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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for klf12a

Z-value: 1.02

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Transcription factors associated with klf12a

Gene Symbol Gene ID Gene Info
klf12a
ENSDARG00000015312 Kruppel-like factor 12a
klf12a
ENSDARG00000115152 Kruppel-like factor 12a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf12adr11_v1_chr1_+_34527213_345272130.223.1e-02Click!

Activity profile of klf12a motif

Sorted Z-values of klf12a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_58221163 20.32 ENSDART00000157939
FO704813.1

chr1_-_59176949 19.02 ENSDART00000128742
CABZ01118678.1

chr10_+_15777064 16.06 ENSDART00000114483
apba1b
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr10_+_1668106 15.16 ENSDART00000142278
sgsm1b
small G protein signaling modulator 1b
chr10_+_19554604 14.04 ENSDART00000063806
atp6v1b2
ATPase H+ transporting V1 subunit B2
chr23_+_44732863 13.73 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr5_-_46273938 13.67 ENSDART00000080033
si:ch211-130m23.3
si:ch211-130m23.3
chr16_-_6821927 13.35 ENSDART00000149070
ENSDART00000149570
mbpb
myelin basic protein b
chr9_+_42095220 13.26 ENSDART00000148317
ENSDART00000134431
pcbp3
poly(rC) binding protein 3
chr5_+_37056818 13.23 ENSDART00000036760
tppp2
tubulin polymerization-promoting protein family member 2
chr2_-_2020044 11.42 ENSDART00000024135
tubb2
tubulin, beta 2A class IIa
chr17_-_4318393 11.31 ENSDART00000167995
ENSDART00000153824
napba
N-ethylmaleimide-sensitive factor attachment protein, beta a
chr20_+_20672163 11.22 ENSDART00000027758
rtn1b
reticulon 1b
chr2_+_59015878 11.20 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
si:ch1073-391i24.1
chr25_-_25736958 10.67 ENSDART00000166308
cib2
calcium and integrin binding family member 2
chr8_-_4618653 10.45 ENSDART00000025535
sept5a
septin 5a
chr7_+_23907692 10.01 ENSDART00000045479
syt4
synaptotagmin IV
chr9_-_48397702 9.72 ENSDART00000147169
zgc:172182
zgc:172182
chr9_-_296169 9.56 ENSDART00000165228
kif5aa
kinesin family member 5A, a
chr13_+_36622100 9.51 ENSDART00000133198
si:ch211-67f24.7
si:ch211-67f24.7
chr2_+_23222939 9.49 ENSDART00000026800
kifap3b
kinesin-associated protein 3b
chr10_+_15777258 9.44 ENSDART00000140511
apba1b
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr2_-_44282796 9.44 ENSDART00000163040
ENSDART00000166923
ENSDART00000056372
ENSDART00000109251
ENSDART00000132682
mpz
myelin protein zero
chr18_+_26895994 9.26 ENSDART00000098347
ch25hl1.2
cholesterol 25-hydroxylase like 1, tandem duplicate 2
chr6_-_52156427 9.18 ENSDART00000082821
rims4
regulating synaptic membrane exocytosis 4
chr15_-_19250543 8.62 ENSDART00000092705
ENSDART00000138895
igsf9ba
immunoglobulin superfamily, member 9Ba
chr6_-_17849786 8.44 ENSDART00000172709
rptor
regulatory associated protein of MTOR, complex 1
chr13_+_4405282 8.28 ENSDART00000148280
prr18
proline rich 18
chr17_+_51764310 8.19 ENSDART00000157171
si:ch211-168d23.3
si:ch211-168d23.3
chr13_+_36764715 8.13 ENSDART00000111832
ENSDART00000085230
atl1
atlastin GTPase 1
chr7_+_30867008 8.08 ENSDART00000193106
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr11_+_1796426 8.02 ENSDART00000173330
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr20_-_53366137 7.99 ENSDART00000146001
wasf1
WAS protein family, member 1
chr13_+_421231 7.95 ENSDART00000188212
ENSDART00000017854
lgi1a
leucine-rich, glioma inactivated 1a
chr5_-_69482891 7.87 ENSDART00000109487
CABZ01032476.1

chr15_+_47161917 7.87 ENSDART00000167860
gap43
growth associated protein 43
chr17_-_43466317 7.54 ENSDART00000155313
hspa4l
heat shock protein 4 like
chr10_+_37500234 7.51 ENSDART00000132096
ENSDART00000099473
msi2a
musashi RNA-binding protein 2a
chr9_+_34425736 7.31 ENSDART00000135147
si:ch211-218d20.15
si:ch211-218d20.15
chr13_-_30028103 7.24 ENSDART00000183889
scdb
stearoyl-CoA desaturase b
chr6_+_34512313 7.23 ENSDART00000102554
lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr11_+_35364445 7.23 ENSDART00000125766
camkvb
CaM kinase-like vesicle-associated b
chr25_+_35375848 6.97 ENSDART00000155721
ano3
anoctamin 3
chr24_+_41931585 6.62 ENSDART00000130310
epb41l3a
erythrocyte membrane protein band 4.1-like 3a
chr5_+_67812062 6.57 ENSDART00000158611
zgc:175280
zgc:175280
chr6_-_15604157 6.43 ENSDART00000141597
lrrfip1b
leucine rich repeat (in FLII) interacting protein 1b
chr6_+_59967994 6.28 ENSDART00000050457
zgc:65895
zgc:65895
chr10_+_39952995 6.26 ENSDART00000183077
BX927333.1

chr12_+_42436328 6.17 ENSDART00000167324
ebf3a
early B cell factor 3a
chr25_+_25737386 5.85 ENSDART00000108476
lrrc61
leucine rich repeat containing 61
chr19_+_8144556 5.83 ENSDART00000027274
ENSDART00000147218
efna3a
ephrin-A3a
chr21_+_34167178 5.82 ENSDART00000158308
trpc5b
transient receptor potential cation channel, subfamily C, member 5b
chr6_-_15604417 5.71 ENSDART00000157817
lrrfip1b
leucine rich repeat (in FLII) interacting protein 1b
chr1_+_57371447 5.70 ENSDART00000152229
ENSDART00000181077
si:dkey-27j5.3
si:dkey-27j5.3
chr10_+_1638876 5.68 ENSDART00000184484
ENSDART00000060946
ENSDART00000181251
sgsm1b
small G protein signaling modulator 1b
chr11_-_38083397 5.60 ENSDART00000086516
ENSDART00000184033
klhdc8a
kelch domain containing 8A
chr11_+_25064519 5.50 ENSDART00000016181
ndrg3a
ndrg family member 3a
chr15_+_47418565 5.32 ENSDART00000155709
clpb
ClpB homolog, mitochondrial AAA ATPase chaperonin
chr3_-_6767440 5.19 ENSDART00000156174
mast1b
microtubule associated serine/threonine kinase 1b
chr16_+_29303971 5.19 ENSDART00000087149
hapln2
hyaluronan and proteoglycan link protein 2
chr5_+_38263240 5.14 ENSDART00000051231
gnb2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr19_+_342094 5.10 ENSDART00000151013
ENSDART00000187622
ensaa
endosulfine alpha a
chr6_-_18976168 5.10 ENSDART00000170039
sept9b
septin 9b
chr21_+_1382078 4.97 ENSDART00000188463
TCF4
transcription factor 4
chr25_-_11088839 4.95 ENSDART00000154748
sv2bb
synaptic vesicle glycoprotein 2Bb
chr20_-_36617313 4.95 ENSDART00000172395
ENSDART00000152856
enah
enabled homolog (Drosophila)
chr7_-_18601206 4.83 ENSDART00000111636
DTX4
si:ch211-119e14.2
chr17_+_35097024 4.75 ENSDART00000026152
asap2a
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2a
chr11_-_4235811 4.71 ENSDART00000121716
si:ch211-236d3.4
si:ch211-236d3.4
chr2_+_25657958 4.55 ENSDART00000161407
tnika
TRAF2 and NCK interacting kinase a
chr24_-_21923930 4.54 ENSDART00000131944
tagln3b
transgelin 3b
chr22_-_881080 4.46 ENSDART00000185489
cept1b
choline/ethanolamine phosphotransferase 1b
chr1_+_9004719 4.46 ENSDART00000006211
ENSDART00000137211
prkcba
protein kinase C, beta a
chr6_+_18520859 4.45 ENSDART00000158263
si:dkey-10p5.10
si:dkey-10p5.10
chr2_+_25658112 4.43 ENSDART00000051234
tnika
TRAF2 and NCK interacting kinase a
chr1_+_42874410 4.40 ENSDART00000153506
ctnna2
catenin (cadherin-associated protein), alpha 2
chr7_+_38762043 4.32 ENSDART00000036461
arhgap1
Rho GTPase activating protein 1
chr8_-_1698155 4.23 ENSDART00000186159
CABZ01065417.1

chr16_-_44399335 4.23 ENSDART00000165058
rims2a
regulating synaptic membrane exocytosis 2a
chr14_+_33264303 4.02 ENSDART00000130680
ENSDART00000075187
pdzd11
PDZ domain containing 11
chr14_-_24391424 4.00 ENSDART00000113376
ENSDART00000126894
fam13b
family with sequence similarity 13, member B
chr15_+_24388782 3.98 ENSDART00000191661
ENSDART00000179995
ENSDART00000111226
sez6b
seizure related 6 homolog b
chr19_-_34011340 3.92 ENSDART00000172618
elmo1
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
chr12_+_11080776 3.92 ENSDART00000079336
raraa
retinoic acid receptor, alpha a
chr8_+_20157798 3.88 ENSDART00000124809
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr3_-_16227490 3.79 ENSDART00000057159
ENSDART00000130611
ENSDART00000012835
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr16_+_53455638 3.75 ENSDART00000045792
ENSDART00000154189
rbm24b
RNA binding motif protein 24b
chr23_+_30730121 3.74 ENSDART00000134141
asxl1
additional sex combs like transcriptional regulator 1
chr4_-_5018705 3.73 ENSDART00000154025
strip2
striatin interacting protein 2
chr9_-_3149896 3.71 ENSDART00000020861
pdk1
pyruvate dehydrogenase kinase, isozyme 1
chr2_+_413370 3.71 ENSDART00000122138
mylk4a
myosin light chain kinase family, member 4a
chr20_+_35058634 3.70 ENSDART00000122696
hnrnpub
heterogeneous nuclear ribonucleoprotein Ub
chr17_+_8925232 3.62 ENSDART00000036668
psmc1a
proteasome 26S subunit, ATPase 1a
chr24_-_12745222 3.54 ENSDART00000151836
si:ch211-196f5.9
si:ch211-196f5.9
chr4_-_5019113 3.49 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr23_-_32129569 3.47 ENSDART00000167761
ENSDART00000139569
zgc:92658
zgc:92658
chr16_+_30002605 3.46 ENSDART00000160555
sema6e
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr3_-_16227683 3.46 ENSDART00000111707
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr3_+_59117136 3.44 ENSDART00000182745
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr20_-_16156419 3.41 ENSDART00000037420
ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr14_+_12109535 3.37 ENSDART00000054620
ENSDART00000121913
kctd12b
potassium channel tetramerisation domain containing 12b
chr19_-_42391383 3.27 ENSDART00000110075
ENSDART00000087002
plekho1a
pleckstrin homology domain containing, family O member 1a
chr6_+_16031189 3.25 ENSDART00000015333
gbx2
gastrulation brain homeobox 2
chr24_-_36238054 3.20 ENSDART00000155725
tmem241
transmembrane protein 241
chr1_-_55058795 3.13 ENSDART00000187293
peli1a
pellino E3 ubiquitin protein ligase 1a
chr19_+_27479563 3.12 ENSDART00000049368
ENSDART00000185426
atat1
alpha tubulin acetyltransferase 1
chr7_+_69528850 3.05 ENSDART00000109507
RAP1GDS1
Rap1 GTPase-GDP dissociation stimulator 1
chr8_-_410199 3.04 ENSDART00000091177
ENSDART00000122979
ENSDART00000151331
ENSDART00000151155
trim36
tripartite motif containing 36
chr5_+_61657702 3.03 ENSDART00000134387
ENSDART00000171248
ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr23_-_41821825 3.01 ENSDART00000184725
GMEB2
si:ch73-302a13.2
chr3_+_24537023 2.96 ENSDART00000077702
sp100.1
SP110 nuclear body protein, tandem duplicate 1
chr4_+_9011825 2.96 ENSDART00000058007
samm50l
sorting and assembly machinery component 50 homolog, like
chr6_-_16406210 2.96 ENSDART00000012023
faimb
Fas apoptotic inhibitory molecule b
chr21_+_11415224 2.92 ENSDART00000049036
zgc:92275
zgc:92275
chr9_+_22375779 2.90 ENSDART00000183956
dgkg
diacylglycerol kinase, gamma
chr6_+_34511886 2.89 ENSDART00000179450
lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr3_-_32362872 2.87 ENSDART00000035545
ENSDART00000012630
prmt1
protein arginine methyltransferase 1
chr7_-_6592142 2.85 ENSDART00000160137
kcnj10a
potassium inwardly-rectifying channel, subfamily J, member 10a
chr6_-_57938043 2.84 ENSDART00000171073
tox2
TOX high mobility group box family member 2
chr20_+_29565906 2.84 ENSDART00000062383
ywhaqa
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a
chr12_+_47909026 2.81 ENSDART00000192472
tbata
thymus, brain and testes associated
chr14_+_12110020 2.79 ENSDART00000192462
kctd12b
potassium channel tetramerisation domain containing 12b
chr17_+_11507131 2.78 ENSDART00000013170
kif26ba
kinesin family member 26Ba
chr19_-_31686252 2.75 ENSDART00000131721
ripor2
RHO family interacting cell polarization regulator 2
chr3_-_22829710 2.73 ENSDART00000055659
cyb561
cytochrome b561
chr9_-_10145795 2.72 ENSDART00000004745
ENSDART00000143295
hnmt
histamine N-methyltransferase
chr17_-_44440832 2.71 ENSDART00000148786
exoc5
exocyst complex component 5
chr25_-_20268027 2.65 ENSDART00000138763
dnajb9a
DnaJ (Hsp40) homolog, subfamily B, member 9a
chr22_-_6801876 2.64 ENSDART00000135726
si:ch1073-188e1.1
si:ch1073-188e1.1
chr22_-_21676364 2.63 ENSDART00000183668
tle2b
transducin like enhancer of split 2b
chr2_+_19236677 2.59 ENSDART00000166292
cc2d1b
coiled-coil and C2 domain containing 1B
chr10_+_3299829 2.58 ENSDART00000183684
zgc:56235
zgc:56235
chr21_-_39670375 2.54 ENSDART00000151567
sgk494b
uncharacterized serine/threonine-protein kinase SgK494b
chr4_+_9011448 2.52 ENSDART00000192357
samm50l
sorting and assembly machinery component 50 homolog, like
chr22_+_34430310 2.52 ENSDART00000109860
amigo3
adhesion molecule with Ig-like domain 3
chr11_-_42554290 2.50 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr3_+_5575313 2.50 ENSDART00000134693
ENSDART00000101807
si:ch211-106h11.3
si:ch211-106h11.3
chr7_-_59159253 2.48 ENSDART00000159285
haus6
HAUS augmin-like complex, subunit 6
chr21_+_10794914 2.48 ENSDART00000084035
znf532
zinc finger protein 532
chr23_-_18707418 2.45 ENSDART00000144668
ENSDART00000141205
ENSDART00000016765
zgc:103759
zgc:103759
chr1_-_58036509 2.45 ENSDART00000081122
COLGALT1
si:ch211-114l13.7
chr1_+_11977426 2.45 ENSDART00000103399
tspan5b
tetraspanin 5b
chr24_-_26632171 2.43 ENSDART00000008374
ENSDART00000017384
tnikb
TRAF2 and NCK interacting kinase b
chr19_-_2421793 2.42 ENSDART00000180238
TMEM196 (1 of many)
transmembrane protein 196
chr11_-_36341189 2.42 ENSDART00000159752
sort1a
sortilin 1a
chr8_+_104114 2.41 ENSDART00000172101
sncaip
synuclein, alpha interacting protein
chr3_+_31925067 2.40 ENSDART00000127330
ENSDART00000055279
snrnp70
small nuclear ribonucleoprotein 70 (U1)
chr18_-_14917296 2.37 ENSDART00000098662
panx2
pannexin 2
chr19_+_27479838 2.35 ENSDART00000103922
atat1
alpha tubulin acetyltransferase 1
chr11_+_29790626 2.32 ENSDART00000067822
dynlt3
dynein, light chain, Tctex-type 3
chr20_-_43786515 2.29 ENSDART00000004601
laptm4a
lysosomal protein transmembrane 4 alpha
chr10_+_5135842 2.28 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr24_-_35534273 2.27 ENSDART00000026578
ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr11_-_36341028 2.23 ENSDART00000146093
sort1a
sortilin 1a
chr5_+_61658282 2.21 ENSDART00000188878
ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr23_-_44466257 2.18 ENSDART00000150126
si:ch1073-228j22.2
si:ch1073-228j22.2
chr22_-_2922053 2.16 ENSDART00000178290
pak2b
p21 protein (Cdc42/Rac)-activated kinase 2b
chr8_-_17167819 2.15 ENSDART00000135042
ENSDART00000143920
mrps36
mitochondrial ribosomal protein S36
chr10_+_6383270 2.13 ENSDART00000170548
zgc:114200
zgc:114200
chr9_+_4378153 2.11 ENSDART00000191264
ENSDART00000182384
kalrna
kalirin RhoGEF kinase a
chr2_+_30916188 2.10 ENSDART00000137012
myom1a
myomesin 1a (skelemin)
chr12_+_49125510 2.10 ENSDART00000185804
FO704607.1

chr1_+_45922699 2.09 ENSDART00000033669
lipt1
lipoyltransferase 1
chr15_-_19128705 2.09 ENSDART00000152428
arhgap32a
Rho GTPase activating protein 32a
chr8_-_13046089 2.09 ENSDART00000137784
si:dkey-208b23.5
si:dkey-208b23.5
chr3_+_472158 2.08 ENSDART00000134971
zgc:194659
zgc:194659
chr21_+_21279159 2.07 ENSDART00000148346
itpkca
inositol-trisphosphate 3-kinase Ca
chr18_-_46258612 2.06 ENSDART00000153930
si:dkey-244a7.1
si:dkey-244a7.1
chr17_-_17759138 2.04 ENSDART00000157128
ENSDART00000123845
adck1
aarF domain containing kinase 1
chr20_-_51656512 2.00 ENSDART00000129965
LO018154.1

chr6_+_29693492 1.99 ENSDART00000114172
pde6d
phosphodiesterase 6D, cGMP-specific, rod, delta
chr14_+_24277556 1.97 ENSDART00000122660
hnrnpa0a
heterogeneous nuclear ribonucleoprotein A0a
chr17_+_6765621 1.97 ENSDART00000156637
ENSDART00000007622
afg1la
AFG1 like ATPase a
chr1_+_45707219 1.96 ENSDART00000143363
si:ch211-214c7.4
si:ch211-214c7.4
chr10_-_42131408 1.96 ENSDART00000076693
stambpa
STAM binding protein a
chr21_-_22122312 1.94 ENSDART00000101726
slc35f2
solute carrier family 35, member F2
chr16_-_20294236 1.94 ENSDART00000059623
plekha8
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
chr10_+_4875262 1.92 ENSDART00000165942
palm2
paralemmin 2
chr11_-_11301283 1.89 ENSDART00000113311
ENSDART00000180466
col9a1a
collagen, type IX, alpha 1a
chr11_+_45287541 1.87 ENSDART00000165321
ENSDART00000173116
pycr1b
pyrroline-5-carboxylate reductase 1b
chr24_-_14712427 1.87 ENSDART00000176316
jph1a
junctophilin 1a
chr7_-_31938938 1.86 ENSDART00000132353
bdnf
brain-derived neurotrophic factor
chr1_-_55196103 1.85 ENSDART00000140153
mri1
methylthioribose-1-phosphate isomerase 1
chr8_-_410728 1.83 ENSDART00000151255
trim36
tripartite motif containing 36
chr13_-_6252498 1.81 ENSDART00000115157
tuba4l
tubulin, alpha 4 like
chr9_-_7655243 1.81 ENSDART00000102706
dnajb2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr14_-_47849216 1.80 ENSDART00000192796
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr10_+_41668483 1.78 ENSDART00000127073
lrrc75bb
leucine rich repeat containing 75Bb
chr2_+_37134281 1.77 ENSDART00000020135
pex19
peroxisomal biogenesis factor 19
chr5_-_64431927 1.75 ENSDART00000158248
brd3b
bromodomain containing 3b
chr3_-_52899394 1.74 ENSDART00000128223
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr10_+_1396940 1.74 ENSDART00000150096
gdnfa
glial cell derived neurotrophic factor a
chr7_-_3470451 1.73 ENSDART00000173387
si:ch211-285c6.6
si:ch211-285c6.6
chr16_+_12812472 1.72 ENSDART00000008535
u2af2a
U2 small nuclear RNA auxiliary factor 2a
chr14_-_24277805 1.70 ENSDART00000054243
dpf2l
D4, zinc and double PHD fingers family 2, like
chr5_-_2689753 1.67 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr17_+_16429826 1.66 ENSDART00000136078
efcab11
EF-hand calcium binding domain 11
chr23_-_27822920 1.66 ENSDART00000023094
acvr1ba
activin A receptor type 1Ba
chr2_+_19236969 1.65 ENSDART00000163875
ENSDART00000168644
cc2d1b
coiled-coil and C2 domain containing 1B
chr3_+_36284986 1.65 ENSDART00000059533
wipi1
WD repeat domain, phosphoinositide interacting 1

Network of associatons between targets according to the STRING database.

First level regulatory network of klf12a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.3 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
2.7 10.7 GO:0007638 mechanosensory behavior(GO:0007638)
2.4 9.6 GO:1990535 neuron projection maintenance(GO:1990535)
1.8 7.2 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
1.7 5.2 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
1.6 4.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.1 4.4 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
1.1 6.6 GO:0089718 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.9 3.7 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.9 3.7 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.9 2.8 GO:1990868 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.9 2.7 GO:0001692 histamine metabolic process(GO:0001692)
0.8 4.0 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.7 6.7 GO:1904861 excitatory synapse assembly(GO:1904861)
0.7 2.9 GO:0034969 histone arginine methylation(GO:0034969)
0.7 7.0 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.7 2.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.7 13.2 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.6 3.1 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.6 13.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.6 4.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.6 1.7 GO:0061213 regulation of neurotransmitter uptake(GO:0051580) regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.5 1.5 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.5 7.9 GO:0016198 axon choice point recognition(GO:0016198)
0.5 5.3 GO:0034605 cellular response to heat(GO:0034605)
0.5 7.2 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.5 1.4 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.5 7.0 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.4 1.8 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.4 2.8 GO:0036268 swimming(GO:0036268)
0.4 2.4 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.4 4.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.4 13.2 GO:0046785 microtubule polymerization(GO:0046785)
0.3 2.4 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.3 3.2 GO:0021871 forebrain regionalization(GO:0021871)
0.3 10.1 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.3 0.9 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.3 2.1 GO:0009249 protein lipoylation(GO:0009249)
0.3 1.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.3 7.2 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.3 1.9 GO:0035627 ceramide transport(GO:0035627)
0.3 3.0 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.3 10.0 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.3 8.1 GO:0048263 determination of dorsal identity(GO:0048263)
0.2 2.1 GO:0007220 Notch receptor processing(GO:0007220)
0.2 16.5 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.2 1.1 GO:0010586 miRNA metabolic process(GO:0010586)
0.2 5.8 GO:0006828 manganese ion transport(GO:0006828)
0.2 9.3 GO:0016126 sterol biosynthetic process(GO:0016126)
0.2 1.5 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 1.9 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2 0.8 GO:0055021 regulation of cardiac muscle tissue growth(GO:0055021) regulation of cardiac muscle cell proliferation(GO:0060043)
0.2 1.5 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 1.6 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2 3.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.2 5.1 GO:0035305 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.2 3.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 1.7 GO:0001709 cell fate determination(GO:0001709)
0.2 1.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 15.6 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.1 2.5 GO:0034661 ncRNA catabolic process(GO:0034661)
0.1 1.1 GO:0021634 optic nerve formation(GO:0021634)
0.1 1.6 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 1.7 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.8 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 3.8 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 0.5 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.1 2.6 GO:0001966 thigmotaxis(GO:0001966)
0.1 3.9 GO:0032526 response to retinoic acid(GO:0032526)
0.1 1.1 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 0.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 14.9 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 1.1 GO:0050819 negative regulation of coagulation(GO:0050819)
0.1 1.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 1.9 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 2.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 2.4 GO:0016180 snRNA processing(GO:0016180)
0.1 1.6 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 10.7 GO:0032147 activation of protein kinase activity(GO:0032147)
0.1 2.7 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 1.5 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 5.5 GO:0045766 positive regulation of angiogenesis(GO:0045766)
0.1 0.4 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.1 7.9 GO:0042552 myelination(GO:0042552)
0.1 1.2 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 10.3 GO:0044782 cilium organization(GO:0044782)
0.1 8.0 GO:1901342 regulation of vasculature development(GO:1901342)
0.1 0.3 GO:0061549 tongue development(GO:0043586) tongue morphogenesis(GO:0043587) taste bud development(GO:0061193) taste bud morphogenesis(GO:0061194) taste bud formation(GO:0061195) sympathetic ganglion development(GO:0061549)
0.1 38.5 GO:0098916 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.1 2.0 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.2 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 2.3 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 1.6 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.1 1.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.6 GO:0031268 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.6 GO:0006735 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 6.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 0.8 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.1 1.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 0.7 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.1 2.8 GO:0048484 enteric nervous system development(GO:0048484)
0.1 4.6 GO:0018393 internal protein amino acid acetylation(GO:0006475) internal peptidyl-lysine acetylation(GO:0018393)
0.0 0.7 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 1.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 8.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 2.2 GO:0051225 spindle assembly(GO:0051225)
0.0 0.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 2.6 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.8 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 2.7 GO:0022900 electron transport chain(GO:0022900)
0.0 0.2 GO:0010159 specification of organ position(GO:0010159)
0.0 1.7 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 2.4 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.8 GO:0042181 ketone biosynthetic process(GO:0042181)
0.0 4.7 GO:0046578 regulation of Ras protein signal transduction(GO:0046578)
0.0 0.7 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 12.1 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
0.0 1.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 2.8 GO:0007018 microtubule-based movement(GO:0007018)
0.0 2.1 GO:0006936 muscle contraction(GO:0006936)
0.0 3.6 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.9 GO:0051607 defense response to virus(GO:0051607)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.7 GO:0034968 histone lysine methylation(GO:0034968)
0.0 6.8 GO:0000278 mitotic cell cycle(GO:0000278)
0.0 0.4 GO:0006623 protein targeting to vacuole(GO:0006623) establishment of protein localization to vacuole(GO:0072666)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
2.0 7.9 GO:0032584 growth cone membrane(GO:0032584)
1.5 6.2 GO:1990498 mitotic spindle microtubule(GO:1990498)
1.4 13.7 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
1.3 22.8 GO:0043209 myelin sheath(GO:0043209)
1.1 8.4 GO:0031931 TORC1 complex(GO:0031931)
1.0 16.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.7 2.1 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.7 2.8 GO:0060171 stereocilium membrane(GO:0060171)
0.7 5.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.5 3.7 GO:0035517 PR-DUB complex(GO:0035517)
0.5 13.4 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.4 7.0 GO:0031209 SCAR complex(GO:0031209)
0.4 3.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.4 15.6 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.4 1.9 GO:0030314 junctional membrane complex(GO:0030314)
0.3 2.1 GO:0001650 fibrillar center(GO:0001650)
0.3 33.6 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.3 1.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.3 3.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.3 2.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.3 7.4 GO:0005844 polysome(GO:0005844)
0.3 9.5 GO:0035869 ciliary transition zone(GO:0035869)
0.2 2.2 GO:0089701 U2AF(GO:0089701)
0.2 2.1 GO:0044447 axoneme part(GO:0044447)
0.2 9.9 GO:0090544 BAF-type complex(GO:0090544)
0.2 1.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 1.6 GO:0061700 GATOR2 complex(GO:0061700)
0.2 1.1 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 5.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 12.8 GO:0005871 kinesin complex(GO:0005871)
0.1 1.6 GO:0061617 MICOS complex(GO:0061617)
0.1 1.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.4 GO:0071004 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.1 1.6 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.7 GO:0048179 activin receptor complex(GO:0048179)
0.1 5.9 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 2.6 GO:0046930 pore complex(GO:0046930)
0.1 31.1 GO:0005874 microtubule(GO:0005874)
0.1 6.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 7.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.7 GO:0000145 exocyst(GO:0000145)
0.1 2.1 GO:0031430 M band(GO:0031430)
0.1 1.6 GO:0000813 ESCRT I complex(GO:0000813)
0.1 2.4 GO:0005921 gap junction(GO:0005921)
0.1 2.0 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.7 GO:0032039 integrator complex(GO:0032039)
0.1 15.7 GO:0070382 exocytic vesicle(GO:0070382)
0.1 1.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 1.4 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 7.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 4.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 5.8 GO:0034703 cation channel complex(GO:0034703)
0.0 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 1.8 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 7.1 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 2.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 15.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.6 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.0 4.4 GO:0030424 axon(GO:0030424)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.6 GO:0005911 cell-cell junction(GO:0005911)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 11.3 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
1.8 7.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
1.4 33.6 GO:0001540 beta-amyloid binding(GO:0001540)
1.3 4.0 GO:0008022 protein C-terminus binding(GO:0008022)
1.3 9.3 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.9 6.6 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.9 2.7 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.9 2.7 GO:0043621 protein self-association(GO:0043621)
0.9 4.5 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.9 13.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.8 2.5 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.8 7.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.7 3.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.7 3.7 GO:0034046 poly(G) binding(GO:0034046)
0.7 2.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.7 13.7 GO:0001671 ATPase activator activity(GO:0001671)
0.6 7.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.6 3.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.5 1.6 GO:0034618 arginine binding(GO:0034618)
0.5 2.6 GO:0015288 porin activity(GO:0015288)
0.5 3.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.4 9.5 GO:0019894 kinesin binding(GO:0019894)
0.4 1.9 GO:0035620 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.4 1.9 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.4 5.6 GO:0005504 fatty acid binding(GO:0005504)
0.3 1.7 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.3 5.1 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.3 3.4 GO:0005522 profilin binding(GO:0005522)
0.3 2.4 GO:0030619 U1 snRNA binding(GO:0030619)
0.3 3.9 GO:0016405 CoA-ligase activity(GO:0016405)
0.3 1.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.3 9.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 3.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 1.7 GO:0016361 activin receptor activity, type I(GO:0016361)
0.3 0.8 GO:0000035 acyl binding(GO:0000035)
0.3 1.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.3 3.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.3 5.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 7.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 13.4 GO:0044325 ion channel binding(GO:0044325)
0.2 0.7 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.2 0.9 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 2.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.2 10.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 0.8 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.2 3.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 0.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 1.6 GO:0043515 kinetochore binding(GO:0043515)
0.2 2.9 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.2 4.5 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.2 1.8 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.2 3.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 10.6 GO:0030674 protein binding, bridging(GO:0030674)
0.2 1.0 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 0.8 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 5.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 7.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.9 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.1 8.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.1 0.5 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 2.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 6.7 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 2.4 GO:0022829 wide pore channel activity(GO:0022829)
0.1 1.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.1 GO:0035198 miRNA binding(GO:0035198)
0.1 11.7 GO:0060090 binding, bridging(GO:0060090)
0.1 1.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 9.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.6 GO:0045159 myosin II binding(GO:0045159)
0.1 2.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.5 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 1.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 28.7 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.1 GO:0015248 sterol transporter activity(GO:0015248)
0.1 2.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 3.9 GO:0030276 clathrin binding(GO:0030276)
0.1 2.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.9 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 2.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 4.3 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.6 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 4.4 GO:0045296 cadherin binding(GO:0045296)
0.0 4.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.7 GO:0002039 p53 binding(GO:0002039)
0.0 5.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 2.5 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 1.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 1.6 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 4.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.3 GO:0015297 antiporter activity(GO:0015297)
0.0 1.2 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 1.5 GO:0019838 growth factor binding(GO:0019838)
0.0 2.2 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 1.4 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 1.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 1.7 GO:0042393 histone binding(GO:0042393)
0.0 0.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 4.1 GO:0016887 ATPase activity(GO:0016887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.7 PID REELIN PATHWAY Reelin signaling pathway
0.4 3.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3 8.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 11.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.3 7.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 8.4 PID LKB1 PATHWAY LKB1 signaling events
0.2 4.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 1.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 5.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 5.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 14.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.8 8.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.8 10.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.5 5.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.4 4.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.4 6.8 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.3 3.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 3.9 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2 7.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 4.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 1.6 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.8 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 5.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.4 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.1 1.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.7 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.8 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 2.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 1.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)