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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for lhx3+lhx4

Z-value: 1.13

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Transcription factors associated with lhx3+lhx4

Gene Symbol Gene ID Gene Info
lhx3
ENSDARG00000003803 LIM homeobox 3
lhx4
ENSDARG00000039458 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx4dr11_v1_chr8_-_14484599_144845990.414.5e-05Click!
LHX3dr11_v1_chr5_+_71802014_71802014-0.056.3e-01Click!

Activity profile of lhx3+lhx4 motif

Sorted Z-values of lhx3+lhx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_9669717 25.69 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr21_-_20939488 21.29 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr20_+_34933183 20.37 ENSDART00000062738
snap25a
synaptosomal-associated protein, 25a
chr8_-_34052019 18.77 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pbx3b
pre-B-cell leukemia homeobox 3b
chr9_+_34641237 18.70 ENSDART00000133996
shox
short stature homeobox
chr16_+_46111849 14.07 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr3_+_29714775 13.67 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr9_-_31278048 12.62 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr15_-_44601331 12.55 ENSDART00000161514
zgc:165508
zgc:165508
chr10_-_27049170 12.31 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr7_-_28148310 12.25 ENSDART00000044208
lmo1
LIM domain only 1
chr25_-_13839743 11.40 ENSDART00000158780
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr2_-_9059955 11.14 ENSDART00000022768
ak5
adenylate kinase 5
chr15_+_22435460 10.99 ENSDART00000031976
tmem136a
transmembrane protein 136a
chr9_+_24159280 10.92 ENSDART00000184624
ENSDART00000178422
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr6_-_11768198 10.58 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr15_-_15449929 10.38 ENSDART00000101918
proca1
protein interacting with cyclin A1
chr18_+_21408794 10.32 ENSDART00000140161
necab2
N-terminal EF-hand calcium binding protein 2
chr18_-_38088099 10.15 ENSDART00000146120
luzp2
leucine zipper protein 2
chr20_+_19512727 10.06 ENSDART00000063696
atraid
all-trans retinoic acid-induced differentiation factor
chr8_+_31821396 9.95 ENSDART00000077053
plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr1_+_33969015 9.42 ENSDART00000042984
ENSDART00000146530
epha6
eph receptor A6
chr17_+_15433671 9.33 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr1_+_12766351 9.28 ENSDART00000165785
pcdh10a
protocadherin 10a
chr20_-_9462433 9.12 ENSDART00000152674
ENSDART00000040557
zgc:101840
zgc:101840
chr18_+_1703984 9.05 ENSDART00000114010
slitrk3a
SLIT and NTRK-like family, member 3a
chr2_+_20430366 9.03 ENSDART00000155108
si:ch211-153l6.6
si:ch211-153l6.6
chr17_+_15433518 8.78 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr13_-_29421331 8.71 ENSDART00000150228
chata
choline O-acetyltransferase a
chr12_+_1139690 8.69 ENSDART00000160442
CABZ01072885.1

chr13_-_29420885 8.43 ENSDART00000024225
chata
choline O-acetyltransferase a
chr9_+_29643036 8.42 ENSDART00000023210
ENSDART00000175160
trim13
tripartite motif containing 13
chr1_+_6172786 8.35 ENSDART00000126468
prkag3a
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr9_-_42418470 8.13 ENSDART00000144353
calcrla
calcitonin receptor-like a
chr22_+_16535575 8.05 ENSDART00000083063
tal1
T-cell acute lymphocytic leukemia 1
chr20_-_48485354 8.05 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr4_-_5019113 7.83 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr16_-_28856112 7.68 ENSDART00000078543
syt11b
synaptotagmin XIb
chr24_-_7697274 7.56 ENSDART00000186077
syt5b
synaptotagmin Vb
chr1_-_30723241 7.56 ENSDART00000152175
ENSDART00000152150
MZT1
si:dkey-15d12.2
chr11_+_30663300 7.43 ENSDART00000161662
ttbk1a
tau tubulin kinase 1a
chr9_+_54039006 7.37 ENSDART00000112441
tlr7
toll-like receptor 7
chr7_+_26629084 7.34 ENSDART00000101044
ENSDART00000173765
hsbp1a
heat shock factor binding protein 1a
chr16_+_54209504 7.32 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr17_-_42213285 7.26 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr11_+_30057762 7.22 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr19_-_30524952 7.20 ENSDART00000103506
hpcal4
hippocalcin like 4
chr21_-_25604603 7.03 ENSDART00000133134
ENSDART00000139460
efemp2b
EGF containing fibulin extracellular matrix protein 2b
chr6_+_7444899 6.97 ENSDART00000053775
arf3b
ADP-ribosylation factor 3b
chr6_+_49551614 6.95 ENSDART00000022581
rab22a
RAB22A, member RAS oncogene family
chr5_-_21422390 6.80 ENSDART00000144198
tenm1
teneurin transmembrane protein 1
chr19_-_41371978 6.59 ENSDART00000166063
ENSDART00000170343
slc25a13
solute carrier family 25 (aspartate/glutamate carrier), member 13
chr7_+_19552381 6.53 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr8_+_10561922 6.52 ENSDART00000133348
fam19a5l
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5-like
chr24_+_24461341 6.51 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr7_+_71547747 6.50 ENSDART00000180869
adcyap1a
adenylate cyclase activating polypeptide 1a
chr23_+_16638639 6.48 ENSDART00000143545
snphb
syntaphilin b
chr21_+_3093419 6.41 ENSDART00000162520
SHC3
SHC adaptor protein 3
chr6_+_52350443 6.41 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr20_+_40457599 6.29 ENSDART00000017553
serinc1
serine incorporator 1
chr23_+_4253957 6.28 ENSDART00000008761
arl6ip5b
ADP-ribosylation factor-like 6 interacting protein 5b
chr12_-_26383242 6.13 ENSDART00000152941
usp54b
ubiquitin specific peptidase 54b
chr13_+_11440389 6.05 ENSDART00000186463
zbtb18
zinc finger and BTB domain containing 18
chr24_+_24461558 5.98 ENSDART00000182424
bhlhe22
basic helix-loop-helix family, member e22
chr4_+_12111154 5.93 ENSDART00000036779
tmem178b
transmembrane protein 178B
chr22_-_22416337 5.87 ENSDART00000142947
ENSDART00000089569
camsap2a
calmodulin regulated spectrin-associated protein family, member 2a
chr16_-_29480335 5.86 ENSDART00000148930
lingo4b
leucine rich repeat and Ig domain containing 4b
chr5_-_67911111 5.77 ENSDART00000051833
gsx1
GS homeobox 1
chr10_+_22381802 5.67 ENSDART00000112484
nlgn2b
neuroligin 2b
chr10_-_34871737 5.67 ENSDART00000138755
dclk1a
doublecortin-like kinase 1a
chr14_+_3411771 5.62 ENSDART00000164778
trpc3
transient receptor potential cation channel, subfamily C, member 3
chr8_+_25959940 5.61 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
si:dkey-72l14.4
chr3_+_34919810 5.58 ENSDART00000055264
ca10b
carbonic anhydrase Xb
chr8_-_34051548 5.57 ENSDART00000105204
pbx3b
pre-B-cell leukemia homeobox 3b
chr11_-_1509773 5.57 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr5_+_21144269 5.55 ENSDART00000028087
cds2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr17_-_2386569 5.52 ENSDART00000121614
PLCB2
phospholipase C beta 2
chr5_-_26566435 5.49 ENSDART00000146070
arvcfb
ARVCF, delta catenin family member b
chr3_-_48716422 5.49 ENSDART00000164979
si:ch211-114m9.1
si:ch211-114m9.1
chr17_+_11675362 5.45 ENSDART00000157911
kif26ba
kinesin family member 26Ba
chr20_-_20931197 5.42 ENSDART00000152726
btbd6b
BTB (POZ) domain containing 6b
chr2_+_2223837 5.26 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr16_+_33593116 5.25 ENSDART00000013148
pou3f1
POU class 3 homeobox 1
chr8_-_39952727 5.20 ENSDART00000181310
cabp1a
calcium binding protein 1a
chr24_-_38657683 5.16 ENSDART00000154843
si:ch1073-164k15.3
si:ch1073-164k15.3
chr9_-_38398789 5.13 ENSDART00000188384
znf142
zinc finger protein 142
chr23_+_30730121 5.12 ENSDART00000134141
asxl1
additional sex combs like transcriptional regulator 1
chr2_+_33368414 5.05 ENSDART00000077462
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr4_-_2219705 5.02 ENSDART00000131046
si:ch73-278m9.1
si:ch73-278m9.1
chr15_-_31514818 5.02 ENSDART00000153978
hmgb1b
high mobility group box 1b
chr9_+_24159725 5.01 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr5_-_41494831 4.93 ENSDART00000051081
eef2l2
eukaryotic translation elongation factor 2, like 2
chr21_-_14811058 4.84 ENSDART00000143100
phpt1
phosphohistidine phosphatase 1
chr10_-_43721530 4.83 ENSDART00000025366
cetn3
centrin 3
chr1_-_22757145 4.83 ENSDART00000134719
prom1b
prominin 1 b
chr12_-_41684729 4.80 ENSDART00000184461
jakmip3
Janus kinase and microtubule interacting protein 3
chr3_+_39853788 4.76 ENSDART00000154869
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr20_-_53981626 4.76 ENSDART00000023550
hsp90aa1.2
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr7_+_17229980 4.76 ENSDART00000184910
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr25_+_7671640 4.74 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr1_+_22851261 4.73 ENSDART00000193925
gtf2e2
general transcription factor IIE, polypeptide 2, beta
chr25_+_13406069 4.68 ENSDART00000010495
znrf1
zinc and ring finger 1
chr10_+_45089820 4.67 ENSDART00000175481
camk2b2
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr3_-_30061985 4.63 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr11_-_25733910 4.57 ENSDART00000171935
brpf3a
bromodomain and PHD finger containing, 3a
chr7_+_10701770 4.46 ENSDART00000167323
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr9_+_2574122 4.45 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2
chr4_+_45148652 4.41 ENSDART00000150798
si:dkey-51d8.9
si:dkey-51d8.9
chr18_+_924949 4.41 ENSDART00000170888
ENSDART00000193163
pkma
pyruvate kinase M1/2a
chr25_-_25058508 4.34 ENSDART00000087570
ENSDART00000178891
FQ311928.1

chr19_+_24872159 4.32 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr1_-_19215336 4.29 ENSDART00000162949
ENSDART00000170680
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr21_-_17482465 4.24 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr19_-_20482261 4.23 ENSDART00000056205
satb1a
SATB homeobox 1a
chr1_-_19502322 4.23 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr10_-_34870667 4.21 ENSDART00000161272
dclk1a
doublecortin-like kinase 1a
chr1_-_22851481 4.21 ENSDART00000054386
qdprb1
quinoid dihydropteridine reductase b1
chr24_+_28953089 4.21 ENSDART00000153761
rnpc3
RNA-binding region (RNP1, RRM) containing 3
chr24_+_15020402 4.18 ENSDART00000148102
dok6
docking protein 6
chr21_+_34976600 4.10 ENSDART00000191672
ENSDART00000139635
rbm11
RNA binding motif protein 11
chr20_-_20930926 4.06 ENSDART00000123909
btbd6b
BTB (POZ) domain containing 6b
chr12_+_31735159 4.06 ENSDART00000185442
RNF157
si:dkey-49c17.3
chr7_-_25895189 3.96 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr17_+_13664442 3.95 ENSDART00000171689
lrfn5a
leucine rich repeat and fibronectin type III domain containing 5a
chr17_-_16422654 3.88 ENSDART00000150149
tdp1
tyrosyl-DNA phosphodiesterase 1
chr6_-_8377055 3.80 ENSDART00000131513
ilf3a
interleukin enhancer binding factor 3a
chr3_-_56456527 3.74 ENSDART00000156553
cyth1a
cytohesin 1a
chr22_-_13466246 3.69 ENSDART00000134035
cntnap5b
contactin associated protein-like 5b
chr22_-_26865361 3.64 ENSDART00000182504
hmox2a
heme oxygenase 2a
chr11_+_7432533 3.61 ENSDART00000180977
adgrl2a
adhesion G protein-coupled receptor L2a
chr5_+_60590796 3.61 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr14_-_4556896 3.57 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr7_+_38811800 3.53 ENSDART00000052322
zgc:110699
zgc:110699
chr15_-_18162647 3.45 ENSDART00000012064
pih1d2
PIH1 domain containing 2
chr1_-_15797663 3.45 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr6_-_40038543 3.44 ENSDART00000154792
si:dkey-197j19.6
si:dkey-197j19.6
chr9_+_10014817 3.43 ENSDART00000132065
nxph2a
neurexophilin 2a
chr13_+_33282095 3.39 ENSDART00000135200
ccdc28b
coiled-coil domain containing 28B
chr14_-_17306261 3.39 ENSDART00000191747
jakmip1
janus kinase and microtubule interacting protein 1
chr11_+_28476298 3.39 ENSDART00000122319
lrrc38b
leucine rich repeat containing 38b
chr1_+_6862917 3.38 ENSDART00000182953
erbb4a
erb-b2 receptor tyrosine kinase 4a
chr17_+_28533102 3.38 ENSDART00000156218
mdga2a
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr19_-_11106315 3.37 ENSDART00000059102
arhgef1a
Rho guanine nucleotide exchange factor (GEF) 1a
chr13_-_30006260 3.36 ENSDART00000049624
wnt8b
wingless-type MMTV integration site family, member 8b
chr4_-_20081621 3.34 ENSDART00000024647
dennd6b
DENN/MADD domain containing 6B
chr19_-_28130658 3.34 ENSDART00000079114
irx1b
iroquois homeobox 1b
chr6_-_51386656 3.32 ENSDART00000154732
ENSDART00000177990
ENSDART00000184928
ENSDART00000180197
ptprt
protein tyrosine phosphatase, receptor type, t
chr19_+_20274944 3.32 ENSDART00000151237
oxnad1
oxidoreductase NAD-binding domain containing 1
chr7_-_71829649 3.15 ENSDART00000160449
cacnb2a
calcium channel, voltage-dependent, beta 2a
chr6_+_23809501 3.10 ENSDART00000168701
glulb
glutamate-ammonia ligase (glutamine synthase) b
chr5_-_34185115 3.09 ENSDART00000192771
fibcd1
fibrinogen C domain containing 1
chr16_+_40024883 3.08 ENSDART00000110100
hint3
histidine triad nucleotide binding protein 3
chr13_-_12006007 3.05 ENSDART00000111438
mgea5
meningioma expressed antigen 5 (hyaluronidase)
chr10_-_5844915 3.05 ENSDART00000185929
ankrd55
ankyrin repeat domain 55
chr20_-_28642061 3.04 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr7_+_13382852 3.02 ENSDART00000166318
dagla
diacylglycerol lipase, alpha
chr6_+_51773873 3.01 ENSDART00000156516
tmem74b
transmembrane protein 74B
chr21_+_13387965 2.99 ENSDART00000134347
zgc:113162
zgc:113162
chr10_-_2524297 2.99 ENSDART00000192475
CU856539.1

chr20_+_27240388 2.98 ENSDART00000123950
si:dkey-85n7.6
si:dkey-85n7.6
chr10_+_43039947 2.98 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr7_+_59212666 2.94 ENSDART00000172046
dok1b
docking protein 1b
chr16_-_41004731 2.93 ENSDART00000102591
KCNV1
si:dkey-201i6.2
chr21_-_5799122 2.93 ENSDART00000129351
ENSDART00000151202
ccni
cyclin I
chr24_+_744713 2.92 ENSDART00000067764
stk17a
serine/threonine kinase 17a
chr14_+_6615564 2.91 ENSDART00000139292
si:dkeyp-44a8.2
si:dkeyp-44a8.2
chr2_-_30668580 2.90 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr5_+_32009542 2.89 ENSDART00000182025
ENSDART00000179879
scai
suppressor of cancer cell invasion
chr8_+_2487250 2.83 ENSDART00000081325
dynll1
dynein, light chain, LC8-type 1
chr2_-_1548330 2.80 ENSDART00000082155
ENSDART00000108481
ENSDART00000111272
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr18_+_25752592 2.78 ENSDART00000111767
si:ch211-39k3.2
si:ch211-39k3.2
chr9_-_48407408 2.78 ENSDART00000058248
zgc:172182
zgc:172182
chr17_-_42213822 2.78 ENSDART00000187904
ENSDART00000180029
nkx2.2a
NK2 homeobox 2a
chr15_+_23550890 2.77 ENSDART00000009796
ENSDART00000152720
MARK4
si:dkey-31m14.7
chr24_-_7995960 2.75 ENSDART00000186594
bloc1s5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr13_+_1089942 2.71 ENSDART00000054322
cnrip1b
cannabinoid receptor interacting protein 1b
chr10_-_2524917 2.71 ENSDART00000188642
CU856539.1

chr12_+_36416173 2.69 ENSDART00000190278
unk
unkempt family zinc finger
chr8_+_17775247 2.68 ENSDART00000112356
si:ch211-150o23.3
si:ch211-150o23.3
chr13_+_40034176 2.67 ENSDART00000189797
golga7bb
golgin A7 family, member Bb
chr14_+_4807207 2.67 ENSDART00000167145
ap1ar
adaptor-related protein complex 1 associated regulatory protein
chr22_+_34784075 2.66 ENSDART00000167538
lcor
ligand dependent nuclear receptor corepressor
chr9_+_10014514 2.65 ENSDART00000185590
nxph2a
neurexophilin 2a
chr21_+_27513859 2.65 ENSDART00000065420
pacs1a
phosphofurin acidic cluster sorting protein 1a
chr3_-_32337653 2.64 ENSDART00000156918
ENSDART00000156551
si:dkey-16p21.8
si:dkey-16p21.8
chr17_-_24603925 2.63 ENSDART00000142589
si:dkey-148f10.4
si:dkey-148f10.4
chr4_+_5255041 2.63 ENSDART00000137966
ccdc167
coiled-coil domain containing 167
chr8_+_2487883 2.62 ENSDART00000101841
dynll1
dynein, light chain, LC8-type 1
chr23_+_22335407 2.59 ENSDART00000147696
rap1gap
RAP1 GTPase activating protein
chr16_-_31351419 2.58 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr16_-_44945224 2.55 ENSDART00000156921
ncam3
neural cell adhesion molecule 3
chr24_-_24118451 2.52 ENSDART00000111096
zgc:112982
zgc:112982
chr7_-_11596450 2.50 ENSDART00000173863
stard5
StAR-related lipid transfer (START) domain containing 5
chr17_-_39772999 2.50 ENSDART00000155727
pimr60
Pim proto-oncogene, serine/threonine kinase, related 60
chr12_+_18543783 2.47 ENSDART00000148326
ENSDART00000134530
mlst8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr17_-_23241393 2.45 ENSDART00000190697
AL935174.4

chr20_+_11731039 2.44 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr24_-_33873451 2.37 ENSDART00000159840
asic1c
acid-sensing (proton-gated) ion channel 1c
chr13_+_5570952 2.32 ENSDART00000134506
si:dkey-196j8.2
si:dkey-196j8.2
chr19_-_5865766 2.30 ENSDART00000191007
LO018585.1

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx3+lhx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.1 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
3.3 10.0 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
2.7 8.1 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
2.5 10.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
2.5 7.4 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
2.2 11.2 GO:0000012 single strand break repair(GO:0000012)
2.0 15.9 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
1.8 12.6 GO:0033278 cell proliferation in midbrain(GO:0033278)
1.6 4.8 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
1.5 10.3 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
1.4 5.5 GO:0099563 modification of synaptic structure(GO:0099563)
1.3 6.5 GO:0051659 maintenance of mitochondrion location(GO:0051659)
1.3 5.1 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
1.1 8.0 GO:0060221 retinal rod cell differentiation(GO:0060221)
1.1 3.4 GO:0021611 facial nerve formation(GO:0021611)
1.1 3.4 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
1.1 4.2 GO:0038093 Fc receptor signaling pathway(GO:0038093)
1.0 4.8 GO:0046677 response to antibiotic(GO:0046677)
0.9 5.4 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.9 5.4 GO:0006788 heme oxidation(GO:0006788)
0.8 13.7 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.8 3.0 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.7 10.4 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.7 2.0 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.7 2.7 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.7 6.6 GO:0015810 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.7 20.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.6 5.6 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.6 12.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 4.8 GO:0043092 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
0.5 7.8 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.5 5.7 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.5 1.5 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.5 5.0 GO:0034605 cellular response to heat(GO:0034605)
0.5 3.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.5 5.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.5 5.0 GO:0034394 protein localization to cell surface(GO:0034394)
0.4 6.7 GO:0032418 lysosome localization(GO:0032418)
0.4 3.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.4 2.1 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.4 5.3 GO:0048798 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.4 1.6 GO:0051876 pigment granule dispersal(GO:0051876)
0.4 16.9 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.4 3.6 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.4 2.8 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.3 8.1 GO:0048844 artery morphogenesis(GO:0048844)
0.3 2.4 GO:0070207 protein homotrimerization(GO:0070207)
0.3 3.7 GO:0021703 locus ceruleus development(GO:0021703)
0.3 7.0 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 4.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.3 1.6 GO:0043584 nose development(GO:0043584)
0.3 2.7 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.3 0.9 GO:0015871 choline transport(GO:0015871)
0.3 4.8 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.3 5.3 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.3 4.1 GO:0097324 melanocyte migration(GO:0097324)
0.3 2.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.3 22.2 GO:0033339 pectoral fin development(GO:0033339)
0.2 1.5 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.2 1.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.2 3.4 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 7.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 0.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 2.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.2 1.3 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.2 5.6 GO:0006828 manganese ion transport(GO:0006828)
0.2 2.0 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.2 0.6 GO:0007414 axonal defasciculation(GO:0007414)
0.2 6.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 2.1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.2 5.0 GO:0030073 insulin secretion(GO:0030073)
0.2 1.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.2 15.6 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.2 2.0 GO:0060079 excitatory postsynaptic potential(GO:0060079) chemical synaptic transmission, postsynaptic(GO:0099565)
0.2 19.3 GO:0006836 neurotransmitter transport(GO:0006836)
0.2 4.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.2 3.6 GO:0003323 type B pancreatic cell development(GO:0003323)
0.2 3.0 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.2 1.4 GO:0046548 retinal rod cell development(GO:0046548)
0.1 5.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 8.8 GO:0046328 regulation of JNK cascade(GO:0046328)
0.1 0.9 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 2.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 1.3 GO:0016074 snoRNA metabolic process(GO:0016074)
0.1 4.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 1.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 0.8 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 5.4 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 1.8 GO:0045471 response to ethanol(GO:0045471)
0.1 1.7 GO:0045116 protein neddylation(GO:0045116)
0.1 1.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.5 GO:0002159 desmosome assembly(GO:0002159)
0.1 7.4 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.1 1.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 5.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 1.8 GO:0006415 translational termination(GO:0006415)
0.1 3.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.4 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 4.9 GO:0006414 translational elongation(GO:0006414)
0.1 0.7 GO:0050975 sensory perception of touch(GO:0050975)
0.1 0.3 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.1 3.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 0.5 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 1.8 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 1.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 1.9 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 1.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 4.0 GO:0051051 negative regulation of transport(GO:0051051)
0.1 0.9 GO:0046599 regulation of centriole replication(GO:0046599)
0.1 1.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 2.5 GO:0031929 TOR signaling(GO:0031929)
0.0 0.8 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 2.4 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 2.9 GO:0051607 defense response to virus(GO:0051607)
0.0 0.5 GO:0006032 chitin catabolic process(GO:0006032)
0.0 4.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 54.3 GO:0030182 neuron differentiation(GO:0030182)
0.0 3.1 GO:1990573 potassium ion import(GO:0010107) potassium ion import across plasma membrane(GO:1990573)
0.0 4.2 GO:0048565 digestive tract development(GO:0048565)
0.0 1.0 GO:0016233 telomere capping(GO:0016233)
0.0 1.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 2.5 GO:0050808 synapse organization(GO:0050808)
0.0 3.2 GO:0048699 generation of neurons(GO:0048699)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 3.7 GO:0022008 neurogenesis(GO:0022008)
0.0 0.9 GO:0051014 actin filament severing(GO:0051014)
0.0 1.7 GO:0007602 phototransduction(GO:0007602)
0.0 8.9 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 1.8 GO:0042552 myelination(GO:0042552)
0.0 6.5 GO:0007018 microtubule-based movement(GO:0007018)
0.0 3.3 GO:0006338 chromatin remodeling(GO:0006338)
0.0 10.3 GO:0009968 negative regulation of signal transduction(GO:0009968)
0.0 2.0 GO:0007030 Golgi organization(GO:0007030)
0.0 2.2 GO:0006497 protein lipidation(GO:0006497)
0.0 1.4 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 3.5 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 12.5 GO:0045893 positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508)
0.0 6.8 GO:0006897 endocytosis(GO:0006897)
0.0 1.3 GO:0030111 regulation of Wnt signaling pathway(GO:0030111)
0.0 0.8 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 1.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 1.4 GO:0022604 regulation of cell morphogenesis(GO:0022604)
0.0 0.1 GO:1900027 regulation of ruffle assembly(GO:1900027) positive regulation of ruffle assembly(GO:1900029)
0.0 0.9 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.3 GO:0050821 protein stabilization(GO:0050821)
0.0 0.8 GO:0043484 regulation of RNA splicing(GO:0043484)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 20.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.9 5.7 GO:0060077 inhibitory synapse(GO:0060077)
0.9 4.7 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.9 3.5 GO:0097255 R2TP complex(GO:0097255)
0.7 5.1 GO:0035517 PR-DUB complex(GO:0035517)
0.6 7.6 GO:0031045 dense core granule(GO:0031045)
0.6 4.8 GO:0071914 prominosome(GO:0071914)
0.6 5.9 GO:0036449 microtubule minus-end(GO:0036449)
0.5 6.5 GO:0044295 axonal growth cone(GO:0044295)
0.4 5.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.4 5.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 1.0 GO:1990879 CST complex(GO:1990879)
0.3 2.2 GO:0071818 BAT3 complex(GO:0071818)
0.3 13.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 2.5 GO:0031931 TORC1 complex(GO:0031931)
0.3 4.8 GO:0043209 myelin sheath(GO:0043209)
0.3 3.9 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 4.6 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.2 8.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 4.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 0.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 13.4 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 1.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 2.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.2 1.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 0.7 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.2 1.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 6.5 GO:0043204 perikaryon(GO:0043204)
0.2 3.4 GO:0009925 basal plasma membrane(GO:0009925)
0.2 1.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 2.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 3.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 3.0 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 10.1 GO:0048786 presynaptic active zone(GO:0048786)
0.1 2.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.2 GO:0000243 commitment complex(GO:0000243)
0.1 7.6 GO:0043025 neuronal cell body(GO:0043025)
0.1 2.6 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.8 GO:1990246 uniplex complex(GO:1990246)
0.1 6.5 GO:0005871 kinesin complex(GO:0005871)
0.1 0.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 51.2 GO:0043005 neuron projection(GO:0043005)
0.1 3.3 GO:0055037 recycling endosome(GO:0055037)
0.1 2.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 2.6 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 2.5 GO:0014069 postsynaptic density(GO:0014069)
0.1 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.0 GO:0016592 mediator complex(GO:0016592)
0.1 1.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.5 GO:0034703 cation channel complex(GO:0034703)
0.1 10.6 GO:0005635 nuclear envelope(GO:0005635)
0.1 1.8 GO:0016605 PML body(GO:0016605)
0.0 3.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.5 GO:0044447 axoneme part(GO:0044447)
0.0 1.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.9 GO:0016342 catenin complex(GO:0016342)
0.0 1.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.3 GO:0038201 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.0 1.7 GO:0030027 lamellipodium(GO:0030027)
0.0 133.8 GO:0005634 nucleus(GO:0005634)
0.0 0.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.2 GO:0005769 early endosome(GO:0005769)
0.0 0.8 GO:0005694 chromosome(GO:0005694)
0.0 3.4 GO:0005815 microtubule organizing center(GO:0005815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
1.7 5.0 GO:0033130 acetylcholine receptor binding(GO:0033130)
1.6 6.5 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
1.4 5.6 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
1.3 17.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
1.3 3.9 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
1.2 4.8 GO:0101006 protein histidine phosphatase activity(GO:0101006)
1.2 18.1 GO:0005504 fatty acid binding(GO:0005504)
1.1 4.2 GO:0030626 U12 snRNA binding(GO:0030626)
1.0 5.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
1.0 3.0 GO:0019777 Atg12 transferase activity(GO:0019777)
0.9 5.4 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.9 2.7 GO:1990715 mRNA CDS binding(GO:1990715)
0.7 4.4 GO:0004743 pyruvate kinase activity(GO:0004743)
0.7 9.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.7 4.8 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.7 26.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 2.5 GO:0032052 bile acid binding(GO:0032052)
0.6 9.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.5 6.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.5 2.6 GO:0016531 copper chaperone activity(GO:0016531)
0.5 2.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 1.5 GO:0030882 lipid antigen binding(GO:0030882)
0.5 2.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.5 5.9 GO:0030507 spectrin binding(GO:0030507)
0.4 3.1 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 1.3 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.4 9.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.4 11.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.3 16.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 4.6 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.3 7.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.3 1.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.3 2.0 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.3 7.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 3.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.3 5.0 GO:0008301 DNA binding, bending(GO:0008301)
0.3 5.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 5.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 1.8 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.2 3.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 3.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 16.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 0.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 15.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 0.9 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 0.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 5.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 5.4 GO:0016208 AMP binding(GO:0016208)
0.2 7.3 GO:0003684 damaged DNA binding(GO:0003684)
0.2 1.8 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 5.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 5.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 3.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.9 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.1 2.7 GO:0019894 kinesin binding(GO:0019894)
0.1 8.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.4 GO:0070122 isopeptidase activity(GO:0070122)
0.1 1.0 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 1.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.8 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 3.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 6.0 GO:0044325 ion channel binding(GO:0044325)
0.1 0.9 GO:0031419 cobalamin binding(GO:0031419)
0.1 4.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 4.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.7 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 1.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 3.4 GO:0005109 frizzled binding(GO:0005109)
0.1 7.3 GO:0045296 cadherin binding(GO:0045296)
0.1 1.1 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 1.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 6.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 10.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.8 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.3 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.5 GO:0004568 chitinase activity(GO:0004568)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 27.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 96.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 4.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 2.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.6 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 8.1 GO:0008017 microtubule binding(GO:0008017)
0.0 4.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.8 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 1.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 9.5 GO:0005525 GTP binding(GO:0005525)
0.0 1.0 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 5.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 1.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.3 9.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.3 4.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 7.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 6.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 5.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 3.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 3.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 1.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.3 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.4 PID RHOA PATHWAY RhoA signaling pathway
0.1 3.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.7 9.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.6 7.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.6 5.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.5 5.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.5 11.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.5 7.3 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.3 4.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.3 2.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 6.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 2.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 3.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 0.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 1.8 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 7.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 3.9 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 3.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.7 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 2.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 5.6 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 0.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.6 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 2.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.0 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 1.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation