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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for jun

Z-value: 0.90

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Transcription factors associated with jun

Gene Symbol Gene ID Gene Info
jun
ENSDARG00000043531 Jun proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
jundr11_v1_chr20_+_15552657_155526570.187.9e-02Click!

Activity profile of jun motif

Sorted Z-values of jun motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_26880668 14.05 ENSDART00000077769
serpinb1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr20_+_28364742 13.60 ENSDART00000103355
rhov
ras homolog family member V
chr16_+_23403602 11.35 ENSDART00000159848
s100w
S100 calcium binding protein W
chr7_+_25033924 8.80 ENSDART00000170873
sb:cb1058
sb:cb1058
chr21_+_25765734 7.60 ENSDART00000021664
cldnb
claudin b
chr19_+_24488403 7.47 ENSDART00000052421
txnipa
thioredoxin interacting protein a
chr16_-_24832038 7.42 ENSDART00000153731
si:dkey-79d12.5
si:dkey-79d12.5
chr1_-_25679339 7.22 ENSDART00000161703
ENSDART00000054230
fgg
fibrinogen gamma chain
chr13_+_23988442 6.34 ENSDART00000010918
agt
angiotensinogen
chr5_+_45677781 6.07 ENSDART00000163120
ENSDART00000126537
gc
group-specific component (vitamin D binding protein)
chr10_+_28428222 5.97 ENSDART00000135003
si:ch211-222e20.4
si:ch211-222e20.4
chr16_-_36834505 5.66 ENSDART00000141275
ENSDART00000139588
ENSDART00000041993
pnp4b
purine nucleoside phosphorylase 4b
chr1_-_58913813 5.61 ENSDART00000056494
zgc:171687
zgc:171687
chr1_+_59088205 5.56 ENSDART00000150649
ENSDART00000100197
zgc:173915
zgc:173915
chr1_-_25177086 5.48 ENSDART00000144711
ENSDART00000177225
tmem154
transmembrane protein 154
chr7_+_33172066 5.43 ENSDART00000174013
si:ch211-194p6.12
si:ch211-194p6.12
chr22_-_10110959 5.31 ENSDART00000031005
ENSDART00000147580
gls2b
glutaminase 2b (liver, mitochondrial)
chr16_-_21785261 5.27 ENSDART00000078858
si:ch73-86n18.1
si:ch73-86n18.1
chr1_+_59090743 5.26 ENSDART00000100199
mfap4
microfibril associated protein 4
chr1_+_14253118 5.26 ENSDART00000161996
cxcl8a
chemokine (C-X-C motif) ligand 8a
chr1_+_59090972 5.07 ENSDART00000171497
mfap4
microfibril associated protein 4
chr16_+_46410520 4.99 ENSDART00000131072
rpz2
rapunzel 2
chr8_-_38201415 4.94 ENSDART00000155189
pdlim2
PDZ and LIM domain 2 (mystique)
chr5_-_30615901 4.90 ENSDART00000147769
si:ch211-117m20.5
si:ch211-117m20.5
chr25_+_10410620 4.84 ENSDART00000151886
ehf
ets homologous factor
chr21_+_33459524 4.82 ENSDART00000053205
cd74b
CD74 molecule, major histocompatibility complex, class II invariant chain b
chr4_+_25181572 4.66 ENSDART00000078529
ENSDART00000136643
kin
Kin17 DNA and RNA binding protein
chr19_+_7567763 4.53 ENSDART00000140411
s100a11
S100 calcium binding protein A11
chr1_+_59073436 4.49 ENSDART00000161642
MFAP4 (1 of many)
si:zfos-2330d3.3
chr10_+_187760 4.46 ENSDART00000161007
ENSDART00000160651
ets2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
chr4_+_16715267 4.39 ENSDART00000143849
pkp2
plakophilin 2
chr2_+_15100742 4.33 ENSDART00000027171
f3b
coagulation factor IIIb
chr8_-_18667693 4.30 ENSDART00000100516
stap2b
signal transducing adaptor family member 2b
chr15_+_963292 4.25 ENSDART00000156586
alox5b.2
arachidonate 5-lipoxygenase b, tandem duplicate 2
chr3_+_32118670 4.21 ENSDART00000055287
ENSDART00000111688
zgc:109934
zgc:109934
chr12_+_25945560 4.21 ENSDART00000109799
mmrn2b
multimerin 2b
chr11_-_24681292 4.19 ENSDART00000089601
olfml3b
olfactomedin-like 3b
chr16_+_11558868 4.16 ENSDART00000112497
ENSDART00000180445
zgc:198329
zgc:198329
chr6_-_49063085 4.14 ENSDART00000156124
si:ch211-105j21.9
si:ch211-105j21.9
chr6_-_40842768 4.13 ENSDART00000076160
mustn1a
musculoskeletal, embryonic nuclear protein 1a
chr3_-_26017592 4.08 ENSDART00000030890
hmox1a
heme oxygenase 1a
chr15_-_46779934 4.08 ENSDART00000085136
clcn2c
chloride channel 2c
chr14_+_33882973 4.01 ENSDART00000019396
clic2
chloride intracellular channel 2
chr23_+_17522867 3.89 ENSDART00000002714
slc17a9b
solute carrier family 17 (vesicular nucleotide transporter), member 9b
chr17_-_53359028 3.78 ENSDART00000185218
CABZ01068208.1

chr2_+_30379650 3.76 ENSDART00000129542
crispld1b
cysteine-rich secretory protein LCCL domain containing 1b
chr4_-_20181964 3.72 ENSDART00000022539
fgl2a
fibrinogen-like 2a
chr3_-_26017831 3.68 ENSDART00000179982
hmox1a
heme oxygenase 1a
chr7_+_14005111 3.63 ENSDART00000187365
furina
furin (paired basic amino acid cleaving enzyme) a
chr14_+_30774032 3.58 ENSDART00000139552
atl3
atlastin 3
chr14_+_30774515 3.56 ENSDART00000191666
atl3
atlastin 3
chr10_+_22771176 3.52 ENSDART00000192046
tmem88a
transmembrane protein 88 a
chr2_-_898899 3.51 ENSDART00000058289
dusp22b
dual specificity phosphatase 22b
chr5_+_24089334 3.51 ENSDART00000183748
tp53
tumor protein p53
chr1_-_59077650 3.47 ENSDART00000043516
MFAP4 (1 of many)
si:zfos-2330d3.1
chr16_-_45225520 3.47 ENSDART00000158855
fxyd1
FXYD domain containing ion transport regulator 1 (phospholemman)
chr25_+_18583877 3.46 ENSDART00000148741
met
MET proto-oncogene, receptor tyrosine kinase
chr2_+_25839940 3.32 ENSDART00000139927
eif5a2
eukaryotic translation initiation factor 5A2
chr19_-_5332784 3.30 ENSDART00000010373
krt1-19d
keratin, type 1, gene 19d
chr22_-_24297510 3.30 ENSDART00000163297
si:ch211-117l17.6
si:ch211-117l17.6
chr3_+_21189766 3.27 ENSDART00000078807
zgc:123295
zgc:123295
chr25_+_29474583 3.27 ENSDART00000191189
il17rel
interleukin 17 receptor E-like
chr5_+_37087583 3.25 ENSDART00000049900
tagln2
transgelin 2
chr7_+_69019851 3.24 ENSDART00000162891
CABZ01057488.1

chr8_+_6576940 3.21 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr7_+_34305903 3.20 ENSDART00000173575
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_+_22375596 3.18 ENSDART00000188243
ENSDART00000181506
arhgap27l
Rho GTPase activating protein 27, like
chr3_-_15734530 3.17 ENSDART00000141142
mvp
major vault protein
chr7_-_28696556 3.09 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr8_+_5024468 3.09 ENSDART00000030938
adra1aa
adrenoceptor alpha 1Aa
chr7_-_29534001 3.08 ENSDART00000124028
anxa2b
annexin A2b
chr3_-_15734358 3.07 ENSDART00000137325
mvp
major vault protein
chr25_-_22191733 3.05 ENSDART00000067478
pkp3a
plakophilin 3a
chr22_+_16497670 3.04 ENSDART00000014330
ier5
immediate early response 5
chr7_+_22688781 3.03 ENSDART00000173509
ugt5g1
UDP glucuronosyltransferase 5 family, polypeptide G1
chr10_+_38610741 2.94 ENSDART00000126444
mmp13a
matrix metallopeptidase 13a
chr23_+_25856541 2.90 ENSDART00000145426
ENSDART00000028236
hnf4a
hepatocyte nuclear factor 4, alpha
chr25_+_32474031 2.88 ENSDART00000152124
sqor
sulfide quinone oxidoreductase
chr21_+_26612777 2.86 ENSDART00000142667
esrra
estrogen-related receptor alpha
chr19_-_7420867 2.86 ENSDART00000081741
rab25a
RAB25, member RAS oncogene family a
chr8_-_44463985 2.84 ENSDART00000016845
mhc1lba
major histocompatibility complex class I LBA
chr20_-_34670236 2.83 ENSDART00000033325
slc25a24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr20_-_35578435 2.78 ENSDART00000142444
adgrf6
adhesion G protein-coupled receptor F6
chr10_+_26747755 2.76 ENSDART00000100329
f9b
coagulation factor IXb
chr3_+_3598555 2.75 ENSDART00000191152
CR589947.3

chr1_-_55116453 2.74 ENSDART00000142348
sertad2a
SERTA domain containing 2a
chr10_-_3295197 2.73 ENSDART00000109131
slc25a1b
slc25a1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1b
chr3_+_46762703 2.72 ENSDART00000133283
prkcsh
protein kinase C substrate 80K-H
chr23_-_1017605 2.72 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr13_+_829585 2.71 ENSDART00000029051
gsta.2
glutathione S-transferase, alpha tandem duplicate 2
chr21_-_2415808 2.71 ENSDART00000171179
si:ch211-241b2.5
si:ch211-241b2.5
chr22_+_4442473 2.70 ENSDART00000170751
ticam1
toll-like receptor adaptor molecule 1
chr22_-_24858042 2.70 ENSDART00000137998
ENSDART00000078216
ENSDART00000138378
vtg7
vitellogenin 7
chr14_+_30774894 2.69 ENSDART00000023054
atl3
atlastin 3
chr8_-_11170114 2.67 ENSDART00000133532
si:ch211-204d2.4
si:ch211-204d2.4
chr20_+_9683994 2.65 ENSDART00000053831
ptger2b
prostaglandin E receptor 2b (subtype EP2)
chr7_-_32981559 2.64 ENSDART00000175614
pkp3b
plakophilin 3b
chr23_+_4324625 2.63 ENSDART00000146302
ENSDART00000136792
ENSDART00000135027
ENSDART00000179819
sgk2a
serum/glucocorticoid regulated kinase 2a
chr5_-_25582721 2.62 ENSDART00000123986
anxa1a
annexin A1a
chr16_+_23398369 2.59 ENSDART00000037694
s100a10b
S100 calcium binding protein A10b
chr5_-_20123002 2.58 ENSDART00000026516
pxmp2
peroxisomal membrane protein 2
chr3_-_58189429 2.57 ENSDART00000156092
si:ch211-256e16.11
si:ch211-256e16.11
chr11_-_23501467 2.52 ENSDART00000169066
plekha6
pleckstrin homology domain containing, family A member 6
chr6_+_42475730 2.50 ENSDART00000150226
mst1ra
macrophage stimulating 1 receptor a
chr13_-_37122217 2.49 ENSDART00000133242
syne2b
spectrin repeat containing, nuclear envelope 2b
chr14_-_1538600 2.46 ENSDART00000180925
CABZ01109480.1

chr5_-_26879302 2.45 ENSDART00000098571
ENSDART00000139086
zgc:64051
zgc:64051
chr3_-_48259289 2.41 ENSDART00000160717
znf750
zinc finger protein 750
chr15_+_3766101 2.41 ENSDART00000042580
ENSDART00000112698
ENSDART00000187035
ENSDART00000165571
ENSDART00000121752
RNF14 (1 of many)
zmp:0000000524
chr22_-_606067 2.39 ENSDART00000136722
cdkn1a
cyclin-dependent kinase inhibitor 1A
chr4_-_17822447 2.39 ENSDART00000185502
dnajb9b
DnaJ (Hsp40) homolog, subfamily B, member 9b
chr13_-_37649595 2.39 ENSDART00000115354
si:dkey-188i13.10
si:dkey-188i13.10
chr2_-_37862380 2.38 ENSDART00000186005
si:ch211-284o19.8
si:ch211-284o19.8
chr24_-_33366188 2.36 ENSDART00000074161
slc4a2b
solute carrier family 4 (anion exchanger), member 2b
chr8_-_30204650 2.33 ENSDART00000133209
zgc:162939
zgc:162939
chr22_-_23006842 2.33 ENSDART00000105607
ptprc
protein tyrosine phosphatase, receptor type, C
chr15_-_28223757 2.28 ENSDART00000110969
ENSDART00000138401
scarf1
scavenger receptor class F, member 1
chr24_+_24726956 2.27 ENSDART00000144574
ENSDART00000066628
mtfr1
mitochondrial fission regulator 1
chr8_+_8671229 2.22 ENSDART00000131963
usp11
ubiquitin specific peptidase 11
chr12_+_20587179 2.21 ENSDART00000170127
arsg
arylsulfatase G
chr20_+_25625872 2.19 ENSDART00000078385
ppat
phosphoribosyl pyrophosphate amidotransferase
chr23_-_1017428 2.19 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr8_-_23573084 2.19 ENSDART00000139084
wasb
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
chr24_-_23839647 2.18 ENSDART00000125190
rrs1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr20_+_7084154 2.17 ENSDART00000136448
ftr85
finTRIM family, member 85
chr22_+_19405517 2.16 ENSDART00000138245
ENSDART00000155144
si:dkey-78l4.2
si:dkey-78l4.2
chr19_+_37120491 2.15 ENSDART00000032341
pef1
penta-EF-hand domain containing 1
chr2_+_36109002 2.13 ENSDART00000158978
traj28
T-cell receptor alpha joining 28
chr1_-_57501299 2.13 ENSDART00000080600
zgc:171470
zgc:171470
chr20_+_6543674 2.11 ENSDART00000134204
tns3.1
tensin 3, tandem duplicate 1
chr23_+_28377360 2.08 ENSDART00000014983
ENSDART00000128831
ENSDART00000135178
ENSDART00000138621
zgc:153867
zgc:153867
chr2_+_25839650 2.07 ENSDART00000134077
ENSDART00000140804
eif5a2
eukaryotic translation initiation factor 5A2
chr25_+_29474982 2.05 ENSDART00000130410
il17rel
interleukin 17 receptor E-like
chr19_+_348729 2.03 ENSDART00000114284
mcl1a
MCL1, BCL2 family apoptosis regulator a
chr10_-_22095505 2.02 ENSDART00000140210
ponzr10
plac8 onzin related protein 10
chr15_-_38129845 2.02 ENSDART00000057095
si:dkey-24p1.1
si:dkey-24p1.1
chr2_+_25378457 2.02 ENSDART00000089108
fndc3ba
fibronectin type III domain containing 3Ba
chr5_+_15819651 2.01 ENSDART00000081230
ENSDART00000186969
ENSDART00000134206
hspb8
heat shock protein b8
chr21_+_28747069 2.00 ENSDART00000014058
zgc:100829
zgc:100829
chr23_-_45398622 2.00 ENSDART00000053571
ENSDART00000149464
zgc:100911
zgc:100911
chr4_+_7822773 1.99 ENSDART00000171391
si:ch1073-67j19.2
si:ch1073-67j19.2
chr2_+_25840463 1.99 ENSDART00000125178
eif5a2
eukaryotic translation initiation factor 5A2
chr5_+_50953240 1.95 ENSDART00000148501
ENSDART00000149892
ENSDART00000190312
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr16_+_49005321 1.95 ENSDART00000160919
CABZ01068499.1

chr24_-_30275204 1.93 ENSDART00000164187
snx7
sorting nexin 7
chr6_+_56141852 1.93 ENSDART00000149665
tfap2c
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr23_-_36316352 1.93 ENSDART00000014840
nfe2
nuclear factor, erythroid 2
chr5_+_42141917 1.90 ENSDART00000172201
ENSDART00000140743
trpv1
transient receptor potential cation channel, subfamily V, member 1
chr1_+_6640437 1.89 ENSDART00000147638
si:ch211-93g23.2
si:ch211-93g23.2
chr4_-_6809323 1.88 ENSDART00000099467
ifrd1
interferon-related developmental regulator 1
chr8_-_38403018 1.88 ENSDART00000134100
sorbs3
sorbin and SH3 domain containing 3
chr19_+_43753995 1.88 ENSDART00000058504
SLC17A3
si:ch1073-513e17.1
chr8_-_38105053 1.86 ENSDART00000131546
adgra2
adhesion G protein-coupled receptor A2
chr11_+_13630107 1.85 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr23_-_5783421 1.84 ENSDART00000131521
ENSDART00000019455
csrp1a
cysteine and glycine-rich protein 1a
chr19_+_24575077 1.83 ENSDART00000167469
si:dkeyp-92c9.4
si:dkeyp-92c9.4
chr1_-_34335752 1.81 ENSDART00000140157
si:dkey-24h22.5
si:dkey-24h22.5
chr10_-_39283883 1.79 ENSDART00000023831
cry5
cryptochrome circadian clock 5
chr5_-_1047504 1.79 ENSDART00000159346
mbd2
methyl-CpG binding domain protein 2
chr10_+_38593645 1.77 ENSDART00000011573
mmp13a
matrix metallopeptidase 13a
chr13_-_51846224 1.74 ENSDART00000184663
LT631684.2

chr8_-_2616326 1.73 ENSDART00000027214
slc25a25a
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr6_-_35439406 1.71 ENSDART00000073784
rgs5a
regulator of G protein signaling 5a
chr13_-_15982707 1.71 ENSDART00000186911
ENSDART00000181072
ikzf1
IKAROS family zinc finger 1 (Ikaros)
chr6_-_43028896 1.71 ENSDART00000149977
glyctk
glycerate kinase
chr4_+_77971104 1.70 ENSDART00000188609
zgc:113921
zgc:113921
chr8_+_32406885 1.69 ENSDART00000167600
epgn
epithelial mitogen homolog (mouse)
chr11_-_18253111 1.68 ENSDART00000125984
mustn1b
musculoskeletal, embryonic nuclear protein 1b
chr5_-_57480660 1.68 ENSDART00000147875
ENSDART00000142776
si:ch211-202f5.2
si:ch211-202f5.2
chr3_-_39648021 1.68 ENSDART00000055171
grapa
GRB2-related adaptor protein a
chr17_-_15600455 1.67 ENSDART00000110272
ENSDART00000156911
si:ch211-266g18.9
si:ch211-266g18.9
chr16_+_37876779 1.66 ENSDART00000140148
si:ch211-198c19.1
si:ch211-198c19.1
chr3_+_1179601 1.65 ENSDART00000173378
triobpb
TRIO and F-actin binding protein b
chr20_+_51479263 1.65 ENSDART00000148798
tlr5a
toll-like receptor 5a
chr19_+_2670130 1.62 ENSDART00000152152
si:ch73-24k9.2
si:ch73-24k9.2
chr19_-_10432134 1.60 ENSDART00000081440
il11b
interleukin 11b
chr4_+_77933084 1.56 ENSDART00000148728
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr5_-_34616599 1.56 ENSDART00000050271
ENSDART00000097975
hexb
hexosaminidase B (beta polypeptide)
chr6_-_59357256 1.56 ENSDART00000074534
fam210b
family with sequence similarity 210, member B
chr1_-_59567685 1.55 ENSDART00000159144
ENSDART00000182913
zmp:0000001082
zmp:0000001082
chr3_-_34034498 1.55 ENSDART00000151145
ighv11-2
immunoglobulin heavy variable 11-2
chr6_-_43449013 1.54 ENSDART00000122423
eevs
2-epi-5-epi-valiolone synthase
chr6_-_33980881 1.53 ENSDART00000057297
mpl
MPL proto-oncogene, thrombopoietin receptor
chr6_+_48348415 1.52 ENSDART00000064826
mov10a
Mov10 RISC complex RNA helicase a
chr4_+_357810 1.51 ENSDART00000163436
ENSDART00000103645
tmem181
transmembrane protein 181
chr13_+_35339182 1.50 ENSDART00000019323
jag1b
jagged 1b
chr25_+_30196039 1.50 ENSDART00000005299
hsd17b12a
hydroxysteroid (17-beta) dehydrogenase 12a
chr11_+_13629528 1.48 ENSDART00000186509
si:ch211-1a19.3
si:ch211-1a19.3
chr1_+_54655160 1.48 ENSDART00000190319
si:ch211-202h22.7
si:ch211-202h22.7
chr23_+_19606291 1.47 ENSDART00000139415
flnb
filamin B, beta (actin binding protein 278)
chr10_-_43850304 1.46 ENSDART00000180052
tlr8b
toll-like receptor 8b
chr23_+_25232711 1.46 ENSDART00000128510
erbb3b
erb-b2 receptor tyrosine kinase 3b
chr18_+_8320165 1.45 ENSDART00000092053
chkb
choline kinase beta
chr2_-_37277626 1.45 ENSDART00000135340
nadkb
NAD kinase b
chr13_-_16222388 1.44 ENSDART00000182861
zgc:110045
zgc:110045
chr21_+_28747236 1.42 ENSDART00000137874
zgc:100829
zgc:100829
chr24_-_23998897 1.41 ENSDART00000130053
zmp:0000000991
zmp:0000000991
chr21_-_21020708 1.40 ENSDART00000064032
eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr7_+_34786591 1.38 ENSDART00000173700
si:dkey-148a17.5
si:dkey-148a17.5
chr6_-_37744430 1.38 ENSDART00000150177
ENSDART00000149722
nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 (human)

Network of associatons between targets according to the STRING database.

First level regulatory network of jun

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.6 GO:0071896 protein localization to adherens junction(GO:0071896)
2.6 7.8 GO:0043576 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
1.8 5.3 GO:0002676 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
1.6 4.8 GO:0060907 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
1.4 2.7 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081) myeloid leukocyte cytokine production(GO:0061082)
1.3 21.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.2 3.5 GO:0061317 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
1.2 3.5 GO:0010526 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
1.2 5.8 GO:0035988 chondrocyte proliferation(GO:0035988)
1.1 7.4 GO:0045901 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
1.0 2.9 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.7 2.7 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.7 5.3 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.7 2.6 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.6 4.4 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 1.9 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.6 3.1 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.5 2.7 GO:0071380 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.5 3.1 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.5 7.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.5 1.9 GO:0048939 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.5 3.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.4 3.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.4 2.6 GO:0006925 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.4 1.3 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.4 6.3 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.4 2.2 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.4 4.2 GO:0043651 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.4 6.0 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.3 3.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.3 2.3 GO:0070836 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.3 2.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.3 6.9 GO:0048246 macrophage chemotaxis(GO:0048246)
0.3 3.6 GO:0016486 peptide hormone processing(GO:0016486) embryonic heart tube left/right pattern formation(GO:0060971)
0.3 1.0 GO:1900060 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.2 2.7 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.2 2.9 GO:0070365 hepatocyte differentiation(GO:0070365)
0.2 0.7 GO:0097095 frontonasal suture morphogenesis(GO:0097095)
0.2 12.5 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.2 1.1 GO:0032527 retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527)
0.2 1.7 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 0.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 1.0 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 1.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.2 2.5 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.2 1.7 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.2 1.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 2.4 GO:0010165 response to X-ray(GO:0010165)
0.2 1.1 GO:0060347 trabecula formation(GO:0060343) heart trabecula formation(GO:0060347)
0.2 5.3 GO:0051180 vitamin transport(GO:0051180)
0.2 0.9 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.2 0.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 8.1 GO:0031102 neuron projection regeneration(GO:0031102)
0.2 1.9 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.1 1.0 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 7.3 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 2.5 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.7 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 1.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 1.0 GO:1902975 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.1 1.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 2.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 1.3 GO:0060325 face morphogenesis(GO:0060325)
0.1 1.1 GO:0034205 beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.1 0.5 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.1 2.7 GO:0006491 N-glycan processing(GO:0006491)
0.1 4.8 GO:0061035 regulation of cartilage development(GO:0061035)
0.1 0.9 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 1.4 GO:0060416 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.1 7.1 GO:0007596 blood coagulation(GO:0007596)
0.1 1.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.1 2.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.7 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 1.9 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.0 GO:0031274 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1 1.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 1.5 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1 1.7 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.1 0.5 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 1.3 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 2.7 GO:0032355 response to estradiol(GO:0032355)
0.1 5.5 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 0.3 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 1.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.3 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 2.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.5 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.1 2.2 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 1.8 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 3.5 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.1 0.7 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.1 0.3 GO:0055130 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.1 4.7 GO:0050673 epithelial cell proliferation(GO:0050673)
0.1 7.4 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.1 2.3 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.6 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 0.6 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 4.2 GO:0007043 cell-cell junction assembly(GO:0007043)
0.1 0.5 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.3 GO:0060324 face development(GO:0060324)
0.1 0.7 GO:0009303 rRNA transcription(GO:0009303)
0.0 1.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 2.8 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 3.4 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.9 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.0 1.0 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 1.0 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.9 GO:0009749 response to glucose(GO:0009749)
0.0 0.6 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 1.3 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 1.0 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.0 0.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 2.0 GO:0034620 cellular response to unfolded protein(GO:0034620)
0.0 0.4 GO:0030719 P granule organization(GO:0030719)
0.0 0.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.7 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.8 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.8 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.0 0.2 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.0 0.1 GO:0006901 vesicle coating(GO:0006901)
0.0 1.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 5.1 GO:0006260 DNA replication(GO:0006260)
0.0 1.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.6 GO:0007164 establishment of planar polarity(GO:0001736) establishment of tissue polarity(GO:0007164)
0.0 0.5 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.0 0.9 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.3 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.5 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 3.2 GO:0009617 response to bacterium(GO:0009617)
0.0 1.0 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 2.4 GO:0008544 epidermis development(GO:0008544)
0.0 1.0 GO:0007602 phototransduction(GO:0007602)
0.0 0.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.2 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 5.5 GO:0009116 nucleoside metabolic process(GO:0009116)
0.0 0.1 GO:1901232 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.3 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.1 GO:0045899 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.6 GO:0002548 monocyte chemotaxis(GO:0002548)
0.0 0.2 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.1 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.3 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 0.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.2 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 1.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.7 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.5 GO:0050852 T cell receptor signaling pathway(GO:0050852)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 GO:0005577 fibrinogen complex(GO:0005577)
0.7 2.7 GO:0017177 glucosidase II complex(GO:0017177)
0.6 4.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.5 1.9 GO:1990909 Wnt signalosome(GO:1990909)
0.4 1.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.4 7.8 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.4 GO:0070195 growth hormone receptor complex(GO:0070195)
0.3 4.4 GO:0014704 intercalated disc(GO:0014704)
0.3 5.7 GO:0030057 desmosome(GO:0030057)
0.3 1.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.3 1.0 GO:0035339 SPOTS complex(GO:0035339)
0.2 0.9 GO:0060171 stereocilium membrane(GO:0060171)
0.2 1.0 GO:0000811 GINS complex(GO:0000811)
0.2 2.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.4 GO:0033391 chromatoid body(GO:0033391)
0.1 7.4 GO:0005643 nuclear pore(GO:0005643)
0.1 1.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.5 GO:0031511 Mis6-Sim4 complex(GO:0031511)
0.1 5.5 GO:0031941 filamentous actin(GO:0031941)
0.1 2.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.4 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.2 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 2.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.7 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 3.5 GO:0016342 catenin complex(GO:0016342)
0.1 4.3 GO:0005604 basement membrane(GO:0005604)
0.1 2.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.6 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 11.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 7.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 1.5 GO:0060293 P granule(GO:0043186) germ plasm(GO:0060293)
0.1 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.9 GO:0055037 recycling endosome(GO:0055037)
0.0 62.7 GO:0005615 extracellular space(GO:0005615)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.4 GO:0035101 FACT complex(GO:0035101)
0.0 1.6 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 3.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 3.7 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.6 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.2 GO:0030428 cell septum(GO:0030428)
0.0 0.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.8 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.8 GO:0005884 actin filament(GO:0005884)
0.0 4.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 1.5 GO:0030018 Z disc(GO:0030018)
0.0 0.9 GO:0030175 filopodium(GO:0030175)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.7 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.6 GO:0005764 lysosome(GO:0005764)
0.0 1.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.7 GO:0030139 endocytic vesicle(GO:0030139)
0.0 3.5 GO:0000785 chromatin(GO:0000785)
0.0 12.9 GO:0005739 mitochondrion(GO:0005739)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0005499 vitamin D binding(GO:0005499)
1.3 5.3 GO:0005153 interleukin-8 receptor binding(GO:0005153)
1.3 7.8 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
1.1 3.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
1.0 2.9 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.7 4.4 GO:0019215 intermediate filament binding(GO:0019215)
0.7 18.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 4.2 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.6 1.8 GO:0003913 DNA photolyase activity(GO:0003913)
0.6 5.3 GO:0004359 glutaminase activity(GO:0004359)
0.6 5.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.5 1.5 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.4 5.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 5.7 GO:0055102 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.4 2.2 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.4 3.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 1.7 GO:0008887 glycerate kinase activity(GO:0008887)
0.4 3.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.4 2.7 GO:0045735 nutrient reservoir activity(GO:0045735)
0.4 1.9 GO:0038131 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.3 1.4 GO:0004903 growth hormone receptor activity(GO:0004903)
0.3 23.0 GO:0003823 antigen binding(GO:0003823)
0.3 1.3 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.3 1.0 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.3 0.9 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.3 1.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 2.7 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.3 6.8 GO:0042805 actinin binding(GO:0042805)
0.3 1.0 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.2 5.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.2 0.9 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 0.9 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.2 5.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 1.1 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.2 4.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 5.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 1.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 0.6 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.2 1.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 6.2 GO:0030165 PDZ domain binding(GO:0030165)
0.2 1.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 1.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 1.5 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 1.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 1.5 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.6 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 2.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 6.3 GO:0043022 ribosome binding(GO:0043022)
0.1 8.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 0.6 GO:0017040 ceramidase activity(GO:0017040)
0.1 2.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 0.5 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.1 9.2 GO:0045296 cadherin binding(GO:0045296)
0.1 1.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 10.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.9 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 2.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.8 GO:0042287 MHC protein binding(GO:0042287)
0.1 0.6 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 3.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 1.7 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 3.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 15.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.5 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 0.5 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 2.2 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.5 GO:0005112 Notch binding(GO:0005112)
0.1 0.3 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.1 0.3 GO:0015288 porin activity(GO:0015288)
0.1 3.1 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.1 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.5 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 1.3 GO:0008483 transaminase activity(GO:0008483)
0.0 4.4 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.3 GO:0032977 membrane insertase activity(GO:0032977)
0.0 1.4 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 1.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.7 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 1.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 4.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.7 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.0 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.0 2.2 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.0 3.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0045182 translation regulator activity(GO:0045182)
0.0 1.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.3 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.5 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 3.7 GO:0008083 growth factor activity(GO:0008083)
0.0 1.0 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 4.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.5 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 2.7 GO:0019901 protein kinase binding(GO:0019901)
0.0 1.0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 2.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.4 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.0 0.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 5.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 5.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 6.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 3.5 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 2.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 13.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.3 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 4.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 1.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.9 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 9.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.6 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.7 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 5.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.8 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 9.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.4 3.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 2.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3 2.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 2.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.3 3.5 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 3.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 6.1 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.2 2.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 1.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 2.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 9.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 10.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.5 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 1.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 1.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 2.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation