ENSDART00000154230
ENSDART00000167443
ftr90
finTRIM family, member 90
chr2_-_707152 0.58 ENSDART00000082304
ftr93
finTRIM family, member 93
chr5_-_58996324 0.51 ENSDART00000033923
mis12
MIS12 kinetochore complex component
chr10_-_22912255 0.42 ENSDART00000131992
si:ch1073-143l10.2
si:ch1073-143l10.2
chr8_+_29986265 0.38 ENSDART00000148258
ptch1
patched 1
chr10_-_28117740 0.38 ENSDART00000134491
med13a
mediator complex subunit 13a
chr23_+_45845423 0.36 ENSDART00000183404
lmnl3
lamin L3
chr14_-_10617127 0.35 ENSDART00000154299
si:dkey-92i17.2
si:dkey-92i17.2
chr7_-_31830936 0.31 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr8_+_23784471 0.27 ENSDART00000189457
si:ch211-163l21.8
si:ch211-163l21.8
chr23_+_45845159 0.26 ENSDART00000023944
lmnl3
lamin L3
chr23_+_40275601 0.26 ENSDART00000076876
fam46ab
family with sequence similarity 46, member Ab
chr21_+_12036238 0.10 ENSDART00000102463
ENSDART00000155426
zgc:162344
zgc:162344

Network of associatons between targets according to the STRING database.

First level regulatory network of irx1b+irx4a+irx4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.5 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.3 5.4 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.2 1.2 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.8 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 0.4 GO:0039689 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.1 2.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.5 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.0 0.4 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 1.6 GO:0061138 morphogenesis of a branching epithelium(GO:0061138)
0.0 1.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.1 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.3 GO:0044090 positive regulation of vacuole organization(GO:0044090)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.8 GO:0042476 odontogenesis(GO:0042476)
0.0 1.0 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 2.9 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 19.3 GO:0006508 proteolysis(GO:0006508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0005960 glycine cleavage complex(GO:0005960)
0.2 1.1 GO:0030914 STAGA complex(GO:0030914)
0.1 0.5 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 2.9 GO:0045180 basal cortex(GO:0045180)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 2.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 20.6 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 7.5 GO:0016594 glycine binding(GO:0016594)
0.5 5.4 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.3 1.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 1.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.4 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 20.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 2.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 1.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID MYC PATHWAY C-MYC pathway
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID CXCR4 PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.8 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation