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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for lhx6-1

Z-value: 0.81

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Transcription factors associated with lhx6-1

Gene Symbol Gene ID Gene Info
lhx6-1
ENSDARG00000052165 si_ch211-236k19.2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-236k19.2dr11_v1_chr5_-_64900552_649005520.214.0e-02Click!

Activity profile of lhx6-1 motif

Sorted Z-values of lhx6-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_6751760 8.96 ENSDART00000135914
olfm1b
olfactomedin 1b
chr21_+_6751405 8.39 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr25_+_3326885 7.91 ENSDART00000104866
ldhbb
lactate dehydrogenase Bb
chr25_+_3327071 6.95 ENSDART00000136131
ENSDART00000133243
ldhbb
lactate dehydrogenase Bb
chr8_-_45277370 6.73 ENSDART00000146364
adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr6_+_57541776 6.71 ENSDART00000157330
necab3
N-terminal EF-hand calcium binding protein 3
chr7_+_30392613 6.66 ENSDART00000075508
lipca
lipase, hepatic a
chr17_+_1063988 6.48 ENSDART00000160400
gchfr
GTP cyclohydrolase I feedback regulator
chr19_+_9295244 6.45 ENSDART00000132255
ENSDART00000144299
si:ch73-15n24.1
si:ch73-15n24.1
chr16_-_28658341 6.36 ENSDART00000148456
abcb4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr1_-_20928772 6.19 ENSDART00000078277
msmo1
methylsterol monooxygenase 1
chr16_+_23975930 6.04 ENSDART00000147858
ENSDART00000144347
ENSDART00000115270
apoc4
apolipoprotein C-IV
chr25_+_21324588 5.98 ENSDART00000151842
lrrn3a
leucine rich repeat neuronal 3a
chr4_+_11375894 5.96 ENSDART00000190471
ENSDART00000143963
pcloa
piccolo presynaptic cytomatrix protein a
chr19_-_617246 5.82 ENSDART00000062551
cyp51
cytochrome P450, family 51
chr17_+_30704068 5.24 ENSDART00000062793
apoba
apolipoprotein Ba
chr10_+_7709724 5.08 ENSDART00000097670
ggcx
gamma-glutamyl carboxylase
chr16_+_23976227 5.07 ENSDART00000193013
apoc4
apolipoprotein C-IV
chr19_-_9882821 5.06 ENSDART00000147128
cacng7a
calcium channel, voltage-dependent, gamma subunit 7a
chr12_+_47446158 4.77 ENSDART00000152857
fmn2b
formin 2b
chr22_-_22719440 4.57 ENSDART00000166794
nr5a2
nuclear receptor subfamily 5, group A, member 2
chr13_+_771403 4.56 ENSDART00000093166
nrxn1b
neurexin 1b
chr13_+_8954667 4.45 ENSDART00000100241
haao
3-hydroxyanthranilate 3,4-dioxygenase
chr17_-_37214196 4.45 ENSDART00000128715
kif3cb
kinesin family member 3Cb
chr16_-_25568512 4.42 ENSDART00000149411
atxn1b
ataxin 1b
chr15_+_45563656 4.33 ENSDART00000157501
cldn15lb
claudin 15-like b
chr1_+_29068654 4.23 ENSDART00000053932
cbsa
cystathionine-beta-synthase a
chr12_-_3940768 4.18 ENSDART00000134292
zgc:92040
zgc:92040
chr7_+_20645121 4.15 ENSDART00000052922
sat2a
spermidine/spermine N1-acetyltransferase family member 2a
chr2_+_50608099 4.15 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr3_-_23407720 3.99 ENSDART00000155658
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr19_-_5805923 3.94 ENSDART00000134340
si:ch211-264f5.8
si:ch211-264f5.8
chr13_-_25198025 3.91 ENSDART00000159585
ENSDART00000144227
adka
adenosine kinase a
chr13_-_4707018 3.78 ENSDART00000128422
oit3
oncoprotein induced transcript 3
chr21_-_39177564 3.77 ENSDART00000065143
unc119b
unc-119 homolog b (C. elegans)
chr16_+_39159752 3.74 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr16_+_47207691 3.65 ENSDART00000062507
ica1
islet cell autoantigen 1
chr4_+_21129752 3.60 ENSDART00000169764
syt1a
synaptotagmin Ia
chr7_+_30787903 3.58 ENSDART00000174000
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr7_+_54642005 3.53 ENSDART00000171864
fgf19
fibroblast growth factor 19
chr14_-_14659023 3.44 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr4_-_28158335 3.41 ENSDART00000134605
gramd4a
GRAM domain containing 4a
chr18_+_7073130 3.22 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
si:dkey-88e18.2
chr16_-_29437373 3.18 ENSDART00000148405
si:ch211-113g11.6
si:ch211-113g11.6
chr22_-_29083070 3.17 ENSDART00000104812
ENSDART00000172576
cbx6a
chromobox homolog 6a
chr20_+_27020201 3.15 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr6_+_27151940 3.15 ENSDART00000088364
kif1aa
kinesin family member 1Aa
chr18_+_21408794 3.05 ENSDART00000140161
necab2
N-terminal EF-hand calcium binding protein 2
chr23_-_30787932 3.03 ENSDART00000135771
myt1a
myelin transcription factor 1a
chr3_-_13147310 2.89 ENSDART00000160840
prkar1b
protein kinase, cAMP-dependent, regulatory, type I, beta
chr5_-_23277385 2.84 ENSDART00000134982
plp1b
proteolipid protein 1b
chr5_-_62306819 2.76 ENSDART00000168993
spata22
spermatogenesis associated 22
chr1_+_29162478 2.74 ENSDART00000141441
ankrd10a
ankyrin repeat domain 10a
chr10_+_15777064 2.73 ENSDART00000114483
apba1b
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr15_+_23799461 2.72 ENSDART00000154885
si:ch211-167j9.4
si:ch211-167j9.4
chr20_+_23947004 2.69 ENSDART00000144195
casp8ap2
caspase 8 associated protein 2
chr2_-_55298075 2.66 ENSDART00000186404
ENSDART00000149062
rab8a
RAB8A, member RAS oncogene family
chr19_-_5103313 2.57 ENSDART00000037007
tpi1a
triosephosphate isomerase 1a
chr21_+_26390549 2.49 ENSDART00000185643
tmsb
thymosin, beta
chr3_-_30625219 2.46 ENSDART00000151698
syt3
synaptotagmin III
chr10_+_44584614 2.43 ENSDART00000163523
sez6l
seizure related 6 homolog (mouse)-like
chr8_-_16464453 2.43 ENSDART00000098691
rnf11b
ring finger protein 11b
chr4_-_73756673 2.40 ENSDART00000174274
ENSDART00000192913
ENSDART00000113546
BX855614.4
si:dkey-262g12.14
zgc:171551

si:dkey-262g12.14
zgc:171551
chr8_-_50888806 2.33 ENSDART00000053750
acsl2
acyl-CoA synthetase long chain family member 2
chr3_+_33345348 2.32 ENSDART00000059262
mpp2a
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr18_+_11506561 2.30 ENSDART00000121647
PRMT8
protein arginine methyltransferase 8
chr24_-_8261786 2.24 ENSDART00000106388
eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr19_+_5604241 2.22 ENSDART00000011025
wipf2b
WAS/WASL interacting protein family, member 2b
chr5_+_37903790 2.21 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr2_-_3038904 2.21 ENSDART00000186795
guk1a
guanylate kinase 1a
chr11_+_7264457 2.19 ENSDART00000154182
reep6
receptor accessory protein 6
chr25_+_26921480 2.19 ENSDART00000155949
grm8b
glutamate receptor, metabotropic 8b
chr6_+_28208973 2.19 ENSDART00000171216
ENSDART00000171377
ENSDART00000167389
ENSDART00000166988
LSM2 (1 of many)
si:ch73-14h10.2
chr15_+_44366556 2.18 ENSDART00000133449
GUCY1A2
guanylate cyclase 1 soluble subunit alpha 2
chr21_+_28958471 2.17 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr23_+_28582865 2.14 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr22_-_16180467 2.12 ENSDART00000171331
ENSDART00000185607
vcam1b
vascular cell adhesion molecule 1b
chr2_+_6255434 2.06 ENSDART00000139429
zp3b
zona pellucida glycoprotein 3b
chr11_-_15296805 2.05 ENSDART00000124968
rpn2
ribophorin II
chr20_-_53366137 2.04 ENSDART00000146001
wasf1
WAS protein family, member 1
chr18_+_38908903 2.04 ENSDART00000159834
myo5aa
myosin VAa
chr3_+_32365811 2.03 ENSDART00000155967
ap2a1
adaptor-related protein complex 2, alpha 1 subunit
chr4_+_11384891 2.02 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr13_-_9875538 2.00 ENSDART00000041609
tm9sf3
transmembrane 9 superfamily member 3
chr15_-_20949692 1.90 ENSDART00000185548
tbcela
tubulin folding cofactor E-like a
chr8_+_14855471 1.89 ENSDART00000134775
si:dkey-21p1.3
si:dkey-21p1.3
chr19_-_1871415 1.89 ENSDART00000004585
clptm1l
CLPTM1-like
chr9_+_17983463 1.86 ENSDART00000182150
akap11
A kinase (PRKA) anchor protein 11
chr24_+_17260001 1.86 ENSDART00000066765
bmi1a
bmi1 polycomb ring finger oncogene 1a
chr24_-_25004553 1.85 ENSDART00000080997
ENSDART00000136860
zdhhc20b
zinc finger, DHHC-type containing 20b
chr12_-_22238004 1.82 ENSDART00000038310
ormdl3
ORMDL sphingolipid biosynthesis regulator 3
chr24_-_24724233 1.79 ENSDART00000127044
ENSDART00000012399
armc1
armadillo repeat containing 1
chr11_-_41130239 1.76 ENSDART00000173268
dnajc11b
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr7_+_15872357 1.73 ENSDART00000165757
pax6b
paired box 6b
chr3_-_30885250 1.71 ENSDART00000109104
kmt5c
lysine methyltransferase 5C
chr6_-_40922971 1.70 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr24_+_17260329 1.70 ENSDART00000129554
bmi1a
bmi1 polycomb ring finger oncogene 1a
chr10_+_16188761 1.69 ENSDART00000193244
ctxn3
cortexin 3
chr20_+_18661624 1.67 ENSDART00000152136
ENSDART00000126959
tnfaip2a
tumor necrosis factor, alpha-induced protein 2a
chr7_+_51795667 1.65 ENSDART00000174201
ENSDART00000073839
slc38a7
solute carrier family 38, member 7
chr19_-_27858033 1.64 ENSDART00000103898
ENSDART00000144884
srd5a1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr5_-_12407194 1.64 ENSDART00000125291
ksr2
kinase suppressor of ras 2
chr9_-_10460087 1.62 ENSDART00000186001
thsd7ba
thrombospondin, type I, domain containing 7Ba
chr22_-_33679277 1.62 ENSDART00000169948
FO904977.1

chr22_-_21897203 1.61 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
gna11a
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr22_-_20403194 1.59 ENSDART00000010048
map2k2a
mitogen-activated protein kinase kinase 2a
chr1_+_33668236 1.56 ENSDART00000122316
ENSDART00000102184
arl13b
ADP-ribosylation factor-like 13b
chr1_+_55755304 1.55 ENSDART00000144983
tecrb
trans-2,3-enoyl-CoA reductase b
chr10_-_34915886 1.54 ENSDART00000141201
ENSDART00000002166
ccna1
cyclin A1
chr7_+_9308625 1.51 ENSDART00000084598
selenos
selenoprotein S
chr19_+_8985230 1.49 ENSDART00000018973
scamp3
secretory carrier membrane protein 3
chr3_-_46817499 1.49 ENSDART00000013717
elavl3
ELAV like neuron-specific RNA binding protein 3
chr7_+_22313533 1.49 ENSDART00000123457
TMEM102
si:dkey-11f12.2
chr2_+_6253246 1.47 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr7_-_5431841 1.47 ENSDART00000173073
arhgef11
Rho guanine nucleotide exchange factor (GEF) 11
chr9_+_44994214 1.45 ENSDART00000141434
retsatl
retinol saturase (all-trans-retinol 13,14-reductase) like
chr6_+_40951227 1.45 ENSDART00000156660
patz1
POZ (BTB) and AT hook containing zinc finger 1
chr10_+_34001444 1.45 ENSDART00000149934
kl
klotho
chr23_+_4646194 1.41 ENSDART00000092344
LO017700.1

chr17_+_11500628 1.40 ENSDART00000155660
efcab2
EF-hand calcium binding domain 2
chr5_+_22098591 1.39 ENSDART00000143676
zc3h12b
zinc finger CCCH-type containing 12B
chr3_-_21062706 1.37 ENSDART00000155605
ENSDART00000153686
ENSDART00000157168
ENSDART00000156614
ENSDART00000155743
ENSDART00000156275
fam57ba
family with sequence similarity 57, member Ba
chr22_-_20011476 1.37 ENSDART00000093312
ENSDART00000093310
celf5a
cugbp, Elav-like family member 5a
chr13_-_24311628 1.37 ENSDART00000004420
rab4a
RAB4a, member RAS oncogene family
chr6_+_34511886 1.35 ENSDART00000179450
lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr4_+_9467049 1.35 ENSDART00000012659
zgc:55888
zgc:55888
chr15_-_20956384 1.32 ENSDART00000135770
tbcela
tubulin folding cofactor E-like a
chr19_+_12406583 1.31 ENSDART00000013865
ENSDART00000151535
seh1l
SEH1-like (S. cerevisiae)
chr14_+_7902374 1.30 ENSDART00000113299
zgc:110843
zgc:110843
chr5_-_27993972 1.29 ENSDART00000175819
ppp3cca
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr3_-_40836081 1.27 ENSDART00000143135
wipi2
WD repeat domain, phosphoinositide interacting 2
chr2_+_21312972 1.27 ENSDART00000080495
zbtb47a
zinc finger and BTB domain containing 47a
chr19_-_20430892 1.27 ENSDART00000111409
tbc1d5
TBC1 domain family, member 5
chr7_+_7151832 1.26 ENSDART00000109485
gal3st3
galactose-3-O-sulfotransferase 3
chr4_+_29206813 1.26 ENSDART00000131893
si:dkey-23a23.1
si:dkey-23a23.1
chr16_+_42471455 1.24 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr1_+_7517454 1.24 ENSDART00000016139
lancl1
LanC antibiotic synthetase component C-like 1 (bacterial)
chr3_-_5067585 1.24 ENSDART00000169609
tefb
thyrotrophic embryonic factor b
chr8_+_11325310 1.23 ENSDART00000142577
fxn
frataxin
chr3_-_6519691 1.23 ENSDART00000165273
ENSDART00000179882
ENSDART00000172292
GGA3 (1 of many)
si:ch73-157i16.3
chr9_-_12886108 1.23 ENSDART00000177283
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr4_+_5506952 1.21 ENSDART00000032857
ENSDART00000160222
mapk11
mitogen-activated protein kinase 11
chr11_+_29790626 1.21 ENSDART00000067822
dynlt3
dynein, light chain, Tctex-type 3
chr10_-_105100 1.21 ENSDART00000145716
ttc3
tetratricopeptide repeat domain 3
chr3_+_50312422 1.21 ENSDART00000157689
gas7a
growth arrest-specific 7a
chr1_+_19708508 1.20 ENSDART00000054581
ENSDART00000131206
march1
membrane-associated ring finger (C3HC4) 1
chr1_-_55873178 1.19 ENSDART00000019936
prkacab
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
chr9_+_219124 1.18 ENSDART00000161484
map3k12
mitogen-activated protein kinase kinase kinase 12
chr19_+_9231766 1.14 ENSDART00000190617
kmt2ba
lysine (K)-specific methyltransferase 2Ba
chr8_-_45867358 1.13 ENSDART00000132810
adam9
ADAM metallopeptidase domain 9
chr14_+_21820034 1.13 ENSDART00000122739
ctbp1
C-terminal binding protein 1
chr21_+_13389499 1.12 ENSDART00000151268
zgc:113162
zgc:113162
chr17_-_37195163 1.11 ENSDART00000108514
asxl2
additional sex combs like transcriptional regulator 2
chr2_-_38284648 1.11 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
si:ch211-14a17.7
chr7_+_69528850 1.10 ENSDART00000109507
RAP1GDS1
Rap1 GTPase-GDP dissociation stimulator 1
chr11_+_5588122 1.10 ENSDART00000113281
zgc:172302
zgc:172302
chr24_-_35707552 1.08 ENSDART00000165199
mapre2
microtubule-associated protein, RP/EB family, member 2
chr18_+_7639401 1.08 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr7_-_17690983 1.08 ENSDART00000009367
map4k2
mitogen-activated protein kinase kinase kinase kinase 2
chr20_-_29532939 1.07 ENSDART00000049224
ENSDART00000062377
taf1b
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
chr4_-_17629444 1.06 ENSDART00000108814
nrip2
nuclear receptor interacting protein 2
chr15_-_22074315 1.05 ENSDART00000149830
drd2a
dopamine receptor D2a
chr5_+_64842730 1.04 ENSDART00000144732
lrrc8ab
leucine rich repeat containing 8 VRAC subunit Ab
chr22_-_22259175 1.03 ENSDART00000113824
hdgfl2
HDGF like 2
chr11_-_42106310 1.03 ENSDART00000164635
si:ch211-193l2.10
si:ch211-193l2.10
chr24_+_14581864 1.03 ENSDART00000134536
thtpa
thiamine triphosphatase
chr12_+_36428052 1.02 ENSDART00000131300
unk
unkempt family zinc finger
chr5_+_20257225 1.02 ENSDART00000127919
ssh1a
slingshot protein phosphatase 1a
chr2_-_15031858 1.01 ENSDART00000191478
hccsa.1
holocytochrome c synthase a
chr18_-_25568994 1.00 ENSDART00000133029
si:ch211-13k12.2
si:ch211-13k12.2
chr14_-_12020653 1.00 ENSDART00000106654
znf711
zinc finger protein 711
chr6_+_40922572 1.00 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr13_+_30903816 1.00 ENSDART00000191727
ercc6
excision repair cross-complementation group 6
chr1_+_30723677 0.99 ENSDART00000177900
bora
bora, aurora kinase A activator
chr23_-_18130264 0.99 ENSDART00000016976
nucks1b
nuclear casein kinase and cyclin-dependent kinase substrate 1b
chr19_+_42983613 0.97 ENSDART00000033724
fabp3
fatty acid binding protein 3, muscle and heart
chr5_+_1079423 0.96 ENSDART00000172231
si:zfos-128g4.2
si:zfos-128g4.2
chr4_-_23873924 0.95 ENSDART00000100391
usp6nl
USP6 N-terminal like
chr5_+_42388464 0.95 ENSDART00000191596
BX548073.13

chr10_-_34916208 0.95 ENSDART00000187371
ccna1
cyclin A1
chr7_-_17690756 0.94 ENSDART00000173759
map4k2
mitogen-activated protein kinase kinase kinase kinase 2
chr17_-_35278763 0.94 ENSDART00000063437
adam17a
ADAM metallopeptidase domain 17a
chr24_-_9979342 0.94 ENSDART00000138576
ENSDART00000191206
zgc:171977
zgc:171977
chr5_-_21970881 0.94 ENSDART00000182907
arhgef9a
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr2_-_40890004 0.94 ENSDART00000191746
uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr25_+_17862338 0.93 ENSDART00000151853
ENSDART00000090867
btbd10a
BTB (POZ) domain containing 10a
chr2_+_56937548 0.93 ENSDART00000189308
CABZ01117752.1

chr19_-_3878548 0.91 ENSDART00000168377
ENSDART00000172271
thrap3b
thyroid hormone receptor associated protein 3b
chr3_+_32842825 0.91 ENSDART00000122228
prr14
proline rich 14
chr18_+_28106139 0.91 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr6_+_7414215 0.89 ENSDART00000049339
sox21a
SRY (sex determining region Y)-box 21a
chr2_+_57848844 0.88 ENSDART00000037279
plekhj1
pleckstrin homology domain containing, family J member 1
chr2_+_36828746 0.88 ENSDART00000186638
nrd1a
nardilysin a (N-arginine dibasic convertase)
chr8_-_39822917 0.87 ENSDART00000067843
zgc:162025
zgc:162025
chr3_-_23406964 0.86 ENSDART00000114723
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr7_+_19528265 0.84 ENSDART00000005326
ttc5
tetratricopeptide repeat domain 5
chr4_+_29967255 0.83 ENSDART00000150383
znf1128
zinc finger protein 1128
chr21_-_2042037 0.82 ENSDART00000171131
ENSDART00000160144
add1
adducin 1 (alpha)
chr6_+_25261297 0.82 ENSDART00000162824
ENSDART00000163490
ENSDART00000157790
ENSDART00000160978
ENSDART00000161545
ENSDART00000159978
kyat3
kynurenine aminotransferase 3
chr13_-_9213207 0.81 ENSDART00000139861
ENSDART00000140524
HTRA2 (1 of many)
si:dkey-33c12.11

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx6-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 9.8 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
1.1 3.2 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
1.0 5.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.9 3.7 GO:0060074 synapse maturation(GO:0060074)
0.9 2.8 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.9 4.4 GO:0043420 anthranilate metabolic process(GO:0043420)
0.9 3.4 GO:0034164 regulation of toll-like receptor 9 signaling pathway(GO:0034163) negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.8 4.2 GO:0006535 cysteine biosynthetic process from serine(GO:0006535) hydrogen sulfide biosynthetic process(GO:0070814)
0.8 5.1 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.8 4.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.8 8.0 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.7 2.7 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.7 3.9 GO:0044209 AMP salvage(GO:0044209)
0.6 2.6 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.6 2.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.6 4.2 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.6 1.7 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.5 1.6 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
0.5 3.8 GO:2001287 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.5 1.8 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.4 6.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.3 2.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.3 1.5 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.3 1.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.3 5.1 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.3 3.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.3 0.8 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.3 4.6 GO:2000344 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.3 12.0 GO:0016126 sterol biosynthetic process(GO:0016126)
0.3 3.6 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 1.7 GO:0003311 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.2 0.7 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.2 4.5 GO:0010737 protein kinase A signaling(GO:0010737)
0.2 1.1 GO:0033700 phospholipid efflux(GO:0033700)
0.2 1.1 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 1.0 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 0.8 GO:0015677 copper ion import(GO:0015677)
0.2 3.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 0.8 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.2 3.6 GO:0050796 regulation of insulin secretion(GO:0050796)
0.2 0.5 GO:0003403 optic vesicle formation(GO:0003403)
0.2 1.0 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.2 1.7 GO:0051601 exocyst localization(GO:0051601)
0.2 3.4 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.2 1.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.6 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.1 1.3 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 2.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 0.9 GO:0097065 anterior head development(GO:0097065)
0.1 1.0 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 2.8 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 4.8 GO:0009636 response to toxic substance(GO:0009636)
0.1 2.0 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 3.5 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.1 5.1 GO:0006694 steroid biosynthetic process(GO:0006694)
0.1 1.5 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 2.7 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 1.1 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 3.5 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.7 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 2.5 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.4 GO:0035521 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 2.3 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 2.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 1.5 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 0.8 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 4.5 GO:0045010 actin nucleation(GO:0045010)
0.1 0.6 GO:0070586 cell-cell adhesion involved in gastrulation(GO:0070586)
0.1 0.9 GO:0001881 receptor recycling(GO:0001881)
0.1 4.6 GO:0031017 exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.1 1.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 1.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.5 GO:0006004 fucose metabolic process(GO:0006004)
0.1 6.0 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.1 0.9 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 1.4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 2.2 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.1 0.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.8 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 4.3 GO:0030048 actin filament-based movement(GO:0030048)
0.1 1.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 2.0 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.1 1.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 3.2 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 1.9 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 2.5 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 1.4 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 1.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.6 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 1.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.9 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.2 GO:0035264 multicellular organism growth(GO:0035264)
0.0 0.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 2.1 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.4 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 1.0 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 4.2 GO:0051346 negative regulation of hydrolase activity(GO:0051346)
0.0 1.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 3.1 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 2.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.4 GO:0035459 cargo loading into vesicle(GO:0035459)
0.0 0.1 GO:0016123 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.0 1.6 GO:0071482 cellular response to light stimulus(GO:0071482)
0.0 4.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.8 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 1.3 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 1.6 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.2 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.6 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.2 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.4 GO:0043153 entrainment of circadian clock(GO:0009649) entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.9 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 2.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.3 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.0 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.5 GO:0032147 activation of protein kinase activity(GO:0032147)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0034359 mature chylomicron(GO:0034359)
0.8 2.5 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.8 8.0 GO:0098982 GABA-ergic synapse(GO:0098982)
0.7 3.6 GO:0042584 chromaffin granule membrane(GO:0042584)
0.6 3.2 GO:0042583 chromaffin granule(GO:0042583)
0.6 3.5 GO:0005955 calcineurin complex(GO:0005955)
0.5 1.8 GO:0035339 SPOTS complex(GO:0035339)
0.4 6.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 3.8 GO:0045171 intercellular bridge(GO:0045171)
0.4 1.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.3 2.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 1.9 GO:0035517 PR-DUB complex(GO:0035517)
0.2 1.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 3.6 GO:0030667 secretory granule membrane(GO:0030667)
0.2 2.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.2 2.1 GO:0044295 axonal growth cone(GO:0044295)
0.2 6.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 1.8 GO:0061617 MICOS complex(GO:0061617)
0.2 2.8 GO:0043209 myelin sheath(GO:0043209)
0.1 3.6 GO:0035102 PRC1 complex(GO:0035102)
0.1 2.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.0 GO:0031209 SCAR complex(GO:0031209)
0.1 5.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.8 GO:0071818 BAT3 complex(GO:0071818)
0.1 2.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 2.2 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 6.6 GO:0031985 Golgi cisterna(GO:0031985)
0.1 1.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 7.3 GO:0005871 kinesin complex(GO:0005871)
0.1 2.7 GO:0016605 PML body(GO:0016605)
0.1 1.6 GO:0060170 ciliary membrane(GO:0060170)
0.1 6.3 GO:0031965 nuclear membrane(GO:0031965)
0.1 1.7 GO:0000145 exocyst(GO:0000145)
0.0 4.7 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 5.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.2 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.5 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 15.2 GO:0045202 synapse(GO:0045202)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 1.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.1 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 14.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.6 GO:0070382 exocytic vesicle(GO:0070382)
0.0 2.0 GO:0016459 myosin complex(GO:0016459)
0.0 1.6 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 2.0 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 5.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 6.1 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.9 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0034185 apolipoprotein binding(GO:0034185)
2.1 14.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
2.1 6.4 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
1.3 5.1 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
1.0 4.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.9 6.2 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.8 4.2 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.8 3.9 GO:0004001 adenosine kinase activity(GO:0004001)
0.6 2.6 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.6 4.2 GO:0019809 spermidine binding(GO:0019809)
0.6 5.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.6 3.5 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.6 1.7 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.5 1.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 8.0 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.4 2.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.4 2.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 2.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 1.6 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.4 3.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.4 1.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.4 1.1 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.4 1.8 GO:0043295 glutathione binding(GO:0043295)
0.3 1.0 GO:1990715 mRNA CDS binding(GO:1990715)
0.3 2.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.3 1.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 3.5 GO:0035804 structural constituent of egg coat(GO:0035804)
0.3 2.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.3 3.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 6.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.3 1.0 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.2 2.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 1.1 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 2.3 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.2 1.0 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.2 0.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 2.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 0.8 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.2 0.9 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.2 1.1 GO:0032190 acrosin binding(GO:0032190)
0.2 1.6 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 5.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 1.2 GO:0016530 metallochaperone activity(GO:0016530)
0.2 0.5 GO:0042806 fucose binding(GO:0042806)
0.1 3.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.7 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 3.9 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 5.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 9.8 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.9 GO:0051018 protein kinase A binding(GO:0051018)
0.1 2.0 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 4.6 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 1.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.1 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 3.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 4.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 5.1 GO:0016247 channel regulator activity(GO:0016247)
0.0 0.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.5 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 1.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 2.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.7 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 4.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 4.6 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.4 GO:0070122 isopeptidase activity(GO:0070122)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.5 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 2.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 4.8 GO:0008017 microtubule binding(GO:0008017)
0.0 1.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.5 GO:0000149 SNARE binding(GO:0000149)
0.0 0.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 2.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.0 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 1.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0046966 vitamin D receptor binding(GO:0042809) thyroid hormone receptor binding(GO:0046966)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.6 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 2.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.0 PID ARF 3PATHWAY Arf1 pathway
0.1 2.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 1.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 1.5 SIG CHEMOTAXIS Genes related to chemotaxis
0.1 3.5 PID FGF PATHWAY FGF signaling pathway
0.1 1.4 PID REELIN PATHWAY Reelin signaling pathway
0.1 2.0 PID TNF PATHWAY TNF receptor signaling pathway
0.1 1.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 1.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.1 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 3.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.2 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.6 5.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.4 9.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.4 3.5 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.3 4.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 5.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 4.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 2.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.2 1.6 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 1.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 1.4 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 2.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.4 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.1 2.2 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 0.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.1 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 6.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 0.5 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 0.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.7 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.0 2.0 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 1.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import